Superfund Research Program
Title: Toxicokinetics and toxicodynamics of tetrachloroethylene in males of 45 Collaborative Cross strains of mice
Accession Number: Rusyn7
Link to Dataset: https://phenome.jax.org/projects/Rusyn7
Repository: Mouse Phenome Database (MPD)
Data Type(s): Genotype/Phenotype
Experiment Type(s): Phenotype measurements
Organism(s): Mus musculus
Summary: Male mice from 45 strains of the Collaborative Cross were orally administered a single dose of tetrachloroethylene (percholorethylene, PERC) or vehicle and euthanized at various time points to generate population-level concentration-time profiles for PERC and its primary oxidative metabolite trichloroacetate (TCA) across multiple tissues. Toxicodynamic phenotyping included study of the expression of CYPs and dysregulation of hepatic lipid metabolism.
Publication(s) associated with this dataset:- Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
- University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene