Superfund Research Program
Title: Impact of nonalcoholic fatty liver disease states on toxicokinetics of tetrachloroethylene exposure in C57BL/6J males
Accession Number: Rusyn9
Link to Dataset: https://phenome.jax.org/projects/Rusyn9
Repository: Mouse Phenome Database (MPD)
Data Type(s): Genotype/Phenotype
Experiment Type(s): Phenotype measurements
Organism(s): Mus musculus
Summary: The effect of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene (PERC) was examined in C57BL/6/J males. Mice were fed control (base diet; BD), high fat (HFD), or methionine/folate/choline-deficient (MCD) diets to model a healthy liver, steatosis, or nonalcoholic steatohepatitis, respectively. After 8 wks on the diets, mice were orally administered a single dose of PERC or vehicle and sacrificed at various time points. Levels of PERC and its oxidative and conjugative metabolites were measured in blood, liver, and fat.
Publication(s) associated with this dataset:- Cichocki JA, Furuya S, Konganti K, Luo Y, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2017. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther 361(1):17-28. doi:10.1124/jpet.116.238790 PMID:28148637 PMCID:PMC5363767
- University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene