Title: Impact of nonalcoholic fatty liver disease states on toxicokinetics of tetrachloroethylene exposure in C57BL/6J males

Accession Number: Rusyn9

Link to Dataset: https://phenome.jax.org/projects/Rusyn9

Repository: Mouse Phenome Database (MPD)

Data Type(s): Genotype/Phenotype

Experiment Type(s): Phenotype measurements

Organism(s): Mus musculus

Summary: The effect of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene (PERC) was examined in C57BL/6/J males. Mice were fed control (base diet; BD), high fat (HFD), or methionine/folate/choline-deficient (MCD) diets to model a healthy liver, steatosis, or nonalcoholic steatohepatitis, respectively. After 8 wks on the diets, mice were orally administered a single dose of PERC or vehicle and sacrificed at various time points. Levels of PERC and its oxidative and conjugative metabolites were measured in blood, liver, and fat.

Publication(s) associated with this dataset:

• Cichocki JA, Furuya S, Konganti K, Luo Y, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2017. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene in mice. J Pharmacol Exp Ther 361(1):17-28. doi:10.1124/jpet.116.238790 PMID:28148637 PMCID:PMC5363767

Project(s) associated with this dataset:

• University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene