Title: Expression data from fetal membranes

Accession Number: GSE96557

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96557

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Homo sapiens

Summary: Genome wide expression profiling was used to identify signifnificantly changed genes in fetal membranes after GBS treatment. Genome-wide expression profiles in GBS-inoculated human extraplacental membranes in vitro were used to identify transcriptomic pathways altered by GBS . Using bioinformatics analysis of these expression profiles we aimed to test our hypothesis that GBS activates pathways related to inflammation and premature birth in human extraplacental membranes.

Publication(s) associated with this dataset:

• Park H, Harris SM, Boldenow E, McEachin RC, Sartor MA, Chames MC, Loch-Caruso R. 2017. Group B streptococcus activates transcriptomic pathways related to premature birth in human extraplacental membranes in vitro. Biol Reprod 98(3):396-407. doi:10.1093/biolre/iox147 PMID:29155939 PMCID:PMC6248496

Project(s) associated with this dataset:

• Northeastern University: Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)
• Northeastern University: Toxicant-Stimulated Disruption of Gestational Tissues with Implications for Adverse Pregnancy Outcomes