Title: Microarray data from BM-MSCs exposed to DMSO, LG268, Rosi, TPhP, TBT, and MEHP

Accession Number: GSE119541

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119541

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Mus musculus

Summary: Primary mouse bone marrow mesenchymal stromal cells (BM-MSCs) cultured for bone differentiation were exposed to vehicle (DMSO), synthetic RXR ligand (LG100268), type 2 diabetes therapeutic and PPAR ligand (Rosiglitazone), and environmental PPAR ligands (Tributyltin, Triphenyl Phosphate, and MEHP) to evaluate differential gene expression as well as nuclear receptor expression and downstream PPARG target gene expression between all chemical exposures

Publication(s) associated with this dataset:

• Kim S, Li A, Monti S, Schlezinger JJ. 2018. Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 1-16. doi:10.1007/s00204-018-2268-y PMID:30027469

Project(s) associated with this dataset:

• Boston University: Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis
• Boston University: Bioinformatics and Molecular Modeling Core