Title: Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress

Accession Number: GSE118062

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118062

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Non-coding RNA profiling by high throughput sequencing

Organism(s): Fundulus heteroclitus

Summary: The Atlantic killifish (Fundulus heteroclitus), native to estuarine areas of the Atlantic coast of the United States, has become a valuable ecotoxicological model due to its ability to acclimate to rapid environmental changes and adapt to polluted habitats. Killifish respond to rapid increases in salinity with an immediate change in gene expression, as well as long-term remodeling of the gills. Arsenic, a major environmental toxicant, was previously shown to inhibit the ability of killifish gill to respond to a rapid increase in salinity. We characterized miRNA expression in killifish gill under salinity acclimation with and without arsenic and identified a small group of highly expressed, well-conserved miRNAs as well as 16 novel miRNAs not yet identified in other organisms.

Publication(s) associated with this dataset:

• Goodale BC, Hampton TH, Notch EG, Jackson CE, Shaw JR, Stanton BA, King BL. 2019. Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress. Aquat Toxicol 206:142-153. doi:10.1016/j.aquatox.2018.11.009 PMID:30476744 PMCID:PMC6298807

Project(s) associated with this dataset:

• Dartmouth College: Arsenic and Innate Immunity in Human Lung