Title: Comparison of gene expression profiles in chromate transformed BEAS-2B cells

Accession Number: GSE24025

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24025

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Summary: We established chromate transformed cell lines by chronic exposure of normal human bronchial epithelial BEAS-2B cells to low doses of hexavalent chromium followed by anchorage-independent growth. The gene expression profiles were analyzed in the established cell lines. The gene expression profiles from six chromate transformed cell lines were remarkably similar to each other yet differed significantly from that of either control cell line or normal Beas-2B cells. A total of 409 differentially expressed genes were identified in chromate transformed cells compared to control cells.

Publication(s) associated with this dataset:

• Sun H, Clancy HA, Kluz T, Zavadil J, Costa M. 2011. Comparison of gene expression profiles in chromate transformed BEAS-2B cells. PLoS One 6(3):1-13. doi:10.1371/journal.pone.0017982 PMID:21437242 PMCID:PMC3060877 (Completed with ARRA Funds)

Project(s) associated with this dataset:

• New York University School of Medicine: Carcinogenic Metals and Their Interactions With Other Toxicants (ARRA Funded)