Title: Benzo[a]pyrene and dibenzo[def,p]chrysene in 3D primary human bronchial epithelial cells [RNA-seq]

Accession Number: GSE128471

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE128471

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Homo sapiens

Summary: In this study, we assess potential differences in mechanism of action for two PAHs, benzo[a]pyrene (BAP) and dibenzo-[def,p]chrysene (DBC), in a primary human 3D bronchial epithelial culture (HBEC) model based on short-term biosignatures identified from global transcriptional profiling.

Publication(s) associated with this dataset:

• Chang Y, Huynh C, Bastin K, Rivera BN, Siddens LK, Tilton SC. 2020. Classifying polycyclic aromatic hydrocarbons by carcinogenic potency using in vitro biosignatures. Toxicol Vitro 69:doi:10.1016/j.tiv.2020.104991 PMID:32890658 PMCID:PMC7572825

• Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644 PMID:31255691 PMCID:PMC6708476

Project(s) associated with this dataset:

• Oregon State University: Data Management and Analysis Core
• Oregon State University: Predicting the Toxicity of Complex PAH Mixtures
• Oregon State University: Research Experience and Training Coordination Core
• Oregon State University: Linking PAH Exposure to Health Outcomes Using Human Primary In Vitro Respiratory Model