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Dataset Details (GSE186121)

Superfund Research Program

Title: Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays

Accession Number: GSE186121

Link to Dataset:

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Homo sapiens

Summary: Six human cell lines were treated in a log dose response to 141 petroleum substance extracts containing unknown or variable composition, complex reaction products and biological materials (UVCBs) to be used for grouping and read across strategies. The six cell lines consisted of human induced pluripotent stem cell (iPSC)-derived hepatocytes, cardiomyocytes, neurons, and endothelial cells, as well as the human MCF7 and A375 cell lines. All transcriptomics were targeted with BioSpyder S1500+ gene list.

Publication(s) associated with this dataset:
  • House JS, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogard PJ, Ketelslegers HB, Gant TW, Rusyn I, Wright FA, Grimm FA, Klaren WD. 2022. Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays. ALTEX doi:10.14573/altex.2107051 PMID:35288757
Project(s) associated with this dataset:
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