Title: Effect of lutein on worms lacking complex I subunit nuo-5 (ortholog of human NDUFS1)

Accession Number: GSE144574

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE144574

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by array

Organism(s): Caenorhabditis elegans

Summary: To gain insight into the pathways accounting for the deleterious effects associated with severe mitochondrial dysfunction, we compared the transcriptomic profile in control L3 larvae with that of strong (arrested) nuo-5 RNAi. We also found that the natural compound lutein was able to rescue some of the defective phenotypes we characterized in nuo-5-depleted animals therefore we compared also the transcriptomic profile of stage-matched (L3) cohorts of C. elegans upon strong nuo-5 RNAi, treated and untreated with lutein, with that of animals fed empty vector control.

Publication(s) associated with this dataset:

• Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N. 2022. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun doi:10.1038/s41467-022-29972-4 PMID:35551180 PMCID:PMC9098500

Project(s) associated with this dataset:

• Duke University: Persistent Mitochondrial and Epigenetic Effects of Early Life Toxicant Exposure