Superfund Research Program

September 2019

NIEHS grantees found that the Collaborative Cross (CC) mouse model - which uses genetically diverse mice to capture over 90 of the known mouse genetic variations can account for individual differences in susceptibility to environmental chemicals. Using the CC mouse model, researchers measured individual variability in kidney toxicity after exposure to tetrachloroethylene (PERC), a solvent frequently used in dry cleaning solutions, adhesives, and metal degreasers.

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