Superfund Research Program

March 2023

Paper of the Month or Year

Researchers at the University of North Carolina at Chapel Hill SRP Center uncovered complex interactions between exposure to arsenic, body weight and composition, and indicators of type 2 diabetes in Diversity Outbred (DO) mice. DO mice better capture the genetic diversity of human populations, which may help explain differences in susceptibility to arsenic-induced disease.

According to the authors, this study is the first to use genetically diverse DO mice to reveal significant interactive effects between body composition and arsenic exposure that related to higher type 2 diabetes indicators. More research is needed to better understand and quantify these complex associations in larger populations, the team noted.

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