Superfund Research Program
Project Leader: Stephen H. Safe
Grant Number: P42ES004917
Funding Period: 1995 - 2000
Project Summary (1995-2000)
Development of toxic equivalency factors (TEFs) for halogenated aromatic hydrocarbons (HAHs) using different in vivo and in vitro bioassays and application of the results for risk assessment are the primary goals of this project. The non-additive interactive effects of mixtures containing polychlorinated biphenyls (PCBs) are reevaluated in order to determine the relevance of the TEF approach for HAHs. Therefore, selected PCB congeners and mixtures are used to determine the response and target organ-specific non-additive interactions using different animal models, cells, and responses.