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Search Results for Most Frequently Published Journals (Superfund Research Program)
Superfund Research Program
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Toxicological Sciences : An Official Journal of the Society of Toxicology (383 articles)
2022
Johnson KJ, Auerbach SS, Stevens T, Barton-Maclaren TS, Costa E, Currie RA, Wilk DD, Haq S, Rager JE, Reardon AJ, Wehmas L, Williams A, O'Brien J, Yauk C, LaRocca JL, Pettit S. 2022. A transformative vision for an omics-based regulatory chemical testing paradigm. Toxicol Sci 190(2):127-132. doi:10.1093/toxsci/kfac097PMID:36165699PMCID:PMC9702989
Nault R, Saha S, Bhattacharya S, Sinha S, Maiti T, Zacharewski TR. 2022. Single cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice. Toxicol Sci doi:10.1093/toxsci/kfac109PMID:36222588
Rusyn I, Chiu WA. 2022. Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data. Toxicol Sci doi:10.1093/toxsci/kfac033PMID:35404442
Sakolish C, Georgescu A, Huh DD, Rusyn I. 2022. A model of human small airway on a chip for studies of subacute effects of inhalation toxicants. Toxicol Sci 187(2):267-278. doi:10.1093/toxsci/kfac036PMID:35357501
Scieszka D, Hunter R, Begay J, Bitsui M, Lin Y, Galewsky J, Morishita M, Klaver Z, Wagner JG, Harkema JR, Herbert G, Lucas S, McVeigh C, Bolt AM, Bleske B, Canal CG, Mostovenko E, Ottens AK, Gu H, Campen M, Noor S. 2022. Neuroinflammatory and neurometabolomic consequences from inhaled wildfire smoke-derived particulate matter in the western United States. Toxicol Sci 186(1):doi:10.1093/toxsci/kfab147PMID:34865172PMCID:PMC8883349
Shankar P, Garcia GR, La Du JK, Sullivan CM, Dunham CL, Goodale BC, Waters KM, Stanisheuski S, Maier C, Thunga P, Reif DM, Tanguay RL. 2022. The Ahr2-Dependent wfikkn1 gene influences zebrafish transcriptome, proteome, and behavior. Toxicol Sci doi:10.1093/toxsci/kfac037PMID:35377459
Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119PMID:34668566PMCID:PMC8714366
2021
Buchholz BA, Ahn K, Huang H, Gee SJ, Stewart BJ, Ognibene T, Hammock BD. 2021. Pharmacokinetics, metabolite measurement, and biomarker identification of dermal exposure to permethrin using accelerator mass spectrometry. Toxicol Sci 183:49-59. doi:10.1093/toxsci/kfab082PMID:34460930PMCID:PMC8404990
Chen Z, Lloyd D, Zhou Y, Chiu WA, Wright FA, Rusyn I. 2021. Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon (PAH) concentrations data. Toxicol Sci 179(1):108-120. doi:10.1093/toxsci/kfaa166PMID:33165562PMCID:PMC7797768
Clark J, Avula V, Ring C, Eaves LA, Howard T, Santos HP, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2021. Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicol Sci 183(2):269-284. doi:10.1093/toxsci/kfab089PMID:34255065PMCID:PMC8478332
Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2021. Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice. Toxicol Sci 182(2):doi:10.1093/toxsci/kfab057PMID:33988684 (ahead of print)
Lin L, Denison MS, Rice RH. 2021. Woodsmoke extracts cross-link proteins and induce cornified envelope formation without stimulating keratinocyte terminal differentiation. Toxicol Sci 183(1):PMID:34086961
Pfohl M, Marques E, Auclair A, Barlock BJ, Jamwal R, Goedken M, Akhlaghi F, Slitt AL. 2021. An 'omics approach to unraveling the paradoxical effect of diet on perfluorooctanesulfonic acid (PFOS) and perfluorononanoic acid (PFNA)-induced hepatic steatosis. Toxicol Sci 180:277-294. doi:10.1093/toxsci/kfaa172PMID:33483757PMCID:PMC8041463
Salter DM, Wei W, Nahar PP, Marques E, Slitt AL. 2021. Perfluorooctanesulfonic acid (PFOS) thwarts the beneficial effects of calorie restriction and Metformin. Toxicol Sci 182(1):doi:10.1093/toxsci/kfab043PMID:33844015 (ahead of print)
Slotkin TA, Levin ED, Seidler FJ. 2021. Paternal cannabis exposure prior to mating, but not 9-tetrahydrocannabinol, elicits deficits in dopaminergic synaptic activity in the offspring. Toxicol Sci 184(2):doi:10.1093/toxsci/kfab117PMID:34590702
Speer RM, Toyoda JH, Croom-Perez TJ, Liu K, Wise Sr. JP. 2021. Particulate hexavalent chromium inhibits E2F1 leading to reduced RAD51 nuclear foci formation in human lung cells. Toxicol Sci 181(1):35-46. doi:10.1093/toxsci/kfab019PMID:33677506PMCID:PMC8081024
Valdiviezo A, Luo Y, Chen Z, Chiu WA, Rusyn I. 2021. Quantitative in vitro-to-in vivo extrapolation for mixtures: A case study of Superfund priority list pesticides. Toxicol Sci 183(1):doi:10.1093/toxsci/kfab076PMID:34142158 (ahead of print)
Zelko I, Dassanayaka S, Malovichko MV, Howard CM, Garrett LF, Uchida S, Brittian KR, Conklin DJ, Jones SP, Srivastava S. 2021. Chronic benzene exposure aggravates pressure overload-induced cardiac dysfunction. Toxicol Sci 185(1):64-76. doi:10.1093/toxsci/kfab125PMID:34718823PMCID:PMC8714365
2020
Blanchette A, Burnett SD, Grimm FA, Rusyn I, Chiu WA. 2020. A Bayesian method for population-wide cardiotoxicity hazard and risk characterization using an in vitro human model. Toxicol Sci 178(2):391-403. doi:10.1093/toxsci/kfaa151PMID:33078833PMCID:PMC7751158
Garland MA, Geier MC, Bugel SM, Shankar P, Dunham CL, Brown JM, Tilton SC, Tanguay RL. 2020. Aryl hydrocarbon receptor mediates larval zebrafish fin duplication following exposure to benzofluoranthenes. Toxicol Sci 176:46-64. doi:10.1093/toxsci/kfaa063PMID:32384158PMCID:PMC7357178
Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. 2020. Polycyclic aromatic hydrocarbon-induced pulmonary carcinogenesis in cytochrome P450 (CYP)1A1-and 1A2-null mice: roles of CYP1A1 and CYP1A2. Toxicol Sci 177:347-361. doi:10.1093/toxsci/kfaa107PMID:32726451
Hsu KS, Goodale BC, Ely KH, Hampton TH, Stanton BA, Enelow RI. 2020. Single-cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection. Toxicol Sci 176:312-328. doi:10.1093/toxsci/kfaa080PMID:32514536PMCID:PMC7416320
Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090PMID:32544245PMCID:PMC7553702
Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007PMID:32040194
Pfohl M, Ingram L, Marques E, Auclair A, Barlock BJ, Jamwal R, Anderson D, Cummings BS, Slitt AL. 2020. Perfluorooctanesulfonic acid and perfluorohexanesulfonic acid alter the blood lipidome and the hepatic proteome in a murine model of diet-induced obesity. Toxicol Sci 178:311-324. doi:10.1093/toxsci/kfaa148PMID:32991729PMCID:PMC7751193
Rusyn I, Chiu WA, Wright FA. 2020. Questioning existing cancer hazard evaluation standards in the name of statistics. Toxicol Sci 177:521-522. doi:10.1093/toxsci/kfaa077PMID:32462183
Truong KM, Feng W, Pessah IN. 2020. Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity. Toxicol Sci 178:159-172. doi:10.1093/toxsci/kfaa139PMID:32894766
Wang H, Matsushita MT, Zhang L, Abel GM, Mommer BC, Huddy T, Storm D, Xia Z. 2020. Inducible and conditional stimulation of adult hippocampal neurogenesis rescues Cadmium-induced impairments of adult hippocampal neurogenesis and hippocampus-dependent memory in mice. Toxicol Sci 177:263-280. doi:10.1093/toxsci/kfaa104PMID:32617577PMCID:PMC7553705
Williams AE, Watt J, Robertson LW, Gadupudi GS, Osborn ML, Soares M, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti N, Suva LJ, Ronis M. 2020. Skeletal toxicity of coplanar polychlorinated biphenyl congener 126 in the rat is aryl hydrocarbon receptor dependent. Toxicol Sci 175:113-125. doi:10.1093/toxsci/kfaa030PMID:32119087PMCID:PMC7197949
Alves VM, Borba J, Capuzzi SJ, Muratov EN, Andrade CH, Rusyn I, Tropsha A. 2019. Oy vey! A comment on machine learning of toxicological big data enables read-across structure activity relationships outperforming animal test reproducibility. Toxicol Sci 167:3-4. doi:10.1093/toxsci/kfy286PMID:30500930PMCID:PMC6317419
Ash P, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna L, Boomhower S, Newland MC, Sherr DH, Wolozin B. 2019. Heavy metal neurotoxicants induce ALS-linked TDP-43 pathology. Toxicol Sci 167(1):105-115. doi:10.1093/toxsci/kfy267PMID:30371865PMCID:PMC6317426
Hagstrom D, Truong L, Zhang S, Tanguay RL, Collins ES. 2019. Comparative analysis of zebrafish and planarian model systems for developmental neurotoxicity screens using an 87-compound library. Toxicol Sci 167(1):15-25. doi:10.1093/toxsci/kfy180PMID:30011007PMCID:PMC6317421
Salanga MC, Brun NR, Francolini RD, Stegeman JJ, Goldstone JV. 2019. CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cyp3a65 in zebrafish. Toxicol Sci 174:51-62. doi:10.1093/toxsci/kfz246PMID:31868891PMCID:PMC7043230
Slotkin TA, Skavicus S, Ko A, Levin ED, Seidler FJ. 2019. The developmental neurotoxicity of tobacco smoke can be mimicked by a combination of nicotine and benzo[a]pyrene: effects on cholinergic and serotonergic systems. Toxicol Sci 168:280. doi:10.1093/toxsci/kfy304PMID:30247698PMCID:PMC6681680
Sobh A, Loguinov AV, Stornetta A, Balbo S, Tagmount A, Zhang L, Vulpe CD. 2019. Genome-wide CRISPR screening identifies the tumor suppressor candidate OVCA2 as a determinant of tolerance to acetaldehyde. Toxicol Sci 169:235-245. doi:10.1093/toxsci/kfz037PMID:31059574PMCID:PMC6484886
Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN, Boekelheide K. 2019. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Toxicol Sci 167:546-558. doi:10.1093/toxsci/kfy260PMID:30329139PMCID:PMC6358251
Spade DJ, Hall SJ, Wortzel J, Reyes G, Boekelheide K. 2019. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Toxicol Sci 168(1):149-159. doi:10.1093/toxsci/kfy283PMID:30476341PMCID:PMC6390659
Stermer A, Reyes G, Hall SJ, Boekelheide K. 2019. Small RNAs in rat sperm are a predictive and sensitive biomarker of exposure to the testicular toxicant ethylene glycol monomethyl ether. Toxicol Sci 169(2):399-408. doi:10.1093/toxsci/kfz041PMID:30768127PMCID:PMC6934889
Truong KM, Cherednichenko G, Pessah IN. 2019. Interactions of Dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) with skeletal muscle ryanodine receptor type 1. Toxicol Sci 170(2):50-524. doi:10.1093/toxsci/kfz120PMID:31127943PMCID:PMC6657572
Truong KM, Pessah IN. 2019. Comparison of chlorantraniliprole and flubendiamide activity toward wild-type and malignant hyperthermia-susceptible ryanodine receptors and heat stress intolerance. Toxicol Sci 167(2):509-523. doi:10.1093/toxsci/kfy256PMID:30329129PMCID:PMC6358238
Wahlang B, Hardesty JE, Head KZ, Jin J, Falkner K, Prough RA, Cave MC, Beier JI. 2019. Hepatic injury caused by the environmental toxicant vinyl chloride is sex-dependent in mice. Toxicol Sci 174(1):79-91. doi:10.1093/toxsci/kfz236PMID:31774537PMCID:PMC7043220
Wang H, Abel GM, Storm D, Xia Z. 2019. Cadmium exposure impairs adult hippocampal neurogenesis. Toxicol Sci 171:501-514. doi:10.1093/toxsci/kfz152PMID:31271426
Watson AT, Nordberg RC, Loboa EG, Kullman SW. 2019. Evidence for aryl hydrocarbon receptor-mediated inhibition of osteoblast differentiation in human mesenchymal stem cells. Toxicol Sci 167(1):145-156. doi:10.1093/toxsci/kfy225PMID:30203000PMCID:PMC6317429
Zhang L, Wang H, Abel GM, Storm D, Xia Z. 2019. The effects of gene-environment interactions between cadmium exposure and apolipoprotein E4 on memory in a mouse model of alzheimer's disease. Toxicol Sci 173(1):189-201. doi:10.1093/toxsci/kfz218PMID:31626305
2018
Caito SW, Jackson BP, Punshon T, Scrimale T, Grier A, Gill SR, Love TM, Watson GE, van Wijngaarden E, Rand MD. 2018. Variation in methylmercury metabolism and elimination status in humans following fish consumption. Toxicol Sci 161:443-453. doi:10.1093/toxsci/kfx226PMID:29145616PMCID:PMC5837402
Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208PMID:30496569PMCID:PMC6260149
Cichocki JA, Luo Y, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. 2018. Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice. Toxicol Sci 167(1):126-137. doi:10.1093/toxsci/kfy223PMID:30202895PMCID:PMC6317418
Clair HB, Pinkston CM, Rai SN, Pavuk M, Dutton ND, Brock GN, Prough RA, Falkner KC, McClain CJ, Cave MC. 2018. Liver disease in a residential cohort with elevated polychlorinated biphenyl exposures. Toxicol Sci 164:39-49. doi:10.1093/toxsci/kfy076PMID:29684222PMCID:PMC6016643
Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. 2018. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci 163:440-453. doi:10.1093/toxsci/kfy041PMID:29474705PMCID:PMC5974782
Glazer L, Hawkey AB, Wells C, Drastal M, Odamah K, Behl M, Levin ED. 2018. Developmental exposure to low concentrations of organophosphate flame retardants causes life-long behavioral alterations in zebrafish. Toxicol Sci 165(2):487-498. doi:10.1093/toxsci/kfy173PMID:29982741PMCID:PMC6154272
Hardesty JE, Al-Eryani L, Wahlang B, Falkner KC, Shi H, Jin J, Vivace BJ, Ceresa BP, Prough RA, Cave MC. 2018. Epidermal growth factor receptor signaling disruption by endocrine and metabolic disrupting chemicals. Toxicol Sci 162:622-634. doi:10.1093/toxsci/kfy004PMID:29329451PMCID:PMC5888991
Kollitz EM, De Carbonnel L, Stapleton HM, Ferguson PL. 2018. The affinity of brominated phenolic compounds for human and zebrafish thyroid receptor beta: Influence of chemical structure. Toxicol Sci doi:10.1093/toxsci/kfy028PMID:29409039
Lille-Langoy R, Karlsen OA, Myklebust LM, Goldstone JV, Mork-Jansson A, Male R, Blumberg B, Stegeman JJ, Goksoyr A. 2018. Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci 168:28-39. doi:10.1093/toxsci/kfy269PMID:30371853PMCID:PMC6390661
Luo Y, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I. 2018. Metabolism and toxicity of trichloroethylene and tetrachloroethylene in cytochrome P450 2E1 knockout and humanized transgenic mice. Toxicol Sci doi:10.1093/toxsci/kfy099PMID:29897530
Petriello MC, Brandon JA, Hoffman JB, Wang C, Tripathi H, Abdel-Latif A, Ye X, Li X, Yang L, Lee EY, Soman S, Barney J, Wahlang B, Hennig B, Morris AJ. 2018. Dioxin-like PCB 126 increases systemic inflammation and accelerates atherosclerosis in lean LDL receptor-deficient mice. Toxicol Sci 162(2):548-558. doi:10.1093/toxsci/kfx275PMID:29216392PMCID:PMC5888982
Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161:276-284. doi:10.1093/toxsci/kfx196PMID:29378069
Ulin A, Henderson J, Pham MT, Meyo J, Chen Y, Karchner SI, Goldstone JV, Hahn ME, Williams LM. 2018. Developmental regulation of nuclear factor erythroid-2 related factors (nrfs) by AHR1b in zebrafish (Danio rerio). Toxicol Sci 167(2):536-545. doi:10.1093/toxsci/kfy257PMID:30321412PMCID:PMC6358246
Zhou J, Henriquez J, Crawford RB, Kaminski NE. 2018. Suppression of the IgM response by aryl hydrocarbon receptor activation in human primary B cells involves impairment of immunoglobulin secretory processes. Toxicol Sci 163(1):doi:10.1093/toxsci/kfy036PMID:29462421 (ahead of print)
Zhou J, Zhang Q, Henriquez J, Crawford RB, Kaminski NE. 2018. Lymphocyte-specific protein tyrosine kinase (LCK) is involved in the aryl hydrocarbon receptor-mediated impairment of immunoglobulin secretion in human primary B cells. Toxicol Sci 165(2):322-334. doi:10.1093/toxsci/kfy133PMID:29860352
Zychowski KE, Kodali V, Harmon M, Tyler CR, Sanchez B, Suarez YO, Herbert G, Wheeler A, Avasarala S, Cerrato JM, Kunda NK, Muttil P, Shuey CL, Brearley AJ, Ali AS, Lin Y, Shoeb M, Erdely A, Campen M. 2018. Respirable Uranyl-Vanadate-Containing Particulate Matter Derived From a Legacy Uranium Mine Site Exhibits Potentiated Cardiopulmonary Toxicity. Toxicol Sci 164:101-114. doi:10.1093/toxsci/kfy064PMID:29660078PMCID:PMC6016706
2017
Chen H, Streifel KM, Singh V, Yang DR, Mangini L, Wulff H, Lein PJ. 2017. BDE-47 and BDE-49 inhibit axonal growth in primary hippocampal neuron-glia co-cultures via ryanodine receptor-dependent mechanisms. Toxicol Sci 156:375-386. doi:10.1093/toxsci/kfw259PMID:28003438
Chlebowski A, Garcia GR, La Du JK, Bisson WH, Simonich SL, Tanguay RL. 2017. Mechanistic investigations into the developmental toxicity of nitrated and heterocyclic PAHs. Toxicol Sci 157(1):246-259. doi:10.1093/toxsci/kfx035PMID:28186253PMCID:PMC5414855
De La Rosa VY, Asfaha J, Fasullo M, Loguinov AV, Li P, Moore LE, Rothman N, Nakamura J, Swenberg JA, Scelo G, Zhang L, Smith MT, Vulpe CD. 2017. Editor's highlight: High-throughput functional genomics identifies modulators of TCE metabolite genotoxicity and candidate susceptibility genes. Toxicol Sci 160:111-120. doi:10.1093/toxsci/kfx159PMID:28973557PMCID:PMC5837773
Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189PMID:27655348PMCID:PMC5216651
Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071PMID:28431184PMCID:PMC6070089
Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100PMID:28510766PMCID:PMC5837364
Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065PMID:28369613
Wahlang B, Barney J, Thompson B, Wang C, Hamad OM, Hoffman JB, Petriello MC, Morris AJ, Hennig B. 2017. Editors highlight: PCB126 exposure increases risk for peripheral vascular diseases in a liver injury mouse model. Toxicol Sci 160:256-267. doi:10.1093/toxsci/kfx180PMID:28973532PMCID:PMC5837513
Wittwehr C, Aladjov H, Ankley GT, Byrne H, de Knecht J, Heinzle E, Klambauer G, Landesmann b, Luijten M, MacKay C, Maxwell G, Meek MB, Paini A, Perkins EJ, Sobanski T, Villeneuve DL, Waters KM, Whelan M. 2017. How adverse outcome pathways can aid the development and use of computational prediction models for regulatory toxicology. Toxicol Sci 155(2):326-336. doi:10.1093/toxsci/kfw207PMID:27994170PMCID:PMC5340205
Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165PMID:28973375PMCID:PMC5837274
2016
Bolt AM, Grant MP, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann KK. 2016. Tungsten promotes sex-specific adipogenesis in the bone by altering differentiation of bone marrow-resident mesenchymal stromal cells. Toxicol Sci 150(2):333-346. doi:10.1093/toxsci/kfw008PMID:26865663PMCID:PMC4900133
Dere E, Wilson SK, Anderson LM, Boekelheide K. 2016. From the cover: sperm molecular biomarkers are sensitive indicators of testicular injury following subchronic model toxicant exposure. Toxicol Sci 153(2):327-340. doi:10.1093/toxsci/kfw137PMID:27466211PMCID:PMC5036622
Dornbos P, Crawford RB, Kaminski NE, Hession SL, LaPres JJ. 2016. The influence of human interindividual variability on the low-dose region of dose-response curve induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary B cells. Toxicol Sci 153(2):352-360. doi:10.1093/toxsci/kfw128PMID:27473338PMCID:PMC5036619
Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. 2016. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci 149(1):98-110. doi:10.1093/toxsci/kfv215PMID:26396156PMCID:PMC4731404
Luz AL, Godebo TR, Bhatt DP, Ilkayeva OR, Maurer LL, Hirschey MD, Meyer JN. 2016. From the cover: arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans. Toxicol Sci 152(2):349-362. doi:10.1093/toxsci/kfw093PMID:27208080PMCID:PMC4960910
Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J, Zacharewski TR. 2016. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicol Sci 154(2):253-266. doi:10.1093/toxsci/kfw163PMID:27562557PMCID:PMC5139066
Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY, Zacharewski TR. 2016. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 149(2):358-371. doi:10.1093/toxsci/kfv245PMID:26582802PMCID:PMC4900217
Nault R, Fader KA, Kopec AK, Harkema JR, Zacharewski TR, Luyendyk J. 2016. From the cover: coagulation-driven hepatic fibrosis requires protease activated receptor-1 (PAR-1) in a mouse model of TCDD-elicited steatohepatitis. Toxicol Sci 154(2):381-391. doi:10.1093/toxsci/kfw175PMID:27613713PMCID:PMC5139072
Rand MD, Vorojeikina D, van Wijngaarden E, Jackson BP, Scrimale T, Zareba G, Love TM, Myers GJ, Watson GE. 2016. Methods for individualized determination of methylmercury elimination rate and de-methylation status in humans following fish consumption. Toxicol Sci 149(2):385-395. doi:10.1093/toxsci/kfv241PMID:26572661PMCID:PMC4757939
Shen H, McHale CM, Haider SI, Jung C, Zhang S, Smith MT, Zhang L. 2016. Identification of genes that modulate susceptibility to formaldehyde and imatinib by functional genomic screening in human haploid KBM7 cells. Toxicol Sci 151(1):10-22. doi:10.1093/toxsci/kfw032PMID:27008852PMCID:PMC4914802
Wang B, Klaren WD, Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status, and MnSOD in the rat. Toxicol Sci 150(1):15-26. doi:10.1093/toxsci/kfv312PMID:26660635PMCID:PMC5009614
Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP. 2016. Olfactory transcriptional analysis of salmon exposed to mixtures of chlorpyrifos and malathion reveal novel molecular pathways of neurobehavioral injury. Toxicol Sci 149(1):145-157. doi:10.1093/toxsci/kfv223PMID:26494550PMCID:PMC4731405
Williams CR, MacDonald JW, Bammler TK, Simpson C, Paulsen M, Gallagher EP. 2016. From the cover: cadmium exposure differentially alters odorant-driven behaviors and expression of olfactory receptors in juvenile Coho salmon (Oncorhynchus kisutch). Toxicol Sci 154(2):267-277. doi:10.1093/toxsci/kfw172PMID:27621283PMCID:PMC5139070
Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084PMID:27208083PMCID:PMC4960907
Xu X, Drobna Z, Voruganti VS, Barron K, Gonzalez-Horta C, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ceron RH, Morales DV, Baeza Terrazas FA, Ishida MC, Gutierrez-Torres DS, Saunders RJ, Crandell J, Fry RC, Loomis D, Garcia-Vargas G, Del Razo LM, Styblo M, Mendez MA. 2016. Association between variants in arsenic (+3 oxidation state) methyltranserase (AS3MT) and urinary metabolites of inorganic arsenic: role of exposure level. Toxicol Sci 153(1):112-123. doi:10.1093/toxsci/kfw112PMID:27370415PMCID:PMC5808745
2015
Anderson DS, Patchin ES, Silva RM, Uyeminami DL, Sharmah A, Guo T, Das GK, Brown JM, Shannahan JH, Gordon T, Chen L, Pinkerton KE, Van Winkle LS. 2015. Influence of particle size on persistence and clearance of aerosolized silver nanoparticles in the rat lung. Toxicol Sci 144(2):366-381. doi:10.1093/toxsci/kfv005PMID:25577195PMCID:PMC4372666
Fader KA, Nault R, Ammendolia DA, Harkema JR, Williams KJ, Crawford RB, Kaminski NE, Potter D, Sharratt B, Zacharewski TR. 2015. 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters lipid metabolism and depletes immune cell populations in the jejunum of C57BL/6 mice. Toxicol Sci 148(2):567-580. doi:10.1093/toxsci/kfv206PMID:26377647PMCID:PMC5009443
Goodale BC, La Du JK, Tilton SC, Sullivan CM, Bisson WH, Waters KM, Tanguay RL. 2015. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs. Toxicol Sci 147(2):397-411. doi:10.1093/toxsci/kfv139PMID:26141390PMCID:PMC4612346
Jayasundara N, Garner LV, Meyer JN, Erwin K, Di Giulio RT. 2015. AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Toxicol Sci 143(2):469-481. doi:10.1093/toxsci/kfu245PMID:25412620PMCID:PMC4306723
Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ. 2015. Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143(2):398-407. doi:10.1093/toxsci/kfu240PMID:25424564PMCID:PMC4306721
Martin EA, Gonzalez-Horta C, Rager JE, Bailey KA, Sanchez-Ramirez B, Ballinas-Casarrubias L, Ishida MC, Gutierrez-Torres DS, Ceron RH, Morales DV, Baeza Terrazas FA, Saunders RJ, Drobna Z, Mendez MA, Buse JB, Loomis D, Jia W, Garcia-Vargas GG, Del Razo LM, Styblo M, Fry RC. 2015. Metabolomic characteristics of arsenic-associated diabetes in a prospective cohort in Chihuahua, Mexico. Toxicol Sci 144(2):338-346. doi:10.1093/toxsci/kfu318PMID:25577196PMCID:PMC4372663
Noyes PD, Haggard DE, Gonnerman GD, Tanguay RL. 2015. Advanced morphological - behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants. Toxicol Sci 145(1):177-195. doi:10.1093/toxsci/kfv044PMID:25711236PMCID:PMC4408965
Phadnis AS, Crawford RB, Kaminski NE. 2015. Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6. Toxicol Sci 144(1):39-50. doi:10.1093/toxsci/kfu257PMID:25543051PMCID:PMC4349138
Rojas D, Rager JE, Smeester L, Bailey KA, Drobna Z, Rubio-Andrade M, Styblo M, Garcia-Vargas GG, Fry RC. 2015. Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci 143(1):97-106. doi:10.1093/toxsci/kfu210PMID:25304211PMCID:PMC4274382
Tilton SC, Siddens LK, Krueger SK, Larkin A, Lohr CV, Williams DE, Baird WM, Waters KM. 2015. Mechanism-based classification of PAH mixtures to predict carcinogenic potential. Toxicol Sci 146(1):135-145. doi:10.1093/toxsci/kfv080PMID:25908611PMCID:PMC4476464
Van Winkle LS, Bein KJ, Anderson DS, Pinkerton KE, Tablin F, Wilson D, Wexler AS. 2015. Biological dose response to PM25: effect of particle extraction method on platelet and lung responses. Toxicol Sci 143(2):349-359. doi:10.1093/toxsci/kfu230PMID:25389146PMCID:PMC4306718
Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar WM, Sweet S, Knap A, Wade TL, Campbell J, Clewell H, Melnyk SB, Chiu WA, Rusyn I. 2015. The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene. Toxicol Sci 147(2):339-349. doi:10.1093/toxsci/kfv134PMID:26136231PMCID:PMC4598794
Yu R, Lai Y, Hartwell HJ, Moeller BC, Doyle-Eisele M, Bodnar WM, Starr TB, Swenberg JA. 2015. Formation, accumulation, and hydrolysis of endogenous and exogenous formaldehyde-induced DNA damage. Toxicol Sci 146(1):170-182. doi:10.1093/toxsci/kfv079PMID:25904104PMCID:PMC4476463
Zhang Q, Bhattacharya S, Clewell RA, Carmichael PL, Andersen ME. 2015. Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment. Toxicol Sci 147(2):302-316. doi:10.1093/toxsci/kfv130PMID:26408567PMCID:PMC4707198
2014
Bailey KA, Laine JE, Rager JE, Sebastian E, Olshan A, Smeester L, Drobna Z, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Fry RC. 2014. Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci 139(2):328-337. doi:10.1093/toxsci/kfu053PMID:24675094PMCID:PMC4031624
Cole TB, Li WF, Co AL, Hay AM, MacDonald JW, Bammler TK, Farin FM, Costa LG, Furlong CE. 2014. Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1) modulated effects in maternal and fetal tissues. Toxicol Sci 141(2):409-422. doi:10.1093/toxsci/kfu144PMID:25070982PMCID:PMC4271046
DeGroot DE, Denison MS. 2014. Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor: ARNT complex is unaffected by Ligand structure. Toxicol Sci 137(1):102-113. doi:10.1093/toxsci/kft234PMID:24136190PMCID:PMC3924043
Dominguez GA, Bisesi JH, Kroll KJ, Denslow ND, Sabo-Attwood TL. 2014. Control of transcriptional repression of the vitellogenin receptor gene in largemouth bass (Micropterus salmoides) by select estrogen receptors isotypes. Toxicol Sci 141(2):423-431. doi:10.1093/toxsci/kfu145PMID:25061109PMCID:PMC4271047
Peluso M, Munnia A, Bollati V, Srivatanakul P, Jedpiyawongse A, Sangrajrang S, Ceppi M, Giese RW, Boffetta P, Baccarelli A. 2014. Aberrant methylation of hypermethylated-in-cancer-1 and exocyclic DNA adducts in tobacco smokers. Toxicol Sci 137(1):47-54. doi:10.1093/toxsci/kft241PMID:24154486PMCID:PMC3871933
Rager JE, Moeller BC, Miller SK, Kracko D, Doyle-Eisele M, Swenberg JA, Fry RC. 2014. Formaldehyde-associated changes in microRNAs: tissue and temporal specificity in the rat nose, white blood cells, and bone marrow. Toxicol Sci 138(1):36-46. doi:10.1093/toxsci/kft267PMID:24304932PMCID:PMC3930361
Rider CV, Boekelheide K, Catlin NR, Gordon CJ, Morata T, Selgrade MK, Sexton K, Simmons JE. 2014. Cumulative risk: toxicity and interactions of physical and chemical stressors. Toxicol Sci 137(1):3-11. doi:10.1093/toxsci/kft228PMID:24154487PMCID:PMC3871930
Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PS, Lehmler H, Negishi M, Birnbaum LS. 2014. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137(2):292-302. doi:10.1093/toxsci/kft243PMID:24218150PMCID:PMC3908718
Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334PMID:24385416PMCID:PMC4007107
Crowell SR, Sharma AK, Amin S, Soelberg JJ, Sadler NC, Wright AT, Baird WM, Williams DE, Corley RA. 2013. Impact of pregnancy on the pharmacokinetics of dibenzo[def,p]chrysene in mice. Toxicol Sci 135(1):48-62. doi:10.1093/toxsci/kft124PMID:23744095PMCID:PMC3748759
Dere E, Anderson LM, Coulson M, McIntyre BS, Boekelheide K, Chapin RE. 2013. SOT symposium highlight: translatable indicators of testicular toxicity: inhibin B, microRNAs, and sperm signatures. Toxicol Sci 136(2):265-273. doi:10.1093/toxsci/kft207PMID:24052563PMCID:PMC3858194
Forgacs AL, Dere E, Angrish MM, Zacharewski TR. 2013. Comparative analysis of temporal and dose-dependent TCDD-elicited gene expression in human, mouse, and rat primary hepatocytes. Toxicol Sci 133(1):54-66. doi:10.1093/toxsci/kft028PMID:23418086PMCID:PMC3627554
Green SE, Luczak MW, Morse JL, DeLoughery Z, Zhitkovich A. 2013. Uptake, p53 pathway activation, and cytotoxic responses for Co(II) and Ni(II) in human lung cells: implications for carcinogenicity. Toxicol Sci 136:467-477. doi:10.1093/toxsci/kft214PMID:24068677PMCID:PMC3858198
Kopec AK, Boverhof DR, Nault R, Harkema JR, Tashiro C, Potter D, Sharratt B, Chittim B, Zacharewski TR. 2013. Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 135(2):465-475. doi:10.1093/toxsci/kft156PMID:23864506PMCID:PMC3807621
Moeller BC, Recio L, Green A, Sun W, Wright FA, Bodnar WM, Swenberg JA. 2013. Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure. Toxicol Sci 133(1):1-12. doi:10.1093/toxsci/kft029PMID:23425604PMCID:PMC3627555
Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler H, Pessah IN. 2013. Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. Toxicol Sci 136(2):500-513. doi:10.1093/toxsci/kft202PMID:24014653PMCID:PMC3858193
Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, Appel KE, Buchmann A, Robertson LW, Lehmler H, Kania-Korwel I, Chahoud I, Schwarz M. 2013. Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci 133(1):29-41. doi:10.1093/toxsci/kft034PMID:23457121PMCID:PMC3627557
Sherwood CL, Lantz RC, Boitano S. 2013. Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells. Toxicol Sci 132:222-234. doi:10.1093/toxsci/kfs331PMID:23204110PMCID:PMC3576008
Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymoniak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. 2013. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci 132(1):53-63. doi:10.1093/toxsci/kfs342PMID:23288052PMCID:PMC3576012
Yang J, Solaimani P, Dong H, Hammock BD, Hankinson O. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. Toxicol Sci 38(6):833-836. PMID:24213002PMCID:PMC4068614
Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186PMID:23997111PMCID:PMC3829572
2012
Benninghoff AD, Orner GA, Buchner CH, Hendricks JD, Duffy AM, Williams DE. 2012. Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout. Toxicol Sci 125(1):69-78. doi:10.1093/toxsci/kfr267PMID:21984479PMCID:PMC3243748
Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244PMID:22889812PMCID:PMC3529644
Guo L, Ghassemian M, Komives EA, Russell P. 2012. Cadmium-induced proteome remodeling regulated by Spc I/Sty I and Zip I in fission yeast. Toxicol Sci 129(1):200-212. doi:10.1093/toxsci/kfs179PMID:22610605PMCID:PMC3713068
Jung D, MacIver B, Jackson BP, Barnaby R, Sato J, Zeidel ML, Shaw JR, Stanton BA. 2012. A novel Aquaporin 3 in Killifish (Fundulus heteroclitus) is not an arsenic channel. Toxicol Sci 127(1):101-109. doi:10.1093/toxsci/kfs078PMID:22323512PMCID:PMC3327866
Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou Y, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. 2012. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci 126(2):578-588. doi:10.1093/toxsci/kfs023PMID:22268004PMCID:PMC3307611
Lu K, Gul H, Upton PB, Moeller BC, Swenberg JA. 2012. Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol. Toxicol Sci 126(1):28-38. doi:10.1093/toxsci/kfr328PMID:22157354PMCID:PMC3289495
Sipos E, Chen L, Andras IE, Wrobel JK, Zhang B, Pu H, Park M, Eum SY, Toborek M. 2012. Proinflammatory adhesion molecules facilitate polychlorinated biphenyl–mediated enhancement of brain metastasis formation. Toxicol Sci 126(2):362-371. doi:10.1093/toxsci/kfr349PMID:22240979PMCID:PMC3307603
Stansfield KH, Pilsner JR, Lu Q, Wright RO, Guilarte TR. 2012. Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): Implications for an environmental basis of neurodevelopmental disorders. Toxicol Sci 127:277-295. doi:10.1093/toxsci/kfs090PMID:22345308PMCID:PMC3327871
2011
Adami H, Berry CL, Breckenridge CB, Smith LL, Swenberg JA, Trichopoulos D, Weiss NS, Pastoor TP. 2011. Toxicology and epidemiology: improving the science with a framework for combining toxicological and epidemiological evidence to establish causal inference. Toxicol Sci 122(2):223-234. doi:10.1093/toxsci/kfr113PMID:21561883PMCID:PMC3155086
Angrish MM, Jones AD, Harkema JR, Zacharewski TR. 2011. Aryl hydrocarbon receptor-mediated induction of stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis. Toxicol Sci 124(2):299-310. doi:10.1093/toxsci/kfr226PMID:21890736PMCID:PMC3216411
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone MC, Threadgill DW, Tryndyak VP, Pogribny IP, Bleyle L, Koop DR, Rusyn I. 2011. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci 120(1):206-217. doi:10.1093/toxsci/kfq362PMID:21135412PMCID:PMC3044200
Chan JK, Fanucchi MV, Anderson DS, Abid AD, Wallis C, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, Van Winkle LS. 2011. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicol Sci 124(2):472-486. doi:10.1093/toxsci/kfr233PMID:21914721PMCID:PMC3216412
Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG, Furlong CE. 2011. Repeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expression. Toxicol Sci 123:155-169. doi:10.1093/toxsci/kfr157PMID:21673326PMCID:PMC3164442
Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B. 2011. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci 124:1-22. doi:10.1093/toxsci/kfr218PMID:21908767PMCID:PMC3196658
He G, Tsutsumi T, Baston DS, Zhao B, Zhao J, Heath-Pagliuso S, Denison MS. 2011. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci 123:511-522. doi:10.1093/toxsci/kfr189PMID:21775728PMCID:PMC3179681
Lai IK, Chai Y, Simmons DL, Watson WH, Tan R, Haschek-Hock WM, Wang K, Wang B, Ludewig G, Robertson LW. 2011. Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats. Toxicol Sci 124:202-214. doi:10.1093/toxsci/kfr215PMID:21865291PMCID:PMC3196656
McClure EA, North CM, Kaminski NE, Goodman JI. 2011. Changes in DNA methylation and gene expression during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced suppression of the lipopolysaccharide-stimulated IgM response in splenocytes. Toxicol Sci 120(2):339-348. doi:10.1093/toxsci/kfq396PMID:21212295PMCID:PMC3061478
Pietruska JR, Liu X, Smith A, McNeil K, Weston P, Zhitkovich A, Hurt RH, Kane AB. 2011. Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. Toxicol Sci 124(1):138-148. doi:10.1093/toxsci/kfr206PMID:21828359PMCID:PMC3196652 (Completed with ARRA Funds)
Sherwood CL, Lantz RC, Burgess JL, Boitano S. 2011. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Toxicol Sci 121:191-206. doi:10.1093/toxsci/kfr044PMID:21357385PMCID:PMC3080191
Sulentic CE, Kaminski NE. 2011. The long winding road toward understanding the molecular mechanisms for B cell suppression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicol Sci 120(suppl1):S171-S191. doi:10.1093/toxsci/kfq324PMID:20952503PMCID:PMC3043085
Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, Nakamura J, Starr TB. 2011. Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment. Toxicol Sci 120(suppl1):S130-S145. doi:10.1093/toxsci/kfq371PMID:21163908PMCID:PMC3043087
2010
Bhattacharya S, Conolly RB, Kaminski NE, Thomas RS, Andersen ME, Zhang Q. 2010. A bistable switch underlying B-cell differentiation and its disruption by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 115(1):51-65. doi:10.1093/toxsci/kfq035PMID:20123757PMCID:PMC2855357
Bissonnette SL, Haas A, Mann KK, Schlezinger JJ. 2010. The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci 118(1):108-118. doi:10.1093/toxsci/kfq256PMID:20810541PMCID:PMC2955217
Boekelheide K, Campion SN. 2010. Toxicity testing in the 21st century: using the new toxicity testing paradigm to create a taxonomy of adverse effects. Toxicol Sci 114(1):20-24. doi:10.1093/toxsci/kfp307PMID:20026472PMCID:PMC2902917
Campion SN, Sandrof MA, Hensley J, Sui Y, Gaido KW, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways. Toxicol Sci 117(2):457-465. doi:10.1093/toxsci/kfq204PMID:20616210PMCID:PMC2940405
Campion SN, Sandrof MA, Yamasaki H, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis. Toxicol Sci 117(2):466-474. doi:10.1093/toxsci/kfq205PMID:20616204PMCID:PMC2940406
Crawford RB, Kaminski NE, Lu H, North CM. 2010. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated suppression of toll-like receptor stimulated B-lymphocyte activation and initiation of plasmacytic differentiation. Toxicol Sci 116:99-112. doi:10.1093/toxsci/kfq095PMID:20348231PMCID:PMC2886857
De Abrew KN, Kaminski NE, Thomas RS. 2010. An integrated genomic analysis of aryl hydrocarbon receptor-mediated inhibition of B-cell differentiation. Toxicol Sci 118(2):454-469. doi:10.1093/toxsci/kfq265PMID:20819909PMCID:PMC3003543
Kopec AK, Burgoon LD, Ibrahim-Aibo D, Burg AR, Lee AW, Tashiro C, Sharratt B, Harkema JR, Rowlands C, Budinsky R, Zacharewski TR. 2010. Automated dose-response analysis and comparative toxicogenomic evaluation of the hepatic effects elicited by TCDD, TCDF, and PCB126 in C57BL/6 mice. Toxicol Sci 118(1):286-297. doi:10.1093/toxsci/kfq236PMID:20702594PMCID:PMC2955213
Leung MC, Goldstone JV, Boyd W, Freedman JH, Meyer JN. 2010. Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B-1 but not benzo a pyrene in vivo. Toxicol Sci 118:444-453. doi:10.1093/toxsci/kfq295PMID:20864627PMCID:PMC2984530
Lu H, Crawford RB, Suarez-Martinez J, Kaplan BL, Kaminski NE. 2010. Induction of the aryl hydrocarbon receptor-responsive genes and modulation of the immunoglobulin M response by 2,3,7,8-tetrachlorodibenzo-p-dioxin in primary human B cells. Toxicol Sci 118(1):86-97. doi:10.1093/toxsci/kfq234PMID:20702590PMCID:PMC2955211
Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. 2010. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not Leukemia. Toxicol Sci 116(2):441-451. doi:10.1093/toxsci/kfq061PMID:20176625PMCID:PMC2905397
Martyniuk CJ, Kroll KJ, Doperalski NJ, Barber DS, Denslow ND. 2010. Genomic and proteomic responses to environmentally relevant exposures to dieldrin: Indicators of neurodegeneration?. Toxicol Sci 117(1):190-199. doi:10.1093/toxsci/kfq192PMID:20584760PMCID:PMC2923291 (Completed with ARRA Funds)
Saini Y, Greenwood K, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ. 2010. Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1 alpha in modulating inflammation. Toxicol Sci 116:673-681. doi:10.1093/toxsci/kfq155PMID:20511350PMCID:PMC2905409
Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi A. 2010. Monomethylarsonous acid produces irreversible events resulting in malignant transformation of a human bladder cell line following 12 weeks of low-level exposure. Toxicol Sci 116(1):44-57. doi:10.1093/toxsci/kfq106PMID:20375083PMCID:PMC2886861
Yamasaki H, Sandrof MA, Boekelheide K. 2010. Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis. Toxicol Sci 117(2):449-456. doi:10.1093/toxsci/kfq203PMID:20616207PMCID:PMC2940404
Crawford RB, North CM, Kaplan BL, Kaminski NE, Lu H. 2009. Establishment of an immunoglobulin m antibody-forming cell response model for characterizing immunotoxicity in primary human B cells. Toxicol Sci 112(2):363-373. doi:10.1093/toxsci/kfp224PMID:19767444PMCID:PMC2777081
Jo WJ, Loguinov AV, Wintz H, Chang M, Smith AH, Vulpe CD, Kalman DA, Zhang L, Smith MT. 2009. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci 111(2):424-436. doi:10.1093/toxsci/kfp162PMID:19635755PMCID:PMC2742584
Lefebvre KA, Tilton SC, Bammler TK, Beyer RP, Srinouanprachanh SL, Stapleton PL, Farin FM, Gallagher EP. 2009. Gene expression profiles in zebrafish brain after acute exposure to domoic acid at symptomatic and asymptomatic doses. Toxicol Sci 107(1):65-77. doi:10.1093/toxsci/kfn207PMID:18936300PMCID:PMC2735419
North CM, Crawford RB, Kaminski NE, Lu H. 2009. Simultaneous in vivo time course and dose response evaluation for TCDD-induced impairment of the LPS-stimulated primary IgM response. Toxicol Sci 112(1):123-132. doi:10.1093/toxsci/kfp187PMID:19675145PMCID:PMC2769062
North CM, Kim B, Snyder N, Crawford RB, Holsapple MP, Kaminski NE. 2009. TCDD-mediated suppression of the in vitro anti-sheep erythrocyte IgM antibody forming cell response is reversed by interferon-gamma. Toxicol Sci 107(1):85-92. doi:10.1093/toxsci/kfn223PMID:18948302PMCID:PMC2638643
Nyagode BA, James MO, Kleinow KM. 2009. Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108(2):320-329. doi:10.1093/toxsci/kfp018PMID:19181613PMCID:PMC2664691
Ren X, Lim S, Smith MT, Zhang L. 2009. Werner syndrome protein, WRN, protects cells from DNA damage induced by the benzene metabolite hydroquinone. Toxicol Sci 107(2):367-375. doi:10.1093/toxsci/kfn254PMID:19064679PMCID:PMC2639759
Schneider D, Yoo B, Kaminski NE. 2009. Involvement of Blimp-1 and AP-1 dysregulation in the 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated suppression of the IgM response by B cells. Toxicol Sci 108(2):377-388. doi:10.1093/toxsci/kfp028PMID:19237549PMCID:PMC2664693
Timme-Laragy AR, Van Tiem LA, Linney EA, Di Giulio RT. 2009. Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicol Sci 109(2):217-227. doi:10.1093/toxsci/kfp038PMID:19233942PMCID:PMC2721659
2008
Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. 2008. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 101(2):294-309. PMID:17977901
Billiard SM, Meyer JN, Wassenberg DM, Hodson PV, Di Giulio RT. 2008. Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment. Toxicol Sci 105(1):5-23. doi:10.1093/toxsci/kfm303PMID:18156145PMCID:PMC2734299
Caldwell P, Thome PA, Johnson PD, Boitano S, Runyan RB, Selmin O. 2008. Trichloroethylene disrupts cardiac gene expression and calcium homeostasis in rat myocytes. Toxicol Sci 104(1):135-143. doi:10.1093/toxsci/kfn078PMID:18411232PMCID:PMC4001797
Hegedus CM, Skibola CF, Warner M, Skibola DR, Zhang L, Steinmaus CM, Smith AH, Smith MT, Moore LE, Alexander D, Lim S, Dangleben NL, Clark M, Pfeiffer RM. 2008. Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenic. Toxicol Sci 106(1):74-82. doi:10.1093/toxsci/kfn104PMID:18511430PMCID:PMC2563143
Holder A, Lucas D, Goth-Goldstein R, Koshland CP. 2008. Cellular response to diesel exhaust particles strongly depends on the exposure method. Toxicol Sci 103(1):108-115. doi:10.1093/toxsci/kfn014PMID:18227103
Kennedy PJ, Vashisht AA, Hoe K, Kim D, Park H, Hayles J, Russell P. 2008. A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci 106(1):124-139. doi:10.1093/toxsci/kfn153PMID:18684775PMCID:PMC2563147
Kopec AK, Boverhof DR, Burgoon LD, Ibrahim-Aibo D, Harkema JR, Tashiro C, Chittim B, Zacharewski TR. 2008. Comparative toxicogenomic examination of the hepatic effects of PCB126 and TCDD in immature, ovariectomized C57BL/6 mice. Toxicol Sci 102(1):61-75. doi:10.1093/toxsci/kfm289PMID:18042819
Meza MM, Kopplin MJ, Burgess JL, Gandolfi A. 2008. Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water. Toxicol Sci 90:957-970. doi:10.1080/02772240701782140
Zhou GD, Donnelly KC, Tian Y, Naspinski C, Gu X, Mertens-Talcott SU. 2008. Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage. Toxicol Sci 104(1):67-73. doi:10.1093/toxsci/kfn058PMID:18381355
2007
Andrew AS, Bernardo V, Warnke L, Davey JC, Hampton TH, Mason RA, Thorpe JE, Ihnat MA, Hamilton JW. 2007. Exposure to arsenic at levels found inUS drinking water modifies expression in the mouse lung. Toxicol Sci 100(1):75-87. doi:10.1093/toxsci/kfm200PMID:17682005
Beyer RP, Lasarev MR, Meira LB, Palmer VS, Ross PK, Bammler TK, Bradford BU, Cunningham ML, Higgins G, Hurban P, Kayton RJ, Kosyk O, Vliet PA, Wolfinger R, Woods CG, Freedman JH, Linney EA, Kaufmann WK, Kavanagh TJ, Rusyn I, Samson LD, Spencer PS, Suk WA, Zarbl HF. 2007. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicol Sci 99(1):326-337. PMID:17562736
Bodwell J, Gosse JA, Hamilton JW, Davey JC. 2007. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci 98(1):75-86. doi:10.1093/toxsci/kfm013PMID:17283378
Eblin KE, Bredfeldt TG, Buffington SE, Gandolfi A. 2007. Mitogenic signal transduction caused by monomethylarsonous acid in human bladder cells: role in arsenic-induced carcinogenesis. Toxicol Sci 95(2):321-330. PMID:17093206
Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
Miller DS, Shaw JR, Stanton CR, Barnaby R, Karlson KH, Hamilton JW, Stanton BA. 2007. MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci 97(1):103-110. doi:10.1093/toxsci/kfm030PMID:17324950
Operana T, Nguyen N, Chen S, Beaton D, Tukey RH. 2007. Human CYP1A1GFP expression in transgenic mice serves as a biomarker for environmental toxicant exposure. Toxicol Sci 95(1):98-107. doi:10.1093/toxsci/kfl144PMID:17065433
Schlezinger JJ, Emberley JK, Sherr DH, Bissonnette SL. 2007. An L-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted capase cascade in bone marrow B cells. Toxicol Sci 98(1):125-36. PMID:17400580
Wilson JY, Wells R, Aguilar AA, Borrell A, Tornero V, Reijnders P, Moore M, Stegeman JJ. 2007. Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicol Sci 97(1):111-9. PMID:17324949
Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. 2007. Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 Cells. Toxicol Sci 100:88-98. PMID:17686921
2006
Billiard SM, Timme-Laragy AR, Wassenberg DM, Cockman C, Di Giulio RT. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicol Sci 92:526-536. PMID:16687390
Burgoon LD, Boutros PC, Dere E, Zacharewski TR. 2006. dbZach: A MIAME-compliant toxicogenomic supportive relational database. Toxicol Sci 90(2):558-68. PMID:16403854
Johns DO, Daniell WE, Shen D, Kalman DA, Dills RL, Morgan MS. 2006. Ethanol-induced increase in the metabolic clearance of 1,1,1-trichloroethane in human volunteers. Toxicol Sci 92(1):61-70. PMID:16638923
Kim D, Andersen ME, Nylander-French LA. 2006. A dermatotoxicokinetic model of human exposures to jet fuel. Toxicol Sci 93(1):22-33. doi:10.1093/toxsci/kfl048PMID:16801332
Kubota A, Iwata H, Handley-Goldstone HM, Kim EY, Stegeman JJ, Tanabe S. 2006. Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicol Sci 92(2):394-408. doi:10.1093/toxsci/kfl001PMID:16679348
Peters AK, Nijmeijer S, Gradin K, Backlund M, Bergman A, Poellinger L, Denison MS, van den Berg M. 2006. Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway. Toxicol Sci 92(1):133-142. PMID:16601081
Rha GB, Eum SY, Hennig B, Toborek M. 2006. c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line. Toxicol Sci 92(1):311-20. PMID:16611624
Schlezinger JJ, Emberley JK, Sherr DH. 2006. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci 92(2):433-44. PMID:16672323
Strathmann J, Schwarz M, Tharappel JC, Glauert HP, Spear BT, Robertson LW, Appel KE, Buchmann A. 2006. PCB 153, a non-dioxin-like tumor promoter, selects for beta-catenin (Catnb)-mutated mouse liver tumors. Toxicol Sci 93(1):34-40. doi:10.1093/toxsci/kfl041PMID:16782779
2005
Balshaw DM, Philbert M, Suk WA. 2005. Research strategies for safety evaluation of nanomaterials, Part III: nanoscale technologies for assessing risk and improving public health. Toxicol Sci 88(2):298-306. PMID:16162851
Bezdecny SA, Roth RA, Ganey PE. 2005. Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2. Toxicol Sci 84(2):328-334. doi:10.1093/toxsci/kfi093PMID:15673847
Hurst CH, Waxman DJ. 2005. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR. Toxicol Sci 87:299-311.
Kamat CD, Green DE, Curilla S, Warnke L, Hamilton JW, Sturup S, Clark C, Ihnat MA. 2005. Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol Sci 86(2):248-257. doi:10.1093/toxsci/kfi190PMID:15888669
Kann S, Estes C, Reichard JF, Huang M, Sartor MA, Schwemberger S, Chen Y, Dalton TP, Shertzer HG, Xia Y, Puga A. 2005. Butylhydroquinone protects cells genetically deficient in glutathione biosynthesis from arsenite-induced apoptosis without significantly changing their prooxidant status. Toxicol Sci 87(2):365-384. PMID:16014739
Loch-Caruso R, Upham BL, Harris C, Trosko JE. 2005. Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85(1):694-702. PMID:15716478
Machemer DE, Tukey RH. 2005. The role of protein kinase C in regulation of TCDD-mediated CYP1A1 gene expression. Toxicol Sci 87(1):27-37. PMID:15947024
Song MO, Freedman JH. 2005. Activation of mitogen activated protein kinases by PCB126 (3,3',4,4',5-pentachlorobiphenyl) in HepG2 cells. Toxicol Sci 84(2):308-318. doi:10.1093/toxsci/kfi084PMID:15647597
Xu S, D'Angelo E, Ghosh D, Feliciano JS, Deo SK, Daunert S. 2005. Detection of polychlorinated biphenyls employing chemical dechlorination followed by biphenyl whole cell sensing system. Toxicol Sci 87(3):287-298. doi:10.1080/02772240400029769
2004
Bielmeier SR, Best DS, Narotsky MG. 2004. Serum hormone characterization and exogeneous hormone rescue of bromodichloromethane-induced pregnancy loss in the F344 rat. Toxicol Sci 77(1):101-108. PMID:14657523
Chen J, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL, Douglas GC. 2004. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci 78(1):166-174. PMID:14691210
Davila JC, Cezar GG, Thiede M, Strom S, Miki T, Trosko JE. 2004. Use and application of stem cells in toxicology. Toxicol Sci 79(2):214-223. PMID:15014205
Dieguez-Acuna FJ, Polk WF, Ellis ME, Simmonds PL, Kushleika JV, Woods JS. 2004. Nuclear factor kappa B activity determines the sensitivity of kidney epithelial cells to apoptosis: Implications for mercury-induced renal failure. Toxicol Sci 82(1):114-123. PMID:15282405
Dong W, Teraoka H, Tsujimoto Y, Stegeman JJ, Hiraga T. 2004. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 77(1):109-116. PMID:14657521
DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci 78(2):187-195. PMID:14737000
Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2004. Initiating activity of 4-chlorobiphenyl metabolites in the resistant hepatocyte model. Toxicol Sci 79(1):41-46. PMID:14976334
Gafni J, Wong PW, Pessah IN. 2004. Non-coplanar 2,2 ',3,5 ',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Toxicol Sci 77(1):72-82. PMID:14600284
Henson KL, Gallagher EP. 2004. Glutathione S-transferase expression in pollution-associated hepatic lesions of brown bullheads (Ameiurus nebulosus) from the Cuyahoga River, Cleveland, Ohio. Toxicol Sci 80(1):26-33. PMID:15071171
Heyer NJ, Echeverria D, Bittner AC, Farin FM, Garabedian CC, Woods JS. 2004. Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood. Toxicol Sci 81(2):354-363. PMID:15254338
Jiang J, Dean D, Burghardt RC, Parrish AR. 2004. Disruption of cadherin/catenin expression, localization, and interactions during HgCl2-induced nephrotoxicity. Toxicol Sci 80(1):170-182. PMID:15084754
Lu Z, Lee EY, Robertson LW, Glauert HP, Spear BT. 2004. Effect of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) on Hepatocyte Proliferation and Apoptosis in Mice Deficient in the p50 Subunit of the Transcription Factor NF-B. Toxicol Sci 81(1):35-42.
Phimister AJ, Lee MG, Morin D, Buckpitt AR, Plopper CG. 2004. Glutathione depletion is a major determinant of inhaled naphthalene respiratory toxicity and naphthalene metabolism in mice. Toxicol Sci 82(1):268-278. PMID:15319489
Tan Z, Huang M, Puga A, Xia Y. 2004. A critical role for MAP kinases in the control of Ah receptor complex activity. Toxicol Sci 82(1):80-87. doi:10.1093/toxsci/kfh228PMID:15272135
2003
Allan LL, Mann KK, Matulka RA, Ryu H, Schlezinger JJ, Sherr DH. 2003. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol Sci 76(2):357-365. PMID:14514961
Andersen ME, Ou YC, Yang RH, Conolly RB, Thomas RS, Gustafson DL, Long ME, Dobrev ID, Chubb LS, Xu Y, Lapidot SA. 2003. Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay. Toxicol Sci 73(2):301-314. PMID:12700395
Andrew AS, Karagas MR, Klei L, Hamilton JW. 2003. Drinking water arsenic exposure is associated with decreased DNA repair gene expression. Toxicol Sci 72(S1):184.
Bae D, Handa RJ, Yang RH, Campain JA. 2003. Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. Toxicol Sci 74(1):32-42. PMID:12773770
Bekris LM, Shephard C, Zarghami M, Griffith WC, Kavanagh TJ, Lernmark A. 2003. Glutamate cysteine ligase catalytic subunit trinucleotide repeat polymorphism and type I diabetes. Toxicol Sci 72(1):480Suppl.S. PMID:17479437
Bezdecny SA, Roth RA, Ganey PE. 2003. Expression of cyclooxygenase-2 in HL-60 cells exposed to polychlorinated biphenyls. Toxicol Sci 72(1):1571Suppl.S..
Carnell AN, Goodman JI, Abriola LM. 2003. The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity. Toxicol Sci 65:229-235. PMID:12773759
Chen J, Douglas GC, Thirkill TL, Lohstroh PN, Bielmeier SR, Narotsky MG, Best DS, Harrison RA, Natarajan K, Pegram RA, Overstreet JW, Lasley BL. 2003. Effect of bromodichloromethane on chorionic gonadotrophin secretion by human placental trophoblast cultures. Toxicol Sci 76(1):75-82. PMID:12970577
Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. 2003. PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol Sci 75(1):47-56. doi:10.1093/toxsci/kfg149PMID:12805654
Chung D, Loch-Caruso R. 2003. Role of oxidative stress in the modification on rat uterine contraction by 2,2 '-dichlorobiphenyl. Toxicol Sci 72(1):376.
Fadhel ZA, Bunaciu RP, Glauert HP, Robertson LW, Ludewig G. 2003. Lipid peroxidation and antioxidant enzymes in testes of rats treated with 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and effects of corn oil, medium-chain triglyceride (MCT) oil and olive oil. Toxicol Sci 72(1):1771Suppl.S.
Garry MR, Sidhu JS, Kavanagh TJ, Faustman EM. 2003. Differential modulation of stress and ubiquitination signaling pathways by cadmium, H202, and serum withdrawal in cultured mouse fibroblasts. Society of Toxicology 42nd annual Meeting in Salt Lake City, Utah, March 2003. Toxicol Sci 72(1):311Suppl.S.
Hamilton JW. 2003. Mechanism of hexavalent chromium (Cr(VI)) toxicity and carcinogenicity. Toxicol Sci 72(1):58.
Hamilton JW, Bodwell J, Kingsley LA, Barnet CS, Davey JC. 2003. Arsenic alters hormone-mediated positive, but not negative, regulatory effects of steroid receptors. Toxicol Sci 72(S1):16.
Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308. doi:10.1093/toxsci/kfg145PMID:12805656
Kavanagh TJ, Shi S, Botta D, White CC, Dabrowski MJ, Shephard C, Quigley SD, Farin FM, Beyer RP, Pierce RH, Franklin CC, Zarbl HF, Bammler TK. 2003. Using toxicogenomic analysis to assess the protective effects of enhanced glutathione synthesis in glutamate cysteine ligase transgenic mice. Toxicol Sci 72(1):805Suppl.S.
Machala M, Blaha L, Vondracek J, Trosko JE, Scott J, Upham BL. 2003. Inhibition of gap junctional intercellular communication by noncoplanar polychlorinated biphenyls: Inhibitory potencies and screening for potential mode(s) of action. Toxicol Sci 76(1):102-111. PMID:12915713
Madhukar BV, Hernandez-Maldonado O. 2003. A diorthochlorinated PCB congener 2,2 ',4,4 '-tetrachlorobiphenyl (TCB) activates extracellular signal regulated kinases (ERKs) independent of protein kinase C (PKC) in JB6 mouse epidermal cells. Toxicol Sci 72(1):1574Suppl.S.
Ramadass P, Meerarani P, Toborek M, Robertson LW, Hennig B. 2003. Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Toxicol Sci 76(1):212-219. PMID:12970578
Shao J, McKone EF, Keener CL, Shephard C, Farin FM, Aitken ML, Kavanagh TJ. 2003. The modification of cystic fibrosis lung disease by a polymorphism in a glutamate cysteine ligase gene. Toxicol Sci 72(1):487Suppl.S.
Shi S, Hendsch MB, Ogburn CE, Rabinovitch PS, Martin GM, Kavanagh TJ. 2003. Female mice transgenic for mitochondrial directed catalase have altered glutathione redox cycle enzyme activities coincident with tissue specific catalase expression. Toxicol Sci 72(1):394Suppl.S.
Shiverick KT, Medrano TA. 2003. Maternal-fetal programming in utero: adult metabolic disease and diabetes. Toxicol Sci 72(1):273Suppl.S.
Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei L, Clark C, Barchowsky A. 2003. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci 76(2):271-279. doi:10.1093/toxsci/kfg231PMID:12970581
Tharappel JC, Glauert HP, Spear BT. 2003. The effect of phenobarbital on cell proliferation in mice deficient in the p50 subunit of NF-kappa B. Toxicol Sci 72(S-1):1160.
Tsai CH, Lin P, Troester MA, Rappaport SM. 2003. Formation and removal of pentachlorophenol-derived protein adducts in rodent liver under acute, multiple, and chronic dosing regimens. Toxicol Sci 73(1):26-35. PMID:12700421
West JA, Van Winkle LS, Morin D, Fleschner CA, Forman HJ, Plopper CG. 2003. Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice. Toxicol Sci 75:161-168. PMID:12805647
Wu J, Eckard J, Rossman TG, Yang C, Frenkel K. 2003. p53 Signaling pathway involved in arsenite-induced HOS cell transformation and its prevention by caffeic acid phenethyl ester (CAPE). Toxicol Sci 72(1):1307Suppl.S.
Yang C, Frenkel K. 2003. Caffeic acid phenethyl ester (CAPE) inhibits arsenite-induced human cell transformation and induces G2/M phase arrest of arsenite-transformed human cells. Toxicol Sci 72(1):1029Suppl.S.
2002
Ablordeppy EA, Medrano TA, Shiverick KT. 2002. Effects of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on proliferation and cell regulation in human placental trophoblastic JEG-3 cells. Toxicol Sci Suppl66(1-S):349.
Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68(2):403-419. PMID:12151636
Andrew AS, Warren AJ, Temple KA, Hamilton JW. 2002. Differential effects of arsenic, chromium, cadmium, nickel and mitomycin C on gene expression as measured by DNA microarray. Toxicol Sci 66(S1):116.
Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC. 2002. Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells. Toxicol Sci 68(2):444-450. PMID:12151640
Blaha L, Kapplova P, Vondracek J, Upham BL, Machala M. 2002. Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons. Toxicol Sci 65:43-51. PMID:11752684
Dean, Jr. CE, Benjamin SA, Chubb LS, Tessari JD, Keefe TJ. 2002. Nonadditive hepatic tumor promoting effects by a mixture of two structurally different polychlorinated biphenyls in female rat livers. Toxicol Sci 66(1):54-61. PMID:11861972
Espandiari P, Glauert HP, Robertson LW. 2002. Replacement of partial hepatectomy with fasting/refeeding or the use of neonatal animals in the resistant hepatocyte model. Toxicol Sci 66:310.
Fadhel ZA, Stafine N, Glauert HP, Robertson LW, Ludewig G. 2002. The effects of purified vs. unrefined diets on lipid peroxidation and antioxidant enzymes in tests of PCB-153 treated rats. Toxicol Sci 66:349.
Hamilton JW, Bodwell J, Kaltreider RC, Davis AM, Davey JC, Kingsley LA, Lariviere JP. 2002. Arsenic is an endocrine disruptor, blocking hormone-mediated gene regulation by the estrogen and glucocorticoid receptors in vivo. Toxicol Sci 66(S1):85.
Hansen LG, Machala M, Fischer L, James MO, Hennig B, Glauert HP, Narbonne J, van Bree L, Schultz T, Grevett P, Suk WA, Holoubek I, Robertson LW. 2002. Research needs identified at the second PCB Workshop in Brno, Czech Republic. Toxicol Sci 87(3):261-265. doi:10.1080/02772240500079011
Hu W, Jones PD, Upham BL, Trosko JE, Lau C, Giesy JP. 2002. Inhibition of gap junctional intercellular communication by perfluorinated compounds in rat liver and dolphin kidney epithelial cell lines in vitro and Sprague-Dawley rats in vivo. Toxicol Sci 68(2):429-436. PMID:12151638
Kleinow KM, Uppu P, Holmes E, Zhang Y. 2002. Alteration of p-glycoprotein expression in catfish by select environmental toxicants. Toxicol Sci 66:327.
Krig SR, Chandraratna RA, Chang MM, Wu R, Rice RH. 2002. Gene-specific TCDD suppression of RAR- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci 68(1):102-108. PMID:12075115
Medrano TA, Schwanke JL, Ablordeppy EA, Shiverick KT. 2002. Identification of differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin on gene expression in human placental JEG-3 cells using cell cycle and DNA microarray analysis. Toxicol Sci Suppl66(1-S):298.
Meyer JN, Nacci DE, Di Giulio RT. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci 68(1):69-81. PMID:12075112
Nagy SR, Sanborn JR, Hammock BD, Denison MS. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicol Sci 65(2):200-210. PMID:11812924
Soucy NV, Barchowsky A, Klei L, Hamilton JW, Ihnat MA. 2002. Potential cellular mechanisms for arsenite-induced vascular diseases. Toxicol Sci 66(S1):86.
Thrall K, Weitz KK, Woodstock AD. 2002. Use of real-time breath analysis and physiologically based pharmacokinetic modeling to evaluate dermal absorption of aqueous toluene in human volunteers. Toxicol Sci 68(2):280-287. PMID:12151623
Troester MA, Lindstrom AB, Waidyanatha S, Kupper LL, Rappaport SM. 2002. Stability of hemoglobin and albumin adducts of naphthalene oxide, 1,2-naphthoquinone, and 1,4-naphthoquinone. Toxicol Sci 68(2):314-321. PMID:12151627
Upham BL, Davis JM, Trosko JE, Schwartz KA. 2002. Polycyclic aromatic hydrocarbons with bay-like structures inhibited gap junctional intercellular communication in neonatal rat cardiomyocytes and caused asynchronous beating. Toxicol Sci 00:1410.
Wolf KK, Davis XM, Kaltreider RC, Davey JC, Lariviere JP, Hamilton JW. 2002. Chromium(III) and chromium(VI) stimulate cAMP-mediated cell signaling in cell culture and in vivo. Toxicol Sci 66(S1):32.
2001
Bae D, Gennings C, Carter, Jr. WH, Yang RH, Campain JA. 2001. Toxicological interactions among arsenic, cadmium, chromium, and lead in human keratinocytes. Toxicol Sci 63(1):132-142. PMID:11509753
Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
Bielmeier SR, Best DS, Guidici DL, Narotsky MG. 2001. Pregnancy loss in the rat caused by bromodichloromethane. Toxicol Sci 59(2):309-315. PMID:11158724
Bunn TL, Parsons PJ, Kao E, Dietert RR. 2001. Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and gender. Toxicol Sci 64:57-66. PMID:11606801
Hamilton JW, Davis AM, Kaltreider RC. 2001. Chromium(VI) alters glucocorticoid receptor (GR)-dependent and cAMP-dependent gene expression through a chromium(III)-sensitive, cAMP-mediated pathway. Toxicol Sci 60(S1):316.
Hamm JT, Wilson BW, Hinton DE. 2001. Increasing uptake and bioactivation with development positively modulate diazinon toxicity in early life stage medaka (Oryzias latipes). Toxicol Sci 61(2):304-313. PMID:11353139
Handley H, Grow MW, Fishman MC, Stegeman JJ. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 60(1):1604S.
Henson KL, Stauffer G, Gallagher EP. 2001. Induction of glutathione S-transferase activity and protein expression in brown bullhead (Ameriurus nebulosus) liver by ethoxyquin. Toxicol Sci 62(1):54-60. PMID:11399793
Li P, Rossman TG. 2001. Genes upregulated in lead-resistant glioma cells reveal possible targets for lead-induced developmental neurotoxicity. Toxicol Sci 64:90-99. PMID:11606805
Lu Z, Lee EY, Robertson LW, Spear BT, Glauert HP. 2001. Effect of dietary vitamin E on the promotion of altered hepatic foci by 3,3',4,4'-tetrachlorobiphenyl (PCB-77) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in rats initiated with diethylnitrosamine. Toxicol Sci 60:161.
Nichols BG, Woods JS, Luchtel DL, Corral J, Koenig JQ. 2001. Effects of ozone exposure on nuclear factor-kappa B activation and tumor necrosis factor-alpha expression in human nasal epithelial cells. Toxicol Sci 60(2):356-362. PMID:11248148
Pingree SD, Simmonds PL, Woods JS. 2001. Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats. Toxicol Sci 61(2):224-233. PMID:11353131
Slim RM, Hammock BD, Toborek M, Robertson LW. 2001. The role of methyl linoleic acid epoxide and diol metabolites in the synergistic toxicity of linoleic acid and PCBs to vascular endothelial cells. Toxicol Sci 60:13.
Srinivasan A, Lehmler H, Robertson LW, Ludewig G. 2001. Production of DNA strand breaks in vitro and Reactive Oxygen Species in vitro and in HL-60 cells by PCB Metabolites. Toxicol Sci 60(1):92-102. PMID:11222876
Trosko JE, Kwan K, Upham BL, Halgren R, Zacharewski TR, Chang C. 2001. Stem cell biology in toxicology. Toxicol Sci 60:150.
Upham BL, Rummel AM, Carbone JM, Trosko JE, Ouyang Y, Kaminski NE. 2001. Cannabinoids inhibited gap junctional intercellular communication and activated extracellular receptor kinase in a rat liver epithelial cell line. Toxicol Sci 60:750.
Upham BL, Trosko JE, Hirose I, Hasegawa R, Kanno J, Inoue T, Sai K. 2001. Structure-activity relationships of perfluorinated fatty acids on gap junctional intercellular communication and MAPK using in vivo and in vitro model systems. Toxicol Sci 60:746.
Waters KM, Safe SH, Gaido KW. 2001. Differential gene expression in response to methoxychlor and estradiol through ERalpha, ERbeta, and AR in reproductive tissues of female mice. Toxicol Sci 63:47-56. PMID:11509743
Wijeweera JB, Gandolfi A, Parrish AR, Lantz RC. 2001. Sodium arsenite enhances AP-1 and NFKB DNA binding and induces stress protein expression in precision-cut rat lung slices. Toxicol Sci 61(2):283-294. PMID:11353137
2000
Barhoumi R, Mouneimne Y, Ramos KS, Safe SH, Phillips TD, Centonze VE, Ainley C, Gupta MS, Burghardt RC. 2000. Analysis of Benzo[a]pyrene partitioning and cellular homeostasis in a rat liver cell line. Toxicol Sci 53:264-270. PMID:10696774
Bordelon NR, Donnelly KC, King LC, Wolf DC, Reeves WR, George S. 2000. Bioavailability of genotoxic compounds in coal tar contaminated soils in Fisher 344 rats. Toxicol Sci 56(1):37-48. doi:10.1093/toxsci/56.1.37PMID:10869452
Bowman CJ, Kroll KJ, Folmar LC, Heurne MJ, Denslow ND. 2000. Vitellogenin transcriptional activation in sheepshead minnow following acute estrogen exposure in vivo. Toxicol Sci 54:326.
Boyer AS, Finch WT, Runyan RB. 2000. Trichloroethylene inhibits development of embryonic heart valve precursors in vitro. Toxicol Sci 53(1):109-117. PMID:10653528
Bunn TL, Ladics GS, Holsapple MP, Dietert RR. 2000. Developmental immunotoxicology assessment in the rat: age, gender, and strain comparisons. Toxicol Sci 54:10.
Calfee-Mason K, Spear BT, Glauert HP. 2000. Effect of dietary vitamin E on other cellular antioxidant defense systems in phenobarbital-treated rats. Toxicol Sci 54(1):946.
Chen S, Golemboski KA, Dietert RR. 2000. Embryonic exposure to lead modulates Th1/Th2 associated immune functions and is influenced by developmental status. Toxicol Sci 49(1-S):5.
Doi AM, Lou Z, Holmes E, Li CL, Venugopal CS, James MO, Kleinow KM. 2000. Effect of micelle fatty acid composition and 3,4,3',4'-tetrachlorobiphenyl (TCB) exposure on intestinal [14C]-TCB bioavailability and biotransformation in channel catfish in situ preparations. Toxicol Sci 55(1):85-96. PMID:10788563
Fadhel ZA, Lu Z, Robertson LW, Glauert HP. 2000. Role of cytochrome P-450 induction and lipid peroxidation in 3,3',4,4'-tetrachlorobiphenyl (PCB-77)- and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153)-induced toxicity in liver of male rats. Toxicol Sci 54:78.
Ganey PE, Olivero-Verbal J, Madhukar BV. 2000. Mechanism of inhibition of stimulated neutrophil degranulation by 2,2',4,4'-tetrachlorobiphenyl. Toxicol Sci 54:77.
Greene JF, Zheng J, Grant DF, Hammock BD. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol Sci 53(2):352-360. PMID:10696783
Gustafson DL, Long ME, Thomas RS, Benjamin SA, Yang RH. 2000. Comparative hepatocarcinogenicity of hexachlorobenzene, pentachlorobenzene, 1,2,4,5-tetrachlorobenzene, and 1,4-dichlorobenzene: application of a medium-term liver focus bioassay and molecular and cellular indices. Toxicol Sci 53(2):245-252. PMID:10696772
Krig SR, Rice RH. 2000. TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. Toxicol Sci 56(2):357-364. PMID:10910994
Krovat BC, Tracy JH, Omiecinski CJ. 2000. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci 55(2):352-360. PMID:10828267
Lee J, Naqui SA, Dietert RR. 2000. Embryonic windows of increased vulnerability to Pb-induced immunotoxicity during avian development. Toxicol Sci 54(1):9.
Lou Z, Celander MC, James MO. 2000. Expression and steroid hydroxylation activity of a CYP3A-like protein in channel catfish proximal and distal intestine. Toxicol Sci 54:97-98.
Lu Z, Spear BT, Robertson LW, Glauert HP. 2000. Activation of hepatic hepatic NF-kB by polychlorinated biphenyls (PCBs) in vivo and in cultured rat hepatocytes. Toxicol Sci 54:254.
Ludewig G, Lehmler H, Boivin R, Srinivasan A, Robertson LW. 2000. Reactivity of halogenated and non-halogenated dihydroxy-biphenyls in vitro and in cells in culture. Toxicol Sci 54(1):76.
McGarry MA, Bubb M, Campbell-Thompson M, Medrano TA, Shiverick KT. 2000. Differential effects of benzo(a)pyrene and 2,3,7,8-tetrachlorodibenzo(a)pyrene on cell adherens junction and actin cytoskeletal proteins in human uterine RL95-2 cells. Toxicol Sci 54:348.
Olivero-Verbal J, Ganey PE. 2000. A common elecrotopological motif among organochlorine compounds that activate neutrophils. Toxicol Sci 54:77.
Pereg D, Tampal N, Robertson LW. 2000. Covalent binding of benzo[a]pyrene, 4-chlorobiphenyl and 3,3',4,4'-tetrachlorobiphenyl to nuclear macromolecules in female mice. Toxicol Sci 54(1):366.
Powell WH, Bright R, Bello SM, Hahn ME. 2000. Developmental and tissue-specific expression of AHR1, AHR2, and ARNT2 in dioxin-sensitive and -resistant populations of the marine fish, Fundulus heteroclitus. Toxicol Sci 57(2):229-239. PMID:11006353
Rael LT, Ayala-Fierro F, Carter DE. 2000. The effects of sulfur-, thiol-, and thiol inhibitor compounds on arsine-induced toxicity in the human erythrocyte membrane. Toxicol Sci 55(2):468-477. PMID:10828280
Safe SH. 2000. Bisphenol A and related endocrine disrupters. Toxicol Sci 56(2):251-252. PMID:10910979
Seidel SD, Li V, Winters GM, Rogers WJ, Martinez EI, Denison MS. 2000. Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. Toxicol Sci 55(1):107-115. PMID:10788565
Srinivasan A, Robertson LW, Ludewig G. 2000. PCB metabolites: cytotoxicity, glutathione depletion and inhibition of topoisomerase II. Toxicol Sci 54(1):78.
Tampal N, Myers S, Pereg D, Robertson LW. 2000. Hemoglobin adducts of polychlorinated biphenyls as potential biomarkers of exposure. Toxicol Sci 54(1):365.
Tharappel JC, Robertson LW, Lee EY, Spear BT, Glauert HP. 2000. Effect of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 3,3',4,4'-tetrachlorobiphenyl (PCB-77) on NF-kB and AP-1 activation, altered hepatic foci formation, cell proliferation, and apoptosis in rats. Toxicol Sci 54:271.
Thompson SA, White CC, Krejsa CM, Eaton DL, Kavanagh TJ. 2000. Modulation of glutathione and glutamate-L-cysteine ligase by methylmercury during mouse development. Toxicol Sci 57:141-6. PMID:10966520
Tithof PK, Olivero J, Ruehle K, Ganey PE. 2000. Activation of neutrophil calcium-dependent and -independent phospholipases A2 by organochlorine compounds. Toxicol Sci 53(1):40-47. PMID:10653519
Troester MA, Lindstrom AB, Waidyanatha S, Kupper LL, Rappaport SM. 2000. Stability of hemoglobin and albumin adducts of benzene oxide and 1,4-benzoquinone after administration of benzene to F344 rats. Toxicol Sci 54:88-94. PMID:10746935
Zheng XH, Wilson CL, Parrish AR, Gandolfi A. 2000. Differential gene expression in rabbit renal cortical slices exposed to arsenic compounds. Toxicol Sci 54:
Ziccardi MH, Gardner IA, Denison MS. 2000. Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. Toxicol Sci 54(1):183-193. PMID:10746945
1999
Ayala-Fierro F, Barber DS, Rael LT, Carter DE. 1999. In vitro tissue specificity for arsine and arsenite toxicity in the rat. Toxicol Sci 52(1):122-129. PMID:10568705
Bunn TL, Marsh JA, Golemboski KA, Dietert RR. 1999. Gender-based differential humoral responses to a foreign versus self antigen after in ovo lead exposure. Toxicol Sci 48(1-S):5.
Clarke RW, Al-Mutairi E, Love JA, Rice T, Antonini JM, Paulauskis JD, Godleski J. 1999. Residual oil ashes with differing composition elicit pro-inflammatory chemokines in the lung and heart. Toxicol Sci 48(15):259.
Draper AJ, Hammock BD. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol Sci 52:26-32. PMID:10568695
Draper AJ, Hammock BD. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicol Sci 50:30-35. PMID:10445750
Garcia-Arenas G, Claudio L, Perez-Severiano F, Rios C. 1999. Low-level lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain. Toxicol Sci 50:244-258.
Korytko PJ, Casey AC, Bush B, Quimby FW. 1999. Induction of hepatic cytochrome P450 in dogs exposed to a chronic low dose of polychlorinated biphenyls. Toxicol Sci 47(1):52-61. PMID:10048153
Lin P, Waidyanatha S, Pollack GM, Swenberg JA, Rappaport SM. 1999. Dose-specific production of chlorinated quinone and semiquinone adducts in rodent livers following administration of pentachlorophenol. Toxicol Sci 47(1):126-133. PMID:10048161
Mann KK, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of DMBA metabolites in preB cell apoptosis. Toxicol Sci 48(1-S):
Morisseau C, Derbel M, Lane TR, Stoutamire DW, Hammock BD. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicol Sci 52(2):148-153. PMID:10630566
Parrish AR, Zheng XH, Turney KD, Younis HS, Gandolfi A. 1999. Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Toxicol Sci 50:98-105. PMID:10445758
Paulauskis JD, Danaee H, Antonini JM, Al-Mutairi E, Rice T, Godleski J, Clarke RW. 1999. Instilled soluble vanadium evokes pulmonary inflammation but does not elicit pro-inflammatory chemokine mRNA in the heart. Toxicol Sci 48(15):52.
Phillips TD. 1999. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol Sci 52:118-126. PMID:10630600
Rummel AM, Trosko JE, Wilson MR, Upham BL. 1999. Polycyclic aromatic hydrocarbons with bay-like regions inhibited gap junctional intercellular communication and stimulated MAPK activity. Toxicol Sci 49:232-240. PMID:10416268
Strupp BJ, Morgan RE, Garavan H. 1999. Enduring effects of early lead exposure: Assessment of sustained attention, inhibitory control, and information processing speed. Toxicol Sci 48(1-S):360.
Turney KD, Parrish AR, Gandolfi A. 1999. Selective activation in the MAPK pathway by Hg(II). Toxicol Sci 48:331.
Twaroski TP, Espandiari P, Robertson LW. 1999. Effects of selected PCB congeners on drug- and glutathione-metabolizing enzymes in the rat. Toxicol Sci 48(1-S):
Zheng XH, Parrish AR, Turney KD, Younis HS, Gandolfi A. 1999. Arsenite [AS(III)] and arsenate [AS(V)] enhance DNA binding of the AP-1 and elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices. Toxicol Sci 48:351.
1998
Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. 1998. Low inducibility of CYP1A activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): characterization of the Ah receptor and the role of CYP1A inhibition. Toxicol Sci 43(2):161-171. doi:10.1006/toxs.1998.2455PMID:9710958
Bunn TL, Golemboski KA, Dietert RR. 1998. In utero exposure to lead modulates Th1/Th2 associated functions and is influenced by gender. Toxicol Sci 42(1-S):206.
Cremin JD, Olsen HE, Seaton C, Woolard D, Littles S, Strupp BJ, Smith DR. 1998. Effects of neo-natal Pb exposure on protein kinase C (PKC) in rat brain regions. Toxicol Sci 42:27.
Doi AM, Kleinow KM, James MO, Venugopalan CS, Holmes E. 1998. Bioavailability and biotransformation of 3,4,3',4'-tetrachlorobiphenyl (TCB) in in situ intestinal preparations of uninduced and TCB-induced channel catfish. Toxicol Sci 42:337.
Fischer L, Seegal R, Ganey PE, Pessah IN, Kodavanti PR. 1998. Symposium overview: toxicity of non-coplanar PCBs. Toxicol Sci 41(1):49-61. doi:10.1006/toxs.1997.2386PMID:9520341
Gadagbui BK, James MO, Faux LR, Sikazwe DN. 1998. Distribution of glutathione S-transferase (GST) activity and anti GST-p cross-reactive protein in intestine of the channel catfish. Toxicol Sci 42:274.
Kodavanti UP, Hauser R, Christiani DC, Meng ZH, McGee J, Ledbetter AD, Richards J, Costa DL. 1998. Pulmonary responses to oil fly ash particles in the rat differ by virtue of their specific soluble metals. Toxicol Sci 43:204-212. PMID:9710962
Koistinen J, Soimasuo R, Tukia K, Blankenship AL, Giesy JP. 1998. Induction of EROD activity in hepa-1 mouse hepatoma cells and estrogenicity in MCF-7 human breast cancer cells by extracts of pulp mill effluents, biosludge, and sediment exposed effluents. Toxicol Sci 17(8):1499-1507.
Legare ME, Barhoumi R, Hebert E, Bratton GR, Burghardt RC, Tiffany-Castiglioni E. 1998. Analysis of Pb2+ entry into cultured astroglia. Toxicol Sci 46(1):90-100. doi:10.1006/toxs.1998.2492PMID:9928672
Mayura K, Abdel-Wahhab MA, McKenzie KS, Sarr AB, Edwards JF, Naguib K, Phillips TD. 1998. Prevention of maternal and developmental toxicity in rats via dietary inclusion of common aflatoxin sorbents: Potential for hidden risks. Toxicol Sci 41:175-182. PMID:9520353
Miller TE, Golemboski KA, Ha R, Bunn TL, Sanders FS, Dietert RR. 1998. Developmental exposure to lead causes persistent immunotoxicity in Fischer 344 rats. Toxicol Sci 42(2):129-135. PMID:9579025
Oakley GG, Roe AL, Blouin RA, Ganguly TC, Vore M, Robertson LW. 1998. Activation of AP-1 and STAT transcription factors by non-coplanar Polychlorinated Biphenyls (PCBs). Toxicol Sci 42:133.
Strupp BJ, Patton L, Smith DR. 1998. Evaluation of succimer chelation for reducing brain-Pb levels in a rodent model. Toxicol Sci 42:27.
Twaroski TP, Robertson LW. 1998. PCB-induced oxidative stress and effects on glutathione, glutathione peroxidase and catalase. Toxicol Sci 42:153.
Wetmur JG, Rosenfeld A, Desnick RJ. 1998. Genetic influences on lead poisoning. Toxicol Sci 42:2335.
Zheng XH, Younis HS, Turney KD, Parrish AR, Gandolfi A. 1998. Molecular alterations in renal cortical slices following exposure to sub-toxic levels of arsenic. Toxicol Sci 42:323.
1996
Starodub ME, Miller PA, Ferguson GM, Giesy JP, Willes RF. 1996. The use of risk assessment techniques to develop a protocol for determining acceptable concentrations of bioaccumulative chlorinated organic chemicals in sediments for the protection of piscivorous wildlife. Toxicol Sci 54:243-259. doi:10.1080/02772249609358316
1995
Johnson KA, Naddy RB, Weisskopf CP. 1995. Passive sampling devices for rapid determination of soil contaminant distributions. Toxicol Sci 51:31-44.
Safe SH, Rodriguez LV, Goldstein L. 1995. Toxic equivalency factor approach for risk assessment of combustion by-products. Toxicol Sci 49:181-191.
Yu C, Conklin MH. 1995. Effect of trichloroethene on the aqueous solubility of chlorobenzenes. Toxicol Sci 49:73-84.
