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Search Results for Most Frequently Published Journals (Superfund Research Program)

Superfund Research Program

Search Results

Proceedings of the National Academy of Sciences of the United States of America (151 articles)


  • Kelly A, Wang W, Rothenberger E, Yang J, Gilligan MM, Kipper FC, Attaya A, Gartung A, Hwang SH, Gillespie M, Bayer R, Quinlivan K, Torres K, Huang S, Mitsiades N, Yang H, Hammock BD, Panigrahy D. 2024. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 121(7):doi:10.1073/pnas.2314085121 PMID:38330013


  • Bajomo MM, Ju Y, Zhou J, Elefterescu S, Farr C, Zhao Y, Neumann O, Nordlander P, Patel AB, Halas N. 2022. Computational chromatography: a machine learning strategy for demixing individual chemical components in complex mixtures. Proc Natl Acad Sci U S A 119(52):e2211406119. doi:10.1073/pnas.2211406119 PMID:36534806
  • Bergmann CB, McReynolds C, Wan D, Singh N, Goetzman H, Caldwell CC, Supp DM, Hammock BD. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2120691119 PMID:35312372 PMCID:PMC9060469
  • Fu T, Li Y, Oh TG, Cayabyab F, He N, Tang Q, Coulter S, Truitt ML, Medina P, He M, Yu RT, Atkins AR, Zheng Y, Liddle C, Downes M, Evans RM. 2022. FXR mediates ILC-intrinsic responses to intestinal inflammation. Proc Natl Acad Sci U S A 119(51):e2213041119. doi:10.1073/pnas.2213041119 PMID:36508655
  • Sun C, Zhou J, Yu Z, Huo X, Zhang J, Morisseau C, Hammock BD, Ma X. 2022. Kurarinone alleviated Parkinsons disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2118818119 PMID:35217618 PMCID:PMC8892522


  • Bomidi C, Robertson M, Coarfa C, Estes MK, Blutt SE. 2021. Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection. Proc Natl Acad Sci U S A 118(45):doi:10.1073/pnas.2112814118 PMID:34732579 PMCID:PMC8609316
  • Deng J, Yang H, Haak VM, Yang J, Kipper FC, Barksdale C, Hwang SH, Gartung A, Bielenberg DR, Subbian S, Ho K, Ye X, Fan D, Sun Y, Hammock BD, Panigrahy D. 2021. Eicosanoid regulation of debris-stimulated metastasis. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2107771118 PMID:34607951 PMCID:PMC8521662
  • Hashimoto K, Hammock BD. 2021. Reply to Reeves and Dunn: Risk for autism in offspring after maternal glyphosate exposure. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2016496118 PMID:33443192 PMCID:PMC7812790
  • Iwashita H, Castillo E, Messina MS, Swanson RA, Chang C. 2021. A tandem activity-based sensing and labeling strategy enables imaging of transcellular hydrogen peroxide signaling. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2018513118 PMID:33622793 PMCID:PMC7936376
  • Kenison JE, Wang Z, Yang K, Snyder M, Quintana FJ, Sherr DH. 2021. The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2012692118 PMID:33941684 PMCID:PMC8126867
  • Wang L, Oh TG, Magida J, Estepa G, Obayomi SB, Chong L, Gatchalian J, Yu RT, Atkins AR, Hargreaves D, Downes M, Wei Z, Evans RM. 2021. Bromodomain containing 9 (BRD9) regulates macrophage inflammatory responses by potentiating glucocorticoid receptor activity. Proc Natl Acad Sci U S A 118(35):e2109517118. doi:10.1073/pnas.2109517118 PMID:34446564 PMCID:PMC8536317


  • Elledge S, Tran HL, Christian A, Steri V, Hann BC, Toste FD, Chang C, Wells JA. 2020. Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site specific antibody bioconjugation. Proc Natl Acad Sci U S A 117:5733-5740. doi:10.1073/pnas.1920561117 PMID:32123103 PMCID:PMC7084160
  • Fishbein A, Wang W, Yang H, Yang J, Hallisey V, Deng J, Verheul S, Hwang SH, Gartung A, Wang Y, Bielenberg DR, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2020. Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proc Natl Acad Sci U S A 117:21576-21587. doi:10.1073/pnas.2007412117 PMID:32801214 PMCID:PMC7474612
  • Nigra AE. 2020. Environmental racism and the need for private well protections. Proc Natl Acad Sci U S A 117(30):doi:10.1073/pnas.2011547117 PMID:32641505 (ahead of print)
  • Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang X, Fujita Y, Ishima T, Wan D, Hee-Hwang S, Hammock BD, Hashimoto K. 2020. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 117:11753-11759. doi:10.1073/pnas.1922287117 PMID:32398374 PMCID:PMC7260984
  • Sriram K, Loomba R, Insel PA. 2020. Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenge. Proc Natl Acad Sci U S A 117:29274-29282. doi:10.1073/pnas.2009875117 PMID:33203679 PMCID:PMC7703541
  • Toh JD, Crossley S, Bruemmer KJ, Ge EJ, He D, Iovan DA, Chang C. 2020. Distinct RNA N-demethylation pathways catalyzed by nonheme iron ALKBH5 and FTO enzymes enable regulation of formaldehyde release rates. Proc Natl Acad Sci U S A 117:25284-25292. doi:10.1073/pnas.2007349117 PMID:32989163 PMCID:PMC7568336
  • Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hee-Hwang S, Kim D, Lee KS, Xiao H, Hammock BD, Zhang G. 2020. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proc Natl Acad Sci U S A 117:8431-8436. doi:10.1073/pnas.1916189117 PMID:32220957 PMCID:PMC7165420
  • Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785


  • Castilho CJ, Li D, Liu M, Liu Y, Gao H, Hurt RH. 2019. Mosquito bite prevention through graphene barrier layers. Proc Natl Acad Sci U S A 116(37):18304-18309. doi:10.1073/pnas.1906612116 PMID:31451645 PMCID:PMC6744866
  • Chang C, Loo C, Zhao X, Solt LA, Liang Y, Bapat SP, Cho H, Kamenecka TM, Leblanc M, Atkins AR, Yu RT, Downes M, Burris TP, Evans RM, Zheng Y. 2019. The nuclear receptor REV-ERB alpha modulates Th17 cell-mediated autoimmune disease. Proc Natl Acad Sci U S A 116:18528-18536. doi:10.1073/pnas.1907563116 PMID:31455731 PMCID:PMC6744854
  • Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hee-Hwang S, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2019. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A 116:1698-1703. doi:10.1073/pnas.1803999116 PMID:30647111 PMCID:PMC6358686
  • Kim SA, LaCroix IS, Gerber SA, Guerinot ML. 2019. The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI. Proc Natl Acad Sci U S A 116:24933-24942. doi:10.1073/pnas.1916892116 PMID:31776249 PMCID:PMC6911256
  • Luo Y, Wu M, Deng B, Huang J, Hwang SH, Li M, Zhou C, Zhang Q, Yu H, Zhao D, Zhang G, Qin L, Peng A, Hammock BD, Liu J. 2019. Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proc Natl Acad Sci U S A 116(11):5154-5159. doi:10.1073/pnas.1815746116 PMID:30804206 PMCID:PMC6421466
  • Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. 2019. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proc Natl Acad Sci U S A 116(14):7083-7088. doi:10.1073/pnas.1819234116 PMID:30890645 PMCID:PMC6452650
  • Wang L, Mazagova M, Pan C, Yang S, Brandl KL, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. 2019. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A 116:15184-15193. doi:10.1073/pnas.1904360116 PMID:31289229 PMCID:PMC6660779


  • Dow M, Pyke RM, Tsui BY, Alexandrov LB, Nakagawa H, Taniguchi K, Seki E, Harismendy O, Shalapour S, Karin M, Carter H, Font-Burgada J. 2018. Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888. doi:10.1073/pnas.1811029115 PMID:30287485 PMCID:PMC6196518
  • Ferdowsi B, Ortiz C, Jerolmack DJ. 2018. Glassy dynamics of landscape evolution. Proc Natl Acad Sci U S A 115(19):4827-4832. doi:10.1073/pnas.1715250115 PMID:29686102 PMCID:PMC5948954
  • Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD. 2018. Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proc Natl Acad Sci U S A 4170-4175:115. doi:10.1073/pnas.1718635115 PMID:29610310 PMCID:PMC5910840
  • Hsu P, Takahashi Y, Munemasa S, Merilo E, Laanemets K, Waadt R, Patar D, KOLLIST H, Schroeder JI. 2018. Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980. doi:10.1073/pnas.1809204115 PMID:30282744 PMCID:PMC6196521
  • Li Z, Takahashi Y, Scavo A, Brandt B, Nguyen D, Rieu P, Schroeder JI. 2018. Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases. Proc Natl Acad Sci U S A 115(19):E4522-E4531. doi:10.1073/pnas.1719659115 PMID:29686103 PMCID:PMC5948973
  • Liu P, de la Vega MR, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JG, Zhang DD. 2018. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115(44):E10352-E10361. doi:10.1073/pnas.1812125115 PMID:30309964 PMCID:PMC6217430
  • Prasse C, Ford B, Nomura DK, Sedlak DL. 2018. Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light. Proc Natl Acad Sci U S A 115:2311-2316. doi:10.1073/pnas.1715821115 PMID:29463747 PMCID:PMC5877969
  • Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa K, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. 2018. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A 115:E5815-E5823. doi:10.1073/pnas.1802179115 PMID:29735655 PMCID:PMC6016799
  • Shoenfelt EM, Winckler G, Lamy F, Anderson RF, Bostick BC. 2018. Highly bioavailable dust-borne iron delivered to the Southern Ocean during glacial periods. Proc Natl Acad Sci U S A 115:11180-11185. doi:10.1073/pnas.1809755115 PMID:30322933 PMCID:PMC6217405
  • Song N, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Xu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. 2018. IKK alpha inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proc Natl Acad Sci U S A 115:E812-E821. doi:10.1073/pnas.1717520115 PMID:29311298 PMCID:PMC5789942
  • Wang W, Yang J, Zhang J, Wang Y, Hee-Hwang S, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu J, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. 2018. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A 115:5283-5288. doi:10.1073/pnas.1721711115 PMID:29717038 PMCID:PMC5960306
  • Yang Y, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A. 2018. Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation. Proc Natl Acad Sci U S A 115:613-618. doi:10.1073/pnas.1716016115 PMID:29295935 PMCID:PMC5776989


  • Cao Q, Zhao X, Bai J, Gery S, Sun H, Lin D, Chen Q, Chen Z, Mack L, Yang H, Deng R, Shi X, Chong L, Cho H, Xie J, Li Q, Muschen M, Atkins AR, Liddle C, Yu RT, Alkan S, Said JW, Zheng Y, Downes M, Evans RM, Koeffler HP. 2017. Circadian clock cryptochrome proteins regulate autoimmunity. Proc Natl Acad Sci U S A 114(47):12548-12553. doi:10.1073/pnas.1619119114 PMID:29109286 PMCID:PMC5703267
  • Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
  • Deng B, Luo Y, Kang X, Li C, Morisseau C, Yang J, Lee KS, Huang J, Hu D, Wu M, Peng A, Hammock BD, Liu J. 2017. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3 beta signaling. Proc Natl Acad Sci U S A 114:12608-12613. doi:10.1073/pnas.1705615114 PMID:29109264 PMCID:PMC5703276
  • Flitter B, Hvorecny KL, Ono E, Eddens TJ, Yang J, Kwak D, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls J, Levy BD, Madden DR, Bomberger JM. 2017. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A 114(1):136-141. doi:10.1073/pnas.1610242114 PMID:27980032 PMCID:PMC5224368
  • Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KS, Hammock BD, Schunck W, Connor KM. 2017. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A 114:e7545-e7553. doi:10.1073/pnas.1620898114 PMID:28827330 PMCID:PMC5594641
  • He N, Fan W, Henriquez B, Yu RT, Atkins AR, Liddle C, Zheng Y, Downes M, Evans RM. 2017. Metabolic control of regulatory T cell (Treg) survival and function by Lkb1. Proc Natl Acad Sci U S A 114(47):12542-12547. doi:10.1073/pnas.1715363114 PMID:29109251 PMCID:PMC5703326
  • Rand A, Barnych B, Morisseau C, Cajka T, Lee KS, Panigrahy D, Hammock BD. 2017. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proc Natl Acad Sci U S A 114:4370-4375. doi:10.1073/pnas.1616893114 PMID:28396419 PMCID:PMC5410821
  • Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM. 2017. Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A 114(5):1129-1134. doi:10.1073/pnas.1620164114 PMID:28096419 PMCID:PMC5293019
  • Shrivastava M, Lou S, Zelenyuk A, Easter RC, Corley RA, Thrall BD, Rasch PJ, Fast JD, Simonich SL, Shen H, Tao S. 2017. Global long-range transport and lung cancer risk from polycyclic aromatic hydrocarbons shielded by coatings of organic aerosol. Proc Natl Acad Sci U S A 114(6):1246-1251. doi:10.1073/pnas.1618475114 PMID:28115713 PMCID:PMC5307436
  • Wu C, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. 2017. Structural basis for specific ligation of the peroxisome proliferater-activated receptor delta. Proc Natl Acad Sci U S A 114:13:E2563-2570. doi:10.1073/pnas.1621513114 PMID:28320959 PMCID:PMC5380080


  • Liu W, Struik D, Nies VJ, Jurdzinski A, Harkema L, de Bruin A, Verkade HJ, Downes M, Evans RM, van Zutephen T, Jonker JW. 2016. Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 113(8):2288-2293. doi:10.1073/pnas.1525093113 PMID:26858440 PMCID:PMC4776526
  • Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang J, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. 2016. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci U S A 113(13):E1944-E1952. doi:10.1073/pnas.1601532113 PMID:26976569 PMCID:PMC4822604
  • Ronjat M, Feng W, Dardevet L, Dong Y, Khoury SA, Chatelain F, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M. 2016. In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A 113(17):E2460-E2468. doi:10.1073/pnas.1517342113 PMID:27071086 PMCID:PMC4855579
  • Stephan AB, Kunz H, Yang E, Schroeder JI. 2016. Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters. Proc Natl Acad Sci U S A 113(35):E5242-E5249. doi:10.1073/pnas.1519555113 PMID:27528686 PMCID:PMC5024618
  • Yazaki J, Galli M, Kim AY, Nito K, Aleman F, Chang KN, Carvunis A, Quan R, Nguyen H, Song L, Alvarez J, Huang SC, Chen H, Ramachandran N, Altmann S, Gutierrez RA, Hill DE, Schroeder JI, Chory J, LaBaer J, Vidal M, Braun P, Ecker JR. 2016. Mapping transcription factor interactome networks using HaloTag protein arrays. Proc Natl Acad Sci U S A 113(29):E4238-E4247. doi:10.1073/pnas.1603229113 PMID:27357687 PMCID:PMC4961138
  • Zhu WP, von dem Bussche A, Yi X, Qiu Y, Wang Z, Weston P, Hurt RH, Kane AB, Gao H. 2016. Nanomechanical mechanism for lipid bilayer damage induced by carbon nanotubes confined in intracellular vesicles. Proc Natl Acad Sci U S A 113(44):12374-12379. doi:10.1073/pnas.1605030113 PMID:27791073 PMCID:PMC5098676


  • Antonucci L, Fagman JB, Kim J, Todoric J, Gukovsky I, Mackey MR, Ellisman MH, Karin M. 2015. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proc Natl Acad Sci U S A 112(45):E6166-E6174. doi:10.1073/pnas.1519384112 PMID:26512112 PMCID:PMC4653219
  • Ding N, Hah N, Yu RT, Sherman MH, Benner CW, Leblanc M, He M, Liddle C, Downes M, Evans RM. 2015. BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A 112(51):15713-15718. doi:10.1073/pnas.1522163112 PMID:26644586 PMCID:PMC4697417
  • Hah N, Benner CW, Chong L, Yu RT, Downes M, Evans RM. 2015. Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs. Proc Natl Acad Sci U S A 112(3):E297-E302. doi:10.1073/pnas.1424028112 PMID:25564661 PMCID:PMC4311831
  • Helb DA, Tetteh K, Felgner PL, Skinner J, Hubbard AE, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya M, Beeson JG, Tappero J, Smith DL, Crompton PD, Rosenthal P, Dorsey G, Drakeley C, Greenhouse B. 2015. Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Proc Natl Acad Sci U S A 112(32):E4438-E4447. doi:10.1073/pnas.1501705112 PMID:26216993 PMCID:PMC4538641
  • Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. 2015. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci U S A 112(29):9082-9087. doi:10.1073/pnas.1510137112 PMID:26150506 PMCID:PMC4517273
  • Lopez-Vicario C, Alcaraz-Quiles J, Garcia-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Claria J. 2015. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proc Natl Acad Sci U S A 112(2):536-541. doi:10.1073/pnas.1422590112 PMID:25550510 PMCID:PMC4299190


  • Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. 2014. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 111(22):8167-8172. doi:10.1073/pnas.1402965111 PMID:24843165 PMCID:PMC4050620
  • Kunz H, Gierth M, Herdean A, Satoh-Cruz M, Kramer DM, Spetea C, Schroeder JI. 2014. Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis. Proc Natl Acad Sci U S A 111(20):7480-7485. doi:10.1073/pnas.1323899111 PMID:24794527 PMCID:PMC4034250
  • Stephan AB, Schroeder JI. 2014. Plant salt stress status is transmitted systemically via propagating calcium waves. Proc Natl Acad Sci U S A 111(17):6126-6127. doi:10.1073/pnas.1404895111 PMID:24737890 PMCID:PMC4036006
  • Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D. 2014. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proc Natl Acad Sci U S A 111(52):18566-18571. doi:10.1073/pnas.1420227112 PMID:25512493 PMCID:PMC4284531
  • Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
  • Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2014. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A 111(30):11127-11132. doi:10.1073/pnas.1410432111 PMID:25024195 PMCID:PMC4121808
  • Zhuang W, Yi S, Bill M, Brisson VL, Feng X, Men Y, Conrad ME, Tang YJ, Alvarez-Cohen L. 2014. Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. Proc Natl Acad Sci U S A 111(17):6419-6424. doi:10.1073/pnas.1321542111 PMID:24733917 PMCID:PMC4035967


  • Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. 2013. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc Natl Acad Sci U S A 110(47):19143-19148. doi:10.1073/pnas.1319123110 PMID:24191041 PMCID:PMC3839688
  • Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. 2013. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proc Natl Acad Sci U S A 110(6):2377-2382. doi:10.1073/pnas.1221729110 PMID:23341606 PMCID:PMC3568328
  • Du L, Bergsneider M, Mirsadraei L, Young SH, Jonker JW, Downes M, Yong WH, Evans RM, Heaney AP. 2013. Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease. Proc Natl Acad Sci U S A 110:8555-8560. doi:10.1073/pnas.1306182110 PMID:23653479 PMCID:PMC3666748
  • Li Y, Yuan H, von dem Bussche A, Creighton M, Hurt RH, Kane AB, Gao H. 2013. Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites. Proc Natl Acad Sci U S A 110(30):12295–12300. doi:10.1073/pnas.1222276110 PMID:23840061 PMCID:PMC3725082
  • Mailloux BJ, Trembath-Reichert E, Cheung J, Watson M, Stute M, Freyer GA, Ferguson AS, Ahmed KM, Alam M, Buchholz BA, Thomas J, Layton AC, Zheng Y, Bostick BC, van Geen AF. 2013. Advection of surface-derived organic carbon fuels microbial reduction in Bangladesh groundwater. Proc Natl Acad Sci U S A 110(14):5331-5335. doi:10.1073/pnas.1213141110 PMID:23487743 PMCID:PMC3619377
  • Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. 2013. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 110(33):13528-13533. doi:10.1073/pnas.1311565110 PMID:23898174 PMCID:PMC3746918
  • Sirish P, Li N, Liu J, Lee KS, Hwang SH, Qiu H, Zhao C, Ma S, Lopez JE, Hammock BD, Chiamvimonvat N. 2013. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A 110(14):5618-5623. doi:10.1073/pnas.1221972110 PMID:23493561 PMCID:PMC3619365
  • Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530-6535. doi:10.1073/pnas.1304321110 PMID:23553837 PMCID:PMC3631682


  • Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos G, Schebb N, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A 109(35):14158-14163. doi:10.1073/pnas.1211314109 PMID:22891308 PMCID:PMC3435154
  • Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb N, Hwang SH, Morisseau C, Haj FG, Hammock BD. 2012. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of Type I Diabetes. Proc Natl Acad Sci U S A 109(28):11390-11395. doi:10.1073/pnas.1208708109 PMID:22733772 PMCID:PMC3396532
  • Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q. 2012. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A 109(11):4146-4151. doi:10.1073/pnas.1200448109 PMID:22315426 PMCID:PMC3306724


  • Cologgi DL, Lampa-Pastirk S, Speers AM, Kelly SD, Reguera G. 2011. Extracellular reduction of uranium via Geobacter conductive pili as a protective cellular mechanism. Proc Natl Acad Sci U S A 108:15248-15252. doi:10.1073/pnas.1108616108 PMID:21896750 PMCID:PMC3174638
  • Gilbert-Diamond D, Cottingham KL, Gruber JF, Punshon T, Sayarath V, Gandolfi A, Baker E, Jackson BP, Folt CL, Karagas MR. 2011. Rice consumption contributes to arsenic exposure in US women. Proc Natl Acad Sci U S A 108(51):20656-20660. doi:10.1073/pnas.1109127108 PMID:22143778 PMCID:PMC3251121
  • Inceoglu B, Wagner KM, Schebb N, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose TE, Hammock BD, Brosnan R. 2011. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A 108(12):5093-5097. doi:10.1073/pnas.1101073108 PMID:21383170 PMCID:PMC3064364
  • Lewis S, Datta S, Gui M, Coker EL, Huggins F, Daunert S, Bachas LG, Bhattacharyya D. 2011. Reactive nanostructured membranes for water purification. Proc Natl Acad Sci U S A 108(21):8577-8582. doi:10.1073/pnas.1101144108 PMID:21606340 PMCID:PMC3102394
  • Luria A, Bettaieb A, Xi Y, Shieh G, Liu H, Inoue H, Tsai H, Imig JD, Haj FG, Hammock BD. 2011. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A 108(22):9038-9043. doi:10.1073/pnas.1103482108 PMID:21571638 PMCID:PMC3107315
  • Osterreicher C, Penz-Osterreicher M, Grivennikov S, Guma M, Koltsova E, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. 2011. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proc Natl Acad Sci U S A 108(1):308-313. doi:10.1073/pnas.1017547108 PMID:21173249 PMCID:PMC3017162
  • Xu D, Dai W. 2011. The function of mammalian Polo-like kinase 1 in microtubule nucleation. Proc Natl Acad Sci U S A 108(28):11301-11302. doi:10.1073/pnas.1107723108 PMID:21705656 PMCID:PMC3136282 (Completed with ARRA Funds)


  • Bourne Y, Radic Z, Araoz R, Talley TT, Benoit E, Servent D, Taylor PW, Molgo J, Marchot P. 2010. Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism. Proc Natl Acad Sci U S A 107(13):6076-6081. doi:10.1073/pnas.0912372107 PMID:20224036 PMCID:PMC2851920
  • Fujiwara R, Nguyen N, Chen S, Tukey RH. 2010. Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. Proc Natl Acad Sci U S A 107(11):5024-5029. doi:10.1073/pnas.0913290107 PMID:20194756 PMCID:PMC2841904
  • Liu J, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, Hammock BD. 2010. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A 107(39):17017-17022. doi:10.1073/pnas.1011278107 PMID:20837537 PMCID:PMC2947894
  • Song W, Park J, Mendoza-Cózatl D, Suter-Grotemeyer M, Shim D, Hortensteiner S, Geisler M, Weder B, Rea PA, Rentsch D, Schroeder JI. 2010. Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Proc Natl Acad Sci U S A 107(49):21187-21192. doi:10.1073/pnas.1013964107 PMID:21078981 PMCID:PMC3000282


  • Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. 2009. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A 106(2):564-569. doi:10.1073/pnas.0811022106 PMID:19126686 PMCID:PMC2626743
  • Datta S, Mailloux BJ, Jung H, Hoque MA, Stute M, Ahmed KM, Zheng Y. 2009. Redox trapping of arsenic during groundwater discharge in sediments from the Meghna riverbank in Bangladesh. Proc Natl Acad Sci U S A 106(40):16930-16935. doi:10.1073/pnas.0908168106 PMID:19805180 PMCID:PMC2761342
  • Song Y, Wagner BA, Witmer JR, Lehmler H, Buettner GR. 2009. Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones. Proc Natl Acad Sci U S A 106(24):9725-9730. doi:10.1073/pnas.0810352106 PMID:19497881 PMCID:PMC2689812
  • Zhang Y, Tao S, Shen H, Ma J. 2009. Inhalation exposure to ambient polycyclic aromatic hydrocarbons and lung cancer risk of Chinese population. Proc Natl Acad Sci U S A 106(50):21063-21067. doi:10.1073/pnas.0905756106 PMID:19995969 PMCID:PMC2789752 (Completed with ARRA Funds)


  • Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner KM, Jones PD, Morisseau C, Hammock BD. 2008. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci U S A 105(48):18901-18906. doi:10.1073/pnas.0809765105 PMID:19028872 PMCID:PMC2596245
  • Stevens RC, Suzuki SM, Cole TB, Park SS, Richter RJ, Furlong CE. 2008. Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning. Proc Natl Acad Sci U S A 105(35):12780-12784. doi:10.1073/pnas.0805865105 PMID:18711144 PMCID:PMC2529096


  • Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. 2007. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A 104(21):9018-23. PMID:17495027
  • Doty SL, James CA, Moore AL, Vajzovic A, Singleton GL, Ma C, Khan Z, Xin G, Kang J, Park J, Meilan R, Strauss SH, Wilkerson J, Farin FM, Strand SE. 2007. Enhanced phytoremediation of volatile environmental pollutants with transgenic trees. Proc Natl Acad Sci U S A 104(43):16816-16821. doi:10.1073/pnas.0703276104 PMID:17940038 PMCID:PMC2040402
  • Karimi R, Chen CY, Pickhardt PC, Fisher NS, Folt CL. 2007. Stoichiometric controls of mercury dilution by growth. Proc Natl Acad Sci U S A 104(18):7477-7482. doi:10.1073/pnas.0611261104 PMID:17456601 PMCID:PMC1863492


  • Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. 2006. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proc Natl Acad Sci U S A 103(15):5694-5699. PMID:16585531
  • Chain PS, Denef VJ, Konstantinidis KT, Vergez LM, Agullo L, Reyes VL, Hauser L, Cordova M, Gomez L, Gonzalez M, Land M, Lao V, Larimer FW, LiPuma JJ, Mahenthiralingam E, Malfatti SA, Marx CJ, Parnell JJ, Ramette A, Richardson PM, Seeger M, Smith D, Spilker T, Sul WJ, Tsoi TV, Ulrich LE, Zhulin IB, Tiedje JM. 2006. Burkholderia xenovorans LB400 harbors a multi-replicon, 973-Mbp genome shaped for versatility. Proc Natl Acad Sci U S A 103(42):15280-15287. doi:10.1073/pnas.0606924103 PMID:17030797 PMCID:PMC1622818
  • Qin J, Rosen BP, Zhang Y, Wang G, Franke S, Rensing CG. 2006. Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase. Proc Natl Acad Sci U S A 103(7):2075-2080. PMID:16452170
  • Sakurai T, Maeda S, Chang L, Karin M. 2006. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103(28):10544-10551. doi:10.1073/pnas.0603499103 PMID:16807293 PMCID:PMC1502270
  • Schmelzer KR, Inceoglu B, Kubala L, Kim I, Jinks SL, Eiserich JP, Hammock BD. 2006. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A 103(37):13646-13651. PMID:16950874
  • Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M. 2006. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci U S A 103(30):11323-11328. PMID:16844773
  • Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai H, Kim I, Tuteja D, Mateo RP, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N. 2006. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A 103(49):18733-18738. PMID:17130447


  • Liu Y, Zhang Y, Schmelzer KR, Lee T, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. 2005. The antiinflammatory effect of laminar flow: the role of PPAR, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A 102(46):16747-16752. PMID:16267130
  • Schmelzer KR, Kubala L, Newman JW, Kim I, Eiserich JP, Hammock BD. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci U S A 102(28):9772-9777. PMID:15994227
  • Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma S, Hammock BD. 2005. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci U S A 102(6):2186-2191. PMID:15684051
  • Stringer JR, Larson JS, Fischer JM, Medvedovic M, Hersh MN, Boivin GP, Stringer SL. 2005. Modeling variation in tumors in vivo. Proc Natl Acad Sci U S A 102(7):2408-2413. doi:10.1073/pnas.0401340102 PMID:15695337 PMCID:PMC548963


  • Feng Z, Hu W, Tang M. 2004. Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A 101(23):8598-8602. PMID:15187227
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  • Pleil JD, Vette AF, Johnson BA, Rappaport SM. 2004. Air levels of carcinogenic polycyclic aromatic hydrocarbons after the World Trade Center disaster. Proc Natl Acad Sci U S A 101(32):11685-11688. PMID:15280534
  • Tiedje JM, Konstantinidis KT. 2004. Trends between gene content and genome size in prokaryotic species with larger genomes. Proc Natl Acad Sci U S A 101(9):3160-3165. PMID:14973198
  • Valledor AF, Hsu L, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. 2004. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proc Natl Acad Sci U S A 101(51):17813-17818. PMID:15601766


  • Gong J, Lee DA, Schroeder JI. 2003. Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis. Proc Natl Acad Sci U S A 100(17):10118-10123. PMID:12909714
  • He L, Perkins GA, Poblenz AT, Harris JB, Hung M, Ellisman MH, Fox DA. 2003. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A 100(3):1022-1027. doi:10.1073/pnas.0333594100 PMID:12540825 PMCID:PMC298719
  • Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. 2003. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A 100(3):922-927. PMID:12552107
  • Newman JW, Morisseau C, Harris TR, Hammock BD. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A 100(4):1558-1563. PMID:12574510
  • Schroeder JI. 2003. Knockout of the guard cell K+ out channel and stomatal movements. Proc Natl Acad Sci U S A 100(9):4976-4977. PMID:12704226
  • Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK. 2003. PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. Proc Natl Acad Sci U S A 100(11):6712-6717. PMID:12740443


  • Cervantes RB, Stringer JR, Shao C, Tischfield JA, Stambrook PJ. 2002. Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc Natl Acad Sci U S A 99:3586-3590. PMID:11891338
  • Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A 99(4):2222-2227. PMID:11842228
  • Dennis S, Kortvelyesi T, Vajda S. 2002. Computational mapping identifies the binding sites of organic solvents on proteins. Proc Natl Acad Sci U S A 99(7):4290-4295. PMID:11904374
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  • Maser P, Hosoo Y, Goshima S, Horie T, Eckelman B, Yamada K, Yoshida K, Bakker EP, Shinmyo A, Oiki S, Schroeder JI, Uozumi N. 2002. Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants. Proc Natl Acad Sci U S A 99(9):6428-6433. PMID:11959905
  • Pickhardt PC, Folt CL, Chen CY, Klaue B, Blum JD. 2002. Algal blooms reduce the uptake of toxic methylmercury in freshwater food webs. Proc Natl Acad Sci U S A 99(7):4419-4423. doi:10.1073/pnas.072531099 PMID:11904388 PMCID:PMC123663
  • Roberts SA, Weichsel A, Grass G, Thakali K, Hazzard JT, Tollin G, Rensing CG, Montfort WR. 2002. Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli. Proc Natl Acad Sci U S A 99(5):2766-2771. doi:10.1073/pnas.052710499 PMID:11867755 PMCID:PMC122422
  • Sobol RW, Watson DE, Nakamura J, Yakes FM, Hou E, Horton JK, Wu J, Van Houten B, Swenberg JA, Tindall KR, Samson LD, Wilson SH. 2002. Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress. Proc Natl Acad Sci U S A 99(14):6860-6865. PMID:11983862
  • Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. 2002. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A 99(23):14952-14957. PMID:12397172
  • Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. 2002. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 99(23):15101-15106. PMID:12415113


  • Liu S, Athar M, Lippai I, Waldren CA, Hei TK. 2001. Induction of oxyradicals by arsenic: Implication for mechanisms of genotoxicity. Proc Natl Acad Sci U S A 98(4):1643-1648. PMID:11172004
  • Miyashita M, Presley JM, Buchholz BA, Lam KS, Lee YM, Vogel JS, Hammock BD. 2001. Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry. Proc Natl Acad Sci U S A 98(8):4403-4408. PMID:11287636
  • Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proc Natl Acad Sci U S A 98(6):3375-3380. PMID:11248086


  • Doty SL, Shang TQ, Wilson AM, Tangen J, Westergreen AD, Newman LA, Strand SE, Gordon MP. 2000. Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1. Proc Natl Acad Sci U S A 97(12):6287-6291. PMID:10841534
  • Gross LA, Baird GS, Hoffman RC, Baldridge KK, Tsien RY. 2000. The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A 97(22):11990-11995. PMID:11050230
  • Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC. 2000. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A 97(4):1427-1432. PMID:10677478 PMCID:PMC26450
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  • Shan G, Huang W, Gee SJ, Buchholz BA, Vogel JS, Hammock BD. 2000. Isotope-labeled immunoassays without radiation waste. Proc Natl Acad Sci U S A 97(6):2445-2449. PMID:10706612
  • Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. 2000. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc Natl Acad Sci U S A 97(9):4991-4996. PMID:10781110


  • Argiriadi MA, Morisseau C, Hammock BD, Christianson DW. 1999. Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase. Proc Natl Acad Sci U S A 96:10637-10642. PMID:10485878
  • Morisseau C, Goodrow MH, Dowdy DL, Zheng J, Greene JF, Sanborn JR, Hammock BD. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci U S A 96(16):8849-8854. PMID:10430859
  • Smith MT. 1999. Benzene, NQO1, and genetic susceptibility to cancer. Proc Natl Acad Sci U S A 96(14):7624-7626. PMID:10393869


  • Hei TK, Liu S, Waldren CA. 1998. Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species. Proc Natl Acad Sci U S A 95:8103-8107. PMID:9653147
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  • Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR. 1996. 17β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci U S A 93:9776-9781. PMID:8790407


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