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Search Results for Most Frequently Published Journals (Superfund Research Program)

Superfund Research Program

Search Results

Chemical Research in Toxicology (148 articles)

2020

  • Avilla MN, Malecki K, Hahn ME, Wilson RH, Bradfield CA. 2020. The ah receptor: adaptive metabolism, ligand diversity, and the xenokine model. Chem Res Toxicol 33:860-879. doi:10.1021/acs.chemrestox.9b00476 PMID:32259433 PMCID:PMC7175458
  • Elkin ER, Bridges D, Harris SM, Loch-Caruso R. 2020. Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine causes compensatory changes to macronutrient utilization and energy metabolism in placental HTR-8/SVneo cells. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00356 PMID:31951115
  • Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33(2):625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946 (in press)

2019

  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
  • Meakin C, Martin EM, Szilagyi JT, Nylander-French LA, Fry RC. 2019. Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation. Chem Res Toxicol 32(3):493-499. doi:10.1021/acs.chemrestox.8b00352 PMID:30746931
  • Melnikov F, Botta D, White CC, Schmuck S, Winfough M, Schaupp C, Gallagher EP, Brooks BW, Williams E, Coish P, Anastas P, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. 2019. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chem Res Toxicol 32(3):421-436. doi:10.1021/acs.chemrestox.8b00259
  • Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal A, Brooks BW, Coish P, Anastas P, Gallagher EP. 2019. CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00346
  • Stoddard EG, Nag S, Martin J, Killinger BJ, Corley RA, Smith JN, Wright AT. 2019. Benzo[a]pyrene induction of glutathione S-transferases: an activity-based protein profiling investigation. Chem Res Toxicol 32(6):1259-1267. doi:10.1021/acs.chemrestox.9b00069 PMID:30938511
  • Wu X, Zhai G, Schnoor JL, Lehmler H. 2019. Atropselective Disposition of 2,2 ,3,4 ,6-Pentachlorobiphenyl (PCB 91) and Identification of Its Metabolites in Mice with Liver-Specific Deletion of Cytochrome P450 Reductase. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00255 PMID:31403789 PMCID:PMC7042073

2018

2017

  • Edrissi B, Taghizadeh K, Moeller BC, Yu R, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2017. N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats. Chem Res Toxicol 30(8):1572-1576. doi:10.1021/acs.chemrestox.7b00075 PMID:28692800 PMCID:PMC5807069
  • Gao L, Mutlu E, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2017. DNA product formation in female Sprague-Dawley rats following polyhalogenated aromatic hydrocarbon (PHAH) exposure. Chem Res Toxicol 30(3):794-803. doi:10.1021/acs.chemrestox.6b00368 PMID:28207250 PMCID:PMC5363288
  • Haggard DE, Das SR, Tanguay RL. 2017. Comparative toxicogenomic responses to the flame retardant mITP in developing zebrafish. Chem Res Toxicol 30(2):508-515. doi:10.1021/acs.chemrestox.6b00423 PMID:27957850
  • Nault R, Fader KA, Lydic TA, Zacharewski TR. 2017. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Res Toxicol 30(4):1060-1075. doi:10.1021/acs.chemrestox.6b00430 PMID:28238261
  • Rager JE, Auerbach SS, Chappell G, Martin EM, Thompson CM, Fry RC. 2017. Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Chem Res Toxicol 30(10):1911-1920. doi:10.1021/acs.chemrestox.7b00221
  • Wang M, Maki CR, Deng Y, Tian Y, Phillips TD. 2017. Development of high capacity enterosorbents for aflatoxin B1 and other hazardous chemicals. Chem Res Toxicol 30(9):1694-1701. doi:10.1021/acs.chemrestox.7b00154 PMID:28768106

2016

  • Anderson DG, Florang V, Schamp J, Buettner GR, Doorn JA. 2016. Antioxidant-mediated modulation of protein reactivity for 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Chem Res Toxicol 29(7):1098-1107. doi:10.1021/acs.chemrestox.5b00528 PMID:27268734 PMCID:PMC5248556
  • Gadupudi GS, Klingelhutz AJ, Robertson LW. 2016. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol 29(9):1504-1509. doi:10.1021/acs.chemrestox.6b00172 PMID:27509375
  • Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851-859. doi:10.1021/acs.chemrestox.6b00022 PMID:26967026 PMCID:PMC5100827
  • Madeen E, Ognibene T, Corley RA, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE, McQuistan TJ. 2016. Human microdosing with carcinogenic polycyclic aromatic hydrocarbons: in vivo pharmacokinetics of dibenzo[def,p]chrysene and metabolites by UPLC accelerator mass spectrometry. Chem Res Toxicol 29(10):1641-1650. doi:10.1021/acs.chemrestox.6b00169 PMID:27494294 PMCID:PMC5380438
  • Mutlu E, Gao L, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2016. Polychlorinated biphenyls induce oxidative DNA adducts in female Sprague-Dawley rats. Chem Res Toxicol 29(8):1335-1344. doi:10.1021/acs.chemrestox.6b00146 PMID:27436759 PMCID:PMC5020703
  • Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371 PMID:27989147 PMCID:PMC5175585

2015

  • Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433r PMID:25932594 PMCID:PMC4737589
  • DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. 2015. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol 28(6):1176-1185. doi:10.1021/acs.chemrestox.5b00003 PMID:26001051 PMCID:PMC4469569
  • Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
  • Madeen E, Corley RA, Crowell SR, Turteltaub KW, Ognibene T, Malfatti MA, McQuistan TJ, Garrard M, Sudakin D, Williams DE. 2015. Human in vivo pharmacokinetics of [(14)C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing. Chem Res Toxicol 28(1):126-134. doi:10.1021/tx5003996 PMID:25418912 PMCID:PMC4303324
  • Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393y PMID:26039340 PMCID:PMC4748849
  • Whitehead TP, Havel C, Metayer C, Benowitz NL, Jacob P. 2015. Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users. Chem Res Toxicol 28(5):1007-1014. doi:10.1021/acs.chemrestox.5b00040 PMID:25794360 PMCID:PMC4827423

2014

  • Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
  • Sharma V, Collins LB, Clement JM, Zhang Z, Nakamura J, Swenberg JA. 2014. Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells. Chem Res Toxicol 27(4):480-482. doi:10.1021/tx5000602 PMID:24628573 PMCID:PMC3998766
  • Zhou X, Sun X, Mobarak C, Gandolfi A, Burchiel SW, Hudson LG, Liu K. 2014. Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol 27(4):690-698. doi:10.1021/tx500022j PMID:24611629 PMCID:PMC3998772

2013

  • Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539 PMID:23713983 PMCID:PMC3703249
  • Edrissi B, Taghizadeh K, Moeller BC, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2013. Dosimetry of n(6)-formyllysine adducts following [(13)c(2)h2]-formaldehyde exposures in rats. Chem Res Toxicol 26(10):1421-1423. doi:10.1021/tx400320u PMID:24087891 PMCID:PMC3805309
  • Kautz R, Wang P, Giese RW. 2013. Nuclear magnetic resonance at the picomole level of a DNA adduct. Chem Res Toxicol 26(10):1424-1429. doi:10.1021/tx400051j PMID:24028148 PMCID:PMC3925674
  • Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227s PMID:24224526 PMCID:PMC4112599
  • Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek-Hock WM, Wang K, Ludewig G, Robertson LW. 2013. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?. Chem Res Toxicol 26(5):634-644. doi:10.1021/tx400049s PMID:23527585 PMCID:PMC3660509
  • Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. 2013. Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol 26(8):1199-1208. doi:10.1021/tx400110f PMID:23848138 PMCID:PMC3818153
  • Qin X, Lehmler H, Teesch LM, Robertson LW, Duffel MW. 2013. Chlorinated biphenyl quinones and phenyl- 2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 26(10):1474-1485. doi:10.1021/tx400207q PMID:24059442 PMCID:PMC3846294
  • Wu X, Duffel MW, Lehmler H. 2013. Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective. Chem Res Toxicol 26(11):16421651. doi:10.1021/tx400229e PMID:24107130 PMCID:PMC3857157

2012

  • Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396
  • Lu K, Craft S, Nakamura J, Moeller BC, Swenberg JA. 2012. Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine. Chem Res Toxicol 25(3):664-675. doi:10.1021/tx200426b PMID:22148432 PMCID:PMC3307879
  • Mutlu E, Jeong Y, Collins LB, Ham AL, Upton PB, Hatch G, Winsett D, Evansky P, Swenberg JA. 2012. A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-oxoethyl)guanine in Sprague–Dawley rats. Chem Res Toxicol 25(2):391-399. doi:10.1021/tx200447w PMID:22211352 PMCID:PMC3288741
  • Sanchez V, Jachak A, Hurt RH, Kane AB. 2012. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol 25(1):15-34. doi:10.1021/tx200339h PMID:21954945 PMCID:PMC3259226
  • Wang P, Gao J, Li G, Shimelis O, Giese RW. 2012. Nontargeted analysis of DNA adducts by mass-tag MS: Reaction of p-Benzoquinone with DNA. Chem Res Toxicol 25:2737-2743. doi:10.1021/tx300363a PMID:23113579 PMCID:PMC3527073

2011

  • Dere E, Forgacs AL, Zacharewski TR, Burgoon LD. 2011. Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes. Chem Res Toxicol 24:494-504. doi:10.1021/tx100328r PMID:21370876 PMCID:PMC4038167
  • Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260h PMID:21913674 PMCID:PMC3196794
  • Lu K, Moeller BC, Doyle-Eisele M, McDonald JD, Swenberg JA. 2011. Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem Res Toxicol 24(2):159-161. doi:10.1021/tx1003886 PMID:21155545 PMCID:PMC3128468
  • Moeller BC, Lu K, Doyle-Eisele M, McDonald JD, Gigliotti A, Swenberg JA. 2011. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. Chem Res Toxicol 24(2):162-164. doi:10.1021/tx1004166 PMID:21222454 PMCID:PMC3273041
  • Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360m PMID:22026639 PMCID:PMC3243785
  • Zhitkovich A. 2011. Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol 24(10):1617–1629. doi:10.1021/tx200251t PMID:21766833 PMCID:PMC3196244 (Completed with ARRA Funds)

2010

  • Bono R, Romanazzi V, Munnia A, Piro S, Allione A, Ricceri F, Guarrera S, Pignata C, Matullo G, Wang P, Giese RW, Peluso M. 2010. Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure. Chem Res Toxicol 23(8):1342-1348. doi:10.1021/tx100083x PMID:20707408 PMCID:PMC2924748
  • Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA. 2010. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following exposure to [13C2]-VC. Chem Res Toxicol 23(9):1485-1491. doi:10.1021/tx1001767 PMID:20799743 PMCID:PMC3104734
  • Zhitkovich A, Hagan E, Macfie A. 2010. Mechanism of DNA-protein cross-linking by chromium. Chem Res Toxicol 23(2):341-347. doi:10.1021/tx9003402 PMID:19877617 PMCID:PMC2822107

2009

  • Klosener J, Peters TM, Adamcakova-Dodd A, Teesch LM, Thorne PS, Robertson LW, Luthe G. 2009. Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures. Chem Res Toxicol 22(1):179-186. doi:10.1021/tx8003032 PMID:19111055 PMCID:PMC3120107
  • Pessah IN, Lehmler H, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. 2009. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol 22(1):201-207. doi:10.1021/tx800328u PMID:18954145 PMCID:PMC2662366
  • Swenberg JA, Starr TB, Albertini R, Walker V. 2009. Response to Keshava et al. Chem Res Toxicol 22(1):10-12. doi:10.1021/tx800438g
  • Wangpradit O, Teesch LM, Mariappan S, Duffel MW, Norstrom K, Robertson LW, Luthe G. 2009. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Toxicol 22(1):64-71. doi:10.1021/tx800300t PMID:19105592 PMCID:PMC2637223
  • Zhu H, Martin T, Ye L, Sedykh A, Young D, Tropsha A. 2009. Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure. Chem Res Toxicol 22(12):1913-1921. doi:10.1021/tx900189p PMID:19845371 PMCID:PMC2796713

2008

  • Gulcan HO, Duffel MW. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 21(8):1503-1508. doi:10.1021/tx800133d PMID:18656962 PMCID:PMC2548291
  • Guttmann D, Poage G, Johnston T, Zhitkovich A. 2008. Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism. Chem Res Toxicol 21(11):2188-2194. doi:10.1021/tx800265g PMID:18808157 PMCID:PMC2665875
  • Kang-Sickel JC, Nam T, Jayaraj K, Ball LM, French JE, Klapper DG, Gold A, Nylander-French LA. 2008. S-arylcysteine-keratin adducts as biomarkers of human dermal exposure to aromatic hydrocarbons. Chem Res Toxicol 21(4):852-858. doi:10.1021/tx7003773 PMID:18361511
  • Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H. 2008. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21(6):1295-1303. doi:10.1021/tx800059j PMID:18494506 PMCID:PMC2574739
  • Lu K, Boysen G, Swenberg JA, Gao L, Collins LB. 2008. Formaldehyde-induced histone modifications in vitro. Chem Res Toxicol 21(8):1586-1593. doi:10.1021/tx8000576 PMID:18656964
  • Luthe G, Boy R, Jacobus JA, Smith B, Rahaman A, Robertson LW, Ludewig G. 2008. Xenobiotic geometry and media pH determine cytotoxicity through solubility. Chem Res Toxicol 21(5):1017-1027. doi:10.1021/tx700214p PMID:18402468
  • Morisseau C, Newman JW, Wheelock CE, Hill T, Morin D, Buckpitt AR, Hammock BD. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol 21(4):951-957. doi:10.1021/tx700446u PMID:18363382
  • Salnikow K, Zhitkovich A. 2008. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21(1):28-44. doi:10.1021/tx700198a PMID:17970581 PMCID:PMC2602826
  • Swenberg JA, Fryar-Tita E, Jeong Y, Boysen G, Starr TB, Walker V, Albertini R. 2008. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol 21(1):253-265. doi:10.1021/tx700408t PMID:18161944
  • Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol 21(3):583-590. doi:10.1021/tx7002454 PMID:18251509

2007

  • Bender RP, Osheroff N. 2007. Mutation of cysteine residue 455 to alanine in human topoisomerase lla confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol 20:975-981.
  • Xu A, Huang SX, Lien Y, Bao L, Yu Z, Hei TK. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol 20(5):724-33. PMID:17447795
  • Yuan W, Chung JS, Gee SJ, Hammock BD, Zheng J. 2007. Development of polyclonal antibodies for the detection of styrene oxide modified proteins. Chem Res Toxicol 20(2):316-321. doi:10.1021/tx600340c PMID:17266334 PMCID:PMC2565645

2006

  • Aposhian HV, Aposhian MM. 2006. Arsenic toxicology: five questions (review). Chem Res Toxicol 19(1):1-15. PMID:16411650
  • Bodwell J, Gosse JA, Nomikos AP, Hamilton JW. 2006. Arsenic disruption of steroid receptor gene activation: complex dose-response effects are shared by several steroid receptors. Chem Res Toxicol 19(12):1619-1629. doi:10.1021/tx060122q PMID:17173375 PMCID:PMC2556599
  • Kaya T, Mohr SC, Waxman DJ, Vajda S. 2006. Computational screening of phthalate monoesters for binding to PPARgamma. Chem Res Toxicol 19(8):999-1009. doi:10.1021/tx050301s PMID:16918238
  • Lee K, Burgoon LD, Lamb L, Dere E, Zacharewski TR, Hogenesch JB, LaPres JJ. 2006. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chem Res Toxicol 19(10):1284-1293. doi:10.1021/tx060068d PMID:17040097 PMCID:PMC3152583
  • Liu Y, Apak TI, Lehmler H, Robertson LW, Duffel MW. 2006. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 19(11):1420-1425. PMID:17112228
  • Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do ZN, Kim K, Wong PW. 2006. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chem Res Toxicol 19(1):92-101. doi:10.1021/tx050196m PMID:16411661
  • Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Ball LM. 2006. A 2-iminohydantoin from the oxidation of guanine. Chem Res Toxicol 19(4):506-10. PMID:16608161

2005

  • Henderson AP, Barnes ML, Bleasdale C, Cameron R, Clegg W, Heath SL, Lindstrom AB, Rappaport SM, Waidyanatha S, Watson WP, Golding BT. 2005. Reactions of benzene oxide with thiols including glutathione. Chem Res Toxicol 18(2):265-270. doi:10.1021/tx049781y PMID:15720131
  • Henderson PT, Neeley WL, Delaney JC, Gu F, Niles JC, Hah SS, Essigmann JM, Tannenbaum SR. 2005. Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations. Chem Res Toxicol 18(1):12-18. PMID:15651843
  • Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. 2005. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chem Res Toxicol 18(9):1371-1377. PMID:16167828
  • Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. 2005. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem Res Toxicol 18(3):516-527. doi:10.1021/tx049773h PMID:15777092
  • Jeong Y, Sangaiah R, Nakamura J, Pachkowski BF, Ranasinghe A, Gold A, Ball LM, Swenberg JA. 2005. Analysis of M(1)G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry. Chem Res Toxicol 18(1):51-60. PMID:15651849
  • Lin C, Isbell MA, Morin D, Boland BC, Salemi MR, Jewell WT, Weir AJ, Fanucchi MV, Baker GL, Plopper CG, Buckpitt AR. 2005. Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs. lung rway incubation in situ vs. lung microsomes. Chem Res Toxicol 18(5):802-813.
  • Lin C, Leow H, Huang S, Nakamura J, Swenberg JA, Lin P. 2005. Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. Chem Res Toxicol 18(2):257-264. PMID:15720130
  • Waidyanatha S, Sangaiah R, Rappaport SM. 2005. Characterization and quantification of cysteinyl adducts of benzene diol epoxide. Chem Res Toxicol 18(7):1178-1185. PMID:16022511
  • Zakharyan RA, Tsaprailis G, Chowdhury UK, Hernandez A, Aposhian HV. 2005. Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase. Chem Res Toxicol 18(8):1287-1295. doi:10.1021/tx0500530 PMID:16097802

2004

  • Bodwell J, Kingsley LA, Hamilton JW. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17(8):1064-1076. PMID:15310238
  • Chiarappa-Zucca ML, Finkel RC, Martinelli RE, McAninch JE, Nelson DO, Turteltaub KW. 2004. Measurement of beryllium in biological samples by accelerator mass spectrometry: applications for studying chronic beryllium disease. Chem Res Toxicol 17(12):1614-20. PMID:15606137
  • Machala M, Blaha L, Lehmler H, Pliskova M, Majkova Z, Kapplova P, Sovadinova I, Vondracek J, Malmberg T, Robertson LW. 2004. Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells. Chem Res Toxicol 17(3):340-347. doi:10.1021/tx030034v PMID:15025504
  • Shan G, Huang H, Stoutamire DW, Gee SJ, Leng G, Hammock BD. 2004. A sensitive class specific immunoassay for the detection of pyrethroid metabolites in human urine. Chem Res Toxicol 17(2):218-225. PMID:14967009
  • Soucy NV, Klei LR, Mayka DD, Barchowsky A. 2004. Signaling pathways for arsenic-stimulated vascular endothelial growth factor-a expression in primary vascular smooth muscle cells. Chem Res Toxicol 17(4):555-563. PMID:15089098

2003

  • Lum KT, Huebner HJ, Li Y, Phillips TD, Raushel FM. 2003. Organophosphate nerve agent toxicity in Hydra attenuata. Chem Res Toxicol 16(8):953-957. PMID:12924922
  • Marnell LL, Garcia-Vargas GG, Chowdhury UK, Zakharyan RA, Walsh B, Avram MD, Kopplin MJ, Cebrian ME, Silbergeld EK, Aposhian HV. 2003. Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles. Chem Res Toxicol 16(12):1507-1513. PMID:14680363
  • Patterson TP, Ngo MA, Aronov PA, Reznikova TV, Green PG. 2003. Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes. Chem Res Toxicol 16(12):1624-1631. PMID:14680377
  • Safe SH, Wormke M. 2003. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chem Res Toxicol 16(7):807-816. doi:10.1021/tx034036r PMID:12870882

2002

  • Gong Z, Jiang G, Cullen WR, Aposhian HV. 2002. Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. Chem Res Toxicol 15(10):1318-1323. PMID:12387631
  • Olivero J, Bezdecny SA, Ganey PE. 2002. A molecular motif required for the activation of rat neutrophil Phospholipase A2 by organochlorine compounds. Chem Res Toxicol 15(2):153-159.
  • Radabaugh TR, Sampayo-Reyes A, Zakharyan RA, Aposhian HV. 2002. Arsenate reductase II. Purine nucleoside phophorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. Chem Res Toxicol 15(5):692-698.
  • Srinivasan A, Robertson LW, Ludewig G. 2002. Sulfhydryl binding and topoisomerase inhibition by PCB Metabolites. Chem Res Toxicol 15(4):497-505. PMID:11952335
  • Tampal N, Lehmler H, Espandiari P, Malmberg T, Robertson LW. 2002. Glucuronidation of hydroxylated polychlorinated biphenyls (PCBs). Chem Res Toxicol 15(10):1259-1266. doi:10.1021/tx0200212 PMID:12387623

2001

  • Lemke SL, Ottinger SE, Ake CL, Mayura K, Phillips TD. 2001. Deamination of fumonisin B1 and biological assessment of reaction product toxicity. Chem Res Toxicol 14(1):11-15. PMID:11170503
  • Morinello EJ, Ham AL, Ranasinghe A, Sangaiah R, Swenberg JA. 2001. Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay. Chem Res Toxicol 14(3):327-334. PMID:11258983
  • Morisseau C, Newman JW, Dowdy DL, Goodrow MH, Hammock BD. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chem Res Toxicol 14(4):409-415. PMID:11304129
  • Petrick JS, Jagadish B, Mash EA, Aposhian HV. 2001. Monomethylarsonous acid (MMAIII) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem Res Toxicol 14(6):651-656. PMID:11409934
  • Wheelock CE, Severson T, Hammock BD. 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chem Res Toxicol 14(12):1563-1572. PMID:11743738
  • Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV. 2001. Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione-S-transferase superfamily. Chem Res Toxicol 14(8):1051-1057. PMID:11511179

2000

  • Aposhian HV, Gurzau ES, Le X, Gurzau A, Healy SM, Lu X, Ma M, Yip L, Zakharyan RA, Maiorino RM, Dart RC, Tircus MG, Gonzalez-Ramirez D, Morgan DL, Avram D, Aposhian MM. 2000. Occurrence of monomethylarsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. Chem Res Toxicol 13(8):693-697. PMID:10956055
  • Greene JF, Newman JW, Williamson K, Hammock BD. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem Res Toxicol 13(4):217-226. PMID:10775319
  • Ham AL, Ranasinghe A, Koc H, Swenberg JA. 2000. 4-Hydroxy-2-nonenal and ethyl linoleate from N2,3-ethenoguanine under peroxidizing conditions. Chem Res Toxicol 13:1243-1250.
  • Lin P, Sangaiah R, Ranasinghe A, Upton PB, La DK, Gold A, Swenberg JA. 2000. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl. Chem Res Toxicol 13(8):710-718. PMID:10956058
  • Radabaugh TR, Aposhian HV. 2000. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem Res Toxicol 13(1):26-30. PMID:10649963
  • Sampayo-Reyes A, Zakharyan RA, Healy SM, Aposhian HV. 2000. Monomethylarsonic acid (MMAV) reductase and monomethylarsonous acid (MMAIII) in hamster tissue. Chem Res Toxicol 13(11):1181-1186.

1999

  • Ham AL, Ranasinghe A, Morinello EJ, Nakamura J, Upton PB, Johnson F, Swenberg JA. 1999. Immunoaffinity/gas chromatography/high resolution mass spectrometry method for the detection of N2,3-ethenoguanine. Chem Res Toxicol 12:1240-1246. PMID:10604874
  • Shan G, Wengatz I, Stoutamire DW, Gee SJ, Hammock BD. 1999. An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine. Chem Res Toxicol 12(11):1033-1041. PMID:10563828
  • Watt KC, Morin D, Kurth M, Mercer RS, Plopper CG, Buckpitt AR. 1999. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: Identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Chem Res Toxicol 12(9):831-839. PMID:10490505
  • Wiemels JL, Wiencke JK, Varkonyi A, Smith MT. 1999. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 12(6):467-475. doi:10.1021/tx9800811 PMID:10368308
  • Wu K, Scheller NA, Ranasinghe A, Yen T, Sangaiah R, Giese RW, Swenberg JA. 1999. A gas chromatography/electron capture/negative chemical ionization-high resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chem Res Toxicol 12(8):722-729. PMID:10458706
  • Zakharyan RA, Aposhian HV. 1999. Enzymatic reduction of arsenic compounds in mammalian systems: the rate limiting enzyme of rabbit liver arsenic biotransformation is MMAV reductase. Chem Res Toxicol 12(12):1278-1283. PMID:10604879

1998

  • Dingley KH, Roberts ML, Velsko CA, Turteltaub KW. 1998. Attomole detection of 3H in biological samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies in conjunction with 14C accelerator mass spectrometry. Chem Res Toxicol 11(10):1217-1222. PMID:9778319
  • Jaeger LL, Jones AD, Hammock BD. 1998. Development of an enzyme-linked immunosorbent assay for atrazine mercapturic acid in human urine. Chem Res Toxicol 11(4):342-352. doi:10.1021/tx9701844 PMID:9548805
  • Lindstrom AB, Yeowell-O'Connell K, Waidyanatha S, McDonald TA, Golding BT, Rappaport SM. 1998. Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood. Chem Res Toxicol 11:302-310. PMID:9548800
  • Ranasinghe A, Scheller NA, Wu K, Upton PB, Swenberg JA. 1998. Application of gas chromatography/electron capture negative chemical ionization/high resolution mass spectrometry for analysis of DNA and protein adducts. Chem Res Toxicol 11:520-526. PMID:9585483
  • Yen T, Holt S, Sangaiah R, Gold A, Swenberg JA. 1998. Quantitation of 1,N6 ethenoadenine in rat urine by immunoaffinity extraction combined with liquid chromatography/electrospray ionization mass spectrometry. Chem Res Toxicol 11(7):810-815. PMID:9671544

1997

  • Brunmark P, Harriman SP, Skipper PL, Wishnok JS, Amin S, Tannenbaum SR. 1997. Identification of subdomain IB in human serum albumin as a major binding site for polycyclic aromatic hydrocarbon epoxides. Chem Res Toxicol 10(8):880-886. PMID:9282837
  • Zheng J, Cho M, Jones AD, Hammock BD. 1997. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene. Chem Res Toxicol 10(9):1008-1014. PMID:9305583

1996

  • Amaro AR, Oakley GG, Bauer U, Spielmann HP, Robertson LW. 1996. Metabolic activation of PCBs to quinones: reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase. Chem Res Toxicol 9:623-629. PMID:8728508
  • McLean MR, Bauer U, Amaro AR, Robertson LW. 1996. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem Res Toxicol 9:158-164. PMID:8924585
  • McLean MR, Robertson LW, Gupta RC. 1996. Detection of PCB-adducts by the 32P- postlabeling technique. Chem Res Toxicol 9:165-171. PMID:8924587
  • Oakley GG, Devanaboyina U, Robertson LW, Gupta RC. 1996. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): Implications for PCB induced oxidative stress in breast cancer. Chem Res Toxicol 9:1285-1292. PMID:8951230
  • Randerath K, Randerath E, Smith CV, Chang J. 1996. Structural origins of bulky oxidative DNA adducts (Type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence. Chem Res Toxicol 9:247-254. PMID:8924599
  • Skipper PL. 1996. Influence of tertiary structure on nucleophilic substitution reactions of proteins. Chem Res Toxicol 9(6):918-923. PMID:8870977
  • Waidyanatha S, Lin P, Rappaport SM. 1996. Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats. Chem Res Toxicol 9(3):647-653. PMID:8728511
  • Warren AJ, Hamilton JW. 1996. Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand crosslink in a model synthetic 23 base pair oligonucleotide DNA duplex. Chem Res Toxicol 9:1063-1071. PMID:8902260
  • Zheng J, Hammock BD. 1996. Development of polyclonal antibodies for detection of protein modification by 1,2-naphthoquinone. Chem Res Toxicol 9(5):904-909. PMID:8828928

1995

  • Bauer U, Amaro AR, Robertson LW. 1995. A new strategy for the synthesis of polychlorinated biphenyl metabolites. Chem Res Toxicol 8:92-95. PMID:7703372
  • Bruenner BA, Jones AD, German JB. 1995. Direct characterization of protein adducts of the lipid peroxidation product 4-hydroxy-2-nonenal using electrospray mass spectrometry. Chem Res Toxicol 8(4):552-559. PMID:7548735
  • El Ghissassi F, Barbin A, Nair J, Bartsch H. 1995. Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chem Res Toxicol 8:278-283. PMID:7766812
  • Fang X, Fernando Q. 1995. Stereoisomeric selectivity of 2,3-dimercaptosuccinic acids in chelation therapy for lead poisoning. Chem Res Toxicol 8(4):525-536. PMID:7548732
  • Mitchell AE, Morin D, Lame MW, Jones AD. 1995. Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases. Chem Res Toxicol 8(8):1054-1062. PMID:8605288
  • Scheller NA, Sangaiah R, Ranasinghe A, Amarnath V, Gold A, Swenberg JA. 1995. Synthesis of [4,5,6,8-13C4]guanine, a reagent for the production of internal standards of guanyl DNA adducts. Chem Res Toxicol 8(3):333-337. PMID:7578918
  • Shertzer HG, Vasiliou V, Liu R, Tabor MW, Nebert DW. 1995. Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells. Chem Res Toxicol 8(3):431-436. PMID:7578930
  • Zakharyan RA, Wu Y, Bogdan GM, Aposhian HV. 1995. Enzymatic methylation of arsenic compounds: I. Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem Res Toxicol 8(8):1029-1038. PMID:8605285
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