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Search Results for Most Frequently Published Journals (Superfund Research Program)

Superfund Research Program

Search Results

Chemical Research in Toxicology (173 articles)


  • Gaither KA, Garcia WL, Tyrrell KJ, Wright AT, Smith JN. 2024. Activity-based protein profiling to probe relationships between cytochrome P450 enzymes and early-age metabolism of two polycyclic aromatic hydrocarbons (PAHs): Phenanthrene and retene. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00424


  • Crisalli AM, Cai A, Cho BP. 2023. Probing the interactions of perfluorocarboxylic acids of various chain lengths with human serum albumin: calorimetric and spectroscopic investigations. Chem Res Toxicol 36(4):703-713. doi:10.1021/acs.chemrestox.3c00011 PMID:37001030
  • Hsiao Y, Matulewicz RS, Sherman SE, Jaspers I, Weitzman ML, Gordon T, Liu C, Yang Y, Lu K, Bjurlin MA. 2023. Untargeted metabolomics to characterize the urinary chemical landscape of e-cigarette users. Chem Res Toxicol 36(4):630-642. doi:10.1021/acs.chemrestox.2c00346 PMID:36912507 PMCID:PMC10371198
  • Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128 PMID:37467352
  • Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR. 2023. Cystine/glutamate Xc- antiprorter induction compensates for transsulfuration pathway repression by 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) to ensure cysteine for heptic glutathione biosynthesis. Chem Res Toxicol 36(6):900-915. doi:10.1021/acs.chemrestox.3c00017 PMID:37184393 PMCID:PMC10284067
  • Paranjape N, Dean LE, Martinez A, Tjalkens RB, Lehmler H, Doorn JA. 2023. Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity. Chem Res Toxicol 36(6):971-981. doi:10.1021/acs.chemrestox.3c00095 PMID:37279407 PMCID:PMC10283044
  • Su AL, Harris S, Elkin ER, Karnovsky A, Colacino JA, Loch-Caruso R. 2023. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-1-cysteine stimulates changes in energy metabolites and amino acids in the BeWo Human Placental Trophoblast Model during syncytialization. Chem Res Toxicol 36(6):882-899. doi:10.1021/acs.chemrestox.3c00007 PMID:37162359
  • Yang Y, Chi L, Liu C, Hsiao Y, Lu K. 2023. Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis in mice. Chem Res Toxicol 36(7):1037-1043. doi:10.1021/acs.chemrestox.2c00410 PMID:37295807


  • Basu AK, Essigmann JM. 2022. Establishing linkages among DNA damage, mutagenesis, and genetic diseases. Chem Res Toxicol doi:10.1021/acs.chemrestox.2c00155 PMID:35881568
  • Garcia WL, Miller CJ, Lomas GX, Gaither KA, Tyrrell KJ, Smith JN, Brandvold KR, Wright AT. 2022. Profiling how the gut microbiome modulates host xenobiotic metabolism in response to benzo[a]pyrene and 1-nitropyrene exposure. Chem Res Toxicol 35(4):585-596. doi:10.1021/acs.chemrestox.1c00360
  • Lehmler H, Uwimana E, Dean LE, Kovalchuk N, Zhang Q, Ding X. 2022. Probing the role of CYP2 enzymes in the atroposelective metabolism of polychlorinated biphenyls using liver microsomes from transgenic mouse models. Chem Res Toxicol 35(12):2310-2323. doi:10.1021/acs.chemrestox.2c00276 PMID:36473170
  • Lorkiewicz P, Keith RJ, Lynch J, Jin L, Theis W, Krivokhizhina T, Riggs D, Bhatnagar A, Srivastava S, Conklin DJ. 2022. Electronic cigarette solvents, JUUL e-liquids, and biomarkers of exposure: In vivo evidence for acrolein and glycidol in e-cig-derived aerosols. Chem Res Toxicol doi:10.1021/acs.chemrestox.1c00328 PMID:35044764


  • Bullert AJ, Doorn JA, Stevens HE, Lehmler H. 2021. The effects of polychlorinated biphenyl exposure during adolescence on the nervous system: A comprehensive review. Chem Res Toxicol 34(9):doi:10.1021/acs.chemrestox.1c00226 PMID:34491731 PMCID:PMC8456429
  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol 34(9):2110-2124. doi:10.1021/acs.chemrestox.1c00203 PMID:34448577
  • Chang Y, Rager JE, Tilton SC. 2021. Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chem Res Toxicol 34(6):1445-1455. doi:10.1021/acs.chemrestox.0c00333 PMID:34048650
  • Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova N, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383. doi:10.1021/acs.chemrestox.1c00291 PMID:34726909 PMCID:PMC8715497
  • Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. 2021. New alkoxy- analogues of expoxyeicosatrienoic acids attenuate cisplatin nephrotoxicity in vitro via reduction of mitochondrial dysfunction, oxidative stress, mitogen-activated protein kinase signaling, and caspase activation. Chem Res Toxicol 34:2579-2591. doi:10.1021/acs.chemrestox.1c00347 PMID:34817988
  • Stoddard EG, Nag S, Martin J, Tyrrell KJ, Gibbins T, Anderson KA, Shukla AK, Corley RA, Wright AT, Smith JN. 2021. Exposure to an environmental mixture of polycyclic aromatic hydrocarbons induces hepatic cytochrome P450 enzymes in mice. Chem Res Toxicol 34(9):2145-2156. doi:10.1021/acs.chemrestox.1c00235 PMID:34472326
  • Zhang C, Klocke CR, Lein PJ, Lehmler H. 2021. Disposition of PCB 11 in mice following acute oral exposure. Chem Res Toxicol 34:988-991. doi:10.1021/acs.chemrestox.1c00067 PMID:33734669 PMCID:PMC8058299


  • Avilla MN, Malecki K, Hahn ME, Wilson RH, Bradfield CA. 2020. The ah receptor: adaptive metabolism, ligand diversity, and the xenokine model. Chem Res Toxicol 33:860-879. doi:10.1021/acs.chemrestox.9b00476 PMID:32259433 PMCID:PMC7175458
  • Chao C, Engelward BP. 2020. Applications of CometChip for environmental health studies. Chem Res Toxicol 33:1528-1538. doi:10.1021/acs.chemrestox.9b00393 PMID:32519858
  • Douillet C, Koller BH, Styblo M. 2020. Metabolism of inorganic arsenic in mice lacking genes encoding GST-P, GST-M, and GST-T. Chem Res Toxicol 33(8):2043-2046. doi:10.1021/acs.chemrestox.0c00273 PMID:32700902 PMCID:PMC7802361
  • Elkin ER, Bridges D, Harris SM, Loch-Caruso R. 2020. Exposure to trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine causes compensatory changes to macronutrient utilization and energy metabolism in placental HTR-8/SVneo cells. Chem Res Toxicol 33:1339-1355. doi:10.1021/acs.chemrestox.9b00356 PMID:31951115 PMCID:PMC7299793
  • Hsiao Y, Liu C, Chi L, Yang Y, Lu K. 2020. Effects of gut microbiome on carcinogenic DNA damage. Chem Res Toxicol 33:2130-2138. doi:10.1021/acs.chemrestox.0c00142 PMID:32677427
  • Phillips AL, Herkert N, Ulrich JC, Hartman JH, Ruis MT, Cooper EM, Ferguson PL, Stapleton HM. 2020. In vitro metabolism of isopropylated and tert-butylated triarylphosphate esters using human liver subcellular fractions. Chem Res Toxicol 33:1428-1441. doi:10.1021/acs.chemrestox.0c00002 PMID:32129605 PMCID:PMC7508416
  • Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher EP, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Kostal J, Brooks BW. 2020. Toward less hazardous industrial compounds: Coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of S(N)2 electrophiles in alternative vertebrate models. Chem Res Toxicol 33(2):367-380. doi:10.1021/acs.chemrestox.9b00290 PMID:31789507
  • Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33:625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946
  • Wu X, Zhai G, Schnoor JL, Lehmler H. 2020. Atropselective disposition of 2,2 ,3,4 ,6-Pentachlorobiphenyl (PCB 91) and identification of its metabolites in mice with liver-specific deletion of Cytochrome P450 Reductase. Chem Res Toxicol 33:1328-1338. doi:10.1021/acs.chemrestox.9b00255 PMID:31403789 PMCID:PMC7042073


  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol 32(5):doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
  • Meakin C, Martin EM, Szilagyi JT, Nylander-French LA, Fry RC. 2019. Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation. Chem Res Toxicol 32(3):493-499. doi:10.1021/acs.chemrestox.8b00352 PMID:30746931
  • Melnikov F, Botta D, White CC, Schmuck S, Winfough M, Schaupp C, Gallagher EP, Brooks BW, Williams E, Coish P, Anastas P, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. 2019. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chem Res Toxicol 32(3):421-436. doi:10.1021/acs.chemrestox.8b00259
  • Mexia N, Koutrakis S, He G, Skaltounis L, Denison MS, Magiatis P. 2019. RETURN TO ISSUEPREVARTICLENEXT Journal Logo A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids with High AhR Potency and Efficacy. Chem Res Toxicol 32:doi:10.1021/acs.chemrestox.9b00270 PMID:31647221 PMCID:PMC7757739 (accepted for publication)
  • Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal A, Brooks BW, Coish P, Anastas P, Gallagher EP. 2019. CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00346
  • Stoddard EG, Nag S, Martin J, Killinger BJ, Corley RA, Smith JN, Wright AT. 2019. Benzo[a]pyrene induction of glutathione S-transferases: an activity-based protein profiling investigation. Chem Res Toxicol 32(6):1259-1267. doi:10.1021/acs.chemrestox.9b00069 PMID:30938511



  • Edrissi B, Taghizadeh K, Moeller BC, Yu R, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2017. N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats. Chem Res Toxicol 30(8):1572-1576. doi:10.1021/acs.chemrestox.7b00075 PMID:28692800 PMCID:PMC5807069
  • Gao L, Mutlu E, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2017. DNA product formation in female Sprague-Dawley rats following polyhalogenated aromatic hydrocarbon (PHAH) exposure. Chem Res Toxicol 30(3):794-803. doi:10.1021/acs.chemrestox.6b00368 PMID:28207250 PMCID:PMC5363288
  • Haggard DE, Das SR, Tanguay RL. 2017. Comparative toxicogenomic responses to the flame retardant mITP in developing zebrafish. Chem Res Toxicol 30(2):508-515. doi:10.1021/acs.chemrestox.6b00423 PMID:27957850
  • Nault R, Fader KA, Lydic TA, Zacharewski TR. 2017. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Res Toxicol 30(4):1060-1075. doi:10.1021/acs.chemrestox.6b00430 PMID:28238261
  • Rager JE, Auerbach SS, Chappell G, Martin EM, Thompson CM, Fry RC. 2017. Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Chem Res Toxicol 30(10):1911-1920. doi:10.1021/acs.chemrestox.7b00221
  • Wang M, Maki CR, Deng Y, Tian Y, Phillips TD. 2017. Development of high capacity enterosorbents for aflatoxin B1 and other hazardous chemicals. Chem Res Toxicol 30(9):1694-1701. doi:10.1021/acs.chemrestox.7b00154 PMID:28768106


  • Anderson DG, Florang V, Schamp J, Buettner GR, Doorn JA. 2016. Antioxidant-mediated modulation of protein reactivity for 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Chem Res Toxicol 29(7):1098-1107. doi:10.1021/acs.chemrestox.5b00528 PMID:27268734 PMCID:PMC5248556
  • Gadupudi GS, Klingelhutz AJ, Robertson LW. 2016. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol 29(9):1504-1509. doi:10.1021/acs.chemrestox.6b00172 PMID:27509375
  • Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851-859. doi:10.1021/acs.chemrestox.6b00022 PMID:26967026 PMCID:PMC5100827
  • Madeen E, Ognibene T, Corley RA, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE, McQuistan TJ. 2016. Human microdosing with carcinogenic polycyclic aromatic hydrocarbons: in vivo pharmacokinetics of dibenzo[def,p]chrysene and metabolites by UPLC accelerator mass spectrometry. Chem Res Toxicol 29(10):1641-1650. doi:10.1021/acs.chemrestox.6b00169 PMID:27494294 PMCID:PMC5380438
  • Mutlu E, Gao L, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2016. Polychlorinated biphenyls induce oxidative DNA adducts in female Sprague-Dawley rats. Chem Res Toxicol 29(8):1335-1344. doi:10.1021/acs.chemrestox.6b00146 PMID:27436759 PMCID:PMC5020703
  • Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371 PMID:27989147 PMCID:PMC5175585


  • Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433r PMID:25932594 PMCID:PMC4737589
  • DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. 2015. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol 28(6):1176-1185. doi:10.1021/acs.chemrestox.5b00003 PMID:26001051 PMCID:PMC4469569
  • Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241 PMID:26271003 PMCID:PMC4579038
  • Madeen E, Corley RA, Crowell SR, Turteltaub KW, Ognibene T, Malfatti MA, McQuistan TJ, Garrard M, Sudakin D, Williams DE. 2015. Human in vivo pharmacokinetics of [(14)C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing. Chem Res Toxicol 28(1):126-134. doi:10.1021/tx5003996 PMID:25418912 PMCID:PMC4303324
  • Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393y PMID:26039340 PMCID:PMC4748849
  • Whitehead TP, Havel C, Metayer C, Benowitz NL, Jacob P. 2015. Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users. Chem Res Toxicol 28(5):1007-1014. doi:10.1021/acs.chemrestox.5b00040 PMID:25794360 PMCID:PMC4827423


  • Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
  • Sharma V, Collins LB, Clement JM, Zhang Z, Nakamura J, Swenberg JA. 2014. Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells. Chem Res Toxicol 27(4):480-482. doi:10.1021/tx5000602 PMID:24628573 PMCID:PMC3998766
  • Zhou X, Sun X, Mobarak C, Gandolfi A, Burchiel SW, Hudson LG, Liu K. 2014. Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol 27(4):690-698. doi:10.1021/tx500022j PMID:24611629 PMCID:PMC3998772


  • Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539 PMID:23713983 PMCID:PMC3703249
  • Edrissi B, Taghizadeh K, Moeller BC, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2013. Dosimetry of n(6)-formyllysine adducts following [(13)c(2)h2]-formaldehyde exposures in rats. Chem Res Toxicol 26(10):1421-1423. doi:10.1021/tx400320u PMID:24087891 PMCID:PMC3805309
  • Kautz R, Wang P, Giese RW. 2013. Nuclear magnetic resonance at the picomole level of a DNA adduct. Chem Res Toxicol 26(10):1424-1429. doi:10.1021/tx400051j PMID:24028148 PMCID:PMC3925674
  • Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227s PMID:24224526 PMCID:PMC4112599
  • Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek-Hock WM, Wang K, Ludewig G, Robertson LW. 2013. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?. Chem Res Toxicol 26(5):634-644. doi:10.1021/tx400049s PMID:23527585 PMCID:PMC3660509
  • Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. 2013. Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol 26(8):1199-1208. doi:10.1021/tx400110f PMID:23848138 PMCID:PMC3818153
  • Qin X, Lehmler H, Teesch LM, Robertson LW, Duffel MW. 2013. Chlorinated biphenyl quinones and phenyl- 2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 26(10):1474-1485. doi:10.1021/tx400207q PMID:24059442 PMCID:PMC3846294
  • Wu X, Duffel MW, Lehmler H. 2013. Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective. Chem Res Toxicol 26(11):16421651. doi:10.1021/tx400229e PMID:24107130 PMCID:PMC3857157


  • Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396
  • Lu K, Craft S, Nakamura J, Moeller BC, Swenberg JA. 2012. Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine. Chem Res Toxicol 25(3):664-675. doi:10.1021/tx200426b PMID:22148432 PMCID:PMC3307879
  • Mutlu E, Jeong Y, Collins LB, Ham AL, Upton PB, Hatch G, Winsett D, Evansky P, Swenberg JA. 2012. A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-oxoethyl)guanine in Sprague–Dawley rats. Chem Res Toxicol 25(2):391-399. doi:10.1021/tx200447w PMID:22211352 PMCID:PMC3288741
  • Sanchez V, Jachak A, Hurt RH, Kane AB. 2012. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol 25(1):15-34. doi:10.1021/tx200339h PMID:21954945 PMCID:PMC3259226
  • Wang P, Gao J, Li G, Shimelis O, Giese RW. 2012. Nontargeted analysis of DNA adducts by mass-tag MS: Reaction of p-Benzoquinone with DNA. Chem Res Toxicol 25:2737-2743. doi:10.1021/tx300363a PMID:23113579 PMCID:PMC3527073


  • Dere E, Forgacs AL, Zacharewski TR, Burgoon LD. 2011. Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes. Chem Res Toxicol 24:494-504. doi:10.1021/tx100328r PMID:21370876 PMCID:PMC4038167
  • Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260h PMID:21913674 PMCID:PMC3196794
  • Lu K, Moeller BC, Doyle-Eisele M, McDonald JD, Swenberg JA. 2011. Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem Res Toxicol 24(2):159-161. doi:10.1021/tx1003886 PMID:21155545 PMCID:PMC3128468
  • Moeller BC, Lu K, Doyle-Eisele M, McDonald JD, Gigliotti A, Swenberg JA. 2011. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. Chem Res Toxicol 24(2):162-164. doi:10.1021/tx1004166 PMID:21222454 PMCID:PMC3273041
  • Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360m PMID:22026639 PMCID:PMC3243785
  • Zhitkovich A. 2011. Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol 24(10):1617–1629. doi:10.1021/tx200251t PMID:21766833 PMCID:PMC3196244 (Completed with ARRA Funds)


  • Bono R, Romanazzi V, Munnia A, Piro S, Allione A, Ricceri F, Guarrera S, Pignata C, Matullo G, Wang P, Giese RW, Peluso M. 2010. Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure. Chem Res Toxicol 23(8):1342-1348. doi:10.1021/tx100083x PMID:20707408 PMCID:PMC2924748
  • Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA. 2010. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following exposure to [13C2]-VC. Chem Res Toxicol 23(9):1485-1491. doi:10.1021/tx1001767 PMID:20799743 PMCID:PMC3104734
  • Zhitkovich A, Hagan E, Macfie A. 2010. Mechanism of DNA-protein cross-linking by chromium. Chem Res Toxicol 23(2):341-347. doi:10.1021/tx9003402 PMID:19877617 PMCID:PMC2822107


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  • Gulcan HO, Duffel MW. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 21(8):1503-1508. doi:10.1021/tx800133d PMID:18656962 PMCID:PMC2548291
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  • Bender RP, Osheroff N. 2007. Mutation of cysteine residue 455 to alanine in human topoisomerase lla confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol 20:975-981.
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  • Aposhian HV, Aposhian MM. 2006. Arsenic toxicology: five questions (review). Chem Res Toxicol 19(1):1-15. PMID:16411650
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  • Henderson AP, Barnes ML, Bleasdale C, Cameron R, Clegg W, Heath SL, Lindstrom AB, Rappaport SM, Waidyanatha S, Watson WP, Golding BT. 2005. Reactions of benzene oxide with thiols including glutathione. Chem Res Toxicol 18(2):265-270. doi:10.1021/tx049781y PMID:15720131
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  • Bodwell J, Kingsley LA, Hamilton JW. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17(8):1064-1076. PMID:15310238
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  • Lum KT, Huebner HJ, Li Y, Phillips TD, Raushel FM. 2003. Organophosphate nerve agent toxicity in Hydra attenuata. Chem Res Toxicol 16(8):953-957. PMID:12924922
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  • Gong Z, Jiang G, Cullen WR, Aposhian HV. 2002. Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. Chem Res Toxicol 15(10):1318-1323. PMID:12387631
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  • Lemke SL, Ottinger SE, Ake CL, Mayura K, Phillips TD. 2001. Deamination of fumonisin B1 and biological assessment of reaction product toxicity. Chem Res Toxicol 14(1):11-15. PMID:11170503
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  • Aposhian HV, Gurzau ES, Le X, Gurzau A, Healy SM, Lu X, Ma M, Yip L, Zakharyan RA, Maiorino RM, Dart RC, Tircus MG, Gonzalez-Ramirez D, Morgan DL, Avram D, Aposhian MM. 2000. Occurrence of monomethylarsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. Chem Res Toxicol 13(8):693-697. PMID:10956055
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  • Ham AL, Ranasinghe A, Morinello EJ, Nakamura J, Upton PB, Johnson F, Swenberg JA. 1999. Immunoaffinity/gas chromatography/high resolution mass spectrometry method for the detection of N2,3-ethenoguanine. Chem Res Toxicol 12:1240-1246. PMID:10604874
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  • Dingley KH, Roberts ML, Velsko CA, Turteltaub KW. 1998. Attomole detection of 3H in biological samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies in conjunction with 14C accelerator mass spectrometry. Chem Res Toxicol 11(10):1217-1222. PMID:9778319
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  • Brunmark P, Harriman SP, Skipper PL, Wishnok JS, Amin S, Tannenbaum SR. 1997. Identification of subdomain IB in human serum albumin as a major binding site for polycyclic aromatic hydrocarbon epoxides. Chem Res Toxicol 10(8):880-886. PMID:9282837
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