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National Institute of Environmental Health Sciences
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Your Environment. Your Health.
Search Results for Most Frequently Published Journals (Superfund Research Program)
Superfund Research Program
Search Results
Chemical Research in Toxicology (174 articles)
2024
Gaither KA, Garcia WL, Tyrrell KJ, Wright AT, Smith JN. 2024. Activity-based protein profiling to probe relationships between cytochrome P450 enzymes and early-age metabolism of two polycyclic aromatic hydrocarbons (PAHs): Phenanthrene and retene. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00424
Tsai H, Ford L, Burnett SD, Dickey AN, Wright FA, Chiu WA, Rusyn I. 2024. Informing hazard identification and risk characterization of environmental chemicals by combining transcriptomic and functional data from human-induced pluripotent stem-cell-derived cardiomyocytes. Chem Res Toxicol 37(8):1428-1444. doi:10.1021/acs.chemrestox.4c00193PMID:39046974
2023
Crisalli AM, Cai A, Cho BP. 2023. Probing the interactions of perfluorocarboxylic acids of various chain lengths with human serum albumin: calorimetric and spectroscopic investigations. Chem Res Toxicol 36(4):703-713. doi:10.1021/acs.chemrestox.3c00011PMID:37001030
Hsiao Y, Matulewicz RS, Sherman SE, Jaspers I, Weitzman ML, Gordon T, Liu C, Yang Y, Lu K, Bjurlin MA. 2023. Untargeted metabolomics to characterize the urinary chemical landscape of e-cigarette users. Chem Res Toxicol 36(4):630-642. doi:10.1021/acs.chemrestox.2c00346PMID:36912507PMCID:PMC10371198
Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128PMID:37467352
Orlowska K, Fling RR, Nault R, Schilmiller AL, Zacharewski TR. 2023. Cystine/glutamate Xc- antiprorter induction compensates for transsulfuration pathway repression by 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) to ensure cysteine for heptic glutathione biosynthesis. Chem Res Toxicol 36(6):900-915. doi:10.1021/acs.chemrestox.3c00017PMID:37184393PMCID:PMC10284067
Paranjape N, Dean LE, Martinez A, Tjalkens RB, Lehmler H, Doorn JA. 2023. Structure-activity relationship of lower chlorinated biphenyls and their human-relevant metabolites for astrocyte toxicity. Chem Res Toxicol 36(6):971-981. doi:10.1021/acs.chemrestox.3c00095PMID:37279407PMCID:PMC10283044
Su AL, Harris S, Elkin ER, Karnovsky A, Colacino JA, Loch-Caruso R. 2023. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-1-cysteine stimulates changes in energy metabolites and amino acids in the BeWo Human Placental Trophoblast Model during syncytialization. Chem Res Toxicol 36(6):882-899. doi:10.1021/acs.chemrestox.3c00007PMID:37162359
Yang Y, Chi L, Liu C, Hsiao Y, Lu K. 2023. Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis in mice. Chem Res Toxicol 36(7):1037-1043. doi:10.1021/acs.chemrestox.2c00410PMID:37295807
Garcia WL, Miller CJ, Lomas GX, Gaither KA, Tyrrell KJ, Smith JN, Brandvold KR, Wright AT. 2022. Profiling how the gut microbiome modulates host xenobiotic metabolism in response to benzo[a]pyrene and 1-nitropyrene exposure. Chem Res Toxicol 35(4):585-596. doi:10.1021/acs.chemrestox.1c00360
Lehmler H, Uwimana E, Dean LE, Kovalchuk N, Zhang Q, Ding X. 2022. Probing the role of CYP2 enzymes in the atroposelective metabolism of polychlorinated biphenyls using liver microsomes from transgenic mouse models. Chem Res Toxicol 35(12):2310-2323. doi:10.1021/acs.chemrestox.2c00276PMID:36473170
Lorkiewicz P, Keith RJ, Lynch J, Jin L, Theis W, Krivokhizhina T, Riggs D, Bhatnagar A, Srivastava S, Conklin DJ. 2022. Electronic cigarette solvents, JUUL e-liquids, and biomarkers of exposure: In vivo evidence for acrolein and glycidol in e-cig-derived aerosols. Chem Res Toxicol doi:10.1021/acs.chemrestox.1c00328PMID:35044764
2021
Bullert AJ, Doorn JA, Stevens HE, Lehmler H. 2021. The effects of polychlorinated biphenyl exposure during adolescence on the nervous system: A comprehensive review. Chem Res Toxicol 34(9):doi:10.1021/acs.chemrestox.1c00226PMID:34491731PMCID:PMC8456429
Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol 34(9):2110-2124. doi:10.1021/acs.chemrestox.1c00203PMID:34448577
Chang Y, Rager JE, Tilton SC. 2021. Linking coregulated gene modules with polycyclic aromatic hydrocarbon-related cancer risk in the 3D human bronchial epithelium. Chem Res Toxicol 34(6):1445-1455. doi:10.1021/acs.chemrestox.0c00333PMID:34048650
Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova N, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383. doi:10.1021/acs.chemrestox.1c00291PMID:34726909PMCID:PMC8715497
Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. 2021. New alkoxy- analogues of expoxyeicosatrienoic acids attenuate cisplatin nephrotoxicity in vitro via reduction of mitochondrial dysfunction, oxidative stress, mitogen-activated protein kinase signaling, and caspase activation. Chem Res Toxicol 34:2579-2591. doi:10.1021/acs.chemrestox.1c00347PMID:34817988
Stoddard EG, Nag S, Martin J, Tyrrell KJ, Gibbins T, Anderson KA, Shukla AK, Corley RA, Wright AT, Smith JN. 2021. Exposure to an environmental mixture of polycyclic aromatic hydrocarbons induces hepatic cytochrome P450 enzymes in mice. Chem Res Toxicol 34(9):2145-2156. doi:10.1021/acs.chemrestox.1c00235PMID:34472326
Elkin ER, Bridges D, Harris SM, Loch-Caruso R. 2020. Exposure to trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine causes compensatory changes to macronutrient utilization and energy metabolism in placental HTR-8/SVneo cells. Chem Res Toxicol 33:1339-1355. doi:10.1021/acs.chemrestox.9b00356PMID:31951115PMCID:PMC7299793
Phillips AL, Herkert N, Ulrich JC, Hartman JH, Ruis MT, Cooper EM, Ferguson PL, Stapleton HM. 2020. In vitro metabolism of isopropylated and tert-butylated triarylphosphate esters using human liver subcellular fractions. Chem Res Toxicol 33:1428-1441. doi:10.1021/acs.chemrestox.0c00002PMID:32129605PMCID:PMC7508416
Steele WB, Kristofco LA, Corrales J, Saari GN, Corcoran EJ, Hill BN, Mills MG, Gallagher EP, Kavanagh TJ, Melnikov F, Zimmerman JB, Voutchkova-Kostal A, Anastas P, Kostal J, Brooks BW. 2020. Toward less hazardous industrial compounds: Coupling quantum mechanical computations, biomarker responses, and behavioral profiles to identify bioactivity of S(N)2 electrophiles in alternative vertebrate models. Chem Res Toxicol 33(2):367-380. doi:10.1021/acs.chemrestox.9b00290PMID:31789507
Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33:625-633. doi:10.1021/acs.chemrestox.9b00444PMID:31841318PMCID:PMC7033946
Wu X, Zhai G, Schnoor JL, Lehmler H. 2020. Atropselective disposition of 2,2 ,3,4 ,6-Pentachlorobiphenyl (PCB 91) and identification of its metabolites in mice with liver-specific deletion of Cytochrome P450 Reductase. Chem Res Toxicol 33:1328-1338. doi:10.1021/acs.chemrestox.9b00255PMID:31403789PMCID:PMC7042073
2019
Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol 32(5):doi:10.1021/acs.chemrestox.9b00035PMID:30990016 (ahead of print)
Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389PMID:30729780PMCID:PMC6465157
Meakin C, Martin EM, Szilagyi JT, Nylander-French LA, Fry RC. 2019. Inorganic Arsenic as an Endocrine Disruptor: Modulation of the Glucocorticoid Receptor Pathway in Placental Cells via CpG Methylation. Chem Res Toxicol 32(3):493-499. doi:10.1021/acs.chemrestox.8b00352PMID:30746931
Melnikov F, Botta D, White CC, Schmuck S, Winfough M, Schaupp C, Gallagher EP, Brooks BW, Williams E, Coish P, Anastas P, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. 2019. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chem Res Toxicol 32(3):421-436. doi:10.1021/acs.chemrestox.8b00259
Mexia N, Koutrakis S, He G, Skaltounis L, Denison MS, Magiatis P. 2019. RETURN TO ISSUEPREVARTICLENEXT Journal Logo A Biomimetic, One-Step Transformation of Simple Indolic Compounds to Malassezia-Related Alkaloids with High AhR Potency and Efficacy. Chem Res Toxicol 32:doi:10.1021/acs.chemrestox.9b00270PMID:31647221PMCID:PMC7757739 (accepted for publication)
Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal A, Brooks BW, Coish P, Anastas P, Gallagher EP. 2019. CRISPR-generated Nrf2a loss- and gain-of-function mutants facilitate mechanistic analysis of chemical oxidative stress-mediated toxicity in zebrafish. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00346
Stoddard EG, Nag S, Martin J, Killinger BJ, Corley RA, Smith JN, Wright AT. 2019. Benzo[a]pyrene induction of glutathione S-transferases: an activity-based protein profiling investigation. Chem Res Toxicol 32(6):1259-1267. doi:10.1021/acs.chemrestox.9b00069PMID:30938511
2018
Dornbos P, Warren M, Crawford RB, Kaminski NE, Threadgill DW, LaPres JJ. 2018. Characterizing Serpinb2 as a modulator of TCDD-induced suppression of the B cell. Chem Res Toxicol 31(11):1248-1259. doi:10.1021/acs.chemrestox.8b00225PMID:30339366 (ahead of print)
Liang Y, Lang AL, Zhang J, Chen J, Wang K, Chen L, Beier JI, Qian Y, Cai L. 2018. Exposure to vinyl chloride and its influence on western diet-induced cardiac remodeling. Chem Res Toxicol 31:482-493. doi:10.1021/acs.chemrestox.8b00043PMID:29727174PMCID:PMC6167925
Sadler NC, Webb-Robertson B, Clauss TR, Pounds J, Corley RA, Wright AT. 2018. High-fat diets alter the modulatory efects of xenobiotics on cytochrome P450 activities. Chem Res Toxicol 31:308-318. doi:10.1021/acs.chemrestox.8b00008PMID:29688711
Wang P, Giese RW. 2018. Interpretation of mass spectral data for the cisplatin 1,2 intrastrand guanine-guanine adduct. Chem Res Toxicol 31:1106-1107. doi:10.1021/acs.chemrestox.8b00134PMID:30280575
2017
Edrissi B, Taghizadeh K, Moeller BC, Yu R, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2017. N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats. Chem Res Toxicol 30(8):1572-1576. doi:10.1021/acs.chemrestox.7b00075PMID:28692800PMCID:PMC5807069
Gao L, Mutlu E, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2017. DNA product formation in female Sprague-Dawley rats following polyhalogenated aromatic hydrocarbon (PHAH) exposure. Chem Res Toxicol 30(3):794-803. doi:10.1021/acs.chemrestox.6b00368PMID:28207250PMCID:PMC5363288
Haggard DE, Das SR, Tanguay RL. 2017. Comparative toxicogenomic responses to the flame retardant mITP in developing zebrafish. Chem Res Toxicol 30(2):508-515. doi:10.1021/acs.chemrestox.6b00423PMID:27957850
Nault R, Fader KA, Lydic TA, Zacharewski TR. 2017. Lipidomic evaluation of aryl hydrocarbon receptor-mediated hepatic steatosis in male and female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Res Toxicol 30(4):1060-1075. doi:10.1021/acs.chemrestox.6b00430PMID:28238261
Rager JE, Auerbach SS, Chappell G, Martin EM, Thompson CM, Fry RC. 2017. Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort. Chem Res Toxicol 30(10):1911-1920. doi:10.1021/acs.chemrestox.7b00221
Wang M, Maki CR, Deng Y, Tian Y, Phillips TD. 2017. Development of high capacity enterosorbents for aflatoxin B1 and other hazardous chemicals. Chem Res Toxicol 30(9):1694-1701. doi:10.1021/acs.chemrestox.7b00154PMID:28768106
2016
Anderson DG, Florang V, Schamp J, Buettner GR, Doorn JA. 2016. Antioxidant-mediated modulation of protein reactivity for 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Chem Res Toxicol 29(7):1098-1107. doi:10.1021/acs.chemrestox.5b00528PMID:27268734PMCID:PMC5248556
Gadupudi GS, Klingelhutz AJ, Robertson LW. 2016. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol 29(9):1504-1509. doi:10.1021/acs.chemrestox.6b00172PMID:27509375
Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851-859. doi:10.1021/acs.chemrestox.6b00022PMID:26967026PMCID:PMC5100827
Madeen E, Ognibene T, Corley RA, Henderson MC, Baird WM, Bench G, Turteltaub KW, Williams DE, McQuistan TJ. 2016. Human microdosing with carcinogenic polycyclic aromatic hydrocarbons: in vivo pharmacokinetics of dibenzo[def,p]chrysene and metabolites by UPLC accelerator mass spectrometry. Chem Res Toxicol 29(10):1641-1650. doi:10.1021/acs.chemrestox.6b00169PMID:27494294PMCID:PMC5380438
Mutlu E, Gao L, Collins LB, Walker N, Hartwell HJ, Olson J, Sun W, Gold A, Ball LM, Swenberg JA. 2016. Polychlorinated biphenyls induce oxidative DNA adducts in female Sprague-Dawley rats. Chem Res Toxicol 29(8):1335-1344. doi:10.1021/acs.chemrestox.6b00146PMID:27436759PMCID:PMC5020703
Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371PMID:27989147PMCID:PMC5175585
2015
Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433rPMID:25932594PMCID:PMC4737589
DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. 2015. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol 28(6):1176-1185. doi:10.1021/acs.chemrestox.5b00003PMID:26001051PMCID:PMC4469569
Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler H. 2015. Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice. Chem Res Toxicol 28(9):1774-1783. doi:10.1021/acs.chemrestox.5b00241PMID:26271003PMCID:PMC4579038
Madeen E, Corley RA, Crowell SR, Turteltaub KW, Ognibene T, Malfatti MA, McQuistan TJ, Garrard M, Sudakin D, Williams DE. 2015. Human in vivo pharmacokinetics of [(14)C]dibenzo[def,p]chrysene by accelerator mass spectrometry following oral microdosing. Chem Res Toxicol 28(1):126-134. doi:10.1021/tx5003996PMID:25418912PMCID:PMC4303324
Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, del Carmen Gonzalez-Horta M, Sanchez-Ramirez B, Ballinas-Casarrubias L, Gutierrez-Torres DS, Drobna Z, Del Razo LM, Garcia-Vargas GG, Kim WY, Zhou Y, Wright FA, Styblo M, Fry RC. 2015. Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol 28(6):1144-1155. doi:10.1021/tx500393yPMID:26039340PMCID:PMC4748849
Whitehead TP, Havel C, Metayer C, Benowitz NL, Jacob P. 2015. Tobacco alkaloids and tobacco-specific nitrosamines in dust from homes of smokeless tobacco users, active smokers, and nontobacco users. Chem Res Toxicol 28(5):1007-1014. doi:10.1021/acs.chemrestox.5b00040PMID:25794360PMCID:PMC4827423
2014
Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150hPMID:24988477PMCID:PMC4137987
Sharma V, Collins LB, Clement JM, Zhang Z, Nakamura J, Swenberg JA. 2014. Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells. Chem Res Toxicol 27(4):480-482. doi:10.1021/tx5000602PMID:24628573PMCID:PMC3998766
Zhou X, Sun X, Mobarak C, Gandolfi A, Burchiel SW, Hudson LG, Liu K. 2014. Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol 27(4):690-698. doi:10.1021/tx500022jPMID:24611629PMCID:PMC3998772
2013
Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539PMID:23713983PMCID:PMC3703249
Edrissi B, Taghizadeh K, Moeller BC, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. 2013. Dosimetry of n(6)-formyllysine adducts following [(13)c(2)h2]-formaldehyde exposures in rats. Chem Res Toxicol 26(10):1421-1423. doi:10.1021/tx400320uPMID:24087891PMCID:PMC3805309
Kelley MA, Hebert VY, Thibeaux TM, Orchard MA, Hasan F, Cormier SA, Thevenot PT, Lomnicki S, Varner KJ, Dellinger B, Latimer BM, Dugas TR. 2013. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol 26(12):1862-1871. doi:10.1021/tx400227sPMID:24224526PMCID:PMC4112599
Lai IK, Klaren WD, Li M, Wels B, Simmons DL, Olivier AK, Haschek-Hock WM, Wang K, Ludewig G, Robertson LW. 2013. Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?. Chem Res Toxicol 26(5):634-644. doi:10.1021/tx400049sPMID:23527585PMCID:PMC3660509
Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. 2013. Integrative chemical-biological read-across approach for chemical hazard classification. Chem Res Toxicol 26(8):1199-1208. doi:10.1021/tx400110fPMID:23848138PMCID:PMC3818153
Qin X, Lehmler H, Teesch LM, Robertson LW, Duffel MW. 2013. Chlorinated biphenyl quinones and phenyl- 2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 26(10):1474-1485. doi:10.1021/tx400207qPMID:24059442PMCID:PMC3846294
Wu X, Duffel MW, Lehmler H. 2013. Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective. Chem Res Toxicol 26(11):16421651. doi:10.1021/tx400229ePMID:24107130PMCID:PMC3857157
2012
Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416vPMID:23137097PMCID:PMC3524396
Lu K, Craft S, Nakamura J, Moeller BC, Swenberg JA. 2012. Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine. Chem Res Toxicol 25(3):664-675. doi:10.1021/tx200426bPMID:22148432PMCID:PMC3307879
Mutlu E, Jeong Y, Collins LB, Ham AL, Upton PB, Hatch G, Winsett D, Evansky P, Swenberg JA. 2012. A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-oxoethyl)guanine in Sprague–Dawley rats. Chem Res Toxicol 25(2):391-399. doi:10.1021/tx200447wPMID:22211352PMCID:PMC3288741
Sanchez V, Jachak A, Hurt RH, Kane AB. 2012. Biological interactions of graphene-family nanomaterials: an interdisciplinary review. Chem Res Toxicol 25(1):15-34. doi:10.1021/tx200339hPMID:21954945PMCID:PMC3259226
Wang P, Gao J, Li G, Shimelis O, Giese RW. 2012. Nontargeted analysis of DNA adducts by mass-tag MS: Reaction of p-Benzoquinone with DNA. Chem Res Toxicol 25:2737-2743. doi:10.1021/tx300363aPMID:23113579PMCID:PMC3527073
2011
Dere E, Forgacs AL, Zacharewski TR, Burgoon LD. 2011. Genome-wide computational analysis of dioxin response element location and distribution in the human, mouse, and rat genomes. Chem Res Toxicol 24:494-504. doi:10.1021/tx100328rPMID:21370876PMCID:PMC4038167
Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260hPMID:21913674PMCID:PMC3196794
Lu K, Moeller BC, Doyle-Eisele M, McDonald JD, Swenberg JA. 2011. Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem Res Toxicol 24(2):159-161. doi:10.1021/tx1003886PMID:21155545PMCID:PMC3128468
Moeller BC, Lu K, Doyle-Eisele M, McDonald JD, Gigliotti A, Swenberg JA. 2011. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. Chem Res Toxicol 24(2):162-164. doi:10.1021/tx1004166PMID:21222454PMCID:PMC3273041
Wu X, Pramanik A, Duffel MW, Hrycay EG, Bandiera SM, Lehmler H, Kania-Korwel I. 2011. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is enantioselectively oxidized to hydroxylated metabolites by rat liver microsomes. Chem Res Toxicol 24(12):2249-2257. doi:10.1021/tx200360mPMID:22026639PMCID:PMC3243785
Zhitkovich A. 2011. Chromium in drinking water: sources, metabolism, and cancer risks. Chem Res Toxicol 24(10):1617–1629. doi:10.1021/tx200251tPMID:21766833PMCID:PMC3196244 (Completed with ARRA Funds)
2010
Bono R, Romanazzi V, Munnia A, Piro S, Allione A, Ricceri F, Guarrera S, Pignata C, Matullo G, Wang P, Giese RW, Peluso M. 2010. Malondialdehyde-deoxyguanosine adduct formation in workers of pathology wards: the role of air formaldehyde exposure. Chem Res Toxicol 23(8):1342-1348. doi:10.1021/tx100083xPMID:20707408PMCID:PMC2924748
Mutlu E, Collins LB, Stout MD, Upton PB, Daye LR, Winsett D, Hatch G, Evansky P, Swenberg JA. 2010. Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N2,3-ethenoguanine in tissues of adult and weanling rats following exposure to [13C2]-VC. Chem Res Toxicol 23(9):1485-1491. doi:10.1021/tx1001767PMID:20799743PMCID:PMC3104734
Klosener J, Peters TM, Adamcakova-Dodd A, Teesch LM, Thorne PS, Robertson LW, Luthe G. 2009. Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures. Chem Res Toxicol 22(1):179-186. doi:10.1021/tx8003032PMID:19111055PMCID:PMC3120107
Pessah IN, Lehmler H, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. 2009. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol 22(1):201-207. doi:10.1021/tx800328uPMID:18954145PMCID:PMC2662366
Swenberg JA, Starr TB, Albertini R, Walker V. 2009. Response to Keshava et al. Chem Res Toxicol 22(1):10-12. doi:10.1021/tx800438g
Wangpradit O, Teesch LM, Mariappan S, Duffel MW, Norstrom K, Robertson LW, Luthe G. 2009. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Toxicol 22(1):64-71. doi:10.1021/tx800300tPMID:19105592PMCID:PMC2637223
Zhu H, Martin T, Ye L, Sedykh A, Young D, Tropsha A. 2009. Quantitative structure-activity relationship modeling of rat acute toxicity by oral exposure. Chem Res Toxicol 22(12):1913-1921. doi:10.1021/tx900189pPMID:19845371PMCID:PMC2796713
2008
Gulcan HO, Duffel MW. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 21(8):1503-1508. doi:10.1021/tx800133dPMID:18656962PMCID:PMC2548291
Guttmann D, Poage G, Johnston T, Zhitkovich A. 2008. Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism. Chem Res Toxicol 21(11):2188-2194. doi:10.1021/tx800265gPMID:18808157PMCID:PMC2665875
Kang-Sickel JC, Nam T, Jayaraj K, Ball LM, French JE, Klapper DG, Gold A, Nylander-French LA. 2008. S-arylcysteine-keratin adducts as biomarkers of human dermal exposure to aromatic hydrocarbons. Chem Res Toxicol 21(4):852-858. doi:10.1021/tx7003773PMID:18361511
Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H. 2008. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21(6):1295-1303. doi:10.1021/tx800059jPMID:18494506PMCID:PMC2574739
Lu K, Boysen G, Swenberg JA, Gao L, Collins LB. 2008. Formaldehyde-induced histone modifications in vitro. Chem Res Toxicol 21(8):1586-1593. doi:10.1021/tx8000576PMID:18656964
Luthe G, Boy R, Jacobus JA, Smith B, Rahaman A, Robertson LW, Ludewig G. 2008. Xenobiotic geometry and media pH determine cytotoxicity through solubility. Chem Res Toxicol 21(5):1017-1027. doi:10.1021/tx700214pPMID:18402468
Morisseau C, Newman JW, Wheelock CE, Hill T, Morin D, Buckpitt AR, Hammock BD. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol 21(4):951-957. doi:10.1021/tx700446uPMID:18363382
Salnikow K, Zhitkovich A. 2008. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 21(1):28-44. doi:10.1021/tx700198aPMID:17970581PMCID:PMC2602826
Swenberg JA, Fryar-Tita E, Jeong Y, Boysen G, Starr TB, Walker V, Albertini R. 2008. Biomarkers in toxicology and risk assessment: informing critical dose-response relationships. Chem Res Toxicol 21(1):253-265. doi:10.1021/tx700408tPMID:18161944
Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol 21(3):583-590. doi:10.1021/tx7002454PMID:18251509
2007
Bender RP, Osheroff N. 2007. Mutation of cysteine residue 455 to alanine in human topoisomerase lla confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol 20:975-981.
Xu A, Huang SX, Lien Y, Bao L, Yu Z, Hei TK. 2007. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Chem Res Toxicol 20(5):724-33. PMID:17447795
Yuan W, Chung JS, Gee SJ, Hammock BD, Zheng J. 2007. Development of polyclonal antibodies for the detection of styrene oxide modified proteins. Chem Res Toxicol 20(2):316-321. doi:10.1021/tx600340cPMID:17266334PMCID:PMC2565645
2006
Aposhian HV, Aposhian MM. 2006. Arsenic toxicology: five questions (review). Chem Res Toxicol 19(1):1-15. PMID:16411650
Bodwell J, Gosse JA, Nomikos AP, Hamilton JW. 2006. Arsenic disruption of steroid receptor gene activation: complex dose-response effects are shared by several steroid receptors. Chem Res Toxicol 19(12):1619-1629. doi:10.1021/tx060122qPMID:17173375PMCID:PMC2556599
Kaya T, Mohr SC, Waxman DJ, Vajda S. 2006. Computational screening of phthalate monoesters for binding to PPARgamma. Chem Res Toxicol 19(8):999-1009. doi:10.1021/tx050301sPMID:16918238
Lee K, Burgoon LD, Lamb L, Dere E, Zacharewski TR, Hogenesch JB, LaPres JJ. 2006. Identification and characterization of genes susceptible to transcriptional cross-talk between the hypoxia and dioxin signaling cascades. Chem Res Toxicol 19(10):1284-1293. doi:10.1021/tx060068dPMID:17040097PMCID:PMC3152583
Liu Y, Apak TI, Lehmler H, Robertson LW, Duffel MW. 2006. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 19(11):1420-1425. PMID:17112228
Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do ZN, Kim K, Wong PW. 2006. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chem Res Toxicol 19(1):92-101. doi:10.1021/tx050196mPMID:16411661
Ye W, Sangaiah R, Degen DE, Gold A, Jayaraj K, Koshlap KM, Boysen G, Williams J, Tomer KB, Ball LM. 2006. A 2-iminohydantoin from the oxidation of guanine. Chem Res Toxicol 19(4):506-10. PMID:16608161
2005
Henderson AP, Barnes ML, Bleasdale C, Cameron R, Clegg W, Heath SL, Lindstrom AB, Rappaport SM, Waidyanatha S, Watson WP, Golding BT. 2005. Reactions of benzene oxide with thiols including glutathione. Chem Res Toxicol 18(2):265-270. doi:10.1021/tx049781yPMID:15720131
Henderson PT, Neeley WL, Delaney JC, Gu F, Niles JC, Hah SS, Essigmann JM, Tannenbaum SR. 2005. Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations. Chem Res Toxicol 18(1):12-18. PMID:15651843
Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. 2005. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chem Res Toxicol 18(9):1371-1377. PMID:16167828
Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. 2005. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem Res Toxicol 18(3):516-527. doi:10.1021/tx049773hPMID:15777092
Jeong Y, Sangaiah R, Nakamura J, Pachkowski BF, Ranasinghe A, Gold A, Ball LM, Swenberg JA. 2005. Analysis of M(1)G-dR in DNA by aldehyde reactive probe labeling and liquid chromatography tandem mass spectrometry. Chem Res Toxicol 18(1):51-60. PMID:15651849
Lin C, Isbell MA, Morin D, Boland BC, Salemi MR, Jewell WT, Weir AJ, Fanucchi MV, Baker GL, Plopper CG, Buckpitt AR. 2005. Characterization of a structurally intact in situ lung model and comparison of naphthalene protein adducts generated in this model vs. lung rway incubation in situ vs. lung microsomes. Chem Res Toxicol 18(5):802-813.
Lin C, Leow H, Huang S, Nakamura J, Swenberg JA, Lin P. 2005. Induction of cytotoxicity, aldehydic DNA lesions, and poly(ADP-ribose) polymerase-1 activation by catechol derivatives of pentachlorophenol in calf thymus DNA and in human breast cancer cells. Chem Res Toxicol 18(2):257-264. PMID:15720130
Waidyanatha S, Sangaiah R, Rappaport SM. 2005. Characterization and quantification of cysteinyl adducts of benzene diol epoxide. Chem Res Toxicol 18(7):1178-1185. PMID:16022511
Zakharyan RA, Tsaprailis G, Chowdhury UK, Hernandez A, Aposhian HV. 2005. Interactions of sodium selenite, glutathione, arsenic species, and omega class human glutathione transferase. Chem Res Toxicol 18(8):1287-1295. doi:10.1021/tx0500530PMID:16097802
2004
Bodwell J, Kingsley LA, Hamilton JW. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17(8):1064-1076. PMID:15310238
Chiarappa-Zucca ML, Finkel RC, Martinelli RE, McAninch JE, Nelson DO, Turteltaub KW. 2004. Measurement of beryllium in biological samples by accelerator mass spectrometry: applications for studying chronic beryllium disease. Chem Res Toxicol 17(12):1614-20. PMID:15606137
Machala M, Blaha L, Lehmler H, Pliskova M, Majkova Z, Kapplova P, Sovadinova I, Vondracek J, Malmberg T, Robertson LW. 2004. Toxicity of hydroxylated and quinoid PCB metabolites: inhibition of gap junctional intercellular communication and activation of aryl hydrocarbon and estrogen receptors in hepatic and mammary cells. Chem Res Toxicol 17(3):340-347. doi:10.1021/tx030034vPMID:15025504
Shan G, Huang H, Stoutamire DW, Gee SJ, Leng G, Hammock BD. 2004. A sensitive class specific immunoassay for the detection of pyrethroid metabolites in human urine. Chem Res Toxicol 17(2):218-225. PMID:14967009
Soucy NV, Klei LR, Mayka DD, Barchowsky A. 2004. Signaling pathways for arsenic-stimulated vascular endothelial growth factor-a expression in primary vascular smooth muscle cells. Chem Res Toxicol 17(4):555-563. PMID:15089098
2003
Lum KT, Huebner HJ, Li Y, Phillips TD, Raushel FM. 2003. Organophosphate nerve agent toxicity in Hydra attenuata. Chem Res Toxicol 16(8):953-957. PMID:12924922
Marnell LL, Garcia-Vargas GG, Chowdhury UK, Zakharyan RA, Walsh B, Avram MD, Kopplin MJ, Cebrian ME, Silbergeld EK, Aposhian HV. 2003. Polymorphisms in the human monomethylarsonic acid (MMA V) reductase/hGSTO1 gene and changes in urinary arsenic profiles. Chem Res Toxicol 16(12):1507-1513. PMID:14680363
Patterson TP, Ngo MA, Aronov PA, Reznikova TV, Green PG. 2003. Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes. Chem Res Toxicol 16(12):1624-1631. PMID:14680377
Safe SH, Wormke M. 2003. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chem Res Toxicol 16(7):807-816. doi:10.1021/tx034036rPMID:12870882
2002
Gong Z, Jiang G, Cullen WR, Aposhian HV. 2002. Determination of arsenic metabolic complex excreted in human urine after administration of sodium 2,3-dimercapto-1-propane sulfonate. Chem Res Toxicol 15(10):1318-1323. PMID:12387631
Olivero J, Bezdecny SA, Ganey PE. 2002. A molecular motif required for the activation of rat neutrophil Phospholipase A2 by organochlorine compounds. Chem Res Toxicol 15(2):153-159.
Radabaugh TR, Sampayo-Reyes A, Zakharyan RA, Aposhian HV. 2002. Arsenate reductase II. Purine nucleoside phophorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. Chem Res Toxicol 15(5):692-698.
Srinivasan A, Robertson LW, Ludewig G. 2002. Sulfhydryl binding and topoisomerase inhibition by PCB Metabolites. Chem Res Toxicol 15(4):497-505. PMID:11952335
Tampal N, Lehmler H, Espandiari P, Malmberg T, Robertson LW. 2002. Glucuronidation of hydroxylated polychlorinated biphenyls (PCBs). Chem Res Toxicol 15(10):1259-1266. doi:10.1021/tx0200212PMID:12387623
2001
Lemke SL, Ottinger SE, Ake CL, Mayura K, Phillips TD. 2001. Deamination of fumonisin B1 and biological assessment of reaction product toxicity. Chem Res Toxicol 14(1):11-15. PMID:11170503
Morinello EJ, Ham AL, Ranasinghe A, Sangaiah R, Swenberg JA. 2001. Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay. Chem Res Toxicol 14(3):327-334. PMID:11258983
Morisseau C, Newman JW, Dowdy DL, Goodrow MH, Hammock BD. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chem Res Toxicol 14(4):409-415. PMID:11304129
Petrick JS, Jagadish B, Mash EA, Aposhian HV. 2001. Monomethylarsonous acid (MMAIII) and arsenite: LD50 in hamsters and in vitro inhibition of pyruvate dehydrogenase. Chem Res Toxicol 14(6):651-656. PMID:11409934
Wheelock CE, Severson T, Hammock BD. 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chem Res Toxicol 14(12):1563-1572. PMID:11743738
Zakharyan RA, Sampayo-Reyes A, Healy SM, Tsaprailis G, Board PG, Liebler DC, Aposhian HV. 2001. Human monomethylarsonic acid (MMAV) reductase is a member of the glutathione-S-transferase superfamily. Chem Res Toxicol 14(8):1051-1057. PMID:11511179
2000
Aposhian HV, Gurzau ES, Le X, Gurzau A, Healy SM, Lu X, Ma M, Yip L, Zakharyan RA, Maiorino RM, Dart RC, Tircus MG, Gonzalez-Ramirez D, Morgan DL, Avram D, Aposhian MM. 2000. Occurrence of monomethylarsonous acid (MMAIII) in urine of humans exposed to inorganic arsenic. Chem Res Toxicol 13(8):693-697. PMID:10956055
Greene JF, Newman JW, Williamson K, Hammock BD. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem Res Toxicol 13(4):217-226. PMID:10775319
Ham AL, Ranasinghe A, Koc H, Swenberg JA. 2000. 4-Hydroxy-2-nonenal and ethyl linoleate from N2,3-ethenoguanine under peroxidizing conditions. Chem Res Toxicol 13:1243-1250.
Lin P, Sangaiah R, Ranasinghe A, Upton PB, La DK, Gold A, Swenberg JA. 2000. Formation of quinonoid-derived protein adducts in the liver and brain of Sprague-Dawley rats treated with 2,2',5,5'-tetrachlorobiphenyl. Chem Res Toxicol 13(8):710-718. PMID:10956058
Radabaugh TR, Aposhian HV. 2000. Enzymatic reduction of arsenic compounds in mammalian systems: reduction of arsenate to arsenite by human liver arsenate reductase. Chem Res Toxicol 13(1):26-30. PMID:10649963
Sampayo-Reyes A, Zakharyan RA, Healy SM, Aposhian HV. 2000. Monomethylarsonic acid (MMAV) reductase and monomethylarsonous acid (MMAIII) in hamster tissue. Chem Res Toxicol 13(11):1181-1186.
1999
Ham AL, Ranasinghe A, Morinello EJ, Nakamura J, Upton PB, Johnson F, Swenberg JA. 1999. Immunoaffinity/gas chromatography/high resolution mass spectrometry method for the detection of N2,3-ethenoguanine. Chem Res Toxicol 12:1240-1246. PMID:10604874
Shan G, Wengatz I, Stoutamire DW, Gee SJ, Hammock BD. 1999. An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine. Chem Res Toxicol 12(11):1033-1041. PMID:10563828
Watt KC, Morin D, Kurth M, Mercer RS, Plopper CG, Buckpitt AR. 1999. Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: Identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Chem Res Toxicol 12(9):831-839. PMID:10490505
Wiemels JL, Wiencke JK, Varkonyi A, Smith MT. 1999. Modulation of the toxicity and macromolecular binding of benzene metabolites by NAD(P)H:Quinone oxidoreductase in transfected HL-60 cells. Chem Res Toxicol 12(6):467-475. doi:10.1021/tx9800811PMID:10368308
Wu K, Scheller NA, Ranasinghe A, Yen T, Sangaiah R, Giese RW, Swenberg JA. 1999. A gas chromatography/electron capture/negative chemical ionization-high resolution mass spectrometry method for analysis of endogenous and exogenous N7-(2-hydroxyethyl)guanine in rodents and its potential for human biological monitoring. Chem Res Toxicol 12(8):722-729. PMID:10458706
Zakharyan RA, Aposhian HV. 1999. Enzymatic reduction of arsenic compounds in mammalian systems: the rate limiting enzyme of rabbit liver arsenic biotransformation is MMAV reductase. Chem Res Toxicol 12(12):1278-1283. PMID:10604879
1998
Dingley KH, Roberts ML, Velsko CA, Turteltaub KW. 1998. Attomole detection of 3H in biological samples using accelerator mass spectrometry: application in low-dose, dual-isotope tracer studies in conjunction with 14C accelerator mass spectrometry. Chem Res Toxicol 11(10):1217-1222. PMID:9778319
Jaeger LL, Jones AD, Hammock BD. 1998. Development of an enzyme-linked immunosorbent assay for atrazine mercapturic acid in human urine. Chem Res Toxicol 11(4):342-352. doi:10.1021/tx9701844PMID:9548805
Lindstrom AB, Yeowell-O'Connell K, Waidyanatha S, McDonald TA, Golding BT, Rappaport SM. 1998. Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood. Chem Res Toxicol 11:302-310. PMID:9548800
Ranasinghe A, Scheller NA, Wu K, Upton PB, Swenberg JA. 1998. Application of gas chromatography/electron capture negative chemical ionization/high resolution mass spectrometry for analysis of DNA and protein adducts. Chem Res Toxicol 11:520-526. PMID:9585483
Yen T, Holt S, Sangaiah R, Gold A, Swenberg JA. 1998. Quantitation of 1,N6 ethenoadenine in rat urine by immunoaffinity extraction combined with liquid chromatography/electrospray ionization mass spectrometry. Chem Res Toxicol 11(7):810-815. PMID:9671544
1997
Brunmark P, Harriman SP, Skipper PL, Wishnok JS, Amin S, Tannenbaum SR. 1997. Identification of subdomain IB in human serum albumin as a major binding site for polycyclic aromatic hydrocarbon epoxides. Chem Res Toxicol 10(8):880-886. PMID:9282837
Zheng J, Cho M, Jones AD, Hammock BD. 1997. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene. Chem Res Toxicol 10(9):1008-1014. PMID:9305583
1996
Amaro AR, Oakley GG, Bauer U, Spielmann HP, Robertson LW. 1996. Metabolic activation of PCBs to quinones: reactivity toward nitrogen and sulfur nucleophiles and influence of superoxide dismutase. Chem Res Toxicol 9:623-629. PMID:8728508
McLean MR, Bauer U, Amaro AR, Robertson LW. 1996. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem Res Toxicol 9:158-164. PMID:8924585
McLean MR, Robertson LW, Gupta RC. 1996. Detection of PCB-adducts by the 32P- postlabeling technique. Chem Res Toxicol 9:165-171. PMID:8924587
Oakley GG, Devanaboyina U, Robertson LW, Gupta RC. 1996. Oxidative DNA damage induced by activation of polychlorinated biphenyls (PCBs): Implications for PCB induced oxidative stress in breast cancer. Chem Res Toxicol 9:1285-1292. PMID:8951230
Randerath K, Randerath E, Smith CV, Chang J. 1996. Structural origins of bulky oxidative DNA adducts (Type II I-compounds) as deduced by oxidation of oligonucleotides of known sequence. Chem Res Toxicol 9:247-254. PMID:8924599
Skipper PL. 1996. Influence of tertiary structure on nucleophilic substitution reactions of proteins. Chem Res Toxicol 9(6):918-923. PMID:8870977
Waidyanatha S, Lin P, Rappaport SM. 1996. Characterization of chlorinated adducts of hemoglobin and albumin following administration of pentachlorophenol to rats. Chem Res Toxicol 9(3):647-653. PMID:8728511
Warren AJ, Hamilton JW. 1996. Synthesis and structural characterization of the N2G-mitomycin C-N2G interstrand crosslink in a model synthetic 23 base pair oligonucleotide DNA duplex. Chem Res Toxicol 9:1063-1071. PMID:8902260
Zheng J, Hammock BD. 1996. Development of polyclonal antibodies for detection of protein modification by 1,2-naphthoquinone. Chem Res Toxicol 9(5):904-909. PMID:8828928
1995
Bauer U, Amaro AR, Robertson LW. 1995. A new strategy for the synthesis of polychlorinated biphenyl metabolites. Chem Res Toxicol 8:92-95. PMID:7703372
Bruenner BA, Jones AD, German JB. 1995. Direct characterization of protein adducts of the lipid peroxidation product 4-hydroxy-2-nonenal using electrospray mass spectrometry. Chem Res Toxicol 8(4):552-559. PMID:7548735
El Ghissassi F, Barbin A, Nair J, Bartsch H. 1995. Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chem Res Toxicol 8:278-283. PMID:7766812
Fang X, Fernando Q. 1995. Stereoisomeric selectivity of 2,3-dimercaptosuccinic acids in chelation therapy for lead poisoning. Chem Res Toxicol 8(4):525-536. PMID:7548732
Mitchell AE, Morin D, Lame MW, Jones AD. 1995. Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases. Chem Res Toxicol 8(8):1054-1062. PMID:8605288
Scheller NA, Sangaiah R, Ranasinghe A, Amarnath V, Gold A, Swenberg JA. 1995. Synthesis of [4,5,6,8-13C4]guanine, a reagent for the production of internal standards of guanyl DNA adducts. Chem Res Toxicol 8(3):333-337. PMID:7578918
Shertzer HG, Vasiliou V, Liu R, Tabor MW, Nebert DW. 1995. Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells. Chem Res Toxicol 8(3):431-436. PMID:7578930
Zakharyan RA, Wu Y, Bogdan GM, Aposhian HV. 1995. Enzymatic methylation of arsenic compounds: I. Assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver. Chem Res Toxicol 8(8):1029-1038. PMID:8605285