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Search Results for Most Frequently Published Journals (Superfund Research Program)

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Search Results

Toxicology and Applied Pharmacology (285 articles)

2020

  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2020. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicol Appl Pharmacol 400:115069. doi:10.1016/j.taap.2020.115069 PMID:32445755
  • Doskey CM, Fader KA, Nault R, Lydic TA, Matthews J, Potter D, Sharratt B, Williams K, Zacharewski TR. 2020. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicol Appl Pharmacol 398:14. doi:10.1016/j.taap.2020.115034 PMID:32387183 PMCID:PMC7294678

2019

  • Bolt AM, Medina S, Lauer FT, Liu K, Burchiel SW. 2019. Minimal uranium immunotoxicity following a 60-day drinking water exposure to uranyl acetate in male and female C57BL/6J mice. Toxicol Appl Pharmacol 372:33-39. doi:10.1016/j.taap.2019.04.003 PMID:30978399
  • Burchiel SW, Lauer FT, Factor-Litvak P, Liu X, Santella RM, Islam T, Eunus M, Alam N, Islam T, Rahman M, Ahmed A, Ahsan H, Graziano JH, Parvez F. 2019. An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh. Toxicol Appl Pharmacol 384:114783. doi:10.1016/j.taap.2019.114783 PMID:31669812 PMCID:PMC6886671
  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644 PMID:31255691 PMCID:PMC6708476
  • Christofidou-Solomidou M, Pietrofesa RA, Park K, Albelda SM, Serve KM, Kiel DE, Pfau JC. 2019. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice. Toxicol Appl Pharmacol 375:81-93. doi:10.1016/j.taap.2019.04.018 PMID:31022494 PMCID:PMC6582645
  • Fry RC, Bangma J, Szilagyi JT, Rager JE. 2019. Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment. Toxicol Appl Pharmacol 378:12. doi:10.1016/j.taap.2019.114635 PMID:31233757 PMCID:PMC6684208
  • Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub KW, Williams DE. 2019. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 364:97-105. doi:10.1016/j.taap.2018.12.010 PMID:30582946 PMCID:PMC6369707
  • Mennillo E, Cappelli F, Arukwe A. 2019. Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to organophosphate esters (OPEs). Toxicol Appl Pharmacol 371:84-94. doi:10.1016/j.taap.2019.04.004
  • Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam S, Chari ST, Cave MC. 2019. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22-33. doi:10.1016/j.taap.2018.10.011 PMID:30312631
  • Wang C, Petriello MC, Zhu B, Hennig B. 2019. PCB 126 induces monocyte/macrophage polarization and inflammation through AhR and NF-kB pathways. Toxicol Appl Pharmacol 367:71-81. doi:10.1016/j.taap.2019.02.006 PMID:30768972 PMCID:PMC6402591
  • Witten M, Chau BT, Saez AE, Boitano S, Lantz RC. 2019. Early life inhalation exposure to mine tailings dust affects lung development. Toxicol Appl Pharmacol 365:124-132. doi:10.1016/j.taap.2019.01.009 PMID:30641074 PMCID:PMC6349506
  • Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308

2018

2017

  • Demidenko E, Glaholt SP, Kyker-Sowman E, Shaw JR, Chen CY. 2017. Single toxin dose-response models revisited. Toxicol Appl Pharmacol 314:12-23. doi:10.1016/j.taap.2016.11.002 PMID:27847315 PMCID:PMC5183473
  • Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. 2017. Convergence of hepcidin defiency, systemic iron overloading, heme accumulation, and REV-ERBalpha/beta activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol 321:1-17. doi:10.1016/j.taap.2017.02.006 PMID:28213091
  • Goodale BC, Rayack EJ, Stanton BA. 2017. Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol 331:154-163. doi:10.1016/j.taap.2017.06.010 PMID:28625800 PMCID:PMC5568502
  • Henriquez J, Zhou J, Li J, Crawford RB, Kaminski NE. 2017. Application of gene specific mRNA level determinations in individual cells using flow cytometry-based PrimeFlow (TM) in immunotoxicology. Toxicol Appl Pharmacol 337:39-44. doi:10.1016/j.taap.2017.10.021 PMID:29107001 PMCID:PMC5718209
  • Knecht AL, Truong L, Marvel S, Reif DM, Garcia A, Lu C, Simonich MT, Teeguarden J, Tanguay RL. 2017. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol 329:148-157. doi:10.1016/j.taap.2017.05.033 PMID:28583304 PMCID:PMC5539966
  • Kovalova N, Nault R, Crawford RB, Zacharewski TR, Kaminski NE. 2017. Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells. Toxicol Appl Pharmacol 316:95-106. doi:10.1016/j.taap.2016.11.009 PMID:27913140 PMCID:PMC5292778
  • Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020 PMID:28259702 PMCID:PMC5734940
  • Zhang G, Roell K, Truong L, Tanguay RL, Reif DM. 2017. A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades. Toxicol Appl Pharmacol 314:109-117. doi:10.1016/j.taap.2016.11.010 PMID:27884602 PMCID:PMC5224523

2016

  • Bugel SM, Wehmas LC, La Du JK, Tanguay RL. 2016. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol 296:31-41. doi:10.1016/j.taap.2016.02.013 PMID:26908177 PMCID:PMC4792761
  • Haggard DE, Noyes PD, Waters KM, Tanguay RL. 2016. Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol 308:32-45. doi:10.1016/j.taap.2016.08.013 PMID:27538710 PMCID:PMC5023494
  • Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. 2016. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol 304:121-132. doi:10.1016/j.taap.2016.04.005 PMID:27105554 PMCID:PMC4930739
  • Kovalova N, Manzan MA, Crawford RB, Kaminski NE. 2016. Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells. Toxicol Appl Pharmacol 309:15-23. doi:10.1016/j.taap.2016.08.011 PMID:27535091 PMCID:PMC5035641
  • Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001 PMID:26853319 PMCID:PMC4807407
  • Phadnis-Moghe AS, Li J, Crawford RB, Kaminski NE. 2016. SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol 310:41-50. doi:10.1016/j.taap.2016.08.014 PMID:27546522 PMCID:PMC5064869
  • Sollome JJ, Martin EM, Sethupathy P, Fry RC. 2016. Environmental contaminants and microRNA regulation: transcription factors as regulators of toxicant-altered microRNA expression. Toxicol Appl Pharmacol 312:61-66. doi:10.1016/j.taap.2016.06.009 PMID:27292125 PMCID:PMC5145741
  • Steinmaus CM, Ferreccio Readi C, Acevedo J, Balmes JR, Liaw J, Troncoso P, Dauphine DC, Nardone A, Smith AH. 2016. High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile. Toxicol Appl Pharmacol 313:10-15. doi:10.1016/j.taap.2016.10.006 PMID:27725189 PMCID:PMC5247272

2015

  • Adebambo OA, Ray PD, Shea D, Fry RC. 2015. Toxicological responses of environmental mixtures: Environmental metal mixtures display synergistic induction of metal-responsive and oxidative stress genes in placental cells. Toxicol Appl Pharmacol 289(3):534-541. doi:10.1016/j.taap.2015.10.005 PMID:26472158 PMCID:PMC4763604
  • Eum SY, Jaraki D, Andras IE, Toborek M. 2015. Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2. Toxicol Appl Pharmacol 287(3):258-266. doi:10.1016/j.taap.2015.06.011 PMID:26080028 PMCID:PMC4574485
  • Farzan S, Karagas MR. 2015. Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicol Appl Pharmacol 287(2):93-97. doi:10.1016/j.taap.2015.05.013 PMID:26048586 PMCID:PMC4536141
  • Farzan S, Karagas MR, Jiang JY, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Eunus M, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich VN, Graziano JH, Ahsan H, Chen Y, Scannell Bryan M, Islam T. 2015. Gene-arsenic interaction in longitudinal changes of blood pressure: findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 288(1):95-105. doi:10.1016/j.taap.2015.07.017 PMID:26220686 PMCID:PMC4606937
  • Fujiwara R, Maruo Y, Chen S, Tukey RH. 2015. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol 289(1):124-132. doi:10.1016/j.taap.2015.08.018 PMID:26342858 PMCID:PMC4708261
  • Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. 2015. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicol Appl Pharmacol 289(3):419-427. doi:10.1016/j.taap.2015.10.018 PMID:26522832 PMCID:PMC4666679
  • Harris TR, Bettaieb A, Kodani SD, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. 2015. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 286(2):102-111. doi:10.1016/j.taap.2015.03.022 PMID:25827057 PMCID:PMC4458210
  • Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. 2015. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1):54-64. doi:10.1016/j.taap.2015.02.001 PMID:25680588 PMCID:PMC4387200
  • Liu D, Perkins JT, Petriello MC, Hennig B. 2015. Exposure to coplanar PCBs induces endothelial cell inflammation through epigenetic regulation of NF-κB subunit p65. Toxicol Appl Pharmacol 289(3):457-465. doi:10.1016/j.taap.2015.10.015 PMID:26519613 PMCID:PMC4662647
  • Munoz A, Chervona Y, Hall MN, Kluz T, Gamble MV, Costa M. 2015. Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water. Toxicol Appl Pharmacol 284(3):330-338. doi:10.1016/j.taap.2015.02.025 PMID:25759245 PMCID:PMC4410068
  • Olivas-Calderon E, Recio-Vega R, Gandolfi A, Lantz RC, Gonzalez-Cortes, Gonzalez-De Alba C, Froines JR, Espinosa-Fematt JA. 2015. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic. Toxicol Appl Pharmacol 287(2):161-167. doi:10.1016/j.taap.2015.06.001 PMID:26048584 PMCID:PMC4751871
  • Reed JR, dela Cruz AL, Lomnicki S, Backes WL. 2015. Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2. Toxicol Appl Pharmacol 289(2):223-230. doi:10.1016/j.taap.2015.09.021 PMID:26423927 PMCID:PMC4651829
  • Siddens LK, Bunde KL, Harper TA, McQuistan TJ, Lohr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM. 2015. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 287(2):149-160. doi:10.1016/j.taap.2015.05.019 PMID:26049101 PMCID:PMC4689210
  • Wincent E, Stegeman JJ, Jonsson ME. 2015. Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol 284(2):163-179. doi:10.1016/j.taap.2015.02.014 PMID:25711857 PMCID:PMC4747639

2014

  • McClintock TR, Chen Y, Parvez F, Makarov DV, Ge W, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich VN, Bjurlin MA, Graziano JH, Ahsan H. 2014. Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol 276(1):21-27. doi:10.1016/j.taap.2014.01.015 PMID:24486435 PMCID:PMC3959280
  • Melak D, Ferreccio Readi C, Kalman DA, Parra RL, Acevedo J, Perez L, Cortes S, Smith AH, Yuan Y, Liaw J, Steinmaus CM. 2014. Arsenic methylation and lung and bladder cancer in a case-control study in Northern Chile. Toxicol Appl Pharmacol 274(2):225-231. doi:10.1016/j.taap.2013.11.014 PMID:24296302 PMCID:PMC4344188
  • Park H, Kamau PW, Loch-Caruso R. 2014. Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro. Toxicol Appl Pharmacol 274(2):283-292. doi:10.1016/j.taap.2013.11.015 PMID:24296301 PMCID:PMC3931445
  • Park H, Loch-Caruso R. 2014. Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicol Appl Pharmacol 281(1):67-77. doi:10.1016/j.taap.2014.09.015 PMID:25305463 PMCID:PMC4393751
  • Petriello MC, Han S, Newsome B, Hennig B. 2014. PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. Toxicol Appl Pharmacol 277(2):192-199. doi:10.1016/j.taap.2014.03.018 PMID:24709675 PMCID:PMC4041015
  • Reed JR, Cawley GF, Ardoin TG, Dellinger B, Lomnicki S, Kiruri LW, Backes WL. 2014. Environmentally persistent free radicals inhibit cytochrome P450 activity in rat liver microsomes. Toxicol Appl Pharmacol 277(2):200-209. doi:10.1016/j.taap.2014.03.021 PMID:24713513 PMCID:PMC4049543
  • Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. 2014. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274(3):408-416. doi:10.1016/j.taap.2013.12.002 PMID:24355420 PMCID:PMC3919493
  • Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Paul-Brutus R, Islam T, Paul RR, Sarwar G, Ahmed A, Jiang JY, Slavkovich VN, Rundek T, Demmer RT, Desvarieux M, Ahsan H, Chen Y. 2014. Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol 276(3):195-203. doi:10.1016/j.taap.2014.02.014 PMID:24593923 PMCID:PMC4080412

2013

2012

2011

  • Arsenescu V, Arsenescu RI, Parulkar M, Karounos M, Zhang X, Baker NA, Cassis LA. 2011. Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice. Toxicol Appl Pharmacol 257(1):148-154. doi:10.1016/j.taap.2011.08.028 PMID:21925196 PMCID:PMC3220787
  • Barhoumi R, Mouneimne Y, Hammock BD, Safe SH, Burghardt RC, Parrish AR, Ramos E. 2011. Multiphoton spectral analysis of benzo a pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56. doi:10.1016/j.taap.2011.03.009 PMID:21420996 PMCID:PMC3081912
  • Crowell SR, Amin S, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA. 2011. Preliminary physiologically based pharmacokinetic models for benzo a pyrene and dibenzo def,p chrysene in rodents. Toxicol Appl Pharmacol 257:365-376. doi:10.1016/j.taap.2011.09.020 PMID:22001385 PMCID:PMC3226888
  • De Abrew KN, Phadnis AS, Crawford RB, Kaminski NE, Thomas RS. 2011. Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 252(2):150-158. doi:10.1016/j.taap.2011.01.020 PMID:21296099 PMCID:PMC3106294
  • Giordano G, Cole TB, Furlong CE, Costa LG. 2011. Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?. Toxicol Appl Pharmacol 256:369-378. doi:10.1016/j.taap.2011.02.014 PMID:21354197 PMCID:PMC3155737
  • Gomez-Rubio P, Roberge J, Arendell L, Harris RB, O'Rourke MK, Chen Z, Cantu-Soto E, Meza-Montenegro MM, Billheimer D, Lu Z, Klimecki WT. 2011. Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico. Toxicol Appl Pharmacol 252:176-182. doi:10.1016/j.taap.2011.02.007 PMID:21320519 PMCID:PMC3075343
  • Jonsson ME, Berg C, Goldstone JV, Stegeman JJ. 2011. New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183. doi:10.1016/j.taap.2010.10.010 PMID:20965207 PMCID:PMC3014448
  • Kopec AK, D'Souza ML, Mets BD, Burgoon LD, Reese SE, Archer KJ, Potter D, Tashiro C, Sharratt B, Harkema JR, Zacharewski TR. 2011. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice. Toxicol Appl Pharmacol 256:154-167. doi:10.1016/j.taap.2011.08.002 PMID:21851831 PMCID:PMC4126514
  • Liu J, Qiu H, Moisseau C, Hwang SH, Tsai H, Ulu A, Chiamvimonvat N, Hammock BD. 2011. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol 255:200-206. doi:10.1016/j.taap.2011.06.017 PMID:21741984 PMCID:PMC3156297
  • Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O. 2011. Exposure to tri-o-cresyl phosphate detected in jet airplant passengers. Toxicol Appl Pharmacol 256:337-347. doi:10.1016/j.taap.2011.06.016 PMID:21723309 PMCID:PMC3205265
  • Lo R, Celius T, Dere E, MacPherson L, Harper PA, Zacharewski TR, Matthews J. 2011. Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 257:38-47. doi:10.1016/j.taap.2011.08.016 PMID:21889950
  • Lu H, Crawford RB, Kaplan BL, Kaminski NE. 2011. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated disruption of the CD40 ligand-induced activation of primary human B cells. Toxicol Appl Pharmacol 255:251-260. doi:10.1016/j.taap.2011.06.026 PMID:21807014 PMCID:PMC3189629
  • Majkova Z, Layne J, Sunkara M, Morris AJ, Toborek M, Hennig B. 2011. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Toxicol Appl Pharmacol 251(1):41-49. doi:10.1016/j.taap.2010.11.013 PMID:21130106 PMCID:PMC3026064
  • Wnek SM, Kuhlman CL, Camarillo JM, Medeiros MK, Liu KJ, Lau SS, Gandolfi A. 2011. Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol Appl Pharmacol 257:1-13. doi:10.1016/j.taap.2011.08.029 PMID:21925530 PMCID:PMC3220758

2010

2009

2008

  • Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
  • Ke Q, Ellen TP, Costa M. 2008. Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity. Toxicol Appl Pharmacol 228(2):190-199. doi:10.1016/j.taap.2007.12.015 PMID:18279901 PMCID:PMC2424130
  • Komissarova EV, Li P, Uddin AN, Chen X, Nadas A, Rossman TG. 2008. Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol 226(2):199-205. PMID:17976673
  • Oesterling EG, Toborek M, Hennig B. 2008. Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway. Toxicol Appl Pharmacol 232(2):309-316. doi:10.1016/j.taap.2008.07.001 PMID:18671994 PMCID:PMC2633733
  • Pysher MD, Chen QM, Vaillancourt RR. 2008. Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways. Toxicol Appl Pharmacol 231(2):135-141. doi:10.1016/j.taap.2008.04.002 PMID:18486177 PMCID:PMC3900024
  • Slotkin TA, Seidler FJ. 2008. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicol Appl Pharmacol 233(2):211-219. doi:10.1016/j.taap.2008.08.020 PMID:18835401 PMCID:PMC2645545
  • Zhang S, Safe SH. 2008. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicol Appl Pharmacol 227(2):196-206. PMID:18048071

2007

  • Bezdecny SA, Karmaus P, Roth RA, Ganey PE. 2007. 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. Toxicol Appl Pharmacol 221(3):285-294. doi:10.1016/j.taap.2007.03.019 PMID:17482227 PMCID:PMC1950673
  • Chen J, Ahn K, Gee SJ, Gee NA, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284. doi:10.1016/j.taap.2007.03.015 PMID:17481686 PMCID:PMC1978490
  • Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol 219(2-3):181-189. PMID:17084875
  • Jonsson ME, Orrego R, Woodin BR, Goldstone JV, Stegeman JJ. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol 221(1):29-41. PMID:17445853
  • Khan S, Liu S, Stoner M, Safe SH. 2007. Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells. Toxicol Appl Pharmacol 223(1):28-38. PMID:17599377
  • Klein C, Leszczynska J, Hickey C, Rossman TG. 2007. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol 222(3):289-97. PMID:17316729
  • Meza MM, Gandolfi A, Klimecki WT. 2007. Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?. Toxicol Appl Pharmacol 222(3):381-387. doi:10.1016/j.taap.2006.12.018 PMID:17306849 PMCID:PMC2040165
  • Patterson TP, Rice RH. 2007. Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential. Toxicol Appl Pharmacol 221(1):119-28. PMID:17400267
  • Pysher MD, Sollome JJ, Regan SP, Cardinal TR, Hoying JB, Brooks HL, Vaillancourt RR. 2007. Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic. Toxicol Appl Pharmacol 224(1):39-48. PMID:17643460
  • Qian Y, Venkatraj J, Barhoumi R, Pal R, Datta A, Wild JR, Tiffany-Castiglioni E. 2007. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. Toxicol Appl Pharmacol 219(2-3):162-171. PMID:17223147
  • Straub AC, Stolz DB, Vin H, Ross MA, Soucy NV, Klei LR, Barchowsky A. 2007. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl Pharmacol 222(3):327-36. PMID:17123562
  • Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830
  • Wang X, Sun Z, Chen W, Eblin KE, Gandolfi A, Zhang DD. 2007. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225(2):206-13. PMID:17765279
  • White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian Y, Basha M. 2007. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol 225(1):1-27. doi:10.1016/j.taap.2007.08.001 PMID:17904601

2006

  • Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi A. 2006. Monomethylarsonous acid induces transformation of human bladder cells. Toxicol Appl Pharmacol 216(1):69-79. PMID:16806342
  • Chowdhury UK, Zakharyan RA, Hernandez A, Avram MD, Kopplin MJ, Aposhian HV. 2006. Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: enzyme and arsenic species concentrations in tissues after arsenate administration. Toxicol Appl Pharmacol 216(3):446-457. doi:10.1016/j.taap.2006.06.014 PMID:16930657
  • Eblin KE, Bowen ME, Cromey DW, Bredfeldt TG, Mash EA, Lau SS, Gandolfi A. 2006. Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture. Toxicol Appl Pharmacol 217(1):7-14. PMID:16930658
  • Li Q, Chen H, Huang X, Costa M. 2006. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245-255. doi:10.1016/j.taap.2005.11.006 PMID:16386771 PMCID:PMC2965073
  • Shipley JM, Waxman DJ. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicol Appl Pharmacol 213(2):87-97. PMID:16257430
  • Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, Tanguay RL, Svoboda K, Handley-Goldstone HM, Stegeman JJ, Hiraga T. 2006. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol 212(1):24-34. PMID:16051294
  • Wlodarczyk BJ, Tang LS, Triplett A, Aleman F, Finnell RH. 2006. Spontaneous neural tube defects in Splotch mice supplemented with selected micronutrients. Toxicol Appl Pharmacol 213(1):55-63. PMID:16226775

2005

  • Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol Appl Pharmacol 203(2):132-144. PMID:15710174
  • Chen H, Davidson T, Singleton S, Garrick MD, Costa M. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275-287. PMID:16039939
  • Holland NT, Pfleger L, Berger E, Ho A, Bastaki M. 2005. Molecular epidemiology biomarkers - sample collection, processing, and banking considerations. Toxicol Appl Pharmacol 206(2):261-268. PMID:15967217
  • Komissarova EV, Saha SK, Rossman TG. 2005. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol Appl Pharmacol 202(1):99-107. PMID:15589980
  • Meyer A, Seidler FJ, Aldridge JE, Slotkin TA. 2005. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicol Appl Pharmacol 203(2):154-166. PMID:15710176
  • Patterson TP, Reznikova TV, Phillips MA, Rice RH. 2005. Arsenite maintains germinative state in cultured human epidermal cells. Toxicol Appl Pharmacol 207(1):69-77. PMID:16054901
  • Qiao D, Seidler FJ, Slotkin TA. 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol Appl Pharmacol 206(1):17-26. PMID:15963341
  • Shabbir A, DiStasio S, Zhao J, Cardozo CP, Wolff MS, Caplan A. 2005. Differential effects of the organochlorine pesticide DDT and its metabolite p,p2-DDE on p-glycoprotein activity and expression. Toxicol Appl Pharmacol 203(2):91-98. PMID:15710169
  • Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
  • Spiegelstein O, Gould A, Wlodarczyk BJ, Tsie M, Lu X, Le X, Troen A, Selhub J, Piedrahita JA, Salbaum JM, Kappen C, Melnyk SB, James S, Finnell RH. 2005. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Toxicol Appl Pharmacol 203(1):18-26. PMID:15694460
  • Woods JS, Echeverria D, Heyer NJ, Simmonds PL, Wilkerson J, Farin FM. 2005. The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans. Toxicol Appl Pharmacol 206(2):113-120. PMID:15967199

2004

  • Bredfeldt TG, Kopplin MJ, Gandolfi A. 2004. Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Toxicol Appl Pharmacol 198(3):412-418. PMID:15276421
  • Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
  • Finnell RH, Shaw GM, Lammer EJ, Brandl KL, Carmichael SL, Rosenquist TH. 2004. Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis. Toxicol Appl Pharmacol 198(2):75-85. PMID:15236946
  • Guo J, Sartor MA, Karyala S, Medvedovic M, Kann S, Puga A, Ryan P, Tomlinson CR. 2004. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol 194(1):79-89. PMID:14728982
  • Hurst CH, Waxman DJ. 2004. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol Appl Pharmacol 199(3):266-274. PMID:15364542
  • Moggs JG, Goodman JI, Trosko JE, Roberts RA. 2004. Epigenetics and cancer: implications for drug discovery and safety assessment. Toxicol Appl Pharmacol 196(3):422-430. PMID:15094313
  • Rhodes MC, Seidler FJ, Qiao D, Tate CA, Cousins MM, Slotkin TA. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicol Appl Pharmacol 195(2):203-217. doi:10.1016/j.taap.2003.11.008 PMID:14998686
  • Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404. PMID:15276419
  • Shipley JM, Waxman DJ. 2004. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199(3):275-284. PMID:15364543
  • Slikker W, Bogdanffy MS, Bus JS, Cohen SD, Conolly RB, David RM, Doerrer NG, Dorman DC, Gaylor DW, Hattis D, Rogers JM, Setzer RW, Swenberg JA, Wallace K, Andersen ME. 2004. Dose-dependent transitions in mechanisms of toxicity. Toxicol Appl Pharmacol 201(3):203-225. PMID:15582645
  • Slotkin TA. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol Appl Pharmacol 198(2):132-151. PMID:15236950
  • Zhao J, Chen H, Davidson T, Kluz T, Zhang Q, Costa M. 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 196(3):404-409. PMID:15094311
  • Zhao J, Yan Y, Salnikow K, Kluz T, Costa M. 2004. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194(1):60-68. PMID:14728980

2003

  • Aposhian HV, Zakharyan RA, Avram MD, Kopplin MJ, Wollenberg ML. 2003. Oxidation and detoxification of trivalent arsenic species. Toxicol Appl Pharmacol 193(1):1-8. PMID:14613711
  • Carter DE, Aposhian HV, Gandolfi A. 2003. The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. Toxicol Appl Pharmacol 193(3):309-334. PMID:14678742
  • Costa M. 2003. Potential hazards of hexavalent Cr in our drinking water. Toxicol Appl Pharmacol 188(1):1-5. PMID:12668116
  • Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2003. Polychlorinated biphenyls (PCBs) as initiators in liver carcinogensis: resistant hepatocyte model. Toxicol Appl Pharmacol 186(1):55-62. PMID:12583993
  • Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol 186(2):110-118. PMID:12639502
  • Kirkpatrick DS, Dale KV, Catania JM, Gandolfi A. 2003. Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK 293 cells. Toxicol Appl Pharmacol 186(2):101-109. PMID:12639501
  • Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. 2003. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol Appl Pharmacol 189(1):1-10. PMID:12758055
  • O'Hara KA, Klei LR, Barchowsky A. 2003. Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol 190(3):214-223. PMID:12902192
  • Suh J, Kang J, Yang K, Kaminski NE. 2003. Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls. Toxicol Appl Pharmacol 187(1):11-21. PMID:12628580
  • Tampal N, Robertson LW, Srinivasan C, Ludewig G. 2003. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicol Appl Pharmacol 187(3):168-177. PMID:12662900
  • Williams KJ, Cruikshank MK, Plopper CG. 2003. Pulmonary heat shock protein expression after exposure to a metabolically activated Clara cell toxicant: relationship to protein adduct formation. Toxicol Appl Pharmacol 192(2):107-118. PMID:14550745
  • Yan Y, Kluz T, Zhang P, Chen H, Costa M. 2003. Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol 190(3):272-277. PMID:12902198
  • Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol 192(3):201-211. PMID:14575637

2002

  • Hennig B, Meerarani P, Slim RM, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 181(3):174-183. PMID:12079426
  • Kim M, Spencer PS, Sabri MI. 2002. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicol Appl Pharmacol 183(1):55-65. PMID:12217642
  • Suh J, Jeon YJ, Kim HM, Kang J, Kaminski NE, Yang K. 2002. Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated B cell dysfunction. Toxicol Appl Pharmacol 181(2):116-123.
  • Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2002. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by Polychlorinated Biphenyls. Toxicol Appl Pharmacol 179(3):172-184. PMID:11906247
  • Zhou Y, Davey HW, McLachlan MJ, Xie T, Waxman DJ. 2002. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol Appl Pharmacol 182(1):1-10. PMID:12127257

2001

  • Dieguez-Acuna FJ, Ellis ME, Kushleika JV, Woods JS. 2001. Mercuric ion attenuates NF-kB activation and DNA binding in normal rat kidney epithelial cells: implications for mercury-induced nephrotoxicity. Toxicol Appl Pharmacol 173:176-187. PMID:11437639
  • Jessen BA, Qin Q, Phillips MA, Phillips DL, Rice RH. 2001. Keratinocyte differentiation marker suppression by arsenic: mediation by AP1 response elements and antagonism by tetradecanoylphorbol acetate. Toxicol Appl Pharmacol 174(3):302-311. PMID:11485391
  • Kim M, Sabri MI, Miller VH, Kayton RJ, Dixon DA, Spencer PS. 2001. 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. Toxicol Appl Pharmacol 177(2):121-131. PMID:11740911
  • Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2001. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176(1):64-71. PMID:11578149
  • Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
  • Twaroski TP, O'Brien ML, Larmonier N, Glauert HP, Robertson LW. 2001. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E and oxidative stress in the rat liver. Toxicol Appl Pharmacol 171(2):85-93. PMID:11222084
  • West JA, Pakehham G, Morin D, Fleschner CA, Plopper CG, Buckpitt AR. 2001. Inhaled naphthalene causes dose dependent Clara cell toxicity in mice but not in rats. Toxicol Appl Pharmacol 173(2):114-119. PMID:11384213
  • Willett KL, Lienesch L, Reichert W, Di Giulio RT. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicol Appl Pharmacol 177(3):264-271. PMID:11749126
  • Wlodarczyk BJ, Spiegelstein O, Gelineau-van Waes J, Vorce RL, Lu X, Le C, Finnell RH. 2001. Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol 177(3):238-246. PMID:11749123

2000

  • Andrew AS, Barchowsky A. 2000. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Toxicol Appl Pharmacol 168(1):50-57. PMID:11000099
  • Aposhian HV, Zheng B, Aposhian MM, Le X, Cebrian ME, Cullen WR, Zakharyan RA, Ma M, Dart RC, Cheng Z, Andrewes P, Yip L, O'Malley GF, Maiorino RM, Van Voorhies W, Healy SM, Titcomb A. 2000. DMPS-arsenic challenge test: II. Modulation of arsenic species, including monomethylarsonous acid (MMAIII ), excreted in human urine. Toxicol Appl Pharmacol 165(1):74-83. PMID:10814555
  • Claudio L, Kwa WC, Russell AL, Wallinga D. 2000. Testing methods for developmental neurotoxicity of environmental chemicals. Toxicol Appl Pharmacol 164:1-14. PMID:10739739
  • Fanucchi MV, Buckpitt AR, Murphy M, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol Appl Pharmacol 168(3):253-267. PMID:11042098
  • Jacobs JM, Nichols C, Marek D, Gorman N, Walton HS, Sinclair PR, Sinclair JF. 2000. Effect of arsenite on induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes. Toxicol Appl Pharmacol 168(3):177-182. PMID:11042089
  • Olivero-Verbal J, Ganey PE. 2000. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242. Toxicol Appl Pharmacol 163:9-16. PMID:10662600
  • Petrick JS, Ayala-Fierro F, Cullen WR, Carter DE, Aposhian HV. 2000. Monomethylarsonous acid (MMAIII) is more toxic than arsenite in chang human hepatocytes. Toxicol Appl Pharmacol 163(2):203-207. PMID:10698679
  • Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates Polychlorinated Biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol 166(1):36-42. PMID:10873716
  • Thomas RS, Conolly RB, Gustafson DL, Long ME, Benjamin SA, Yang RH. 2000. A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator. Toxicol Appl Pharmacol 166(2):128-137. PMID:10896854

1999

  • Bae J, Stuenkel E, Loch-Caruso R. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicol Appl Pharmacol 155(3):261-272. PMID:10079212
  • Barchowsky A, Roussel RR, Klei LR, James PE, Ganju N, Smith KR, Dudek EJ. 1999. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol Appl Pharmacol 159(1):65-75. PMID:10448126
  • Fischer L, Wagner MA, Madhukar BV. 1999. Potential involvement of calcium, CaM kinase II and MAP kinases in PCB-stimulated insulin release from RINm5F cells. Toxicol Appl Pharmacol 159:194-203. PMID:10486306
  • Grabowski GM, Paulauskis JD, Godleski J. 1999. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol Appl Pharmacol 156:170-178. PMID:10222309
  • Jacobs JM, Nichols C, Andrew AS, Marek D, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF. 1999. Effect of arsenite on induction of CYP1A, CYP2B and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 157(1):51-59. PMID:10329507
  • Maloney EK, Waxman DJ. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161(2):209-218. PMID:10581215
  • Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced pre-B cell apoptosis. Toxicol Appl Pharmacol 161:10-22.
  • Mann KK, Matulka RA, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of cytochrome P-450 enzymes in 7,12-dimethylbenz[a]anthracene-induced apoptosis. Toxicol Appl Pharmacol 161:10. PMID:10558919
  • Ou YC, Thompson SA, Ponce RA, Schroeder JI, Kavanagh TJ, Faustman EM. 1999. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicol Appl Pharmacol 157:203-212. PMID:10373404
  • Raha A, Hamilton JW, Bresnick E. 1999. The existence of the 4S polycyclic aromatic hydrocarbon-protein binding in 14-day-old chick embryo liver. Toxicol Appl Pharmacol 158:1-8. PMID:10387926
  • Shumilla JA, Barchowsky A. 1999. Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. Toxicol Appl Pharmacol 158(3):288-295. PMID:10438662
  • Thurmond TS, Silverstone AW, Baggs RB, Quimby FW, Staples JE, Gasiewcz TA. 1999. A chimeric Ah receptor knockout mouse model indicates that hematopoietic cells contribute to the hepatic lesions induced by 2,3, 7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 158:33-40. PMID:10387930
  • Turney KD, Parrish AR, Orozco J, Gandolfi A. 1999. Selective activation in the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices. Toxicol Appl Pharmacol 160(3):262-270. PMID:10544060
  • Woods JS, Ellis ME, Dieguez-Acuna FJ, Corral J. 1999. Activation of NF-kB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway. Toxicol Appl Pharmacol 154:219-227. PMID:9931281
  • Woods JS, Kavanagh TJ, Corral J, Reese AW, Diaz D, Ellis ME. 1999. The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis. Toxicol Appl Pharmacol 160(3):207-216. PMID:10544055
  • Zakharyan RA, Aposhian HV. 1999. Arsenite methylation by methylvitamin B12 and glutathione does not require an enzyme. Toxicol Appl Pharmacol 154(30):287-291. PMID:9931288
  • Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DE, Aposhian HV. 1999. Enzymatic methylation of arsenic compounds: VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes. Toxicol Appl Pharmacol 158(1):9-15. PMID:10387927

1998

  • Bentivegna CS, Ihnat MA, Baptiste NS, Hamilton JW. 1998. Developmental regulation of the 3 methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo. Toxicol Appl Pharmacol 151(1):166-173. PMID:9705900
  • Denison MS, Phelan D, Winters GM, Ziccardi MH. 1998. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol Appl Pharmacol 152(2):406-414. PMID:9853009
  • Healy SM, Casarez EA, Ayala-Fierro F, Aposhian HV. 1998. Enzymatic methylation of arsenic compounds: V. Arsenite methyltransferase activity in tissues of mice. Toxicol Appl Pharmacol 148(1):65-70. PMID:9465265
  • Hutchinson RW, Barhoumi R, Miles J, Burghardt RC. 1998. Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. Toxicol Appl Pharmacol 151:311-318. PMID:9707507
  • Jacobs JM, Roussel RR, Roberts M, Marek D, Wood SG, Walton HS, Dwyer B, Sinclair PR, Sinclair JF. 1998. Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes. Toxicol Appl Pharmacol 150(2):376-382. PMID:9653069
  • Kodavanti PR, Ward TR, Derr-Yellin EC, Mundy WR, Casey AC, Bush B, Tilson HA. 1998. Congener-specific distribution of polychlorinated biphenyls in brain regions, blood, liver, and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol Appl Pharmacol 153:199-210. PMID:9878591
  • Parrish AR, Fisher RL, Bral CM, Burghardt RC, Gandolfi A, Brendel K, Ramos KS. 1998. Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver slices. Toxicol Appl Pharmacol 152:302-308. PMID:9852999
  • Thomas RS, Gustafson DL, Ramsdell HS, El-Masri HA, Benjamin SA, Yang RH. 1998. Enhanced regional expression of glutathioneS-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria. Toxicol Appl Pharmacol 150(1):22-31. PMID:9630449
  • Thompson DC, Barhoumi R, Burghardt RC. 1998. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol 149:55-63. PMID:9512727
  • Wildfang E, Zakharyan RA, Aposhian HV. 1998. Enzymatic methylation of arsenic compounds: VI. Characterization of hamster liver arsenite and monomethylarsonic acid methyltransferase activities in vitro. Toxicol Appl Pharmacol 152(2):366-375. PMID:9853005

1997

  • Barchowsky A, Lannon BM, Elmore LC, Treadwell MD. 1997. Increased focal adhesion kinase- and urokinase-type plasminogen activator receptor-associated cell signaling in endothelial cells exposed to asbestos. Toxicol Appl Pharmacol 105(Suppl.5):1131-1137. PMID:9400712
  • Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe SH, Zacharewski TR, Gillesby B, Joyeux A, Belaguer P. 1997. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. Toxicol Appl Pharmacol 145:111-123. PMID:9221830
  • Guiney PD, Smolowitz RM, Peterson RE, Stegeman JJ. 1997. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P450 1A in vascular endothelium with toxicity in early life stages of lake trout. Toxicol Appl Pharmacol 143(2):256-273. PMID:9144443
  • Jeon YJ, Han SH, Yang K, Kaminski NE. 1997. Induction of transforming growth factor β1 transcription by carbon tetrachloride leads to the inhibition of T helper 2 cell associated lymphokines. Toxicol Appl Pharmacol 144:27-35.
  • Kramer VJ, Helferich WG, Bergman A, Klasson-Wehler E, Giesy JP. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line. Toxicol Appl Pharmacol 144(2):363-376. doi:10.1006/taap.1997.8163 PMID:9194421
  • Lin P, Waidyanatha S, Pollack GM, Rappaport SM. 1997. Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts. Toxicol Appl Pharmacol 145(2):399-408. PMID:9266814
  • Moore M, Mustain M, Daniel KD, Chen I, Safe SH, Zacharewski TR, Gillesby B, Joyeux A, Belaguer P. 1997. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicol Appl Pharmacol 142:160-168. PMID:9007045
  • Ou YC, Thompson SA, Kirchner SC, Kavanagh TJ, Faustman EM. 1997. Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicol Appl Pharmacol 147:31-38. PMID:9356304
  • Paige R, Wong VJ, Plopper CG. 1997. Dose-related airway-selective epithelial toxicity of 1-nitronaphthalene in rats. Toxicol Appl Pharmacol 147(2):224-233. PMID:9439718
  • Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe SH, McDonnell DP, Leonard LS, Gaido KW. 1997. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicol Appl Pharmacol 147:93-100. PMID:9356311
  • Seegal R, Brosch KO, Okoniewski RJ. 1997. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2',4'- and 3,4,3',4'-tetrachlorobiphenyl on dopamine function. Toxicol Appl Pharmacol 146:95-103. PMID:9299601
  • Sieg DJ, Billings RE. 1997. Lead/cytokine-mediated DNA damage in cultured mousehepatocytes. Toxicol Appl Pharmacol 142:106-115. PMID:9007039
  • Sinclair PR, Walton HS, Gorman N, Jacobs JM, Sinclair JF. 1997. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes. Toxicol Appl Pharmacol 147(2):171-179. PMID:9439713
  • Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao X, Tilly JL, Near RI, Sherr DH. 1997. Induction of preB cell apoptosis by 7,12 dimethylbenz[a]anthracene in long term primary bone marrow cultures. Toxicol Appl Pharmacol 147(2):190-203. PMID:9439715

1996

  • Anderson MJ, Olsen H, Matsumura F, Hinton DE. 1996. In vivo modulation of 17²-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by ²-naphthoflavone. Toxicol Appl Pharmacol 137(2):210-218. doi:10.1006/taap.1996.0074 PMID:8661346
  • El-Masri HA, Constan AA, Ramsdell HS, Yang RH. 1996. Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats. Toxicol Appl Pharmacol 141(1):124-132. PMID:8917684
  • Gebremichael A, Tullis K, Denison MS, Cheek JM, Pinkerton KE. 1996. Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. Toxicol Appl Pharmacol 141(1):76-83. PMID:8917678
  • Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. 1996. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-226. PMID:8806837
  • La DK, Schoonhoven R, Ito N, Swenberg JA. 1996. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. Toxicol Appl Pharmacol 140(1):108-114. PMID:8806876
  • Li S, Thompson SA, Kavanagh TJ, Woods JS. 1996. Localization by in situ hybridizatioin of glutamylcysteine synthetase mRNA expression in rat kidney following acute methylmercury treatment. Toxicol Appl Pharmacol 141:59-67. PMID:8917676
  • Li S, Thompson SA, Woods JS. 1996. Localization of glutamylcysteine synthetase mRNA expression in mouse brain following methylmercury treatment using reverse transcription in situ PCR amplification. Toxicol Appl Pharmacol 140:180-187. PMID:8806884
  • Pierce CH, Dills RL, Morgan MS, Nothstein GL, Shen D, Kalman DA. 1996. Interindividual differences in 2H8-toluene toxicokinetics assessed by a semi-empirical physiologically-based model. Toxicol Appl Pharmacol 139(1):49-61.
  • Pierce LM, Alessandrini F, Godleski J, Paulauskis JD. 1996. Vanadium-induced chemokine mRNA expression and pulmonary inflammation. Toxicol Appl Pharmacol 138(1):1-11. doi:10.1006/taap.1996.9999 PMID:8658498
  • Sanderson J, Aarts JM, Brouwer A, Froese KL, Denison MS, Giesy JP. 1996. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 137(2):316-325. PMID:8661358
  • van Birgelen AP, DeVito MJ, Akins JM, Ross DG, Diliberto JJ, Birnbaum LS. 1996. Relative potencies of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls derived from hepatic porphyrin accumulation in mice. Toxicol Appl Pharmacol 138(1):98-109. PMID:8658519
  • Yamaguchi K, Near RI, Shneider AM, Cui H, Ju S, Sherr DH. 1996. Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol 139(1):144-152. PMID:8685897
  • Zakharyan RA, Wildfang E, Aposhian HV. 1996. Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. Toxicol Appl Pharmacol 140(1):77-84. PMID:8806872

1995

  • Brown AP, Ganey PE. 1995. Neutrophil degranulation and superoxide production induced by polychlorinated biphenyl are calcium dependent. Toxicol Appl Pharmacol 131(2):198-205. PMID:7716762
  • Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL. 1995. Induction of phase I and phase II drug metabolizing enzyme mRNA, protein and activity by BHA, ethoxyquin and oltipraz. Toxicol Appl Pharmacol 135(1):45-57. PMID:7482539
  • Criswell KA, Loch-Caruso R. 1995. Lindane-induced elimination of gap junctional communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol Appl Pharmacol 135(1):127-138. PMID:7482532
  • Criswell KA, Loch-Caruso R, Stuenkel E. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicol Appl Pharmacol 130:280-293. PMID:7532876
  • Dickerson R, Howie-Keller L, Safe SH. 1995. Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: Structure-Activity Studies. Toxicol Appl Pharmacol 135:287-298. PMID:8545839
  • Gallagher EP, Buetler TM, Wang C, Stapleton PL, Stahl DL, Eaton DL. 1995. The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol Appl Pharmacol 134(1):81-91. PMID:7676460
  • Gallagher EP, Eaton DL. 1995. In vitro biotransformation of aflatoxin B1 in channel catfish liver. Toxicol Appl Pharmacol 132:82-90. PMID:7747288
  • Jonsson BA, Wishnok JS, Skipper PL, Stillwell WG, Tannenbaum SR. 1995. Lysine adducts between methyltetrahydropthalic anhydride and collagen in guinea-pig lung. Toxicol Appl Pharmacol 135(1):156-162. PMID:7482535
  • Ramasamy S, Wang E, Hennig B, Merrill AH. 1995. Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol Appl Pharmacol 133(2):343-348. PMID:7645031
  • Tithof PK, Contreras ML, Ganey PE. 1995. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Toxicol Appl Pharmacol 131:136-143. PMID:7878669
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