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Search Results for Most Frequently Published Journals (Superfund Research Program)
Superfund Research Program
Search Results
Toxicology and Applied Pharmacology (315 articles)
2024
Medina S, Zhang Q, Lauer FT, Santos-Medina LV, Factor-Litvak P, Islam T, Eunus M, Rahman M, Uddin M, Liu K, Parvez F. 2024. Arsenic exposure is associated with alterations to multiple red blood cell parameters among adults in rural Bangladesh. Toxicol Appl Pharmacol 484:doi:10.1016/j.taap.2024.116858 (out of scope)
Speer RM, Yu H, Zhou X, Nandi S, Alexandrov LB, Guo Y, Hudson LG, Liu K. 2024. Arsenic and UVR co-exposure results in unique gene expression profile identifying key co-carcinogenic mechanisms. Toxicol Appl Pharmacol 482:116773. doi:10.1016/j.taap.2023.116773PMID:38036231
2023
Dashner-Titus EJ, Schilz JR, Alvarez SA, Wong Cp, Simmons KA, Ho E, Hudson LG. 2023. Zinc supplementation alters tissue distribution of arsenic in Mus musculus. Toxicol Appl Pharmacol 478:116709. doi:10.1016/j.taap.2023.116709PMID:37797845
Liu S, He L, Bannister OB, Li J, Schnegelberger RD, Vanderpuye C, Althouse AD, Schopfer FJ, Wahlang B, Cave MC, Monga SP, Zhang X, Arteel GE, Beier JI. 2023. Western diet unmasks transient low-level vinyl chloride-induced tumorigenesis; potential role of the (epi-)transcriptome. Toxicol Appl Pharmacol 468:116514. doi:10.1016/j.taap.2023.116514PMID:37061008PMCID:PMC1016411
Maier ML, Siddens LK, Pennington JM, Uesugi S, Tilton SC, Vertel EA, Anderson KA, Tidwell LG, Ognibene T, Turteltaub KW, Smith JN, Williams DE. 2023. Benzo[a]pyrene toxicokinetics in humans following dietary supplementation with 3,3'-diindolylmethane (DIM) or brussels sprouts. Toxicol Appl Pharmacol 460:116377. doi:10.1016/j.taap.2023.116377PMID:36642108PMCID:PMC9946811
2022
Cooper KL, Volk L, Dominguez DR, Duran AD, Liu K, Hudson LG. 2022. Contribution of NADPH oxidase to the retention of UVR-induced DNA damage by arsenic. Toxicol Appl Pharmacol 434:115799. doi:10.1016/j.taap.2021.115799PMID:34798142
Huang J, El-Kersh K, Mann KK, James KA, Cai L. 2022. Overview of the cardiovascular effects of environmental metals: New preclinical and clinical insights. Toxicol Appl Pharmacol 454:116247. doi:10.1016/j.taap.2022.116247PMID:36122736
Marques E, Pfohl M, Wei W, Tarantola G, Ford L, Amaeze O, Alesio J, Ryu S, Jia X, Zhu H, Bothun GD, Slitt AL. 2022. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicol Appl Pharmacol 442:115991. doi:10.1016/j.taap.2022.115991PMID:35337807PMCID:PMC9036616
Medina S, Zhang H, Santos-Medina LV, Wan G, Bolt AM, Zhou X, Burchiel SW, Liu K. 2022. Arsenic impairs the lineage commitment of hematopoietic progenitor cells through the attenuation of GATA-2 DNA binding activity. Toxicol Appl Pharmacol 452:116193. doi:10.1016/j.taap.2022.116193PMID:35961411PMCID:PMC9583771
Pande P, Madeen E, Williams DE, Crowell SR, Ognibene T, Turteltaub KW, Corley RA, Smith JN. 2022. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling. Toxicol Appl Pharmacol 438:doi:10.1016/j.taap.2021.115830PMID:34933053PMCID:PMC9264404
Riggs DW, Malovichko MV, Gao H, McGraw KE, Taylor BS, Krivokhizhina T, Rai SN, Keith RJ, Bhatnagar A, Srivastava S. 2022. Environmental exposure to volatile organic compounds is associated with endothelial injury. Toxicol Appl Pharmacol 437:115877. doi:10.1016/j.taap.2022.115877PMID:35045333
Schilz JR, Dashner-Titus EJ, Simmons KA, Erdei E, Bolt AM, MacKenzie D, Hudson LG. 2022. The immunotoxicity of natural and depleted uranium: From cells to people. Toxicol Appl Pharmacol 454:116252. doi:10.1016/j.taap.2022.116252PMID:36152676
Shang B, Venkatratnam A, Hartwell HJ, Douillet C, Cable P, Liu T, Zou F, Ideraabdullah FY, Fry RC, Styblo M. 2022. Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells. Toxicol Appl Pharmacol 455:116266. doi:10.1016/j.taap.2022.116266PMID:36209798
Shi Z, Xia M, Xiao S, Zhang Q. 2022. Identification of nonmonotonic concentration-responses in Tox21 high-throughput screening estrogen receptor assays. Toxicol Appl Pharmacol 452:116206. doi:10.1016/j.taap.2022.116206PMID:35988584PMCID:PMC9452481
Volk L, Cooper KL, Jiang T, Paffett ML, Hudson LG. 2022. Impacts of arsenic on Rad18 and translesion synthesis. Toxicol Appl Pharmacol 454:116230. doi:10.1016/j.taap.2022.116230PMID:36087615
Wise JT, Salazar-Gonzalez R, Habil MR, Doll MA, Hein DW. 2022. Expression of arylamine N-acetyltransferase 2 activity in immortalized human bronchial epithelial cells. Toxicol Appl Pharmacol 442:115993. doi:10.1016/j.taap.2022.115993PMID:35353990
Wise JT, Salazar-Gonzalez R, Walls KM, Doll MA, Habil MR, Hein DW. 2022. Hexavalent chromium increases the metabolism and genotoxicity of aromatic amine carcinogens 4-aminobiphenyl and B-naphthylamine in immortalized human lung epithelial cells. Toxicol Appl Pharmacol 449:doi:10.1016/j.taap.2022.116095PMID:35662664
Chau BT, Witten M, Cromey DW, Chen Y, Lantz RC. 2021. Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate. Toxicol Appl Pharmacol 432:115754. doi:10.1016/j.taap.2021.115754PMID:34634286PMCID:PMC8572171
Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin DJ. 2021. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicol Appl Pharmacol 426:115647. doi:10.1016/j.taap.2021.115647PMID:34271065PMCID:PMC8343963
Klenov V, Flor S, Ganesan S, Adur M, Eti N, Iqbal K, Soares M, Ludewig G, Ross J, Robertson LW, Keating A. 2021. The aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats. Toxicol Appl Pharmacol 426:115639. doi:10.1016/j.taap.2021.115639PMID:34256052PMCID:PMC8500329
Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko I, Uchida S, Hill BG, Sutaria S, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. 2021. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol 431(9):115742. doi:10.1016/j.taap.2021.115742PMID:34624356PMCID:PMC8647905
Medina S, Zhou X, Lauer FT, Zhang H, Liu K, Lewis JL, Burchiel SW. 2021. Modulation of PARP activity by Monomethylarsonous (MMA +3) acid and uranium in mouse thymus. Toxicol Appl Pharmacol 411:115362. doi:10.1016/j.taap.2020.115362PMID:33279514PMCID:PMC7855914
Schlezinger JJ, Hyotylainen T, Sinjoja T, Moore Boston C, Puckett H, Oliver J, Heiger-Bernays WJ, Webster TF. 2021. Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPAR(alpha) mice fed an American diet. Toxicol Appl Pharmacol 426:115644. doi:10.1016/j.taap.2021.115644PMID:34252412PMCID:PMC8338894
Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2020. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicol Appl Pharmacol 400:115069. doi:10.1016/j.taap.2020.115069PMID:32445755PMCID:PMC7339121
Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B. 2020. Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol Appl Pharmacol 409:115301. doi:10.1016/j.taap.2020.115301PMID:33096110PMCID:PMC7725976
Doskey CM, Fader KA, Nault R, Lydic TA, Matthews J, Potter D, Sharratt B, Williams K, Zacharewski TR. 2020. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats. Toxicol Appl Pharmacol 398:14. doi:10.1016/j.taap.2020.115034PMID:32387183PMCID:PMC7294678
Marques E, Pfohl M, Auclair A, Jamwal R, Barlock BJ, Sammoura FM, Goedken M, Akhlaghi F, Slitt AL. 2020. Perfluorooctanesulfonic acid (PFOS) administration shifts the hepatic proteome and augments dietary outcomes related to hepatic steatosis in mice. Toxicol Appl Pharmacol 408:doi:10.1016/j.taap.2020.115250PMID:32979393
Medina S, Lauer FT, Castillo EF, Bolt AM, Ali AS, Liu K, Burchiel SW. 2020. Exposures to uranium and arsenic alter intraepithelial and innate immune cells in the small intestine of male and female mice. Toxicol Appl Pharmacol 403:doi:10.1016/j.taap.2020.115155PMID:32710956
Schlezinger JJ, Puckett H, Nielsen OG, Heiger-Bernays WJ, Webster TF. 2020. Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPAR alpha mice fed an American diet. Toxicol Appl Pharmacol 405:115204. doi:10.1016/j.taap.2020.115204PMID:32822737PMCID:PMC7503133
Schmidlin CJ, Zeng T, Liu P, Wei Y, Dodson M, Chapman E, Zhang DD. 2020. Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9. Toxicol Appl Pharmacol 402:12. doi:10.1016/j.taap.2020.115138PMID:32682831
2019
Bolt AM, Medina S, Lauer FT, Liu K, Burchiel SW. 2019. Minimal uranium immunotoxicity following a 60-day drinking water exposure to uranyl acetate in male and female C57BL/6J mice. Toxicol Appl Pharmacol 372:33-39. doi:10.1016/j.taap.2019.04.003PMID:30978399
Burchiel SW, Lauer FT, Factor-Litvak P, Liu X, Santella RM, Islam T, Eunus M, Alam N, Islam T, Rahman M, Ahmed A, Ahsan H, Graziano JH, Parvez F. 2019. An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh. Toxicol Appl Pharmacol 384:114783. doi:10.1016/j.taap.2019.114783PMID:31669812PMCID:PMC6886671
Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711PMID:31425687PMCID:PMC6745256
Chang Y, Siddens LK, Heine L, Sampson D, Yu Z, Fischer K, Lohr CV, Tilton SC. 2019. Comparative mechanisms of PAH toxicity by benzo a pyrene and dibenzo def,p chrysene in primary human bronchial epithelial cells cultured at air-liquid interface. Toxicol Appl Pharmacol 379:114644. doi:10.1016/j.taap.2019.114644PMID:31255691PMCID:PMC6708476
Christofidou-Solomidou M, Pietrofesa RA, Park K, Albelda SM, Serve KM, Kiel DE, Pfau JC. 2019. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice. Toxicol Appl Pharmacol 375:81-93. doi:10.1016/j.taap.2019.04.018PMID:31022494PMCID:PMC6582645
Fry RC, Bangma J, Szilagyi JT, Rager JE. 2019. Developing novel in vitro methods for the risk assessment of developmental and placental toxicants in the environment. Toxicol Appl Pharmacol 378:12. doi:10.1016/j.taap.2019.114635PMID:31233757PMCID:PMC6684208
Madeen E, Siddens LK, Uesugi S, McQuistan TJ, Corley RA, Smith JN, Waters KM, Tilton SC, Anderson KA, Ognibene T, Turteltaub KW, Williams DE. 2019. Toxicokinetics of benzo[a]pyrene in humans: Extensive metabolism as determined by UPLC-accelerator mass spectrometry following oral micro-dosing. Toxicol Appl Pharmacol 364:97-105. doi:10.1016/j.taap.2018.12.010PMID:30582946PMCID:PMC6369707
Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam S, Chari ST, Cave MC. 2019. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22-33. doi:10.1016/j.taap.2018.10.011PMID:30312631
Wang C, Petriello MC, Zhu B, Hennig B. 2019. PCB 126 induces monocyte/macrophage polarization and inflammation through AhR and NF-kB pathways. Toxicol Appl Pharmacol 367:71-81. doi:10.1016/j.taap.2019.02.006PMID:30768972PMCID:PMC6402591
Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749PMID:31521729PMCID:PMC6957308
2018
Adebambo OA, Shea D, Fry RC. 2018. Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-beta) pathways in placental JEG-3 trophoblast cells via reactive oxygen species. Toxicol Appl Pharmacol 342:108-115. doi:10.1016/j.taap.2018.01.010PMID:29408318
Balakrishnan P, Navas-Acien A, Haack KW, Vaidya D, Umans JG, Best LG, Goessler W, Francesconi KA, Franceschini N, North KE, Cole SA, Voruganti VS, Gribble MO. 2018. Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129. doi:10.1016/j.taap.2018.03.034PMID:29621497PMCID:PMC5961497
Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033PMID:29857080PMCID:PMC6051410
Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. 2018. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol 341:106-113. doi:10.1016/j.taap.2018.01.014PMID:29408041PMCID:PMC5929483
Elkin ER, Harris SM, Loch-Caruso R. 2018. Trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine induces lipid peroxidation-associated apoptosis via the intrinsic and extrinsic apoptosis pathways in a first-trimester placental cell line. Toxicol Appl Pharmacol 338:30-42. doi:10.1016/j.taap.2017.11.006PMID:29129777PMCID:PMC5741094
Fader KA, Nault R, Raehtz S, McCabe LR, Zacharewski TR. 2018. 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98. doi:10.1016/j.taap.2018.04.013PMID:29673856PMCID:PMC5984050
Geier MC, Minick DJ, Truong L, Tilton SC, Pande P, Anderson KA, Teeguardan J, Tanguay RL. 2018. Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125. doi:10.1016/j.taap.2018.03.029PMID:29630969PMCID:PMC6087484
Yellowhair M, Romanotto MR, Stearns DM, Lantz RC. 2018. Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38. doi:10.1016/j.taap.2018.04.022PMID:29698738PMCID:PMC5972677
Fader KA, Nault R, Kirby MP, Markous G, Matthews J, Zacharewski TR. 2017. Convergence of hepcidin defiency, systemic iron overloading, heme accumulation, and REV-ERBalpha/beta activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol 321:1-17. doi:10.1016/j.taap.2017.02.006PMID:28213091
Goodale BC, Rayack EJ, Stanton BA. 2017. Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol 331:154-163. doi:10.1016/j.taap.2017.06.010PMID:28625800PMCID:PMC5568502
Henriquez J, Zhou J, Li J, Crawford RB, Kaminski NE. 2017. Application of gene specific mRNA level determinations in individual cells using flow cytometry-based PrimeFlow (TM) in immunotoxicology. Toxicol Appl Pharmacol 337:39-44. doi:10.1016/j.taap.2017.10.021PMID:29107001PMCID:PMC5718209
Knecht AL, Truong L, Marvel S, Reif DM, Garcia A, Lu C, Simonich MT, Teeguarden J, Tanguay RL. 2017. Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish. Toxicol Appl Pharmacol 329:148-157. doi:10.1016/j.taap.2017.05.033PMID:28583304PMCID:PMC5539966
Kovalova N, Nault R, Crawford RB, Zacharewski TR, Kaminski NE. 2017. Comparative analysis of TCDD-induced AhR-mediated gene expression in human, mouse and rat primary B cells. Toxicol Appl Pharmacol 316:95-106. doi:10.1016/j.taap.2016.11.009PMID:27913140PMCID:PMC5292778
Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020PMID:28259702PMCID:PMC5734940
Bugel SM, Wehmas LC, La Du JK, Tanguay RL. 2016. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicol Appl Pharmacol 296:31-41. doi:10.1016/j.taap.2016.02.013PMID:26908177PMCID:PMC4792761
Haggard DE, Noyes PD, Waters KM, Tanguay RL. 2016. Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish. Toxicol Appl Pharmacol 308:32-45. doi:10.1016/j.taap.2016.08.013PMID:27538710PMCID:PMC5023494
Hwang HJ, Dornbos P, Steidemann M, Dunivin TK, Rizzo M, LaPres JJ. 2016. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol Appl Pharmacol 304:121-132. doi:10.1016/j.taap.2016.04.005PMID:27105554PMCID:PMC4930739
Kovalova N, Manzan MA, Crawford RB, Kaminski NE. 2016. Role of aryl hydrocarbon receptor polymorphisms on TCDD-mediated CYP1B1 induction and IgM suppression by human B cells. Toxicol Appl Pharmacol 309:15-23. doi:10.1016/j.taap.2016.08.011PMID:27535091PMCID:PMC5035641
Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001PMID:26853319PMCID:PMC4807407
Phadnis-Moghe AS, Li J, Crawford RB, Kaminski NE. 2016. SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Appl Pharmacol 310:41-50. doi:10.1016/j.taap.2016.08.014PMID:27546522PMCID:PMC5064869
Sollome JJ, Martin EM, Sethupathy P, Fry RC. 2016. Environmental contaminants and microRNA regulation: transcription factors as regulators of toxicant-altered microRNA expression. Toxicol Appl Pharmacol 312:61-66. doi:10.1016/j.taap.2016.06.009PMID:27292125PMCID:PMC5145741
Steinmaus CM, Ferreccio Readi C, Acevedo J, Balmes JR, Liaw J, Troncoso P, Dauphine DC, Nardone A, Smith AH. 2016. High risks of lung disease associated with early-life and moderate lifetime arsenic exposure in northern Chile. Toxicol Appl Pharmacol 313:10-15. doi:10.1016/j.taap.2016.10.006PMID:27725189PMCID:PMC5247272
2015
Adebambo OA, Ray PD, Shea D, Fry RC. 2015. Toxicological responses of environmental mixtures: Environmental metal mixtures display synergistic induction of metal-responsive and oxidative stress genes in placental cells. Toxicol Appl Pharmacol 289(3):534-541. doi:10.1016/j.taap.2015.10.005PMID:26472158PMCID:PMC4763604
Eum SY, Jaraki D, Andras IE, Toborek M. 2015. Lipid rafts regulate PCB153-induced disruption of occludin and brain endothelial barrier function through protein phosphatase 2A and matrix metalloproteinase-2. Toxicol Appl Pharmacol 287(3):258-266. doi:10.1016/j.taap.2015.06.011PMID:26080028PMCID:PMC4574485
Farzan S, Karagas MR. 2015. Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study. Toxicol Appl Pharmacol 287(2):93-97. doi:10.1016/j.taap.2015.05.013PMID:26048586PMCID:PMC4536141
Farzan S, Karagas MR, Jiang JY, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Eunus M, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich VN, Graziano JH, Ahsan H, Chen Y, Scannell Bryan M, Islam T. 2015. Gene-arsenic interaction in longitudinal changes of blood pressure: findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 288(1):95-105. doi:10.1016/j.taap.2015.07.017PMID:26220686PMCID:PMC4606937
Fujiwara R, Maruo Y, Chen S, Tukey RH. 2015. Role of extrahepatic UDP-glucuronosyltransferase 1A1: advances in understanding breast milk-induced neonatal hyperbilirubinemia. Toxicol Appl Pharmacol 289(1):124-132. doi:10.1016/j.taap.2015.08.018PMID:26342858PMCID:PMC4708261
Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. 2015. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicol Appl Pharmacol 289(3):419-427. doi:10.1016/j.taap.2015.10.018PMID:26522832PMCID:PMC4666679
Harris TR, Bettaieb A, Kodani SD, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. 2015. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 286(2):102-111. doi:10.1016/j.taap.2015.03.022PMID:25827057PMCID:PMC4458210
Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. 2015. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1):54-64. doi:10.1016/j.taap.2015.02.001PMID:25680588PMCID:PMC4387200
Liu D, Perkins JT, Petriello MC, Hennig B. 2015. Exposure to coplanar PCBs induces endothelial cell inflammation through epigenetic regulation of NF-κB subunit p65. Toxicol Appl Pharmacol 289(3):457-465. doi:10.1016/j.taap.2015.10.015PMID:26519613PMCID:PMC4662647
Munoz A, Chervona Y, Hall MN, Kluz T, Gamble MV, Costa M. 2015. Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water. Toxicol Appl Pharmacol 284(3):330-338. doi:10.1016/j.taap.2015.02.025PMID:25759245PMCID:PMC4410068
Olivas-Calderon E, Recio-Vega R, Gandolfi A, Lantz RC, Gonzalez-Cortes, Gonzalez-De Alba C, Froines JR, Espinosa-Fematt JA. 2015. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic. Toxicol Appl Pharmacol 287(2):161-167. doi:10.1016/j.taap.2015.06.001PMID:26048584PMCID:PMC4751871
Siddens LK, Bunde KL, Harper TA, McQuistan TJ, Lohr CV, Bramer LM, Waters KM, Tilton SC, Krueger SK, Williams DE, Baird WM. 2015. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Toxicol Appl Pharmacol 287(2):149-160. doi:10.1016/j.taap.2015.05.019PMID:26049101PMCID:PMC4689210
Wincent E, Stegeman JJ, Jonsson ME. 2015. Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol 284(2):163-179. doi:10.1016/j.taap.2015.02.014PMID:25711857PMCID:PMC4747639
2014
McClintock TR, Chen Y, Parvez F, Makarov DV, Ge W, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich VN, Bjurlin MA, Graziano JH, Ahsan H. 2014. Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol 276(1):21-27. doi:10.1016/j.taap.2014.01.015PMID:24486435PMCID:PMC3959280
Melak D, Ferreccio Readi C, Kalman DA, Parra RL, Acevedo J, Perez L, Cortes S, Smith AH, Yuan Y, Liaw J, Steinmaus CM. 2014. Arsenic methylation and lung and bladder cancer in a case-control study in Northern Chile. Toxicol Appl Pharmacol 274(2):225-231. doi:10.1016/j.taap.2013.11.014PMID:24296302PMCID:PMC4344188
Park H, Kamau PW, Loch-Caruso R. 2014. Involvement of reactive oxygen species in brominated diphenyl ether-47-induced inflammatory cytokine release from human extravillous trophoblasts in vitro. Toxicol Appl Pharmacol 274(2):283-292. doi:10.1016/j.taap.2013.11.015PMID:24296301PMCID:PMC3931445
Park H, Loch-Caruso R. 2014. Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. Toxicol Appl Pharmacol 281(1):67-77. doi:10.1016/j.taap.2014.09.015PMID:25305463PMCID:PMC4393751
Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. 2014. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274(3):408-416. doi:10.1016/j.taap.2013.12.002PMID:24355420PMCID:PMC3919493
Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Paul-Brutus R, Islam T, Paul RR, Sarwar G, Ahmed A, Jiang JY, Slavkovich VN, Rundek T, Demmer RT, Desvarieux M, Ahsan H, Chen Y. 2014. Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol 276(3):195-203. doi:10.1016/j.taap.2014.02.014PMID:24593923PMCID:PMC4080412
Goodale BC, Tilton SC, Corvi MM, Wilson GR, Janszen DB, Anderson KA, Waters KM, Tanguay RL. 2013. Structurally distinct polycyclic aromatic hydrocarbons induce differential transcriptional responses in developing zebrafish. Toxicol Appl Pharmacol 272(3):656-670. doi:10.1016/j.taap.2013.04.024PMID:23656968PMCID:PMC4098828
Knecht AL, Goodale BC, Truong L, Simonich MT, Swanson AJ, Matzke MM, Anderson KA, Waters KM, Tanguay RL. 2013. Comparative developmental toxicity of environmentally relevant oxygenated PAHs. Toxicol Appl Pharmacol 271(2):266-275. doi:10.1016/j.taap.2013.05.006PMID:23684558PMCID:PMC3976560
Kubota A, Bainy AC, Woodin BR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicol Appl Pharmacol 272(1):172–179. doi:10.1016/j.taap.2013.05.017PMID:23726801PMCID:PMC3846545
Larkin A, Siddens LK, Krueger SK, Tilton SC, Waters KM, Williams DE, Baird WM. 2013. Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Toxicol Appl Pharmacol 267(2):192-199. doi:10.1016/j.taap.2012.12.011PMID:23274566PMCID:PMC3626406
Nault R, Kim S, Zacharewski TR. 2013. Comparison of TCDD-elicited genome-wide hepatic gene expression in Sprague-Dawley rats and C57BL/6 mice. Toxicol Appl Pharmacol 267(2):184-191. doi:10.1016/j.taap.2012.11.028PMID:23238561PMCID:PMC4104405
Tetz LM, Cheng AA, Korte C, Giese RW, Wang P, Harris C, Meeker JD, Loch-Caruso R. 2013. Mono-2-ethylhexyl phthalate induces oxidative stress responses in human placental cells in vitro. Toxicol Appl Pharmacol 268(1):47-54. doi:10.1016/j.taap.2013.01.020PMID:23360888PMCID:PMC3657603
Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. 2013. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol 266(2):224-232. doi:10.1016/j.taap.2012.11.019PMID:23200774PMCID:PMC3534780
Wang L, Gallagher EP. 2013. Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. Toxicol Appl Pharmacol 266(2):177-186. doi:10.1016/j.taap.2012.11.010PMID:23174481
Wong VC, Morse JL, Zhitkovich A. 2013. P53 activation by Ni(II) is a HIF-1alpha independent response causing caspases 9/3-mediated apoptosis in human lung cells. Toxicol Appl Pharmacol 269(3):233-239. doi:10.1016/j.taap.2013.03.023PMID:23566959PMCID:PMC3666101
Zhang Q, Kline DE, Bhattacharya S, Crawford RB, Conolly RB, Thomas RS, Andersen ME, Kaminski NE. 2013. All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 268(1):17-26. doi:10.1016/j.taap.2013.01.015PMID:23357550PMCID:PMC3594464
Gomez-Rubio P, Klimentidis YC, Cantu-Soto E, Meza-Montenegro MM, Billheimer D, Lu Z, Chen Z, Klimecki WT. 2012. Indigenous American ancestry is associated with arsenic methylation efficiency in an admixed population of northwest Mexico. Toxicol Appl Pharmacol 75(1):36-49. doi:10.1080/15287394.2011.615107PMID:22047162PMCID:PMC3572940
Han S, Han SS, Toborek M, Hennig B. 2012. EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes. Toxicol Appl Pharmacol 261(2):181-188. doi:10.1016/j.taap.2012.03.024PMID:22521609PMCID:PMC3358429
Jonsson ME, Kubota A, Timme-Laragy AR, Woodin BR, Stegeman JJ. 2012. Ahr2-dependence of PCB126 effects on the swim bladder in relation to expression of CYPI and cox-2 genes in developing zebrafish. Toxicol Appl Pharmacol 265:166-174. doi:10.1016/j.taap.2012.09.023PMID:23036320PMCID:PMC3529150
Munoz A, Costa M. 2012. Elucidating the mechanisms of nickel compound uptake: A review of particulate and nano-nickel endocytosis and toxicity. Toxicol Appl Pharmacol 260(1):1-16. doi:10.1016/j.taap.2011.12.014PMID:22206756PMCID:PMC3306469
Senthilkumar PK, Robertson LW, Ludewig G. 2012. PCB153 reduces telomerase activity and telomere length in immortalized human skin keratinocytes (HaCaT) but not in human foreskin keratinocytes (NFK). Toxicol Appl Pharmacol 259(1):115-123. doi:10.1016/j.taap.2011.12.015PMID:22210444PMCID:PMC3288560
Siddens LK, Larkin A, Krueger SK, Bradfield CA, Waters KM, Tilton SC, Pereira CB, Lohr CV, Arlt VM, Phillips DH, Williams DE, Baird WM. 2012. Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol 264(3):377-386. doi:10.1016/j.taap.2012.08.014PMID:22935520PMCID:PMC3483092
Wu F, Sun H, Kluz T, Clancy HA, Kiok K, Costa M. 2012. Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol 258:166-175. doi:10.1016/j.taap.2011.10.018PMID:22079256PMCID:PMC3259276 (Completed with ARRA Funds)
Zhang J, Ouyang W, Li J, Zhang D, Yu Y, Wang Y, Li X, Huang C. 2012. Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability. Toxicol Appl Pharmacol 263:218-224. doi:10.1016/j.taap.2012.06.012PMID:22749963PMCID:PMC3758130
Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. 2012. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol 265(3):292-299. doi:10.1016/j.taap.2012.08.028PMID:22975029PMCID:PMC3725323
2011
Arsenescu V, Arsenescu RI, Parulkar M, Karounos M, Zhang X, Baker NA, Cassis LA. 2011. Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice. Toxicol Appl Pharmacol 257(1):148-154. doi:10.1016/j.taap.2011.08.028PMID:21925196PMCID:PMC3220787
Barhoumi R, Mouneimne Y, Hammock BD, Safe SH, Burghardt RC, Parrish AR, Ramos E. 2011. Multiphoton spectral analysis of benzo a pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56. doi:10.1016/j.taap.2011.03.009PMID:21420996PMCID:PMC3081912
Crowell SR, Amin S, Anderson KA, Krishnegowda G, Sharma AK, Soelberg JJ, Williams DE, Corley RA. 2011. Preliminary physiologically based pharmacokinetic models for benzo a pyrene and dibenzo def,p chrysene in rodents. Toxicol Appl Pharmacol 257:365-376. doi:10.1016/j.taap.2011.09.020PMID:22001385PMCID:PMC3226888
De Abrew KN, Phadnis AS, Crawford RB, Kaminski NE, Thomas RS. 2011. Regulation of Bach2 by the aryl hydrocarbon receptor as a mechanism for suppression of B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 252(2):150-158. doi:10.1016/j.taap.2011.01.020PMID:21296099PMCID:PMC3106294
Gomez-Rubio P, Roberge J, Arendell L, Harris RB, O'Rourke MK, Chen Z, Cantu-Soto E, Meza-Montenegro MM, Billheimer D, Lu Z, Klimecki WT. 2011. Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico. Toxicol Appl Pharmacol 252:176-182. doi:10.1016/j.taap.2011.02.007PMID:21320519PMCID:PMC3075343
Jonsson ME, Berg C, Goldstone JV, Stegeman JJ. 2011. New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183. doi:10.1016/j.taap.2010.10.010PMID:20965207PMCID:PMC3014448
Kopec AK, D'Souza ML, Mets BD, Burgoon LD, Reese SE, Archer KJ, Potter D, Tashiro C, Sharratt B, Harkema JR, Zacharewski TR. 2011. Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2 ',4,4 ',5,5 '-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice. Toxicol Appl Pharmacol 256:154-167. doi:10.1016/j.taap.2011.08.002PMID:21851831PMCID:PMC4126514
Liu J, Qiu H, Moisseau C, Hwang SH, Tsai H, Ulu A, Chiamvimonvat N, Hammock BD. 2011. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol 255:200-206. doi:10.1016/j.taap.2011.06.017PMID:21741984PMCID:PMC3156297
Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O. 2011. Exposure to tri-o-cresyl phosphate detected in jet airplant passengers. Toxicol Appl Pharmacol 256:337-347. doi:10.1016/j.taap.2011.06.016PMID:21723309PMCID:PMC3205265
Lo R, Celius T, Dere E, MacPherson L, Harper PA, Zacharewski TR, Matthews J. 2011. Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 257:38-47. doi:10.1016/j.taap.2011.08.016PMID:21889950
Lu H, Crawford RB, Kaplan BL, Kaminski NE. 2011. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated disruption of the CD40 ligand-induced activation of primary human B cells. Toxicol Appl Pharmacol 255:251-260. doi:10.1016/j.taap.2011.06.026PMID:21807014PMCID:PMC3189629
Majkova Z, Layne J, Sunkara M, Morris AJ, Toborek M, Hennig B. 2011. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Toxicol Appl Pharmacol 251(1):41-49. doi:10.1016/j.taap.2010.11.013PMID:21130106PMCID:PMC3026064
Wnek SM, Kuhlman CL, Camarillo JM, Medeiros MK, Liu KJ, Lau SS, Gandolfi A. 2011. Interdependent genotoxic mechanisms of monomethylarsonous acid: Role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells. Toxicol Appl Pharmacol 257:1-13. doi:10.1016/j.taap.2011.08.029PMID:21925530PMCID:PMC3220758
Dreiem A, Rykken S, Lehmler H, Robertson LW, Fonnum F. 2010. Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells. Toxicol Appl Pharmacol 240:306-313. doi:10.1016/j.taap.2009.07.016PMID:19631230PMCID:PMC2753730
Escudero-Lourdes C, Medeiros MK, Cardenas-Gonzalez MC, Wnek SM, Gandolfi A. 2010. Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model. Toxicol Appl Pharmacol 244(2):162-173. doi:10.1016/j.taap.2009.12.029PMID:20045430PMCID:PMC2846965
Forgacs AL, Burgoon LD, Lynn SG, LaPres JJ, Zacharewski TR. 2010. Effects of TCDD on the expression of nuclear encoded mitochondrial genes. Toxicol Appl Pharmacol 246(1-2):58-65. doi:10.1016/j.taap.2010.04.006PMID:20399798PMCID:PMC4030424
Han S, Eum SY, Toborek M, Smart EJ, Hennig B. 2010. Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice. Toxicol Appl Pharmacol 246(1-2):74-82. doi:10.1016/j.taap.2010.04.009PMID:20406653PMCID:PMC2895770
Kopec AK, Burgoon LD, Ibrahim-Aibo D, Mets BD, Tashiro C, Potter D, Sharratt B, Harkema JR, Zacharewski TR. 2010. PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. Toxicol Appl Pharmacol 243(3):359-371. doi:10.1016/j.taap.2009.12.003PMID:20005886PMCID:PMC3987113
Sinitsyna NN, Reznikova TV, Qin Q, Song H, Phillips MA, Rice RH. 2010. Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes. Toxicol Appl Pharmacol 243(3):275-282. doi:10.1016/j.taap.2009.12.006PMID:20006635PMCID:PMC2830317
Steinmaus CM, Yuan Y, Kalman DA, Rey OA, Skibola CF, Dauphine DC, Basu A, Porter KE, Hubbard AE, Bates MN, Smith MT, Smith AH. 2010. Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicol Appl Pharmacol 247(2):138-145. doi:10.1016/j.taap.2010.06.006PMID:20600216PMCID:PMC3849353
Chen Y, Parvez F, Gamble MV, Islam T, Ahmed A, Argos M, Graziano JH, Ahsan H. 2009. Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 239(2):184-192. doi:10.1016/j.taap.2009.01.010PMID:19371619PMCID:PMC3904798
Eum SY, Andras IE, Hennig B, Toborek M. 2009. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicol Appl Pharmacol 240(2):299-305. doi:10.1016/j.taap.2009.07.022PMID:19632255PMCID:PMC2760772
Inan SY, Berman RF, Kim K, Pessah IN. 2009. Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicol Appl Pharmacol 237(2):168-177. doi:10.1016/j.taap.2009.03.002PMID:19289137PMCID:PMC2693412
Jansen KL, Cole TB, Park SS, Furlong CE, Costa LG. 2009. Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds. Toxicol Appl Pharmacol 236(2):142-153. doi:10.1016/j.taap.2009.02.001PMID:19371602PMCID:PMC2717945
Jensen TJ, Wozniak RJ, Eblin KE, Gandolfi A, Futscher BW, Wnek SM. 2009. Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation. Toxicol Appl Pharmacol 235(1):39-46. doi:10.1016/j.taap.2008.10.013PMID:19061910PMCID:PMC4438681
Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame AL, Smith MT, Vulpe CD, Zhang L. 2009. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Toxicol Appl Pharmacol 241(3):294-302. doi:10.1016/j.taap.2009.08.027PMID:19732783PMCID:PMC2784148
Kim S, Kim D, Pollack GM, Collins LB, Rusyn I. 2009. Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicol Appl Pharmacol 238(1):90-99. doi:10.1016/j.taap.2009.04.019PMID:19409406PMCID:PMC2737827
Komissarova EV, Rossman TG. 2009. Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. Toxicol Appl Pharmacol 243(3):399-404. doi:10.1016/j.taap.2009.12.014PMID:20036271PMCID:PMC2830301 (Completed with ARRA Funds)
Lantz RC, Witten M, Chau BT, Sarihan P, Pivniouk V, Chen GJ. 2009. In utero and postnatal exposure to arsenic alters pulmonary structure and function. Toxicol Appl Pharmacol 235(1):105-113. doi:10.1016/j.taap.2008.11.012PMID:19095001PMCID:PMC2669654
Lavado R, Rimoldi JM, Schlenk D. 2009. Mechanisms of fenthion activation in rainbow trout (Oncorhynchus mykiss) acclimated to hypersaline environments. Toxicol Appl Pharmacol 235(2):143-152. doi:10.1016/j.taap.2008.11.017PMID:19111563PMCID:PMC2858921
Li Q, Suen T, Sun H, Arita A, Costa M. 2009. Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Toxicol Appl Pharmacol 235(2):191-198. doi:10.1016/j.taap.2008.12.005PMID:19135467PMCID:PMC2657554 (Completed with ARRA Funds)
Majkova Z, Smart EJ, Hennig B. 2009. Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. Toxicol Appl Pharmacol 237(1):1-7. doi:10.1016/j.taap.2009.02.016PMID:19265715PMCID:PMC2680936
Mitchell LE, Finnell RH, Hill DS, Wlodarczyk BJ. 2009. Arsenate-induced maternal glucose intolerance and neural tube defects in a mouse model. Toxicol Appl Pharmacol 239(1):29-36. doi:10.1016/j.taap.2009.05.009PMID:19446573PMCID:PMC3998373
Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I. 2009. Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. Toxicol Appl Pharmacol 235(2):199-207. doi:10.1016/j.taap.2008.12.011PMID:19136022PMCID:PMC2654411
Sun H, Zhou X, Chen H, Li Q, Costa M. 2009. Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium. Toxicol Appl Pharmacol 237(3):258-266. doi:10.1016/j.taap.2009.04.008PMID:19376149PMCID:PMC2701251 (Completed with ARRA Funds)
Wnek SM, Medeiros MK, Eblin KE, Gandolfi A. 2009. Persistence of DNA damage following exposure of human bladder cells to chronic monomethylarsonous acid. Toxicol Appl Pharmacol 241(2):202-209. doi:10.1016/j.taap.2009.08.016PMID:19699219PMCID:PMC2783778
Zhang Q, Pi J, Woods CG, Andersen ME. 2009. Phase I to II cross-induction of xenobiotic metabolizing enzymes: a feedforward control mechanism for potential hormetic responses. Toxicol Appl Pharmacol 237(3):345-356. doi:10.1016/j.taap.2009.04.005PMID:19371757PMCID:PMC2696203
Zhou X, Li Q, Arita A, Sun H, Costa M. 2009. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol Appl Pharmacol 236(1):78-84. doi:10.1016/j.taap.2009.01.009PMID:19371620PMCID:PMC2684878 (Completed with ARRA Funds)
2008
Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013PMID:18644402PMCID:PMC2583134
Komissarova EV, Li P, Uddin AN, Chen X, Nadas A, Rossman TG. 2008. Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol 226(2):199-205. PMID:17976673
Oesterling EG, Toborek M, Hennig B. 2008. Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway. Toxicol Appl Pharmacol 232(2):309-316. doi:10.1016/j.taap.2008.07.001PMID:18671994PMCID:PMC2633733
Pysher MD, Chen QM, Vaillancourt RR. 2008. Arsenic alters vascular smooth muscle cell focal adhesion complexes leading to activation of FAK-src mediated pathways. Toxicol Appl Pharmacol 231(2):135-141. doi:10.1016/j.taap.2008.04.002PMID:18486177PMCID:PMC3900024
Slotkin TA, Seidler FJ. 2008. Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. Toxicol Appl Pharmacol 233(2):211-219. doi:10.1016/j.taap.2008.08.020PMID:18835401PMCID:PMC2645545
Zhang S, Safe SH. 2008. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicol Appl Pharmacol 227(2):196-206. PMID:18048071
2007
Bezdecny SA, Karmaus P, Roth RA, Ganey PE. 2007. 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. Toxicol Appl Pharmacol 221(3):285-294. doi:10.1016/j.taap.2007.03.019PMID:17482227PMCID:PMC1950673
Chen J, Ahn K, Gee SJ, Gee NA, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284. doi:10.1016/j.taap.2007.03.015PMID:17481686PMCID:PMC1978490
Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. 2007. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol 219(2-3):181-189. PMID:17084875
Jonsson ME, Orrego R, Woodin BR, Goldstone JV, Stegeman JJ. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol 221(1):29-41. PMID:17445853
Khan S, Liu S, Stoner M, Safe SH. 2007. Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells. Toxicol Appl Pharmacol 223(1):28-38. PMID:17599377
Klein C, Leszczynska J, Hickey C, Rossman TG. 2007. Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol 222(3):289-97. PMID:17316729
Meza MM, Gandolfi A, Klimecki WT. 2007. Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?. Toxicol Appl Pharmacol 222(3):381-387. doi:10.1016/j.taap.2006.12.018PMID:17306849PMCID:PMC2040165
Patterson TP, Rice RH. 2007. Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential. Toxicol Appl Pharmacol 221(1):119-28. PMID:17400267
Pysher MD, Sollome JJ, Regan SP, Cardinal TR, Hoying JB, Brooks HL, Vaillancourt RR. 2007. Increased hexokinase II expression in the renal glomerulus of mice in response to arsenic. Toxicol Appl Pharmacol 224(1):39-48. PMID:17643460
Qian Y, Venkatraj J, Barhoumi R, Pal R, Datta A, Wild JR, Tiffany-Castiglioni E. 2007. Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. Toxicol Appl Pharmacol 219(2-3):162-171. PMID:17223147
Straub AC, Stolz DB, Vin H, Ross MA, Soucy NV, Klei LR, Barchowsky A. 2007. Low level arsenic promotes progressive inflammatory angiogenesis and liver blood vessel remodeling in mice. Toxicol Appl Pharmacol 222(3):327-36. PMID:17123562
Uddin AN, Burns FJ, Rossman TG, Chen H, Kluz T, Costa M. 2007. Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice. Toxicol Appl Pharmacol 221(3):329-38. PMID:17499830
Wang X, Sun Z, Chen W, Eblin KE, Gandolfi A, Zhang DD. 2007. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol 225(2):206-13. PMID:17765279
White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian Y, Basha M. 2007. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol 225(1):1-27. doi:10.1016/j.taap.2007.08.001PMID:17904601
2006
Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi A. 2006. Monomethylarsonous acid induces transformation of human bladder cells. Toxicol Appl Pharmacol 216(1):69-79. PMID:16806342
Chowdhury UK, Zakharyan RA, Hernandez A, Avram MD, Kopplin MJ, Aposhian HV. 2006. Glutathione-S-transferase-omega [MMA(V) reductase] knockout mice: enzyme and arsenic species concentrations in tissues after arsenate administration. Toxicol Appl Pharmacol 216(3):446-457. doi:10.1016/j.taap.2006.06.014PMID:16930657
Eblin KE, Bowen ME, Cromey DW, Bredfeldt TG, Mash EA, Lau SS, Gandolfi A. 2006. Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture. Toxicol Appl Pharmacol 217(1):7-14. PMID:16930658
Li Q, Chen H, Huang X, Costa M. 2006. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes. Toxicol Appl Pharmacol 213(3):245-255. doi:10.1016/j.taap.2005.11.006PMID:16386771PMCID:PMC2965073
Shipley JM, Waxman DJ. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicol Appl Pharmacol 213(2):87-97. PMID:16257430
Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, Tanguay RL, Svoboda K, Handley-Goldstone HM, Stegeman JJ, Hiraga T. 2006. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol 212(1):24-34. PMID:16051294
Wlodarczyk BJ, Tang LS, Triplett A, Aleman F, Finnell RH. 2006. Spontaneous neural tube defects in Splotch mice supplemented with selected micronutrients. Toxicol Appl Pharmacol 213(1):55-63. PMID:16226775
2005
Aldridge JE, Meyer A, Seidler FJ, Slotkin TA. 2005. Developmental exposure to terbutaline and chlorpyrifos: pharmacotherapy of preterm labor and an environmental neurotoxicant converge on serotonergic systems in neonatal rat brain regions. Toxicol Appl Pharmacol 203(2):132-144. PMID:15710174
Chen H, Davidson T, Singleton S, Garrick MD, Costa M. 2005. Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells. Toxicol Appl Pharmacol 206(3):275-287. PMID:16039939
Holland NT, Pfleger L, Berger E, Ho A, Bastaki M. 2005. Molecular epidemiology biomarkers - sample collection, processing, and banking considerations. Toxicol Appl Pharmacol 206(2):261-268. PMID:15967217
Komissarova EV, Saha SK, Rossman TG. 2005. Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol Appl Pharmacol 202(1):99-107. PMID:15589980
Meyer A, Seidler FJ, Aldridge JE, Slotkin TA. 2005. Developmental exposure to terbutaline alters cell signaling in mature rat brain regions and augments the effects of subsequent neonatal exposure to the organophosphorus insecticide chlorpyrifos. Toxicol Appl Pharmacol 203(2):154-166. PMID:15710176
Patterson TP, Reznikova TV, Phillips MA, Rice RH. 2005. Arsenite maintains germinative state in cultured human epidermal cells. Toxicol Appl Pharmacol 207(1):69-77. PMID:16054901
Qiao D, Seidler FJ, Slotkin TA. 2005. Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifos. Toxicol Appl Pharmacol 206(1):17-26. PMID:15963341
Shabbir A, DiStasio S, Zhao J, Cardozo CP, Wolff MS, Caplan A. 2005. Differential effects of the organochlorine pesticide DDT and its metabolite p,p2-DDE on p-glycoprotein activity and expression. Toxicol Appl Pharmacol 203(2):91-98. PMID:15710169
Smith MT, McHale CM, Wiemels JL, Zhang L, Wiencke JK, Zheng S, Gunn L, Skibola CF, Ma X, Buffler PA. 2005. Molecular biomarkers for the study of childhood leukemia. Toxicol Appl Pharmacol 206(2):237-245. PMID:15967214
Spiegelstein O, Gould A, Wlodarczyk BJ, Tsie M, Lu X, Le X, Troen A, Selhub J, Piedrahita JA, Salbaum JM, Kappen C, Melnyk SB, James S, Finnell RH. 2005. Developmental consequences of in utero sodium arsenate exposure in mice with folate transport deficiencies. Toxicol Appl Pharmacol 203(1):18-26. PMID:15694460
Woods JS, Echeverria D, Heyer NJ, Simmonds PL, Wilkerson J, Farin FM. 2005. The association between genetic polymorphisms of coproporphyrinogen oxidase and an atypical porphyrinogenic response to mercury exposure in humans. Toxicol Appl Pharmacol 206(2):113-120. PMID:15967199
2004
Bredfeldt TG, Kopplin MJ, Gandolfi A. 2004. Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Toxicol Appl Pharmacol 198(3):412-418. PMID:15276421
Davidson T, Kluz T, Burns FJ, Rossman TG, Zhang Q, Uddin AN, Nadas A, Costa M. 2004. Exposure to chromium(VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice. Toxicol Appl Pharmacol 196(3):431-437. PMID:15094314
Finnell RH, Shaw GM, Lammer EJ, Brandl KL, Carmichael SL, Rosenquist TH. 2004. Gene-nutrient interactions: importance of folates and retinoids during early embryogenesis. Toxicol Appl Pharmacol 198(2):75-85. PMID:15236946
Guo J, Sartor MA, Karyala S, Medvedovic M, Kann S, Puga A, Ryan P, Tomlinson CR. 2004. Expression of genes in the TGF-beta signaling pathway is significantly deregulated in smooth muscle cells from aorta of aryl hydrocarbon receptor knockout mice. Toxicol Appl Pharmacol 194(1):79-89. PMID:14728982
Moggs JG, Goodman JI, Trosko JE, Roberts RA. 2004. Epigenetics and cancer: implications for drug discovery and safety assessment. Toxicol Appl Pharmacol 196(3):422-430. PMID:15094313
Rhodes MC, Seidler FJ, Qiao D, Tate CA, Cousins MM, Slotkin TA. 2004. Does pharmacotherapy for preterm labor sensitize the developing brain to environmental neurotoxicants? Cellular and synaptic effects of sequential exposure to terbutaline and chlorpyrifos in neonatal rats. Toxicol Appl Pharmacol 195(2):203-217. doi:10.1016/j.taap.2003.11.008PMID:14998686
Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198(3):394-404. PMID:15276419
Shipley JM, Waxman DJ. 2004. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicol Appl Pharmacol 199(3):275-284. PMID:15364543
Slotkin TA. 2004. Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicol Appl Pharmacol 198(2):132-151. PMID:15236950
Zhao J, Chen H, Davidson T, Kluz T, Zhang Q, Costa M. 2004. Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway. Toxicol Appl Pharmacol 196(3):404-409. PMID:15094311
Zhao J, Yan Y, Salnikow K, Kluz T, Costa M. 2004. Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol 194(1):60-68. PMID:14728980
Carter DE, Aposhian HV, Gandolfi A. 2003. The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review. Toxicol Appl Pharmacol 193(3):309-334. PMID:14678742
Costa M. 2003. Potential hazards of hexavalent Cr in our drinking water. Toxicol Appl Pharmacol 188(1):1-5. PMID:12668116
Espandiari P, Glauert HP, Lehmler H, Lee EY, Srinivasan C, Robertson LW. 2003. Polychlorinated biphenyls (PCBs) as initiators in liver carcinogensis: resistant hepatocyte model. Toxicol Appl Pharmacol 186(1):55-62. PMID:12583993
Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol 186(2):110-118. PMID:12639502
Kirkpatrick DS, Dale KV, Catania JM, Gandolfi A. 2003. Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK 293 cells. Toxicol Appl Pharmacol 186(2):101-109. PMID:12639501
Lee YW, Park HJ, Son KW, Hennig B, Robertson LW, Toborek M. 2003. 2,2',4,6,6'-Pentachlorobiphenyl (PCB104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB. Toxicol Appl Pharmacol 189(1):1-10. PMID:12758055
O'Hara KA, Klei LR, Barchowsky A. 2003. Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol 190(3):214-223. PMID:12902192
Suh J, Kang J, Yang K, Kaminski NE. 2003. Antagonism of aryl hydrocarbon receptor-dependent induction of CYP1A1 and inhibition of IgM expression by di-ortho-substituted polychlorinated biphenyls. Toxicol Appl Pharmacol 187(1):11-21. PMID:12628580
Tampal N, Robertson LW, Srinivasan C, Ludewig G. 2003. Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1. Toxicol Appl Pharmacol 187(3):168-177. PMID:12662900
Williams KJ, Cruikshank MK, Plopper CG. 2003. Pulmonary heat shock protein expression after exposure to a metabolically activated Clara cell toxicant: relationship to protein adduct formation. Toxicol Appl Pharmacol 192(2):107-118. PMID:14550745
Yan Y, Kluz T, Zhang P, Chen H, Costa M. 2003. Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure. Toxicol Appl Pharmacol 190(3):272-277. PMID:12902198
Zhang Q, Salnikow K, Kluz T, Chen L, Su W, Costa M. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol 192(3):201-211. PMID:14575637
2002
Hennig B, Meerarani P, Slim RM, Toborek M, Daugherty A, Silverstone AE, Robertson LW. 2002. Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence. Toxicol Appl Pharmacol 181(3):174-183. PMID:12079426
Kim M, Spencer PS, Sabri MI. 2002. Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy. Toxicol Appl Pharmacol 183(1):55-65. PMID:12217642
Suh J, Jeon YJ, Kim HM, Kang J, Kaminski NE, Yang K. 2002. Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated B cell dysfunction. Toxicol Appl Pharmacol 181(2):116-123.
Tharappel JC, Lee EY, Robertson LW, Spear BT, Glauert HP. 2002. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by Polychlorinated Biphenyls. Toxicol Appl Pharmacol 179(3):172-184. PMID:11906247
Zhou Y, Davey HW, McLachlan MJ, Xie T, Waxman DJ. 2002. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicol Appl Pharmacol 182(1):1-10. PMID:12127257
2001
Dieguez-Acuna FJ, Ellis ME, Kushleika JV, Woods JS. 2001. Mercuric ion attenuates NF-kB activation and DNA binding in normal rat kidney epithelial cells: implications for mercury-induced nephrotoxicity. Toxicol Appl Pharmacol 173:176-187. PMID:11437639
Jessen BA, Qin Q, Phillips MA, Phillips DL, Rice RH. 2001. Keratinocyte differentiation marker suppression by arsenic: mediation by AP1 response elements and antagonism by tetradecanoylphorbol acetate. Toxicol Appl Pharmacol 174(3):302-311. PMID:11485391
Kim M, Sabri MI, Miller VH, Kayton RJ, Dixon DA, Spencer PS. 2001. 1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy. Toxicol Appl Pharmacol 177(2):121-131. PMID:11740911
Rossman TG, Uddin AN, Burns FJ, Bosland MC. 2001. Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis. Toxicol Appl Pharmacol 176(1):64-71. PMID:11578149
Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
Twaroski TP, O'Brien ML, Larmonier N, Glauert HP, Robertson LW. 2001. Polychlorinated biphenyl-induced effects on metabolic enzymes, AP-1 binding, vitamin E and oxidative stress in the rat liver. Toxicol Appl Pharmacol 171(2):85-93. PMID:11222084
West JA, Pakehham G, Morin D, Fleschner CA, Plopper CG, Buckpitt AR. 2001. Inhaled naphthalene causes dose dependent Clara cell toxicity in mice but not in rats. Toxicol Appl Pharmacol 173(2):114-119. PMID:11384213
Willett KL, Lienesch L, Reichert W, Di Giulio RT. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicol Appl Pharmacol 177(3):264-271. PMID:11749126
Wlodarczyk BJ, Spiegelstein O, Gelineau-van Waes J, Vorce RL, Lu X, Le C, Finnell RH. 2001. Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol 177(3):238-246. PMID:11749123
2000
Andrew AS, Barchowsky A. 2000. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Toxicol Appl Pharmacol 168(1):50-57. PMID:11000099
Aposhian HV, Zheng B, Aposhian MM, Le X, Cebrian ME, Cullen WR, Zakharyan RA, Ma M, Dart RC, Cheng Z, Andrewes P, Yip L, O'Malley GF, Maiorino RM, Van Voorhies W, Healy SM, Titcomb A. 2000. DMPS-arsenic challenge test: II. Modulation of arsenic species, including monomethylarsonous acid (MMAIII ), excreted in human urine. Toxicol Appl Pharmacol 165(1):74-83. PMID:10814555
Claudio L, Kwa WC, Russell AL, Wallinga D. 2000. Testing methods for developmental neurotoxicity of environmental chemicals. Toxicol Appl Pharmacol 164:1-14. PMID:10739739
Fanucchi MV, Buckpitt AR, Murphy M, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol Appl Pharmacol 168(3):253-267. PMID:11042098
Jacobs JM, Nichols C, Marek D, Gorman N, Walton HS, Sinclair PR, Sinclair JF. 2000. Effect of arsenite on induction of CYP1A4 and CYP1A5 in cultured chick embryo hepatocytes. Toxicol Appl Pharmacol 168(3):177-182. PMID:11042089
Olivero-Verbal J, Ganey PE. 2000. Role of protein phosphorylation in activation of phospholipase A2 by the polychlorinated biphenyl mixture Aroclor 1242. Toxicol Appl Pharmacol 163:9-16. PMID:10662600
Petrick JS, Ayala-Fierro F, Cullen WR, Carter DE, Aposhian HV. 2000. Monomethylarsonous acid (MMAIII) is more toxic than arsenite in chang human hepatocytes. Toxicol Appl Pharmacol 163(2):203-207. PMID:10698679
Slim RM, Toborek M, Robertson LW, Lehmler H, Hennig B. 2000. Cellular glutathione status modulates Polychlorinated Biphenyl-induced stress response and apoptosis in vascular endothelial cells. Toxicol Appl Pharmacol 166(1):36-42. PMID:10873716
Thomas RS, Conolly RB, Gustafson DL, Long ME, Benjamin SA, Yang RH. 2000. A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator. Toxicol Appl Pharmacol 166(2):128-137. PMID:10896854
1999
Bae J, Stuenkel E, Loch-Caruso R. 1999. Stimulation of oscillatory uterine contraction by the PCB mixture Aroclor 1242 may involve increased [Ca2+]i through voltage-operated calcium channels. Toxicol Appl Pharmacol 155(3):261-272. PMID:10079212
Barchowsky A, Roussel RR, Klei LR, James PE, Ganju N, Smith KR, Dudek EJ. 1999. Low levels of arsenic trioxide stimulate proliferative signals in primary vascular cells without activating stress effector pathways. Toxicol Appl Pharmacol 159(1):65-75. PMID:10448126
Fischer L, Wagner MA, Madhukar BV. 1999. Potential involvement of calcium, CaM kinase II and MAP kinases in PCB-stimulated insulin release from RINm5F cells. Toxicol Appl Pharmacol 159:194-203. PMID:10486306
Grabowski GM, Paulauskis JD, Godleski J. 1999. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol Appl Pharmacol 156:170-178. PMID:10222309
Jacobs JM, Nichols C, Andrew AS, Marek D, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, Sinclair JF. 1999. Effect of arsenite on induction of CYP1A, CYP2B and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 157(1):51-59. PMID:10329507
Maloney EK, Waxman DJ. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 161(2):209-218. PMID:10581215
Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced pre-B cell apoptosis. Toxicol Appl Pharmacol 161:10-22.
Mann KK, Matulka RA, Lawrence BP, Kerkvliet NI, Sherr DH. 1999. The role of cytochrome P-450 enzymes in 7,12-dimethylbenz[a]anthracene-induced apoptosis. Toxicol Appl Pharmacol 161:10. PMID:10558919
Ou YC, Thompson SA, Ponce RA, Schroeder JI, Kavanagh TJ, Faustman EM. 1999. Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo. Toxicol Appl Pharmacol 157:203-212. PMID:10373404
Raha A, Hamilton JW, Bresnick E. 1999. The existence of the 4S polycyclic aromatic hydrocarbon-protein binding in 14-day-old chick embryo liver. Toxicol Appl Pharmacol 158:1-8. PMID:10387926
Shumilla JA, Barchowsky A. 1999. Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. Toxicol Appl Pharmacol 158(3):288-295. PMID:10438662
Thurmond TS, Silverstone AW, Baggs RB, Quimby FW, Staples JE, Gasiewcz TA. 1999. A chimeric Ah receptor knockout mouse model indicates that hematopoietic cells contribute to the hepatic lesions induced by 2,3, 7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 158:33-40. PMID:10387930
Turney KD, Parrish AR, Orozco J, Gandolfi A. 1999. Selective activation in the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices. Toxicol Appl Pharmacol 160(3):262-270. PMID:10544060
Woods JS, Ellis ME, Dieguez-Acuna FJ, Corral J. 1999. Activation of NF-kB in normal rat kidney epithelial (NRK52E) cells is mediated via a redox-insensitive, calcium-dependent pathway. Toxicol Appl Pharmacol 154:219-227. PMID:9931281
Woods JS, Kavanagh TJ, Corral J, Reese AW, Diaz D, Ellis ME. 1999. The role of glutathione in chronic adaptation to oxidative stress: studies in a normal rat kidney epithelial (NRK52E) cell model of sustained upregulation of glutathione biosynthesis. Toxicol Appl Pharmacol 160(3):207-216. PMID:10544055
Zakharyan RA, Aposhian HV. 1999. Arsenite methylation by methylvitamin B12 and glutathione does not require an enzyme. Toxicol Appl Pharmacol 154(30):287-291. PMID:9931288
Zakharyan RA, Ayala-Fierro F, Cullen WR, Carter DE, Aposhian HV. 1999. Enzymatic methylation of arsenic compounds: VII. Monomethylarsonous acid (MMAIII) is the substrate for MMA methyltransferase of rabbit liver and human hepatocytes. Toxicol Appl Pharmacol 158(1):9-15. PMID:10387927
1998
Bentivegna CS, Ihnat MA, Baptiste NS, Hamilton JW. 1998. Developmental regulation of the 3 methylcholanthrene- and dioxin-inducible CYP1A5 gene in chick embryo liver in vivo. Toxicol Appl Pharmacol 151(1):166-173. PMID:9705900
Denison MS, Phelan D, Winters GM, Ziccardi MH. 1998. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol Appl Pharmacol 152(2):406-414. PMID:9853009
Healy SM, Casarez EA, Ayala-Fierro F, Aposhian HV. 1998. Enzymatic methylation of arsenic compounds: V. Arsenite methyltransferase activity in tissues of mice. Toxicol Appl Pharmacol 148(1):65-70. PMID:9465265
Hutchinson RW, Barhoumi R, Miles J, Burghardt RC. 1998. Attenuation of gossypol cytotoxicity by cyclic AMP in a rat liver cell line. Toxicol Appl Pharmacol 151:311-318. PMID:9707507
Jacobs JM, Roussel RR, Roberts M, Marek D, Wood SG, Walton HS, Dwyer B, Sinclair PR, Sinclair JF. 1998. Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes. Toxicol Appl Pharmacol 150(2):376-382. PMID:9653069
Kodavanti PR, Ward TR, Derr-Yellin EC, Mundy WR, Casey AC, Bush B, Tilson HA. 1998. Congener-specific distribution of polychlorinated biphenyls in brain regions, blood, liver, and fat of adult rats following repeated exposure to Aroclor 1254. Toxicol Appl Pharmacol 153:199-210. PMID:9878591
Parrish AR, Fisher RL, Bral CM, Burghardt RC, Gandolfi A, Brendel K, Ramos KS. 1998. Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut adult rat liver slices. Toxicol Appl Pharmacol 152:302-308. PMID:9852999
Thomas RS, Gustafson DL, Ramsdell HS, El-Masri HA, Benjamin SA, Yang RH. 1998. Enhanced regional expression of glutathioneS-transferase P1-1 with colocalized AP-1 and CYP 1A2 induction in chlorobenzene-induced porphyria. Toxicol Appl Pharmacol 150(1):22-31. PMID:9630449
Thompson DC, Barhoumi R, Burghardt RC. 1998. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol 149:55-63. PMID:9512727
Wildfang E, Zakharyan RA, Aposhian HV. 1998. Enzymatic methylation of arsenic compounds: VI. Characterization of hamster liver arsenite and monomethylarsonic acid methyltransferase activities in vitro. Toxicol Appl Pharmacol 152(2):366-375. PMID:9853005
1997
Barchowsky A, Lannon BM, Elmore LC, Treadwell MD. 1997. Increased focal adhesion kinase- and urokinase-type plasminogen activator receptor-associated cell signaling in endothelial cells exposed to asbestos. Toxicol Appl Pharmacol 105(Suppl.5):1131-1137. PMID:9400712
Connor K, Ramamoorthy K, Moore M, Mustain M, Chen I, Safe SH, Zacharewski TR, Gillesby B, Joyeux A, Belaguer P. 1997. Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: structure-activity relationships. Toxicol Appl Pharmacol 145:111-123. PMID:9221830
Guiney PD, Smolowitz RM, Peterson RE, Stegeman JJ. 1997. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P450 1A in vascular endothelium with toxicity in early life stages of lake trout. Toxicol Appl Pharmacol 143(2):256-273. PMID:9144443
Jeon YJ, Han SH, Yang K, Kaminski NE. 1997. Induction of transforming growth factor β1 transcription by carbon tetrachloride leads to the inhibition of T helper 2 cell associated lymphokines. Toxicol Appl Pharmacol 144:27-35.
Kramer VJ, Helferich WG, Bergman A, Klasson-Wehler E, Giesy JP. 1997. Hydroxylated polychlorinated biphenyl metabolites are anti-estrogenic in a stably transfected human breast adenocarcinoma (MCF7) cell line. Toxicol Appl Pharmacol 144(2):363-376. doi:10.1006/taap.1997.8163PMID:9194421
Lin P, Waidyanatha S, Pollack GM, Rappaport SM. 1997. Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts. Toxicol Appl Pharmacol 145(2):399-408. PMID:9266814
Moore M, Mustain M, Daniel KD, Chen I, Safe SH, Zacharewski TR, Gillesby B, Joyeux A, Belaguer P. 1997. Antiestrogenic activity of hydroxylated polychlorinated biphenyl congeners identified in human serum. Toxicol Appl Pharmacol 142:160-168. PMID:9007045
Ou YC, Thompson SA, Kirchner SC, Kavanagh TJ, Faustman EM. 1997. Induction of growth arrest and DNA damage-inducible genes Gadd45 and Gadd153 in primary rodent embryonic cells following exposure to methylmercury. Toxicol Appl Pharmacol 147:31-38. PMID:9356304
Paige R, Wong VJ, Plopper CG. 1997. Dose-related airway-selective epithelial toxicity of 1-nitronaphthalene in rats. Toxicol Appl Pharmacol 147(2):224-233. PMID:9439718
Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe SH, McDonnell DP, Leonard LS, Gaido KW. 1997. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicol Appl Pharmacol 147:93-100. PMID:9356311
Seegal R, Brosch KO, Okoniewski RJ. 1997. Effects of in utero and lactational exposure of the laboratory rat to 2,4,2',4'- and 3,4,3',4'-tetrachlorobiphenyl on dopamine function. Toxicol Appl Pharmacol 146:95-103. PMID:9299601
Sieg DJ, Billings RE. 1997. Lead/cytokine-mediated DNA damage in cultured mousehepatocytes. Toxicol Appl Pharmacol 142:106-115. PMID:9007039
Sinclair PR, Walton HS, Gorman N, Jacobs JM, Sinclair JF. 1997. Multiple roles of polyhalogenated biphenyls in causing increases in cytochrome P450 and uroporphyrin accumulation in cultured hepatocytes. Toxicol Appl Pharmacol 147(2):171-179. PMID:9439713
Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao X, Tilly JL, Near RI, Sherr DH. 1997. Induction of preB cell apoptosis by 7,12 dimethylbenz[a]anthracene in long term primary bone marrow cultures. Toxicol Appl Pharmacol 147(2):190-203. PMID:9439715
1996
Anderson MJ, Olsen H, Matsumura F, Hinton DE. 1996. In vivo modulation of 17²-estradiol-induced vitellogenin synthesis and estrogen receptor in rainbow trout (Oncorhynchus mykiss) liver cells by ²-naphthoflavone. Toxicol Appl Pharmacol 137(2):210-218. doi:10.1006/taap.1996.0074PMID:8661346
El-Masri HA, Constan AA, Ramsdell HS, Yang RH. 1996. Physiologically based pharmacodynamic modeling of an interaction threshold between trichloroethylene and 1,1-dichloroethylene in Fischer 344 rats. Toxicol Appl Pharmacol 141(1):124-132. PMID:8917684
Gebremichael A, Tullis K, Denison MS, Cheek JM, Pinkerton KE. 1996. Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. Toxicol Appl Pharmacol 141(1):76-83. PMID:8917678
Jaeschke H, Smith CW, Clemens MG, Ganey PE, Roth RA. 1996. Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils. Toxicol Appl Pharmacol 139:213-226. PMID:8806837
La DK, Schoonhoven R, Ito N, Swenberg JA. 1996. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. Toxicol Appl Pharmacol 140(1):108-114. PMID:8806876
Li S, Thompson SA, Kavanagh TJ, Woods JS. 1996. Localization by in situ hybridizatioin of glutamylcysteine synthetase mRNA expression in rat kidney following acute methylmercury treatment. Toxicol Appl Pharmacol 141:59-67. PMID:8917676
Li S, Thompson SA, Woods JS. 1996. Localization of glutamylcysteine synthetase mRNA expression in mouse brain following methylmercury treatment using reverse transcription in situ PCR amplification. Toxicol Appl Pharmacol 140:180-187. PMID:8806884
Pierce CH, Dills RL, Morgan MS, Nothstein GL, Shen D, Kalman DA. 1996. Interindividual differences in 2H8-toluene toxicokinetics assessed by a semi-empirical physiologically-based model. Toxicol Appl Pharmacol 139(1):49-61.
Sanderson J, Aarts JM, Brouwer A, Froese KL, Denison MS, Giesy JP. 1996. Comparison of Ah receptor-mediated luciferase and ethoxyresorufin-O-deethylase induction in H4IIE cells: implications for their use as bioanalytical tools for the detection of polyhalogenated aromatic hydrocarbons. Toxicol Appl Pharmacol 137(2):316-325. PMID:8661358
van Birgelen AP, DeVito MJ, Akins JM, Ross DG, Diliberto JJ, Birnbaum LS. 1996. Relative potencies of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls derived from hepatic porphyrin accumulation in mice. Toxicol Appl Pharmacol 138(1):98-109. PMID:8658519
Yamaguchi K, Near RI, Shneider AM, Cui H, Ju S, Sherr DH. 1996. Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicol Appl Pharmacol 139(1):144-152. PMID:8685897
Zakharyan RA, Wildfang E, Aposhian HV. 1996. Enzymatic methylation of arsenic compounds: III. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. Toxicol Appl Pharmacol 140(1):77-84. PMID:8806872
1995
Brown AP, Ganey PE. 1995. Neutrophil degranulation and superoxide production induced by polychlorinated biphenyl are calcium dependent. Toxicol Appl Pharmacol 131(2):198-205. PMID:7716762
Buetler TM, Gallagher EP, Wang C, Stahl DL, Hayes JD, Eaton DL. 1995. Induction of phase I and phase II drug metabolizing enzyme mRNA, protein and activity by BHA, ethoxyquin and oltipraz. Toxicol Appl Pharmacol 135(1):45-57. PMID:7482539
Criswell KA, Loch-Caruso R. 1995. Lindane-induced elimination of gap junctional communication in rat uterine myocytes is mediated by an arachidonic acid-sensitive cAMP-independent mechanism. Toxicol Appl Pharmacol 135(1):127-138. PMID:7482532
Criswell KA, Loch-Caruso R, Stuenkel E. 1995. Lindane inhibition of gap junctional communication in myometrial myocytes is partially dependent on phosphoinositide-generated second messenger. Toxicol Appl Pharmacol 130:280-293. PMID:7532876
Dickerson R, Howie-Keller L, Safe SH. 1995. Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: Structure-Activity Studies. Toxicol Appl Pharmacol 135:287-298. PMID:8545839
Gallagher EP, Buetler TM, Wang C, Stapleton PL, Stahl DL, Eaton DL. 1995. The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol Appl Pharmacol 134(1):81-91. PMID:7676460
Gallagher EP, Eaton DL. 1995. In vitro biotransformation of aflatoxin B1 in channel catfish liver. Toxicol Appl Pharmacol 132:82-90. PMID:7747288
Jonsson BA, Wishnok JS, Skipper PL, Stillwell WG, Tannenbaum SR. 1995. Lysine adducts between methyltetrahydropthalic anhydride and collagen in guinea-pig lung. Toxicol Appl Pharmacol 135(1):156-162. PMID:7482535
Ramasamy S, Wang E, Hennig B, Merrill AH. 1995. Fumonisin B1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol Appl Pharmacol 133(2):343-348. PMID:7645031
Tithof PK, Contreras ML, Ganey PE. 1995. Aroclor 1242 stimulates the production of inositol phosphates in polymorphonuclear neutrophils. Toxicol Appl Pharmacol 131:136-143. PMID:7878669
