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Superfund Research Program

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Cancer Research (60 articles)



  • Kohale I, Burgenske DM, Mladek AC, Bakken KK, Kuang J, Boughey J, Wang L, Carter JM, Haura EB, Goetz MP, Sarkaria JN, White FM. 2021. Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient-specific signaling networks. Cancer Res doi:10.1158/0008-5472.CAN-21-0214 PMID:34016623
  • Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM. 2021. High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors. Cancer Res 81:2495-2509. doi:10.1158/0008-5472.CAN-20-3804 PMID:33509940 PMCID:PMC8137532


  • Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Antal CE, Downes M, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee J, Ye Z, Yan H, Hernandez MC, Leiting JL, Evans RM, Ordog T, Truty MJ, Borad MJ, Reya T, Von Hoff DD, Fernandez-Zapico ME, Barrett MT. 2020. Genomic and epigenomic landscaping defines new therapeutic targets for adenosquamous carcinoma of the pancreas. Cancer Res 80:4324-4334. doi:10.1158/0008-5472.CAN-20-0078 PMID:32928922


  • Grigoryan H, Schiffman C, Gunter MJ, Naccarati A, Polidoro S, Dagnino S, Dudoit S, Vineis P, Rappaport SM. 2019. Cys34 adductomics links colorectal cancer with the gut microbiota and redox biology. Cancer Res 79(23):6024-6031. doi:10.1158/0008-5472.CAN-19-1529 PMID:31641032 PMCID:PMC6891211
  • Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song C, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih P, Sing K, Lee S, Minter LM, Kim D, Xiao H, Liu J, Hammock BD, Zeldin DC, Zhang G. 2019. Targeted Metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis. Cancer Res 79:1822-1830. doi:10.1158/0008-5472.CAN-18-3221 PMID:30803995 PMCID:PMC6467714


  • Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. 2016. Bap1 is a bona fide tumor suppressor: genetic evidence from mouse models carrying heterozygous germline Bap1 mutations. Cancer Res 76(9):2836-2844. doi:10.1158/0008-5472.CAN-15-3371 PMID:26896281 PMCID:PMC4873414
  • Lai Y, Yu R, Hartwell HJ, Moeller BC, Bodnar WM, Swenberg JA. 2016. Measurement of endogenous versus exogenous formaldehyde-induced DNA-protein crosslinks in animal tissues by stable isotope labeling and ultrasensitive mass spectrometry. Cancer Res 76(9):2652-2661. doi:10.1158/0008-5472.CAN-15-2527 PMID:26984759 PMCID:PMC4879886
  • Ohar J, Cheung M, Talarchek J, Howard S, Howard T, Hesdorffer M, Peng H, Rauscher FJ, Testa JR. 2016. Germline BAP1 mutational landscape of asbestos-exposed malignant mesothelioma patients with family history of cancer. Cancer Res 76(2):206-215. doi:10.1158/0008-5472.CAN-15-0295 PMID:26719535 PMCID:PMC4715907




  • Fei DL, Li H, Kozul-Horvath CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ. 2010. Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res 70(5):1981-1988. doi:10.1158/0008-5472.CAN-09-2898 PMID:20179202 PMCID:PMC2831120
  • Zhang D, Li J, Costa M, Gao J, Huang C. 2010. JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70. Cancer Res 70(2):813-823. doi:10.1158/0008-5472.CAN-09-0448 PMID:20068160 PMCID:PMC2939838 (Completed with ARRA Funds)


  • Ivanov VN, Zhou HZ, Partridge MA, Hei TK. 2009. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res 69(8):3510-3519. doi:10.1158/0008-5472.CAN-08-3883 PMID:19351839 PMCID:PMC4070218
  • Stern MC, Lin J, Figueroa JD, Kelsey KT, Kiltie AE, Yuan J, Matullo G, Fletcher T, Benhamou S, Taylor JA, Placidi D, Zhang Z, Steineck G, Rothman N, Kogevinas M, Silverman DT, Malats N, Chanock SJ, Wu X, Karagas MR, Andrew AS, Nelson HH, Bishop DT, Sak S, Choudhury A, Barrett JH, Elliot F, Corral R, Joshi AD, Gago-Dominguez M, Cortessis VK, Gao Y, Xiang Y, Vineis P, Sacerdote C, Guarrera S, Polidoro S, Allione A, Gurzau ES, Koppova K, Kumar R, Rudnai P, Porru S, Carta A, Campagna M, Arici C, Park S, Garcia-Closas M. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Cancer Res 69(17):6857-6864. doi:10.1158/0008-5472.CAN-09-1091 PMID:19706757 PMCID:PMC2782435


  • Wiemels JL, Hofmann J, Kang M, Selzer R, Green R, Zhou M, Zhong S, Zhang L, Smith MT, Marsit CJ, Loh ML, Buffler PA, Yeh R. 2008. Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally. Cancer Res 68(23):9935-9944. doi:10.1158/0008-5472.CAN-08-2139 PMID:19047175 PMCID:PMC2597307


  • Partridge MA, Huang SX, Hernandez-Rosa E, Davidson MM, Hei TK. 2007. Arsenic induced mitochondrial DNA damage and alteredmitochondrial oxidative function: implication for genotoxic mechanismsin mammalian cells. Cancer Res 67(11):5239-5247.
  • Pietruska JR, Kane AB. 2007. SV40 oncoproteins enhance asbestos-induced dna double-strand breaks and abrogate senescence in murine mesothelial cells. Cancer Res 67:3637-45. PMID:17440075
  • Ridpath JR, Nakamura J, Tano K, Luke AM, Sonoda E, Arakawa H, Buerstedde J, Gillespie DA, Sale JE, Yamazoe M, Bishop DK, Takata M, Takeda S, Watanabe M, Swenberg JA. 2007. Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. Cancer Res 67(23):11117-11122. doi:10.1158/0008-5472.CAN-07-3028 PMID:18056434
  • Vladimir I, Zhou HZ, Hei TK. 2007. Gamma-irradiation or alpha-particle exposure sensitize human melanoma cells to TRAIL-mediated apoptosis through upregulation of TRAIL R2/DR5 expression and translocation to the cell surface. Cancer Res 67:5397-5407.
  • Vladimir I, Zhou HZ, Hei TK. 2007. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Res 67(11):5397-5407. PMID:17545621


  • Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt RC, Liu S, Hill DS, Finnell RH, Wlodarczyk BJ, Jordan VC, Safe SH. 2006. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Res 66(4):2459-2467. doi:10.1158/0008-5472.CAN-05-3132 PMID:16489053
  • Marsit CJ, Eddy K, Kelsey KT. 2006. MicroRNA responses to cellular stress. Cancer Res 66(22):10843-10848. PMID:17108120
  • Marsit CJ, Houseman EA, Eddy K, Bueno R, Sugarbaker DJ, Nelson HH, Karagas MR, Kelsey KT, Christensen BC. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res 66(21):10621-9. PMID:17079487
  • Pachkowski BF, Winkel S, Kubota Y, Swenberg JA, Millikan RC, Nakamura J. 2006. XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. Cancer Res 66(5):2860-2868. doi:10.1158/0008-5472.CAN-05-3388 PMID:16510609


  • Canter JA, Kallianpur AR, Parl FF, Millikan RC. 2005. Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Cancer Res 65(17):8028-8033. doi:10.1158/0008-5472.CAN-05-3774 PMID:16140977
  • Lan Q, Zhang L, Shen M, Smith MT, Li G, Vermeulen R, Rappaport SM, Forrest MS, Hayes RB, Linet MS, Dosemeci M, Alter BP, Weinberg RS, Yin S, Yeager M, Welch R, Waidyanatha S, Kim S, Chanock SJ, Rothman N. 2005. Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. Cancer Res 65(20):9574-9581. doi:10.1158/0008-5472.CAN-05-1419 PMID:16230423
  • Liu S, Davidson MM, Tang X, Walker WF, Athar M, Ivanov VN, Hei TK. 2005. Mitochondrial damage mediates genotoxicity of arsenic in mammalian cells. Cancer Res 65(8):3236-3242. PMID:15833855
  • Marsit CJ, Karagas MR, Andrew AS, Liu M, Danaee H, Schned AR, Nelson HH, Kelsey KT. 2005. Epigenetic inactivation of SFRP genes and TP53 alteration act jointly as markers of invasive bladder cancer. Cancer Res 65(16):7081-7085. PMID:16103055


  • Li J, Davidson G, Huang Y, Jiang B, Shi X, Costa M, Huang C. 2004. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res 64(1):94-101. PMID:14729612
  • Rusyn I, Asakura S, Pachkowski BF, Bradford BU, Denissenko MF, Peters JM, Holland SM, Reddy JK, Cunningham ML, Swenberg JA. 2004. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: Identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Res 64(3):1050-1057. PMID:14871837
  • Wiemels JL, Wiencke JK, Patoka J, Moghadassi M, Chew T, McMillan A, Miike R, Barger G, Wrensch MR. 2004. Reduced immunoglobulin E and allergy among adults with glioma compared with controls. Cancer Res 64(22):8468-8473. PMID:15548720
  • Yoon J, Besaratinia A, Feng Z, Tang M, Amin S, Luch A, Pfeifer GP. 2004. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res 64(20):7321-7328. doi:10.1158/0008-5472.CAN-04-1094 PMID:15492252
  • Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. 2004. Hypermethylation of the 5 ' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia. Cancer Res 64(6):2000-2006. PMID:15026336


  • Chen F, Castranova V, Li Z, Karin M, Shi X. 2003. Inhibitor of nuclear factor kappa B kinase deficiency enhances oxidative stress and prolongs c-jun NH2-terminal kinase activation induced by arsenic. Cancer Res 63(22):7689-7693. PMID:14633691
  • Martin EA, Brown K, Gaskell M, Al-Azzawi F, Garner RC, Boocock DJ, Mattock E, Pring DW, Dingley KH, Turteltaub KW, Smith LL, White IN. 2003. Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry. Cancer Res 63(23):8461-8465. PMID:14679010
  • Qin C, Burghardt RC, Smith RL, Wormke M, Stewart J, Safe SH. 2003. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Res 63(5):958-964. PMID:12615709
  • Salnikow K, Davidson T, Zhang Q, Chen L, Su W, Costa M. 2003. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res 63(13):3524-3530. PMID:12839937


  • Li X, Eckard J, Shah R, Malluck C, Frenkel K. 2002. Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses. Cancer Res 62(2):417-423. PMID:11809690
  • Morinello EJ, Ham AL, Ranasinghe A, Nakamura J, Upton PB, Swenberg JA. 2002. Molecular dosimetry and repair of N2,3-ethenoguanine in rats exposed to vinyl chloride. Cancer Res 62:5189-5195. PMID:12234983
  • Morinello EJ, Koc H, Ranasinghe A, Swenberg JA. 2002. Differential induction of N2,3-ethenoguanine in rat brain and liver after exposure to vinyl chloride. Cancer Res 62:5183-5188.
  • Rappaport SM, Waidyanatha S, Qu Q, Shore R, Jin X, Cohen B, Chen L, Melikian AA, Li G, Yin S, Yan H, Xu B, Mu R, Li Y, Zhang X, Li K. 2002. Albumin adducts of benzene oxide and 1,4-benzoquinone as measures of human benzene metabolism. Cancer Res 62(5):1330-1337. PMID:11888901


  • Chen P, Aldape K, Wiencke JK, Kelsey KT, Miike R, Davis RL, Liu J, Kesler-Diaz A, Takahashi M, Wrensch MR. 2001. Ethnicity delineates different genetic pathways in malignant glioma. Cancer Res 61:3949-3954. PMID:11358811
  • Hirao T, Nelson HH, Devi-Ashok T, Wain JC, Mark EJ, Christiani DC, Wiencke JK, Kelsey KT. 2001. Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer. Cancer Res 61(2):612-615. PMID:11212258
  • Huang C, Li J, Costa M, Zhang Z, Leonard SS, Castranova V, Vallyathan V, Ju G, Shi X. 2001. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res 61:8051-8057. PMID:11719426
  • Ou YC, Conolly RB, Thomas RS, Xu Y, Andersen ME, Chubb LS, Pitot HC, Yang RH. 2001. A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res 61(5):1879-1889. PMID:11280742


  • Nakamura J, Swenberg JA. 1999. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Res 59(11):2522-2526. PMID:10363965
  • Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT. 1999. K-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. Cancer Res 59:4570-4573. PMID:10493509


  • Cistulli CA, Kaufmann WK. 1998. P53-dependent signaling sustains DNA replication and enhances clonogenic survival in 254 nm ultraviolet-irradiated human fibroblasts. Cancer Res 58:1993-2002. PMID:9581844
  • Coller HA, Khrapko K, Torres A, Frampton MW, Utell MJ, Thilly WG. 1998. Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. Cancer Res 58(6):1268-1277. PMID:9515815
  • Marcelino LA, Andre PC, Khrapko K, Coller HA, Griffith J, Thilly WG. 1998. Chemically induced mutations in mitochondrial DNA of human cells: Mutational spectrum of N-Methyl-N'-nitro-N-nitrosoguanidine. Cancer Res 58:2857-2862. PMID:9661902
  • Nakamura J, Walker V, Upton PB, Chiang S, Kow YW, Swenberg JA. 1998. Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions. Cancer Res 58(2):222-225. PMID:9443396
  • Nelson HH, Wiencke JK, Gunn L, Wain JC, Christiani DC, Kelsey KT. 1998. Chromosome 3p14 alterations in lung cancer: evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res 58(9):1804-1807. PMID:9581816
  • Smith MT, Zhang L, Wang Y, Hayes RB, Li G, Wiemels JL, Dosemeci M, Holland NT, Xi L, Kolachana P, Yin S, Rothman N. 1998. Increased translocations and aneusomy in chromosomes 8 and 21 among workers exposed to benzene. Cancer Res 58(10):2176-2181. PMID:9605763
  • Warren AJ, Maccubbin AE, Hamilton JW. 1998. Detection of mitomycin C-DNA adducts in vivo by 32P-postlabeling: Time course for formation and removal of adducts and biochemical modulation. Cancer Res 58:453-461. PMID:9458089


  • Barbin A, Froment O, Boivin S, Marion M, Belpoggi F, Maltoni C, Montesano R. 1997. P53 Gene mutation pattern in rat liver tumors induced by vinyl chloride. Cancer Res 57(9):1695-1698. PMID:9135010
  • Rothman N, Smith MT, Hayes RB, Traver RD, Hoener B, Campleman S, Li G, Dosemeci M, Linet MS, Zhang L, Xi L, Wacholder S, Lu W, Meyer KB, Titenko-Holland N, Stewart JT, Yin S, Ross D. 1997. Benzene poisoning, a risk factor for hematologic malignancy, is associated with the NQ01 609C->T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res 57(14):2839-2842. PMID:9230185


  • Malins DC, Polissar NL, Garner MM, Gunselman SJ. 1996. Mutagenic DNA base modifications are correlated with lesions in nonneoplastic hepatic tissue of the English sole carcinogenesis model. Cancer Res 56(24):5563-5565. PMID:8971153


  • Wiencke JK, Kelsey KT, Varkonyi A, Semey K, Wain JC, Mark EJ, Christiani DC. 1995. Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung. Cancer Res 55(21):4910-4914. PMID:7585529
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