Superfund Research Program

Cell (impact factor: 41.582)

2020

• Gou L, Lim D, Ma W, Aubol BE, Hao Y, Wang X, Zhao J, Liang Z, Shao C, Zhang X, Meng F, Li H, Zhang X, Xu R, Li D, Rosenfeld MG, Mellon PL, Adams JA, Liu M, Fu X. 2020. Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1 catalyzed protamine phosphorylation. Cell 180:doi:10.1016/j.cell.2020.02.020 PMID:32169215
• Lowey B, Whiteley AT, Keszei AF, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee AS, Kranzusch PJ. 2020. CBASS immunity uses CARF-related effectors to sense 3'-5'- and 2'-5'-linked cyclic oligonucleotide signals and protect bacteria from phage infection. Cell 182:38. doi:10.1016/j.cell.2020.05.019 PMID:32544385 PMCID:PMC7728545

2019

• Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Zhang T, Leblanc M, Liu S, He M, Waizenegger W, Gasser E, Schnabl B, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. 2019. FXR regulates intestinal cancer stem cell proliferation. Cell 176:1098-1112. doi:10.1016/j.cell.2019.01.036 PMID:30794774 PMCID:PMC6701863
• Xia J, Chiu L, Nehring R, Bravo Nunez M, Mei Q, Perez M, Zhai Y, Fitzgerald D, Pribis J, Wang Y, Hu C, Powell R, LaBonte S, Jalali A, Matadamas Guzman M, Lentzsch A, Szafran AT, Joshi M, Richters M, Gibson J, Frisch R, Hastings P, Bates D, Queitsch C, Hilsenbeck SG, Coarfa C, Hu JC, Siegele DA, Scott KL, Liang H, Mancini MA, Herman C, Miller KM, Rosenberg SM. 2019. Bacteria-to-human protein networks reveal origins of endogenous DNA damage. Cell 176(1-2):127-143. doi:10.1016/j.cell.2018.12.008 PMID:30633903 PMCID:PMC6344048

2018

• Dangl J, Osbourn A, Orzaez D, Li Z, Long SP, Schroeder JI. 2018. What Is the Next Frontier in Plant Engineering?. Cell 174(3):499-500. doi:10.1016/j.cell.2018.07.012 PMID:30053421
• Kim J, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. 2018. ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P. Cell 175(1):133-145. doi:10.1016/j.cell.2018.08.020 PMID:30220454 PMCID:PMC6159928
• Wei Z, Yoshihara E, He N, Hah N, Fan W, Pinto AF, Huddy T, Wang Y, Ross B, Estepa G, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. 2018. Vitamin D Switches BAF Complexes to Protect Beta Cells. Cell 173:1135-1149. doi:10.1016/j.cell.2018.04.013 PMID:29754817 PMCID:PMC5987229

2016

• Moscat J, Karin M, Diaz-Meco MT. 2016. p62 in cancer: signaling adaptor beyond autophagy. Cell 167(3):606-609. doi:10.1016/j.cell.2016.09.030 PMID:27768885 PMCID:PMC5114003
• Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins GA, Ali S, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. 2016. NF-κB restricts inflammasome activation via elimination of damaged mitochondria. Cell 164(5):896-910. doi:10.1016/j.cell.2015.12.057 PMID:26919428 PMCID:PMC4769378

2015

• Font-Burgada J, Shalapour S, Ramasamy S, Hsueh B, Rossell D, Umemura A, Taniguchi K, Nakagawa H, Valasek MA, Ye L, Kopp JL, Sander M, Carter H, Deisseroth K, Verma IM, Karin M. 2015. Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer. Cell 162(4):766-779. doi:10.1016/j.cell.2015.07.026 PMID:26276631 PMCID:PMC4545590
• Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM. 2015. Reduced expression of MYC increases longevity and enhances healthspan. Cell 160(3):477-488. doi:10.1016/j.cell.2014.12.016 PMID:25619689 PMCID:PMC4624921

2014

• Evans RM, Mangelsdorf DJ. 2014. Nuclear receptors, RXR, and the Big Bang. Cell 157(1):255-266. doi:10.1016/j.cell.2014.03.012 PMID:24679540 PMCID:PMC4029515
• Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM. 2014. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell 159(1):80-93. doi:10.1016/j.cell.2014.08.007 PMID:25259922 PMCID:PMC4177038

2013

• Ding N, Yu RT, Subramaniam N, Sherman MH, Wilson C, Rao R, Leblanc M, Coulter S, He M, Scott C, Lau SL, Atkins AR, Barish GD, Gunton JE, Liddle C, Downes M, Evans RM. 2013. A vitamin D receptor / SMAD genomic circuit gates hepatic fibrotic response. Cell 153(3):601-613. doi:10.1016/j.cell.2013.03.028 PMID:23622244 PMCID:PMC3673534
• He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, Hoffman RM, Tateishi R, Koike K, Karin M. 2013. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell 155(2):384-396. doi:10.1016/j.cell.2013.09.031 PMID:24120137 PMCID:PMC4015514

2011

• Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D. 2011. An HNF4alpha-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis. Cell 147(6):1233-1247. doi:10.1016/j.cell.2011.10.043 PMID:22153071 PMCID:PMC3251960
• Holzer RG, Park E, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. 2011. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell 147(1):173-184. doi:10.1016/j.cell.2011.08.034 PMID:21962514 PMCID:PMC3295636

2010

• Park E, Lee J, Yu G, He G, Ali S, Holzer RG, Osterreicher CH, Takahashi H, Karin M. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140(2):197-208. doi:10.1016/j.cell.2009.12.052 PMID:20141834 PMCID:PMC2836922

2008

• Karin M, Budanov AV. 2008. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134(3):451-460. doi:10.1016/j.cell.2008.06.028 PMID:18692468 PMCID:PMC2758522

2006

• Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, Liu Y, Karin M. 2006. The E3 ubiquitin ligase itch couples JNK activation to TNF±-induced cell death by inducing c-FLIPL turnover. Cell 124:601-603. PMID:16469705
• Schroeder JI, Nambara E. 2006. A quick release mechanism for abscisic acid. Cell 126(6):1023-1025. PMID:16990126

2005

• Kamata H, Honda S, Maeda S, Hirata H, Karin M. 2005. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120(5):649-661. doi:10.1016/j.cell.2004.12.041 PMID:15766528
• Maeda S, Kamata H, Luo J, Leffert HL, Karin M. 2005. IKKB couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-990. PMID:15989949

2004

• Greten FR, Eckmann L, Greten TF, Park JM, Li Z, Egan LJ, Kagnoff MF, Karin M. 2004. IKKB links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118(3):285-296. PMID:15294155

2001

• Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson RS, Schmidt EV, Karin M. 2001. IKK± provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell 107:763-775. PMID:11747812
• Glass CK, Witzum JL. 2001. Atherosclerosis, the road ahead. Cell 104:503-516. PMID:11239408