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Who We Fund: Publications associated with Basic Cellular And Molecular Research - Metabolism

These search results have not been confirmed by NIEHS and are therefore, not official. They are to be used only for general information and to inform the public and grantees on the breadth of research funded by NIEHS.

Viewing 192 publications
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Publication Title Authors Grant Number(s) Journal (Pub date) PubMed Link Pub Year
"Ready-to-use" immunosensor for the detection of small molecules with fast readout.   Ding, Yuan; Cui, Panpan; Chen, He; Li, Jiao; Huang, Lianrun; González-Sapienza, Gualberto; Ham ... P42ES004699, R35ES030443 Biosens Bioelectron (2022 Apr 01) 35007993 Exiting the NIEHS site 2022 
A Fast and Selective Approach for Profiling Vicinal Diols Using Liquid Chromatography-Post Column De ...   Wan, Debin; Morisseau, Christophe; Hammock, Bruce D; Yang, Jun P42ES004699, R35ES030443 Molecules (2022 Jan 03) 35011515 Exiting the NIEHS site 2022 
Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P ...   Zhou, Guodong; Jiang, Weiwu; Xia, Guobin; Wang, Lihua; Richardson, Molly; Chu, Chun; Moorthy, ... P30ES030285, P42ES027725, R01ES029382 Antioxidants (Basel) (2022 Jan 05) 35052622 Exiting the NIEHS site 2022 
Camelization of a murine single-domain antibody against aflatoxin B1 and its antigen-binding analysi ...   Pang, Qian; Chen, Yanhong; Mukhtar, Hina; Xiong, Jing; Wang, Xiaohong; Xu, Ting; Hammock, Bru ... P42ES004699, R35ES030443 Mycotoxin Res (2022 Feb) 35023020 Exiting the NIEHS site 2022 
Clinical and Preclinical Evidence for Roles of Soluble Epoxide Hydrolase in Osteoarthritis Knee Pain ...   Gowler, Peter R W; Turnbull, James; Shahtaheri, Mohsen; Gohir, Sameer; Kelly, Tony; McReynolds, ... P42ES004699, R35ES030443 Arthritis Rheumatol (2022 04) 34672113 Exiting the NIEHS site 2022 
Design and Characterization of a Novel Hapten and Preparation of Monoclonal Antibody for Detecting A ...   Xu, Lingyuan; Abd El-Aty, A M; Shim, Jae-Han; Eun, Jong-Bang; Lei, Xingmei; Zhao, Jing; Zhang, ... P42ES004699, R35ES030443 Foods (2022 Jun 13) 35741925 Exiting the NIEHS site 2022 
Development of a Rapid Gold Nanoparticle Immunochromatographic Strip Based on the Nanobody for Detec ...   Zhou, Hui; He, Cong; Li, Zhenfeng; Huo, Jingqian; Xue, Yu; Xu, Xiaotong; Qi, Meng; Chen, Lai ... P42ES004699, R35ES030443 Biosensors (Basel) (2022 Jan 30) 35200344 Exiting the NIEHS site 2022 
Fluonanobody-based nanosensor via fluorescence resonance energy transfer for ultrasensitive detectio ...   Su, Benchao; Zhang, Zhong; Sun, Zhichang; Tang, Zongwen; Xie, Xiaoxia; Chen, Qi; Cao, Hongmei ... P42ES004699, R35ES030443 J Hazard Mater (2022 01 15) 34411960 Exiting the NIEHS site 2022 
Generation of bioluminescent enzyme immunoassay for ferritin by single-chain variable fragment and i ...   He, Qiyi; Yang, Li; Lin, Mingxia; Yang, Huiyi; Cui, Xiping; McCoy, Mark R; Hammock, Bruce D; ... P42ES004699, R35ES030443 Anal Bioanal Chem (2022 Sep) 35945290 Exiting the NIEHS site 2022 
Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary trace ...   Singh, Nalin; Li, Dongyang; McReynolds, Cindy B; Morisseau, Christophe; Hammock, Bruce D P42ES004699, R35ES030443 Anal Methods (2022 05 13) 35481804 Exiting the NIEHS site 2022 
Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imp ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2022 Jun 30) 35806297 Exiting the NIEHS site 2022 
Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal m ...   Sun, Cheng-Peng; Zhou, Jun-Jun; Yu, Zhen-Long; Huo, Xiao-Kui; Zhang, Juan; Morisseau, Christop ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2022 03 01) 35217618 Exiting the NIEHS site 2022 
Metabolism of Benzalkonium Chloride by CYP-Mediated ω-Oxidation and C-C Cleavage Followed by β-Oxida ...   Seguin, Ryan; Xu, Libin P30ES007033, R01ES031927, T32ES007032 FASEB J (2022 May) 35567457 Exiting the NIEHS site 2022 
Nanobodies for Accurate Recognition of Iso-tenuazonic Acid and Development of Sensitive Immunoassay ...   Wang, Feng; Yang, Yuan-Yuan; Wan, De-Bin; Li, Jia-Dong; Liang, Yi-Fan; Li, Zhen-Feng; Shen, Y ... P42ES004699, R35ES030443 Food Control (2022 Jun) 35989708 Exiting the NIEHS site 2022 
Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with ...   Zhang, Chuanzhen; Li, Wei; Li, Xiyuan; Wan, Debin; Mack, Savannah; Zhang, Jingjing; Wagner, K ... P30ES023513, P42ES004699, R35ES030443 PLoS One (2022) 35443010 Exiting the NIEHS site 2022 
Omega-6 Polyunsaturated Fatty Acids Enhance Tumor Aggressiveness in Experimental Lung Cancer Model: ...   Montecillo-Aguado, Mayra; Tirado-Rodriguez, Belen; Antonio-Andres, Gabriela; Morales-Martinez, M ... P42ES004699, R35ES030443 Int J Mol Sci (2022 May 31) 35682855 Exiting the NIEHS site 2022 
Phosphate-triggered ratiometric fluoroimmunoassay based on nanobody-alkaline phosphatase fusion for ...   Chen, Zi-Jian; Wu, Hui-Ling; Shen, Yu-Dong; Wang, Hong; Zhang, Yi-Feng; Hammock, Bruce; Li, Z ... P42ES004699, R35ES030443 J Hazard Mater (2022 02 15) 34629198 Exiting the NIEHS site 2022 
Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth.   Naeem, Zumer; Zukunft, Sven; Günther, Stephan; Liebner, Stefan; Weigert, Andreas; Hammock, Bru ... P42ES004699, R35ES030443 Pflugers Arch (2022 09) 35648219 Exiting the NIEHS site 2022 
sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate im ...   Bergmann, Christian B; McReynolds, Cindy B; Wan, Debin; Singh, Nalin; Goetzman, Holly; Caldwell ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2022 03 29) 35312372 Exiting the NIEHS site 2022 
Structural and mechanistic basis of σ-dependent transcriptional pausing.   Pukhrambam, Chirangini; Molodtsov, Vadim; Kooshkbaghi, Mahdi; Tareen, Ammar; Vu, Hoa; Skalenko, ... R21ES030791 Proc Natl Acad Sci U S A (2022 06 07) 35653571 Exiting the NIEHS site 2022 
The Aryl Hydrocarbon Receptor (AHR): A Novel Therapeutic Target for Pulmonary Diseases?   Shivanna, Binoy; Chu, Chun; Moorthy, Bhagavatula R01ES029382 Int J Mol Sci (2022 Jan 28) 35163440 Exiting the NIEHS site 2022 
The reproductive effects of the cancer chemotherapy agent, Carmofur, on Daphnia magna are mediated b ...   Gessner, Emily E; Shah, Manav H; Ghent, Bricen N; Westbrook, Nathaniel E; van den Hurk, Peter; ... R15ES017321, R15ES017321 Ecotoxicology (2022 Jul) 35579761 Exiting the NIEHS site 2022 
The Role of Hydrolases in Biology and Xenobiotics Metabolism.   Morisseau, Christophe P42ES004699, R35ES030443 Int J Mol Sci (2022 Apr 28) 35563260 Exiting the NIEHS site 2022 
2-(Piperidin-4-yl)acetamides as Potent Inhibitors of Soluble Epoxide Hydrolase with Anti-Inflammator ...   Martín-López, Juan; Codony, Sandra; Bartra, Clara; Morisseau, Christophe; Loza, María Isabel; S ... P42ES004699, R35ES030443 Pharmaceuticals (Basel) (2021 Dec 17) 34959721 Exiting the NIEHS site 2021 
A Soluble Epoxide Hydrolase Inhibitor, 1-TrifluoromethoxyPhenyl-3-(1-Propionylpiperidin-4-yl) Urea, ...   Jonnalagadda, Deepa; Wan, Debin; Chun, Jerold; Hammock, Bruce D; Kihara, Yasuyuki P42ES004699, R35ES030443 Int J Mol Sci (2021 Apr 28) 33925035 Exiting the NIEHS site 2021 
Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis.   Mavangira, Vengai; Kuhn, Matthew J; Abuelo, Angel; Morisseau, Christophe; Hammock, Bruce D; Sor ... P42ES004699, R35ES030443 Antioxidants (Basel) (2021 May 20) 34065244 Exiting the NIEHS site 2021 
Adrenic Acid-Derived Epoxy Fatty Acids Are Naturally Occurring Lipids and Their Methyl Ester Prodrug ...   Singh, Nalin; Barnych, Bogdan; Wagner, Karen M; Wan, Debin; Morisseau, Christophe; Hammock, Br ... P42ES004699, R35ES030443 ACS Omega (2021 Mar 16) 33748630 Exiting the NIEHS site 2021 
Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 ...   Cheng, Shen; Bo, Zhiyuan; Hollenberg, Paul; Osawa, Yoichi; Zhang, Haoming R21ES030791 J Biol Chem (2021 Jan-Jun) 33839156 Exiting the NIEHS site 2021 
Autism-like Behaviors in Male Juvenile Offspring after Maternal Glyphosate Exposure.   Pu, Yaoyu; Ma, Li; Shan, Jiajing; Wan, Xiayun; Hammock, Bruce D; Hashimoto, Kenji P42ES004699, R35ES030443 Clin Psychopharmacol Neurosci (2021 Aug 31) 34294625 Exiting the NIEHS site 2021 
Carcinogenesis: Failure of resolution of inflammation?   Fishbein, Anna; Hammock, Bruce D; Serhan, Charles N; Panigrahy, Dipak P42ES004699, R35ES030443 Pharmacol Ther (2021 02) 32891711 Exiting the NIEHS site 2021 
Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Ca ...   Thai, Phung N; Ren, Lu; Xu, Wilson; Overton, James; Timofeyev, Valeriy; Nader, Carol E; Haddad ... P42ES004699, R35ES030443 Cardiovasc Drugs Ther (2021 Sep 09) 34499283 Exiting the NIEHS site 2021 
COX-2/sEH Dual Inhibitor PTUPB Alleviates CCl 4 -Induced Liver Fibrosis and Portal Hypertension.   Zhao, Zhifeng; Zhang, Chihao; Lin, Jiayun; Zheng, Lei; Li, Hongjie; Qi, Xiaoliang; Huo, Haizh ... P42ES004699, R35ES030443 Front Med (Lausanne) (2021) 35004731 Exiting the NIEHS site 2021 
Development of a chemiluminescence immunoassay for detection of tenuazonic acid mycotoxin in fruit j ...   Wang, Feng; Wan, De-Bin; Shen, Yu-Dong; Tian, Yuan-Xin; Xiao, Zhi-Li; Xu, Zhen-Lin; Yang, Jin ... R35ES030443 Anal Methods (2021 04 22) 33885655 Exiting the NIEHS site 2021 
Development of a nanobody-based ELISA for the detection of the insecticides cyantraniliprole and chl ...   Xu, Bojie; Wang, Kai; Vasylieva, Natalia; Zhou, Hang; Xue, Xianle; Wang, Baomin; Li, Qing X; ... P42ES004699, R35ES030443 Anal Bioanal Chem (2021 Apr) 33580830 Exiting the NIEHS site 2021 
Development of a sensitive non-competitive immunoassay via immunocomplex binding peptide for the det ...   Fu, Hui-Jun; Chen, Zi-Jian; Wang, Hong; Luo, Lin; Wang, Yu; Huang, Ri-Ming; Xu, Zhen-Lin; Ham ... P42ES004699, R35ES030443 J Hazard Mater (2021 03 15) 33525128 Exiting the NIEHS site 2021 
Differential Effects of 17,18-EEQ and 19,20-EDP Combined with Soluble Epoxide Hydrolase Inhibitor t- ...   Yang, Yang; Xu, Xinyun; Wu, Haoying; Yang, Jun; Chen, Jiangang; Morisseau, Christophe; Hammock ... P42ES004699, R35ES030443 Int J Mol Sci (2021 Jul 31) 34361032 Exiting the NIEHS site 2021 
Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopo ...   Du, Fangyu; Sun, Wenjiao; Morisseau, Christophe; Hammock, Bruce D; Bao, Xuefei; Liu, Qiu; Wang ... P42ES004699, R35ES030443 Eur J Med Chem (2021 Nov 05) 34218083 Exiting the NIEHS site 2021 
Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.   Sun, Cheng-Peng; Zhang, Xin-Yue; Morisseau, Christophe; Hwang, Sung Hee; Zhang, Zhan-Jun; Hammo ... P42ES004699, R35ES030443 J Med Chem (2021 01 14) 33369424 Exiting the NIEHS site 2021 
Dual sEH/COX-2 Inhibition Using PTUPB-A Promising Approach to Antiangiogenesis-Induced Nephrotoxicit ...   Jankiewicz, Wojciech K; Barnett, Scott D; Stavniichuk, Anna; Hwang, Sung Hee; Hammock, Bruce D; ... P42ES004699, R35ES030443 Front Pharmacol (2021) 34955823 Exiting the NIEHS site 2021 
Effect of sex chromosomes versus hormones in neonatal lung injury.   Grimm, Sandra L; Dong, Xiaoyu; Zhang, Yuhao; Carisey, Alexandre F; Arnold, Arthur P; Moorthy, ... P30ES030285, P42ES027725, R01ES029382 JCI Insight (2021 07 08) 34061778 Exiting the NIEHS site 2021 
Eicosanoid regulation of debris-stimulated metastasis.   Deng, Jianjun; Yang, Haixia; Haak, Victoria M; Yang, Jun; Kipper, Franciele C; Barksdale, Chan ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2021 10 12) 34607951 Exiting the NIEHS site 2021 
EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increa ...   Gautheron, Jeremie; Morisseau, Christophe; Chung, Wendy K; Zammouri, Jamila; Auclair, Martine; ... P42ES004699, R35ES030443 Elife (2021 08 03) 34342583 Exiting the NIEHS site 2021 
From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase I ...   Codony, Sandra; Calvó-Tusell, Carla; Valverde, Elena; Osuna, Sílvia; Morisseau, Christophe; Loz ... P42ES004699, R35ES030443 J Med Chem (2021 05 13) 33945278 Exiting the NIEHS site 2021 
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty a ...   Wilt, Stephanie; Kodani, Sean; Valencia, Leah; Hudson, Paula K; Sanchez, Stephanie; Quintana, ... P42ES004699, R35ES030443 Bioorg Med Chem (2021 12 01) 34794001 Exiting the NIEHS site 2021 
Fusion expression of nanobodies specific for the insecticide fipronil on magnetosomes in Magnetospir ...   Wu, Sha; Ma, Fengfei; He, Jinxin; Li, Qing X; Hammock, Bruce D; Tian, Jiesheng; Xu, Ting P42ES004699, R35ES030443 J Nanobiotechnology (2021 Jan 19) 33468141 Exiting the NIEHS site 2021 
Generation of Dual functional Nanobody-Nanoluciferase Fusion and its potential in Bioluminescence En ...   Yu, Sheng; Li, Zhenfeng; Li, Jingzhang; Zhao, Shimei; Wu, Shanguang; Liu, Hongjing; Bi, Xiong ... P42ES004699, R35ES030443 Sens Actuators B Chem (2021 Jun 01) 35250176 Exiting the NIEHS site 2021 
Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat d ...   Koike, Shinichiro; Hsu, Ming-Fo; Bettaieb, Ahmed; Chu, Bryan; Matsumoto, Naoki; Morisseau, Chr ... P42ES004699, R35ES030443 Free Radic Biol Med (2021 08 20) 34038767 Exiting the NIEHS site 2021 
Highly specific nanobody against herbicide 2,4-dichlorophenoxyacetic acid for monitoring of its cont ...   Li, Zhen-Feng; Dong, Jie-Xian; Vasylieva, Natalia; Cui, Yong-Liang; Wan, De-Bin; Hua, Xiu-De; ... P42ES004699, R35ES030443 Sci Total Environ (2021 Jan 20) 32906044 Exiting the NIEHS site 2021 
HIV-related Neuropathy: Pathophysiology, Treatment and Challenges.   Jazebi, Noushin; Evans, Chad; Kadaru, Hima S; Kompella, Divya; Raji, Mukaila; Fang, Felix; Pap ... P42ES004699, R35ES030443 J Neurol Exp Neurosci (2021) 35252633 Exiting the NIEHS site 2021 
Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different ...   Tiwari, Shuchita; Yang, Jun; Morisseau, Christophe; Durbin-Johnson, Blythe; Hammock, Bruce D; G ... P42ES004699, R35ES030443 Sci Rep (2021 03 29) 33782432 Exiting the NIEHS site 2021 
Identification of the Functional Binding Site for the Convulsant Tetramethylenedisulfotetramine in t ...   Pressly, Brandon; Lee, Ruth D; Barnych, Bogdan; Hammock, Bruce D; Wulff, Heike R35ES030443 Mol Pharmacol (2021 01) 33109687 Exiting the NIEHS site 2021 
Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic ...   Hamilton, Matthew C; Heintz, Melissa M; Pfohl, Marisa; Marques, Emily; Ford, Lucie; Slitt, Ang ... P42ES027706, R15ES017321, R15ES017321 Food Chem Toxicol (2021 Jun) 33838175 Exiting the NIEHS site 2021 
Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out ...   Wang, Siming; Ishima, Tamaki; Qu, Youge; Shan, Jiajing; Chang, Lijia; Wei, Yan; Zhang, Jianch ... P42ES004699, R35ES030443 J Affect Disord (2021 09 01) 34147969 Exiting the NIEHS site 2021 
Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3β sig ...   Sun, Cheng-Peng; Zhang, Xin-Yue; Zhou, Jun-Jun; Huo, Xiao-Kui; Yu, Zhen-Long; Morisseau, Chris ... P42ES004699, R35ES030443 Food Chem Toxicol (2021 Oct) 34411643 Exiting the NIEHS site 2021 
Inhibition of the Soluble Epoxide Hydrolase as an Analgesic Strategy: A Review of Preclinical Eviden ...   Wang, Yuxin; Wagner, Karen M; Morisseau, Christophe; Hammock, Bruce D R35ES030443 J Pain Res (2021) 33488116 Exiting the NIEHS site 2021 
Innovative C2-symmetric testosterone and androstenedione dimers: Design, synthesis, biological evalu ...   Paquin, Alexis; Oufqir, Yassine; Sevrioukova, Irina F; Reyes-Moreno, Carlos; Bérubé, Gervais R01ES025767 Eur J Med Chem (2021 Aug 05) 33933755 Exiting the NIEHS site 2021 
Molecular docking-guided synthesis of NSAID-glucosamine bioconjugates and their evaluation as COX-1/ ...   Jones Lipinski, Rachel A; Thillier, Yann; Morisseau, Christophe; Sebastiano Jr, Christopher S; S ... R35ES030443 Chem Biol Drug Des (2021 07) 33955172 Exiting the NIEHS site 2021 
Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implica ...   Stading, Rachel; Gastelum, Grady; Chu, Chun; Jiang, Weiwu; Moorthy, Bhagavatula P30ES030285, P42ES027725, R01ES029382, R21ES032739 Semin Cancer Biol (2021 11) 34242741 Exiting the NIEHS site 2021 
Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats.   Khan, Md Abdul Hye; Hwang, Sung Hee; Barnett, Scott D; Stavniichuk, Anna; Jankiewicz, Wojciech ... R35ES030443 Br J Pharmacol (2021 11) 34255857 Exiting the NIEHS site 2021 
Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor ...   Mo, Fengzhen; Duan, Siliang; Jiang, Xiaobing; Yang, Xiaomei; Hou, Xiaoqiong; Shi, Wei; Carlos, ... P42ES004699, R35ES030443 Signal Transduct Target Ther (2021 02 25) 33627635 Exiting the NIEHS site 2021 
New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via R ...   Singh, Nalin; Vik, Anders; Lybrand, Daniel B; Morisseau, Christophe; Hammock, Bruce D P42ES004699, R35ES030443 Chem Res Toxicol (2021 12 20) 34817988 Exiting the NIEHS site 2021 
Nutrition, one-carbon metabolism and arsenic methylation.   Abuawad, Ahlam; Bozack, Anne K; Saxena, Roheeni; Gamble, Mary V P30ES009089, R01ES030945, R01ES030945 Toxicology (2021 06 15) 33905762 Exiting the NIEHS site 2021 
Pharmacokinetics, Metabolite Measurement and Biomarker Identification of Dermal Exposure to Permethr ...   Buchholz, Bruce A; Ahn, KiChang; Huang, Huazhang; Gee, Shirley J; Stewart, Benjamin; Ognibene, ... P42ES004699, R35ES030443 Toxicol Sci (2021 Jun 21) 34152416 Exiting the NIEHS site 2021 
Pharmacokinetics, Metabolite Measurement, and Biomarker Identification of Dermal Exposure to Permeth ...   Buchholz, Bruce A; Ahn, Ki Chang; Huang, Huazhang; Gee, Shirley J; Stewart, Benjamin J; Ogniben ... P42ES004699, R35ES030443 Toxicol Sci (2021 08 30) 34460930 Exiting the NIEHS site 2021 
Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.   Toupin, Nicholas; Steinke, Sean J; Nadella, Sandeep; Li, Ao; Rohrabaugh Jr, Thomas N; Samuels, ... R01ES025767 J Am Chem Soc (2021 06 23) 34110801 Exiting the NIEHS site 2021 
Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections.   McReynolds, Cindy B; Cortes-Puch, Irene; Ravindran, Resmi; Khan, Imran H; Hammock, Bruce G; Shi ... P42ES004699, R35ES030443 Front Physiol (2021) 33868029 Exiting the NIEHS site 2021 
Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and ca ...   Duflot, Thomas; Laurent, Charlotte; Soudey, Anne; Fonrose, Xavier; Hamzaoui, Mouad; Iacob, Mic ... P42ES004699, R35ES030443 Sci Rep (2021 02 12) 33580125 Exiting the NIEHS site 2021 
Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2021 Jan 16) 33467005 Exiting the NIEHS site 2021 
Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty A ...   Morisseau, Christophe; Kodani, Sean D; Kamita, Shizuo G; Yang, Jun; Lee, Kin Sing Stephen; Hamm ... P42ES004699, R35ES030443 Int J Mol Sci (2021 May 08) 34066758 Exiting the NIEHS site 2021 
Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative D ...   Burke, Rebecca; Chu, Chun; Zhou, Guo-Dong; Putluri, Vasanta; Putluri, Nagireddy; Stading, Rach ... P30ES030285, P42ES027725, R01ES029382 Oxid Med Cell Longev (2021) 34691356 Exiting the NIEHS site 2021 
Sex-Specific Differences in Resolution of Airway Inflammation in Fat-1 Transgenic Mice Following Rep ...   Ulu, Arzu; Velazquez, Jalene V; Burr, Abigail; Sveiven, Stefanie N; Yang, Jun; Bravo, Carissa; ... P42ES004699, R35ES030443 Front Pharmacol (2021) 35095496 Exiting the NIEHS site 2021 
Smartphone-Based Dual-Channel Immunochromatographic Test Strip with Polymer Quantum Dot Labels for S ...   Zhao, Yuting; Ruan, Xiaofan; Song, Yang; Smith, Jordan N; Vasylieva, Natalia; Hammock, Bruce D ... P42ES004699, R35ES030443 Anal Chem (2021 10 12) 34591463 Exiting the NIEHS site 2021 
Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mT ...   Wang, Luyun; Zhao, Daqiang; Tang, Liangqiu; Li, Huihui; Liu, Zhaoyu; Gao, Jingwei; Edin, Matt ... P42ES004699, R35ES030443 J Mol Cell Cardiol (2021 05) 33378686 Exiting the NIEHS site 2021 
Soluble Epoxide Hydrolase Deletion Limits High-Fat Diet-Induced Inflammation.   Wagner, Karen M; Yang, Jun; Morisseau, Christophe; Hammock, Bruce D P42ES004699, R35ES030443 Front Pharmacol (2021) 34975481 Exiting the NIEHS site 2021 
Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease.   Mello, Aline; Hsu, Ming-Fo; Koike, Shinichiro; Chu, Bryan; Cheng, Jeff; Yang, Jun; Morisseau, ... P42ES004699, R35ES030443 Cell Mol Gastroenterol Hepatol (2021) 33068774 Exiting the NIEHS site 2021 
Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury.   Jamieson, K Lockhart; Darwesh, Ahmed M; Sosnowski, Deanna K; Zhang, Hao; Shah, Saumya; Zhabyeye ... P42ES004699, R35ES030443 Int J Mol Sci (2021 Feb 08) 33567578 Exiting the NIEHS site 2021 
Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in ...   Matin, Nusrat; Fisher, Courtney; Lansdell, Theresa A; Hammock, Bruce D; Yang, Jun; Jackson, Wi ... P42ES004699, R35ES030443 Microcirculation (2021 01) 32767848 Exiting the NIEHS site 2021 
Sortase-Mediated Phage Decoration for Analytical Applications.   Ding, Yuan; Chen, He; Li, Jiao; Huang, Lianrun; Song, Guangyue; Li, Zhenfeng; Hua, Xiude; Gon ... P42ES004699, R35ES030443 Anal Chem (2021 08 31) 34415158 Exiting the NIEHS site 2021 
Species Differences in Metabolism of Soluble Epoxide Hydrolase Inhibitor, EC1728, Highlight the Impo ...   McReynolds, Cindy B; Yang, Jun; Guedes, Alonso; Morisseau, Christophe; Garcia, Roberto; Knych, ... P42ES004699, R35ES030443 Molecules (2021 Aug 19) 34443621 Exiting the NIEHS site 2021 
Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2021 May 29) 34072457 Exiting the NIEHS site 2021 
Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reducta ...   Ducharme, Julie; Sevrioukova, Irina F; Thibodeaux, Christopher J; Auclair, Karine R01ES025767 Biochemistry (2021 07 20) 34196520 Exiting the NIEHS site 2021 
Target-Mediated Drug Disposition-A Class Effect of Soluble Epoxide Hydrolase Inhibitors.   An, Guohua; Lee, Kin Sing Stephen; Yang, Jun; Hammock, Bruce D P42ES004699, R35ES030443 J Clin Pharmacol (2021 04) 33078430 Exiting the NIEHS site 2021 
The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury.   Stading, Rachel; Couroucli, Xanthi; Lingappan, Krithika; Moorthy, Bhagavatula P30ES030285, P42ES027725, R01ES029382 Expert Opin Drug Metab Toxicol (2021 Feb) 33215946 Exiting the NIEHS site 2021 
TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs ne ...   Bergmann, Christian B; Hammock, Bruce D; Wan, Debin; Gogolla, Falk; Goetzman, Holly; Caldwell, ... P42ES004699, R35ES030443 Sci Rep (2021 08 16) 34400718 Exiting the NIEHS site 2021 
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhi ...   Bukhari, I A; Alorainey, B I; Al-Motrefi, A A; Mahmoud, A; Campbell, W B; Hammock, B D P42ES004699, R35ES030443 Eur Rev Med Pharmacol Sci (2020 08) 32767352 Exiting the NIEHS site 2020 
2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Mode ...   Codony, Sandra; Pujol, Eugènia; Pizarro, Javier; Feixas, Ferran; Valverde, Elena; Loza, M Isab ... P42ES004699, R35ES030443 J Med Chem (2020 09 10) 32787085 Exiting the NIEHS site 2020 
A COX-2/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via ...   Zhang, Yan-Feng; Sun, Chen-Chen; Duan, Jia-Xi; Yang, Hui-Hui; Zhang, Chen-Yu; Xiong, Jian-Bing ... P42ES004699, R35ES030443 Biomed Pharmacother (2020 Jun) 32114358 Exiting the NIEHS site 2020 
A facile, sensitive and rapid sensing platform based on CoZnO for detection of fipronil; an environm ...   Kumar, Sanni; Vasylieva, Natalia; Singh, Vikrant; Hammock, Bruce; Singh, Shiv Govind P42ES004699, R35ES030443 Electroanalysis (2020 Sep) 33456276 Exiting the NIEHS site 2020 
A rapid and simple fluorescence enzyme-linked immunosorbent assay for tetrabromobisphenol A in soil ...   Fu, Hui-Jun; Wang, Yu; Xiao, Zhi-Li; Wang, Hong; Li, Zhen-Feng; Shen, Yu-Dong; Lei, Hong-Tao; ... P42ES004699, R35ES030443 Ecotoxicol Environ Saf (2020 Jan 30) 31704326 Exiting the NIEHS site 2020 
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease.   Ghosh, Anamitra; Comerota, Michele M; Wan, Debin; Chen, Fading; Propson, Nicholas E; Hwang, Su ... P42ES004699, R35ES030443 Sci Transl Med (2020 12 09) 33298560 Exiting the NIEHS site 2020 
An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors o ...   Samuels, Eric R; Sevrioukova, Irina F R01ES025767 Bioorg Med Chem (2020 03 15) 32044230 Exiting the NIEHS site 2020 
An Ultrasensitive Bioluminescent Enzyme Immunoassay Based on Nanobody/Nanoluciferase Heptamer Fusion ...   Li, Zhenfeng; Wang, Yi; Vasylieva, Natalia; Wan, Debin; Yin, Zihan; Dong, Jiexian; Hammock, B ... P42ES004699, R35ES030443 Anal Chem (2020 07 21) 32559059 Exiting the NIEHS site 2020 
Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid met ...   Huerta-Yepez, Sara; Tirado-Rodriguez, Ana; Montecillo-Aguado, Mayra R; Yang, Jun; Hammock, Bruc ... P42ES004699, R35ES030443 Sci Rep (2020 05 12) 32398692 Exiting the NIEHS site 2020 
Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach.   Stefanovski, Darko; Shih, Pei-An Betty; Hammock, Bruce D; Watanabe, Richard M; Youn, Jang H P42ES004699, R35ES030443 Prostaglandins Other Lipid Mediat (2020 06) 31931080 Exiting the NIEHS site 2020 
Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of ...   Burmistrov, Vladimir; Morisseau, Christophe; Karlov, Dmitry; Pitushkin, Dmitry; Vernigora, Andr ... P42ES004699, R35ES030443 Bioorg Med Chem Lett (2020 09 15) 32736212 Exiting the NIEHS site 2020 
Chemiluminescent Enzyme Immunoassay and Bioluminescent Enzyme Immunoassay for Tenuazonic Acid Mycoto ...   Wang, Feng; Li, Zhen-Feng; Yang, Yuan-Yuan; Wan, De-Bin; Vasylieva, Natalia; Zhang, Yu-Qi; Cai ... P42ES004699, R35ES030443 Anal Chem (2020 09 01) 32702970 Exiting the NIEHS site 2020 
Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine ...   Pressly, Brandon; Vasylieva, Natalia; Barnych, Bogdan; Singh, Vikrant; Singh, Latika; Bruun, D ... R35ES030443 Arch Toxicol (2020 06) 32239239 Exiting the NIEHS site 2020 
Cryo-EM reveals the architecture of the dimeric cytochrome P450 CYP102A1 enzyme and conformational c ...   Su, Min; Chakraborty, Sumita; Osawa, Yoichi; Zhang, Haoming R21ES030791 J Biol Chem (2020 02 07) 31901079 Exiting the NIEHS site 2020 
Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies.   Hildreth, Kelsey; Kodani, Sean D; Hammock, Bruce D; Zhao, Ling P42ES004699, R35ES030443 J Nutr Biochem (2020 12) 32827665 Exiting the NIEHS site 2020 
Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrol ...   Li, Dongyang; Cui, Yongliang; Morisseau, Christophe; Wagner, Karen M; Cho, Young Sik; Hammock, ... P42ES004699, R35ES030443 Anal Chem (2020 09 01) 32786492 Exiting the NIEHS site 2020 
Development of Improved Double-Nanobody Sandwich ELISAs for Human Soluble Epoxide Hydrolase Detectio ...   Li, Dongyang; Morisseau, Christophe; McReynolds, Cindy B; Duflot, Thomas; Bellien, Jérémy; Nagr ... P42ES004699, R35ES030443 Anal Chem (2020 05 19) 32253910 Exiting the NIEHS site 2020 
Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evalu ...   Wilt, Stephanie; Kodani, Sean; Le, Thanh N H; Nguyen, Lato; Vo, Nghi; Ly, Tanya; Rodriguez, M ... P42ES004699, R35ES030443 Bioorg Chem (2020 10) 32891856 Exiting the NIEHS site 2020 
Development of potent inhibitors of the human microsomal epoxide hydrolase.   Barnych, Bogdan; Singh, Nalin; Negrel, Sophie; Zhang, Yue; Magis, Damien; Roux, Capucine; Hua, ... P42ES004699, R35ES030443 Eur J Med Chem (2020 May 01) 32203787 Exiting the NIEHS site 2020 
Early antihypertensive treatment and ischemia-induced acute kidney injury.   Greite, Robert; Derlin, Katja; Hensen, Bennet; Thorenz, Anja; Rong, Song; Chen, Rongjun; Hellm ... R35ES030443 Am J Physiol Renal Physiol (2020 10 01) 32799675 Exiting the NIEHS site 2020 
Editorial: Clinical Paths for Soluble Epoxide Hydrolase Inhibitors.   Imig, John D; Morisseau, Christophe R35ES030443 Front Pharmacol (2020) 33071800 Exiting the NIEHS site 2020 
Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in I ...   Xie, Minhao; Yang, Jun; Zhang, Jianan; Sherman, Heather L; Zhang, Zhenyu; Minter, Lisa M; Hamm ... P42ES004699, R35ES030443 J Agric Food Chem (2020 Jul 22) 32594738 Exiting the NIEHS site 2020 
Eicosanoids: The Overlooked Storm in Coronavirus Disease 2019 (COVID-19)?   Hammock, Bruce D; Wang, Weicang; Gilligan, Molly M; Panigrahy, Dipak P42ES004699, R35ES030443 Am J Pathol (2020 09) 32650004 Exiting the NIEHS site 2020 
Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic.   Coarfa, Cristian; Grimm, Sandra L; Katz, Tiffany; Zhang, Yuhao; Jangid, Rahul K; Walker, Chery ... P30ES030285, P42ES027725, R01ES029382 Redox Biol (2020 10) 32961439 Exiting the NIEHS site 2020 
EpOMEs act as immune suppressors in a lepidopteran insect, Spodoptera exigua.   Vatanparast, Mohammad; Ahmed, Shabbir; Lee, Dong-Hee; Hwang, Sung Hee; Hammock, Bruce; Kim, Yo ... R35ES030443 Sci Rep (2020 11 19) 33214688 Exiting the NIEHS site 2020 
Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indi ...   McReynolds, Cindy; Morisseau, Christophe; Wagner, Karen; Hammock, Bruce P42ES004699, R35ES030443 Adv Exp Med Biol (2020) 32894508 Exiting the NIEHS site 2020 
Gender differences in diet-induced steatotic disease in Cyp2b-null mice.   Heintz, Melissa M; McRee, Rebecca; Kumar, Ramiya; Baldwin, William S R15ES017321, R15ES017321 PLoS One (2020) 32155178 Exiting the NIEHS site 2020 
Imidazolidine-2,4,5- and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hy ...   Burmistrov, Vladimir; Morisseau, Christophe; D'yachenko, Vladimir; Karlov, Dmitry; Butov, Genna ... P42ES004699, R35ES030443 Bioorg Med Chem Lett (2020 02 01) 31870649 Exiting the NIEHS site 2020 
Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major ps ...   Zhang, Jiancheng; Tan, Yunfei; Chang, Lijia; Hammock, Bruce D; Hashimoto, Kenji P42ES004699, R35ES030443 J Affect Disord (2020 06 01) 32339103 Exiting the NIEHS site 2020 
Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?   Panigrahy, Dipak; Gilligan, Molly M; Huang, Sui; Gartung, Allison; Cortés-Puch, Irene; Sime, P ... P42ES004699, R35ES030443 Cancer Metastasis Rev (2020 06) 32385712 Exiting the NIEHS site 2020 
Macromolecular modeling and design in Rosetta: recent methods and frameworks.   Leman, Julia Koehler; Weitzner, Brian D; Lewis, Steven M; Adolf-Bryfogle, Jared; Alam, Nawsad; ... P42ES004699, R35ES030443 Nat Methods (2020 07) 32483333 Exiting the NIEHS site 2020 
Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression ...   Pu, Yaoyu; Yang, Jun; Chang, Lijia; Qu, Youge; Wang, Siming; Zhang, Kai; Xiong, Zhongwei; Zha ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2020 05 26) 32398374 Exiting the NIEHS site 2020 
Molecular role of cytochrome P4501A enzymes inoxidative stress.   Stading, Rachel; Chu, Chun; Couroucli, Xanthi; Lingappan, Krithika; Moorthy, Bhagavatula P42ES027725, R01ES029382 Curr Opin Toxicol (2020 Apr-Jun) 33283080 Exiting the NIEHS site 2020 
N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Ep ...   Singh, Nalin; Barnych, Bogdan; Morisseau, Christophe; Wagner, Karen M; Wan, Debin; Takeshita, ... P42ES004699, R35ES030443 J Nat Prod (2020 12 24) 33320645 Exiting the NIEHS site 2020 
Novel metabolomic method to assess the effect-based removal efficiency of advanced wastewater treatm ...   Späth, Jana; Nording, Malin; Lindberg, Richard; Brodin, Tomas; Jansson, Stina; Yang, Jun; Wan, ... P42ES004699, R35ES030443 Environ Chem (2020) 33692653 Exiting the NIEHS site 2020 
Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-ind ...   Callaway, Danielle A; Jiang, Weiwu; Wang, Lihua; Lingappan, Krithika; Moorthy, Bhagavatula P42ES027725, R01ES029382 Free Radic Biol Med (2020 11 20) 32791187 Exiting the NIEHS site 2020 
Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin ...   Teixeira, Juliana Maia; Abdalla, Henrique Ballassini; Basting, Rosanna Tarkany; Hammock, Bruce D ... P42ES004699, R35ES030443 Int Immunopharmacol (2020 Oct) 32736189 Exiting the NIEHS site 2020 
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease.   Griñán-Ferré, Christian; Codony, Sandra; Pujol, Eugènia; Yang, Jun; Leiva, Rosana; Escolano, C ... P42ES004699, R35ES030443 Neurotherapeutics (2020 10) 32488482 Exiting the NIEHS site 2020 
Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A ...   Gastelum, Grady; Jiang, Weiwu; Wang, Lihua; Zhou, Guodong; Borkar, Roshan; Putluri, Nagireddy; ... P42ES027725, R01ES029382 Toxicol Sci (2020 10 01) 32726451 Exiting the NIEHS site 2020 
Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and he ...   Tao, Gabriel; Huang, Junqing; Moorthy, Bhagavatula; Wang, Cathryn; Hu, Ming; Gao, Song; Ghose, ... P30ES030285, P42ES027725, R01ES029382 Expert Opin Drug Metab Toxicol (2020 Nov) 32841068 Exiting the NIEHS site 2020 
Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties ...   Lee, Kin Sing Stephen; Ng, Jen C; Yang, Jun; Hwang, Sung-Hee; Morisseau, Christophe; Wagner, K ... P42ES004699, R35ES030443 Bioorg Med Chem (2020 11 15) 33007552 Exiting the NIEHS site 2020 
Production of a specific monoclonal antibody for 1-naphthol based on novel hapten strategy and devel ...   Chen, Zi-Jian; Liu, Xi-Xia; Xiao, Zhi-Li; Fu, Hui-Jun; Huang, Yu-Ping; Huang, Shu-Yi; Shen, Y ... P42ES004699, R35ES030443 Ecotoxicol Environ Saf (2020 Jun 15) 32247241 Exiting the NIEHS site 2020 
Protostane-type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials ...   Sun, Cheng-Peng; Zhang, Juan; Zhao, Wen-Yu; Yi, Jing; Yan, Jian-Kun; Wang, Ya-Li; Morisseau, ... P42ES004699, R35ES030443 Bioorg Chem (2020 03) 32032849 Exiting the NIEHS site 2020 
PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 infla ...   Sun, Chen-Chen; Zhang, Chen-Yu; Duan, Jia-Xi; Guan, Xin-Xin; Yang, Hui-Hui; Jiang, Hui-Ling; H ... P42ES004699, R35ES030443 Biochem Biophys Res Commun (2020 03 19) 31973813 Exiting the NIEHS site 2020 
Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellula ...   Fishbein, Anna; Wang, Weicang; Yang, Haixia; Yang, Jun; Hallisey, Victoria M; Deng, Jianjun; V ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2020 09 01) 32801214 Exiting the NIEHS site 2020 
Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine.   Shihadih, Diyala S; Harris, Todd R; Kodani, Sean D; Hwang, Sung-Hee; Lee, Kin Sing Stephen; Mav ... P42ES004699, R35ES030443 Front Vet Sci (2020) 33005645 Exiting the NIEHS site 2020 
Sensitive Immunochromatographic Assay Using Highly Luminescent Quantum Dot Nanobeads as Tracer for t ...   Li, Pan; Yang, Cuifeng; Liu, Beibei; Wu, Qin; Wang, Yulong; Dong, Sa; Zhang, Hanxiaoya; Vasyl ... P42ES004699, R35ES030443 Front Chem (2020) 32760698 Exiting the NIEHS site 2020 
Simultaneous Target-Mediated Drug Disposition Model for Two Small-Molecule Compounds Competing for T ...   Wu, Nan; Hammock, Bruce D; Lee, Kin Sing Stephen; An, Guohua P42ES004699, R35ES030443 J Pharmacol Exp Ther (2020 07) 32238455 Exiting the NIEHS site 2020 
Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglyc ...   Overby, Haley; Yang, Yang; Xu, Xinyun; Graham, Katherine; Hildreth, Kelsey; Choi, Sue; Wan, D ... P42ES004699, R35ES030443 Int J Mol Sci (2020 Sep 24) 32987880 Exiting the NIEHS site 2020 
Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis mode ...   Trindade-da-Silva, Carlos A; Clemente-Napimoga, Juliana T; Abdalla, Henrique B; Rosa, Sergio Mar ... P42ES004699, R35ES030443 FASEB J (2020 07) 32400048 Exiting the NIEHS site 2020 
Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfuncti ...   Wang, Yuxin; Yang, Jun; Wang, Weicang; Sanidad, Katherine Z; Cinelli, Maris A; Wan, Debin; Hwa ... P42ES004699, R35ES030443 Proc Natl Acad Sci U S A (2020 04 14) 32220957 Exiting the NIEHS site 2020 
Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain.   Wagner, Karen M; Gomes, Aldrin; McReynolds, Cindy B; Hammock, Bruce D P42ES004699, R35ES030443 Neurotherapeutics (2020 07) 32875445 Exiting the NIEHS site 2020 
Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac ...   Sirish, Padmini; Thai, Phung N; Lee, Jeong Han; Yang, Jun; Zhang, Xiao-Dong; Ren, Lu; Li, Nin ... P42ES004699, R35ES030443 Stem Cells Transl Med (2020 12) 32790136 Exiting the NIEHS site 2020 
Unexpected Differences between Two Closely Related Bacterial P450 Camphor Monooxygenases.   Murarka, Vidhi C; Batabyal, Dipanwita; Amaya, Jose A; Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Biochemistry (2020 07 28) 32551522 Exiting the NIEHS site 2020 
Using sulfuramidimidoyl fluorides that undergo sulfur(VI) fluoride exchange for inverse drug discove ...   Brighty, Gabriel J; Botham, Rachel C; Li, Suhua; Nelson, Luke; Mortenson, David E; Li, Genchen ... P42ES004699, R35ES030443 Nat Chem (2020 10) 32868886 Exiting the NIEHS site 2020 
Vascular Lipidomic Profiling of Potential Endogenous Fatty Acid PPAR Ligands Reveals the Coronary Ar ...   Edin, Matthew L; Lih, Fred B; Hammock, Bruce D; Thomson, Scott; Zeldin, Darryl C; Bishop-Bailey ... P42ES004699, R35ES030443 Cells (2020 04 29) 32365470 Exiting the NIEHS site 2020 
Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish.   Knuth, Megan M; Mahapatra, Debabrata; Jima, Dereje; Wan, Debin; Hammock, Bruce D; Law, Mac; Ku ... P30ES025128, P42ES004699, R35ES030443, T32ES007046 Sci Rep (2020 09 29) 32994480 Exiting the NIEHS site 2020 
ω-3 Polyunsaturated Fatty Acids on Colonic Inflammation and Colon Cancer: Roles of Lipid-Metabolizin ...   Tu, Maolin; Wang, Weicang; Zhang, Guodong; Hammock, Bruce D P42ES004699, R35ES030443 Nutrients (2020 Oct 28) 33126566 Exiting the NIEHS site 2020 
1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea, a Selective and Potent Dual Inhibitor o ...   Liang, Zhibin; Zhang, Bei; Xu, Meng; Morisseau, Christophe; Hwang, Sung Hee; Hammock, Bruce D; ... P42ES004699, R35ES030443 ACS Chem Neurosci (2019 09 18) 31378059 Exiting the NIEHS site 2019 
Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epile ...   Shen, Yijun; Peng, Weifeng; Chen, Qinglan; Hammock, Bruce D; Liu, Junyan; Li, Dongyang; Yang, ... P42ES004699, R35ES030443 Brain Behav Immun (2019 10) 31306773 Exiting the NIEHS site 2019 
Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts f ...   Suter, Melissa A; Aagaard, Kjersti M; Coarfa, Cristian; Robertson, Matthew; Zhou, Guodong; Jack ... P30ES030285, P42ES027725, R01ES029382 Biochem Biophys Res Commun (2019 08 20) 31208719 Exiting the NIEHS site 2019 
Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced N ...   Rooney, John P; Oshida, Keiyu; Kumar, Ramiya; Baldwin, William S; Corton, J Christopher R15ES017321, R15ES017321 Toxicol Sci (2019 01 01) 30203046 Exiting the NIEHS site 2019 
Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution.   Chuo, Shih-Wei; Liou, Shu-Hao; Wang, Lee-Ping; Britt, R David; Poulos, Thomas L; Sevrioukova, ... R01ES025767 Biochemistry (2019 09 17) 31456404 Exiting the NIEHS site 2019 
Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis.   Heintz, Melissa M; Kumar, Ramiya; Rutledge, Meredith M; Baldwin, William S R15ES017321, R15ES017321 J Nutr Biochem (2019 08) 31202118 Exiting the NIEHS site 2019 
Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways.   Lee, Kin Sing Stephen; Yang, Jun; Niu, Jun; Ng, Connie J; Wagner, Karen M; Dong, Hua; Kodani, ... R35ES030443 ACS Cent Sci (2019 Sep 25) 31572788 Exiting the NIEHS site 2019 
Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation.   Dileepan, Mythili; Rastle-Simpson, Stephanie; Greenberg, Yana; Wijesinghe, Dayanjan S; Kumar, N ... R35ES030443 Front Pharmacol (2019) 31611798 Exiting the NIEHS site 2019 
Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic ac ...   Rand, Amy A; Rajamani, Anita; Kodani, Sean D; Harris, Todd R; Schlatt, Lukas; Barnych, Bodgan; ... P42ES004699, R35ES030443 J Lipid Res (2019 12) 31641036 Exiting the NIEHS site 2019 
Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules.   Sevrioukova, Irina R01ES025767 Biochemistry (2019 02 19) 30676743 Exiting the NIEHS site 2019 
Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and earl ...   Hassanin, A A I; Tavera-Garcia, M; Moorthy, B; Zhou, G D; Ramos, K S P30ES030285, P42ES027725, R01ES029382 Am J Physiol Lung Cell Mol Physiol (2019 12 01) 31596105 Exiting the NIEHS site 2019 
Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine.   Luo, Lin; Wei, Xiao-Qun; Jia, Bao-Zhu; Yang, Jin-Yi; Shen, Yu-Dong; Hammock, Bruce; Dong, Jie ... P42ES004699, R35ES030443 Biomolecules (2019 10 11) 31614550 Exiting the NIEHS site 2019 
Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors as a First Ste ...   Baldwin, William S R15ES017321, R15ES017321 Nucl Receptor Res (2019) 31815118 Exiting the NIEHS site 2019 
Pilot-Scale Pyrolytic Remediation of Crude-Oil-Contaminated Soil in a Continuously-Fed Reactor: Trea ...   Song, Wen; Vidonish, Julia E; Kamath, Roopa; Yu, Pingfeng; Chu, Chun; Moorthy, Bhagavatula; Ga ... P30ES030285, P42ES027725, R01ES029382 Environ Sci Technol (2019 02 19) 30681845 Exiting the NIEHS site 2019 
Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deox ...   Chen, Yu-Jie; Zhang, Jian; Zhu, Ping-Ping; Tan, Xian-Wen; Lin, Qiu-Hong; Wang, Wen-Xia; Yin, ... R01ES025767 Drug Metab Dispos (2019 06) 30918015 Exiting the NIEHS site 2019 
Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, ...   Sevrioukova, Irina F R01ES025767 Int J Mol Sci (2019 Aug 30) 31480231 Exiting the NIEHS site 2019 
Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group St ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Biochemistry (2019 04 16) 30912932 Exiting the NIEHS site 2019 
Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome ...   Taneja, Guncha; Maity, Suman; Jiang, Weiwu; Moorthy, Bhagavatula; Coarfa, Cristian; Ghose, Rom ... P30ES030285, R01ES029382 Sci Rep (2019 04 30) 31040347 Exiting the NIEHS site 2019 
Cyp2b-Knockdown Mice Poorly Metabolize Corn Oil and Are Age-Dependent Obese.   Damiri, Basma; Baldwin, William S R15ES017321, R15ES017321 Lipids (2018 09) 30421529 Exiting the NIEHS site 2018 
Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids.   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Tetrahedron Lett (2018 Mar 21) 30140110 Exiting the NIEHS site 2018 
High fat diet induced obesity is mitigated in Cyp3a-null female mice.   Kumar, Ramiya; Litoff, Elizabeth J; Boswell, W Tyler; Baldwin, William S R15ES017321, R15ES017321 Chem Biol Interact (2018 Jun 01) 29738703 Exiting the NIEHS site 2018 
Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of ...   Samuels, Eric R; Sevrioukova, Irina R01ES025767 Mol Pharm (2018 01 02) 29232137 Exiting the NIEHS site 2018 
Non-Mammalian Nuclear Receptors: From Evolution to Human Disease.   Gissendanner, Chris R; Baldwin, William S; Schaaf, Marcel J M R15ES017321, R15ES017321 Nucl Receptor Res (2018) 30221173 Exiting the NIEHS site 2018 
Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling ...   Polic, Vanja; Sevrioukova, Irina F; Auclair, Karine R01ES025767 Arch Biochem Biophys (2018 09 01) 29958895 Exiting the NIEHS site 2018 
Annotation of the Nuclear Receptors in an Estuarine Fish species, Fundulus heteroclitus.   Baldwin, William S; Boswell, W Tyler; Ginjupalli, Gautam; Litoff, Elizabeth J R15ES017321, R15ES017321 Nucl Receptor Res (2017) 28804711 Exiting the NIEHS site 2017 
Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-n ...   Kumar, Ramiya; Mota, Linda C; Litoff, Elizabeth J; Rooney, John P; Boswell, W Tyler; Courter, ... R15ES017321, R15ES017321 PLoS One (2017) 28350814 Exiting the NIEHS site 2017 
Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin al ...   Sengupta, Namrata; Reardon, Delaney C; Gerard, Patrick D; Baldwin, William S R15ES017321, R15ES017321 PLoS One (2017) 28542405 Exiting the NIEHS site 2017 
Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.   Guo, Zhijun; Sevrioukova, Irina F; Denisov, Ilia G; Zhang, Xia; Chiu, Ting-Lan; Thomas, Dafydd ... P30ES013508, R01ES025767 Cell Chem Biol (2017 Oct 19) 28919040 Exiting the NIEHS site 2017 
High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4.   Sevrioukova, Irina F R01ES025767 Biochemistry (2017 06 20) 28590129 Exiting the NIEHS site 2017 
RNA sequencing indicates that atrazine induces multiple detoxification genes in Daphnia magna and th ...   Schmidt, Allison M; Sengupta, Namrata; Saski, Christopher A; Noorai, Rooksana E; Baldwin, Willi ... R15ES017321, R15ES017321 Chemosphere (2017 Dec) 28968576 Exiting the NIEHS site 2017 
Soluble Epoxide Hydrolase Inhibitor Suppresses the Expression of Triggering Receptor Expressed on My ...   Dong, Liang; Zhou, Yong; Zhu, Zhao-Qiong; Liu, Tian; Duan, Jia-Xi; Zhang, Jun; Li, Ping; Hamm ... P42ES004699, R35ES030443 Inflammation (2017 Feb) 27696333 Exiting the NIEHS site 2017 
Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4.   Sevrioukova, Irina F; Poulos, Thomas L R01ES025767 Proc Natl Acad Sci U S A (2017 01 17) 28031486 Exiting the NIEHS site 2017 
Perturbations in polar lipids, starvation survival and reproduction following exposure to unsaturate ...   Sengupta, Namrata; Gerard, Patrick D; Baldwin, William S R15ES017321, R15ES017321 Chemosphere (2016 Feb) 26606184 Exiting the NIEHS site 2016 
Arachidonic acid enhances reproduction in Daphnia magna and mitigates changes in sex ratios induced ...   Ginjupalli, Gautam K; Gerard, Patrick D; Baldwin, William S R15ES017321, R15ES017321 Environ Toxicol Chem (2015 Mar) 25393616 Exiting the NIEHS site 2015 
Repression of multiple CYP2D genes in mouse primary hepatocytes with a single siRNA construct.   Elraghy, Omaima; Baldwin, William S R15ES017321, R15ES017321 In Vitro Cell Dev Biol Anim (2015 Jan) 25124873 Exiting the NIEHS site 2015 
The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA.   Sengupta, Namrata; Litoff, Elizabeth J; Baldwin, William S R15ES017321, R15ES017321 Chemosphere (2015 Jun) 25747156 Exiting the NIEHS site 2015 
Annotation of the Daphnia magna nuclear receptors: comparison to Daphnia pulex.   Litoff, Elizabeth J; Garriott, Travis E; Ginjupalli, Gautam K; Butler, LaToya; Gay, Claudy; Sco ... R15ES017321, R15ES017321 Gene (2014 Nov 15) 25239664 Exiting the NIEHS site 2014 
The HR97 (NR1L) group of nuclear receptors: a new group of nuclear receptors discovered in Daphnia s ...   Li, Yangchun; Ginjupalli, Gautam K; Baldwin, William S R15ES017321, R15ES017321 Gen Comp Endocrinol (2014 Sep 15) 25092536 Exiting the NIEHS site 2014 
The time- and age-dependent effects of the juvenile hormone analog pesticide, pyriproxyfen on Daphni ...   Ginjupalli, Gautam K; Baldwin, William S R15ES017321, R15ES017321 Chemosphere (2013 Aug) 23714148 Exiting the NIEHS site 2013 
Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor.   Karimullina, Elina; Li, Yangchun; Ginjupalli, Gautam K; Baldwin, William S R15ES017321, R15ES017321 Aquat Toxicol (2012 Jul 15) 22466357 Exiting the NIEHS site 2012 
Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function.   Damiri, Basma; Holle, Eric; Yu, Xianzhong; Baldwin, William S R15ES017321, R15ES017321 Toxicol Sci (2012 Feb) 22083726 Exiting the NIEHS site 2012 
Nonylphenol-mediated CYP induction is PXR-dependent: The use of humanized mice and human hepatocytes ...   Mota, Linda C; Barfield, Christina; Hernandez, Juan P; Baldwin, William S R15ES017321, R15ES017321 Toxicol Appl Pharmacol (2011 May 1) 21376070 Exiting the NIEHS site 2011 
Selective imaging and killing of cancer cells with protein-activated near-infrared fluorescing nanop ...   Rungta, Parul; Bandera, Yuriy P; Roeder, Ryan D; Li, Yangchun; Baldwin, William S; Sharma, Dee ... R15ES017321, R15ES017321 Macromol Biosci (2011 Jul 07) 21480531 Exiting the NIEHS site 2011 
Constitutive androstane receptor -null mice are sensitive to the toxic effects of parathion: associa ...   Mota, Linda C; Hernandez, Juan P; Baldwin, William S R15ES017321, R15ES017321 Drug Metab Dispos (2010 Sep) 20573718 Exiting the NIEHS site 2010 
Dose-responsive gene expression changes in juvenile and adult mummichogs (Fundulus heteroclitus) aft ...   Gonzalez, Horacio O; Hu, Jianjun; Gaworecki, Kristen M; Roling, Jonathan A; Baldwin, William S; ... R15ES017321, R15ES017321 Mar Environ Res (2010 Aug) 20451245 Exiting the NIEHS site 2010 
Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: ...   Van Aggelen, Graham; Ankley, Gerald T; Baldwin, William S; Bearden, Daniel W; Benson, William H ... R15ES017321, R15ES017321 Environ Health Perspect (2010 Jan) 20056575 Exiting the NIEHS site 2010 
Interactions of the crustacean nuclear receptors HR3 and E75 in the regulation of gene transcription ...   Hannas, Bethany R; Wang, Ying H; Baldwin, William S; Li, Yangchun; Wallace, Andrew D; LeBlanc, ... R15ES017321, R15ES017321, T32ES007046 Gen Comp Endocrinol (2010 Jun 1) 20346363 Exiting the NIEHS site 2010 
A concentration addition model for the activation of the constitutive androstane receptor by xenobio ...   Baldwin, William S; Roling, Jonathan A R15ES017321, R15ES017321 Toxicol Sci (2009 Jan) 18832183 Exiting the NIEHS site 2009 
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolis ...   Hernandez, J P; Mota, L C; Baldwin, W S R15ES017321, R15ES017321 Curr Pharmacogenomics Person Med (2009 Jun 01) 20871735 Exiting the NIEHS site 2009 
Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).   Hernandez, J P; Mota, L C; Huang, W; Moore, D D; Baldwin, W S R15ES017321, R15ES017321 Toxicology (2009 Feb 4) 19041682 Exiting the NIEHS site 2009 
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