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Michigan State University

Superfund Research Program

Modulated Gap Junctional Intercellular Communication as a Biomarker for Epigenetic Toxicants after Remediation

Project Leader: James E. Trosko
Grant Number: P42ES004911
Funding Period: 1995 - 2006

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Project Summary (1995-2000)

The aims of this project are to: (1) assess the toxicity of environmental contaminants, before and after remediation, using an in vitro assay of the ability of cells to communicate with each other through gap junctions; (2) modify remediation systems that use ozone and/or Fenton's reagent to minimize toxicity of the products; and (3) to delineate the biochemical mechanisms by which non-genotoxic chemicals might affect gap junctional intercellular communication (GJIC). The working hypothesis is that GJIC is necessary for control of proliferation, differentiation and adaptive responses of cells.

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