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University of Arizona

Superfund Research Program

Research Support Core

Project Leader: Jon Chorover
Grant Number: P42ES004940
Funding Period: 2000-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Project Summary (2010-2015)

The objective of the Hazard Identification Core is to provide toxicological and analytical services that are utilized by virtually all of the program's Biomedical and Environmental Sciences Research Projects. This Core provides a number of services that many investigators require and that some investigators need, but are not technologically equipped to perform. The objectives of this Core are to provide research support in two areas: Biological Response and Metal Analysis. The Biological Response section includes ecotoxicity (bacterial and daphnia), mammalian cytotoxicity (HepG2 cells), and genotoxicity (Ames) assays. The daphnia - ecotoxicity analyses is performed in a consortium agreement with the Dartmouth SBRP. The Metal Analyses section uses ICP-Mass Spectrometer analysis for total metal content and HPLC-ICP-MS for analysis of chemical species of metal. Multiple metals are analyzed but the majority of the analyses is for arsenic and its chemical species (e.g. metabolites). The Hazard Identification Core efficiently provides common analyses (biological or metal analyses) to its SBRP investigators thus allowing for more SBRP funds to be directed to the individual research projects as well as uniform quality control of the analyses.

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