Skip Navigation

Dartmouth College

Maintenance notice: We are currently addressing issues with broken links due to recent major website changes. We apologize for any inconvenience and appreciate your patience. Please contact brittany.trottier@niehs.nih.gov for assistance.

Superfund Research Program

Molecular Biology Core

Project Leader: Joshua W. Hamilton (Marine Biological Laboratory)
Grant Number: P42ES007373
Funding Period: 2000-2008

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Twitter page Visit the grantee's Facebook page Visit the grantee's Video page

Project Summary (2000-2005)

The Molecular Biology Core Facility is a shared resource that provides and integrates a number of related molecular biology and biochemistry services. The overall goal is to provide these services in a low-cost, timely and high quality manner, using existing and pending state-of-the-art equipment and full-time technical personnel. This Core provides macromolecular (DNA, RNA, peptides, proteins) sequencing and synthesis services including standard and custom oligonucleotide synthesis; automated cycle DNA sequencing; peptide synthesis and purification; automated protein sequencing; LCQ-Mass spectral analysis macromolecules; and HPLC and PCR support services. Project investigators provide image generation and analysis services including phosphorimaging, digital densitometry and analysis; x-ray film processing; and flow cytometry. Additionally, the researchers provide support for development of molecular biomarkers including differential display analysis; ribonuclease protection assay analysis; Affymetrix-based cDNA/gene "chip" technology; user-generated custom cDNA array capabilities; cloning and sequencing support for newly identified sequences; support for computer-based sequence analysis; genetic polymorphism analysis; method development for potential protein and nucleic acid-based biomarkers for application in ecological and epidemiological tials as well as for further hypothesis testing in the more basic research projects.

Back
to Top