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University of California-Davis

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Superfund Research Program

Development of Rapid, Miniaturized Biosensors

Project Leader: Ian M. Kennedy
Grant Number: P42ES004699
Funding Period: 2000-2015

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Project Summary (2010-2015)

The goal of Kennedy's research is to apply new and emerging technologies to implement bioassays that his colleagues at Davis have developed with improvements in speed and/or sensitivity compared to conventional methods. Several new schemes for detection are being tested, including a nanowell format for trapping and interrogating non-bleaching nanoparticle labels for DNA and immune assays; a magnetic/luminescent nanoparticle format for DNA assays; and a nanostructured liquid core waveguide for enhancement of fluorescence detection. The targets under investigation include the pyrethroid metabolite 3-PBA, emerging problem compounds such as TCC, TCS and PBDE, and genes for microbes that are used in bioremediation activities. A sensor for TCDD and related compounds is being developed based on AhR technology.

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