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University of California-Berkeley

Superfund Research Program

Toxicogenomics Laboratory

Project Leader: Christine F. Skibola
Co-Investigator: Christopher D. Vulpe
Grant Number: P42ES004705
Funding Period: 2006-2017

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Project Summary (2006-2011)

The overall goal of the Berkeley Superfund Basic Research Program (SBRP) is to apply functional genomics, proteomics, transcriptomics, and nanotechnology to better detect arsenic, mercury, benzene, polycyclic aromatic hydrocarbons, trichloroethylene, and other Superfund priority chemicals in the environment; evaluate their effects on human health, especially the health of susceptible populations such as children; and remediate their presence and reduce their toxicity. The individual research projects use functional genomics, proteomics, and transcriptomics in their studies. Their success largely depends on the effective handling and management of biological samples, as well as access to and expertise in the latest "-omic" technologies. Thus, detailed collection and storage protocols have been designed and core facilities are being provided for the cytogenetic, genotyping, gene expression and proteomic analyses to be undertaken in the research projects. Specific Core activities include: 1) processing, maintaining and storeing biological samples and cell lines; 2) providing facilities and methodologies for cytogenetic analysis; 3) providing facilities for gene expression profiling using Affymetrix, Illumina, and custom array technologies; 4) providing facilities for proteomic analyses using various mass spectrometric technologies; and, 5) providing facilities and methodologies for the analysis of genetic polymorphisms by Taqman-based and bead array technologies using the ABI 7900 Sequence Detection System and Illumina Bead Station platforms.

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